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    #307 ‒ Exercise for aging people: where to begin, and how to minimize risk while maximizing potential | Peter Attia, M.D.

    enJune 24, 2024

    Podcast Summary

    • Exercising after 50It's essential to start exercising after 50 to maintain strength and reduce the risk of falling, but the longer you wait, the more effort and risk you may need to put in to see significant results.

      It's never too late to start exercising, no matter your age. Using the analogy of saving for retirement, the longer you wait to begin, the more effort and risk you may need to put in to see significant results. The host emphasizes this point for those over 50, as this age range begins to notice reductions in strength and increased risk of falling. Exercise remains crucial for longevity, and the four pillars – cardio, resistance training, flexibility, and balance – should be considered for an effective routine. While this conversation is more conversational and less technical than usual, studies and resources will be provided in the show notes for further exploration.

    • Aging and FitnessMaintaining muscle mass and physical activity levels throughout life is crucial for optimal health and independence as we age. Comprehensive training targeting stability, strength, aerobic efficiency, and peak aerobic output is ideal.

      Maintaining stability, strength, aerobic efficiency, and peak aerobic output throughout our lives is crucial for optimal health and functioning. These elements are interconnected and essential for various activities. While some training may focus on one aspect, comprehensive training that targets all four elements is ideal. Muscle mass and physical activity levels decline as we age, and these trends become more significant after age 75. This decline can lead to a vicious cycle of muscle loss and decreased activity. It's essential to avoid major setbacks and maintain these elements to age gracefully and independently. The graphs showing muscle mass and physical activity levels across different age groups illustrate these trends. Regardless of initial fitness levels, everyone can expect a significant drop in these areas as they age.

    • Exercise variability and movement qualityFocusing on exercise variability and movement quality is essential for injury prevention and effective training, especially for those over 50. Start with realistic goals and habits, and prioritize aerobic capacity improvement for overall fitness success.

      No matter your age, focusing on exercise variability and movement quality is crucial for injury prevention and effective training. This is especially important for those over 50, as we become more prone to injury despite our training history. When starting or returning to exercise, it's essential to begin with realistic goals and habits, such as daily activity and bodyweight exercises. Aerobic capacity, a key aspect of fitness, can be significantly improved in older and untrained individuals, making it a valuable area of focus. By prioritizing these principles, we can set ourselves up for a positive and successful exercise journey.

    • Cardio fitness in older and younger adultsOlder and younger adults can significantly improve their cardio fitness levels through regular aerobic exercise, but older adults may decline faster during deconditioning periods, emphasizing the importance of consistency in maintaining gains.

      Older adults and younger adults have the ability to significantly improve their cardio fitness levels through regular aerobic exercise, as shown in a study using a cycling training program. Both age groups saw a similar percentage increase in VO2 max, maximal workload, and endurance capacity. However, the older group declined faster during an eight-week deconditioning period, emphasizing the importance of consistency in maintaining fitness gains. This study highlights the malleability of the cardio system and the potential for continuous improvement over a long period of time. To help someone get started on a cardio training program, it's recommended to begin with base building, starting with two days a week, 30-minute sessions, as even low-volume training can provide benefits for those who are deconditioned. Additionally, using the rate of perceived exertion, such as the talk test, or the Maffetone Maximum Aerobic Performance formula can help determine the appropriate heart rate zones for training.

    • Exercise Intensity FactorsHeart rate and RPE are crucial factors for determining exercise intensity, but conditioned individuals may rely more on RPE or lactate threshold. VO2 Max, the maximum volume of oxygen an individual can utilize, is a significant biomarker for both lifespan and healthspan, and maintaining a healthy VO2 Max level is essential for a good quality of life as it declines with age.

      Both heart rate and RPE (Rate of Perceived Exertion) are important factors in determining exercise intensity, but as individuals get more conditioned, they may rely more on RPE or even lactate threshold to guide their workouts. Additionally, VO2 Max (maximum volume of oxygen an individual can utilize) is a crucial biomarker for both lifespan and healthspan. It integrates the volume of work done over time, and the benefits of that work are reflected in the VO2 Max number. As VO2 Max declines with age, individuals lose capacity, making it essential to maintain a healthy VO2 Max level for a good quality of life.

    • Cardiovascular fitness in midlifeMaintaining a high VO2 max in midlife is crucial for performing daily activities in old age. Build a solid aerobic base and gradually add interval training with a focus on 3-8 minute workouts.

      Maintaining a high level of cardiovascular fitness throughout midlife is crucial for being able to perform activities of daily living in the last decade of life. The data shows that having a VO2 max in the high 20s to 30 is necessary for most people in their final decade. To achieve this level of fitness, it's essential to build a solid aerobic base first and gradually add more intense interval training. The sweet spot for VO2 max training is three to eight minutes of work, where you push yourself as hard as possible and aim to maintain a consistent work output. Remember, the goal is to improve fitness without increasing the risk of injury.

    • Cardio and strength training for older adultsCardio: focus on low-intensity steady state exercises like walking or cycling for heart health and injury prevention, gradually increase intensity and duration including VO2 max intervals. Strength training: resistance training increases muscle strength and hypertrophy at any age, even for those over 80, offsetting muscle loss and improving overall health.

      Both cardio and strength training are crucial components of an effective fitness routine for older adults. For cardio, focusing on low-intensity steady state exercises like walking or cycling can help improve heart health and minimize injury. Gradually increasing the intensity and duration of these workouts, including VO2 max intervals, can further enhance fitness benefits. On the strength training front, research consistently shows that resistance training can increase muscle strength and hypertrophy at any age, even for those over 80. By incorporating both types of training, older adults can offset muscle loss, improve overall health, and potentially extend their lifespan.

    • Muscle improvement for all agesOlder adults and everyone else can enhance muscle strength and fiber preservation through gradual resistance training, starting with low-impact methods like machines and bodyweight exercises, and progressively increasing weight and complexity as confidence and endurance grow.

      No matter your age, everyone has the capacity to improve muscle strength and preserve type two muscle fibers through resistance training. However, it's essential to start slowly and safely, especially for older adults. Begin by focusing on type one fibers with high volume and gradually increasing weight as you build confidence and muscle endurance. Incorporate stability exercises and ensure proper muscle recruitment and control to minimize injury risk. For older adults, starting with machines and bodyweight exercises is recommended, gradually progressing to free weights and more advanced techniques as strength and confidence build.

    • Aging and injury preventionTo minimize injuries during aging, progress intensity gradually, focus on frequency and duration before intensity, and prioritize neuromuscular control and movement variability.

      As we age, starting resistance training to build muscle is crucial, but the risk of injury is a valid concern. To minimize injuries, it's essential to progress intensity gradually, focusing on frequency and duration before intensity. Neuromuscular control and movement variability are also crucial. The risk of falls increases significantly with age, posing a severe threat to aging individuals, with up to 50% of octogenarians and non-agenarians falling annually. Falls can lead to fatalities, especially if they result in a broken hip. Understanding the significance of falls and taking preventative measures, such as focusing on neuromuscular control and movement variability, is essential for maintaining health and independence as we age.

    • Aging and fallsAs we age, factors such as lower limb weakness, vestibular changes, foot pain, poorly fitting footwear, medications, and uneven surfaces increase our susceptibility to falls. Toe strength and calf strength are crucial to prevent falls, and regular exercise, including resistance training, can help improve bone mineral density and reduce the risk.

      As we age, our susceptibility to falls increases, and the severity of those falls becomes more catastrophic. This is due to factors such as lower limb weakness, vestibular changes, foot pain, and poorly fitting footwear. Additionally, medications and uneven surfaces can also contribute to falls. The severity of falls is often a result of frailty, which includes poor muscle mass, poor reactivity, and low bone density. One specific area of focus is toe strength, which is the biggest predictor of falling in people over 65. Tests for toe strength include pushing down on a card with your toes and a lean forward test. Calf strength is also crucial, and most people have underdeveloped strength in their lower leg. Ankle mobility, specifically dorsiflexion and tibial rotation, is another important factor. Regular exercise, including resistance training, can help improve bone mineral density and reduce the risk of falls.

    • Bone health assessmentEnsure segmental reporting for accurate bone health assessment, obtain T-scores for lumbar spine and hips, hormones like estrogen play a role, strength training beneficial, protein intake crucial, older adults may need more protein

      When getting a DEXA scan to assess bone health, it's essential to ensure segmental reporting for accurate assessment of risk. This means obtaining T-scores for the lumbar spine and both hips. A T-score below -1 indicates osteopenia, and a score below -2.5 indicates osteoporosis. Bone health is influenced by hormones like estrogen, which plays a crucial role in bone building by signaling the need for new bone material when bones are under load. Strength training, including activities like weightlifting and Jiu Jitsu, is particularly beneficial for bone health as it provides the necessary compressive force for bone growth. Additionally, protein intake is vital for muscle building, and older adults may require higher protein intakes due to anabolic resistance, making them less responsive to amino acids. Aim for at least 1.6 grams of protein per kilogram of body weight, and consider increasing this amount as you age. Proper nutrition, including adequate protein intake, is crucial for supporting the benefits of bone-healthy lifestyle choices.

    • Exercise for older adultsStart with small steps like daily walks, gradually progress, avoid injury, make it enjoyable, consult healthcare professionals, and utilize available resources.

      Starting an exercise routine as an older adult can lead to numerous health benefits, but it's essential to approach it safely and enjoyably. Begin with small steps, such as daily walks, and gradually progress to resistance training and challenging different energy systems. The goal is to avoid injury and make exercise a sustainable part of your routine. Remember, consistency is key, and the most important thing is to have fun and look back on your progress with satisfaction. Additionally, there are various resources available to help you get started, such as comprehensive podcast show notes, monthly Ask Me Anything episodes, and a private podcast feed for members. These resources offer detailed information on various topics related to longevity and exercise. Lastly, always consult with healthcare professionals before starting a new exercise routine and disregard any advice given on this podcast as a substitute for professional medical advice. Stay informed about potential conflicts of interest by visiting peteratiamd.com/about.

    Recent Episodes from The Peter Attia Drive

    #307 ‒ Exercise for aging people: where to begin, and how to minimize risk while maximizing potential | Peter Attia, M.D.

    #307 ‒ Exercise for aging people: where to begin, and how to minimize risk while maximizing potential | Peter Attia, M.D.

    View the Show Notes Page for This Episode

    Become a Member to Receive Exclusive Content

    Sign Up to Receive Peter’s Weekly Newsletter

    In this special episode, Peter addresses the common questions about starting or returning to an exercise routine over the age of 50. Individuals in this age group have frequently reached out with questions about whether it's too late to start exercising and often express concern over a lack of prior training, a fear of injury, or uncertainty about where to begin. Peter delves into the importance of fitness for older adults, examining all four pillars of exercise, and provides practical advice on how to start exercising safely, minimize injury risk, and maximize potential benefits. Although this conversation focuses on people in the “older” age category, it also applies to anyone of any age who is deconditioned and looking to ease into regular exercise.

    We discuss:

    • Key points about starting exercise as an older adult [2:45];
    • Why it’s never too late to begin exercising and incorporating the four pillars of exercise [5:45];
    • The gradual, then sharp, decline in muscle mass and activity level that occur with age [10:00];
    • The decline of VO2 max that occurs with age [15:30];
    • Starting a training program: exercise variability, movement quality, realistic goals, and more [18:30];
    • Improving aerobic capacity: the malleability of the system, the importance of consistency, and setting long-term fitness goals [25:15];
    • Starting cardio training: base building, starting with low volume, and zone 2 training [30:45];
    • The critical role of VO2 max in longevity [36:45];
    • How to introduce VO2 max training to older or deconditioned individuals [46:15];
    • Options for performing zone 2 and VO2 max training [53:45];
    • The ability to make gains in strength and muscle mass as we age [57:00];
    • How to implement strength training for older individuals [1:01:00];
    • Advice for avoiding injury when strength training [1:07:30];
    • Risk of falls: the devastating consequences and the factors that increase fall risk [1:12:15];
    • Mitigating fall risk: the importance of foot and lower leg strength, ankle mobility, and balance [1:19:45];
    • Improving bone mineral density through resistance training [1:24:30];
    • The importance of protein in stimulating muscle protein synthesis, especially in older adults [1:31:00];
    • Parting advice from Peter [1:34:00]; and
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    View the Show Notes Page for This Episode

    Become a Member to Receive Exclusive Content

    Sign Up to Receive Peter’s Weekly Newsletter

    In this “Ask Me Anything” (AMA) episode, Peter provides insights on a broad range of important topics. He delves into the prevention of cognitive decline, the link between cardiovascular disease and Alzheimer's disease, and methods to lower blood glucose, insulin, and apoB. He also addresses nutrition-related queries, exploring the impact of dietary habits on weight loss and longevity, how a person can identify the best diet for themselves, and common nutrition myths. Additional discussions include optimal blood pressure, daily step goals, the benefits of standing versus sitting desks, and much more.

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    #305 ‒ Heart rate variability: how to measure, interpret, and utilize HRV for training and health optimization | Joel Jamieson

    View the Show Notes Page for This Episode

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    Joel Jamieson is a conditioning expert who developed Morpheus to give people a smarter way to build their conditioning regimen and improve their recovery. In this episode, Joel dives deep into the world of heart rate variability (HRV), explaining its scientific foundation, how it measures the balance between the sympathetic and parasympathetic nervous systems, the various methods of measurement, and how it can guide healthier lifestyle choices and improved training performance. He explores the nuances of HRV calculation, the impact of aging on HRV, and the roles of genetics, exercise, and other lifestyle factors in this process. He also covers Morpheus, the innovative training tool that won Peter over after his initial skepticism, highlighting its practicality and effectiveness in guiding training and optimizing fitness outcomes.

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    View the Show Notes Page for This Episode

    Become a Member to Receive Exclusive Content

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    In this quarterly podcast summary (QPS) episode, Peter introduces a new format aimed at summarizing his biggest takeaways from the last three months of guest interviews on the podcast. Peter shares key insights from each episode, covering diverse topics such as protein and muscle building with Luc van Loon, toe strength with Courtney Conley, VO2 max with Olav Aleksander Bu, liquid biopsies for cancer with Alex Aravanis, gut health and probiotics with Colleen Cutcliffe, and road safety with Mark Rosekind. Additionally, Peter shares any personal behavioral adjustments or modifications to his patient care practices that have arisen from these engaging discussions.

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    • Mark Rosekind: the significant issue of road fatalities and injuries, their causes, and practical safety measures to reduce risks [1:27:00]; and
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    #303 - A breakthrough in Alzheimer’s disease: the promising potential of klotho for brain health, cognitive decline, and as a therapeutic tool for Alzheimer's disease | Dena Dubal, M.D., Ph.D.

    View the Show Notes Page for This Episode

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    Sign Up to Receive Peter’s Weekly Newsletter

    Dena Dubal is a physician-scientist and professor of neurology at UCSF whose work focuses on mechanisms of longevity and brain resilience. In this episode, Dena delves into the intricacies of the longevity factor klotho: its formation and distribution in the body, the factors such as stress and exercise that impact its levels, and its profound impact on cognitive function and overall brain health. Dena shares insights from exciting research in animal models showing the potential of klotho in treating neurodegenerative diseases as well as its broader implications for organ health and disease prevention. She concludes with an optimistic outlook for future research in humans and the potential of klotho for the prevention and treatment of Alzheimer’s disease.

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    We discuss:

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    #302 - Confronting a metabolic epidemic: understanding liver health and how to prevent, diagnose, and manage liver disease | Julia Wattacheril, M.D., M.P.H.

    View the Show Notes Page for This Episode

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    Sign Up to Receive Peter’s Weekly Newsletter

    Julia Wattacheril is a physician scientist and director of the Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) program at Columbia University Irving Medical Center. In this episode, Julia delves deep into the complex world of liver health, beginning with a foundational overview of liver physiology. She provides an in-depth look at how alcohol impacts liver function, breaking down the metabolism of ethanol and its detrimental effects. Julia then shifts the focus to understanding liver function tests and optimal enzyme levels, providing a detailed explanation of AST and ALT and elucidating why fluctuations in these levels may or may not be concerning. She provides a primer on the four major stages of liver disease, discussing risk and emphasizing the importance of early diagnosis. Julia highlights the role of liver disease in increasing the risk of cancer and cardiovascular disease and covers in detail the various strategies for diagnosing, treating, and preventing the progression of liver disease.

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    • Methods of diagnosing liver disease and how insights guide treatment and management strategies [33:30];
    • The poisonous nature of ethanol to the liver [40:30];
    • Varied responses to alcohol, damaging effects of alcohol beyond the liver, and the process of advising patients on their alcohol consumption [47:15];
    • Understanding liver enzymes AST and ALT—interpreting levels, lifestyle factors that affect them, and diagnostic approaches [58:30];
    • Interpreting liver function tests for fatty liver disease, and the challenges of diagnosing liver pathologies, particularly in children versus adults [1:13:15];
    • Comprehensive liver health assessments via imaging and various diagnostic tools to prevent overlooking potential liver pathologies [1:18:45];
    • Potential impact of recreational drugs, statins, and other medications on liver function test results [1:26:45];
    • Shifting nomenclature from NAFLD to MASLD to reflect accuracy in the underlying pathophysiology and understanding of liver diseases [1:30:30];
    • Pathophysiology of MASLD, the need for proactive screening, and the significance of liver fat percentage as an indicator of metabolic health [1:36:30];
    • The importance of screening for rare conditions alongside common metabolic diseases associated with fatty liver accumulation [1:42:45];
    • Practical strategies for managing MAFLD [1:45:30];
    • The impact of fructose consumption on liver health and the challenges of disentangling its effects from other factors like obesity and insulin resistance [1:52:45];
    • The potential of GLP-1 agonists for the treatment of MASLD [1:57:45];
    • How the four stages of liver disease have evolved [2:00:30];
    • Increased cancer and heart disease risk associated with early-stage MAFLD [2:05:15];
    • Emerging drugs and therapies for addressing fat accumulation and fibrosis related to MAFLD [2:12:15];
    • Peter’s major takeaways [2:18:45]; and
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    Connect With Peter on TwitterInstagramFacebook and YouTube

    The Peter Attia Drive
    enMay 20, 2024

    #301 - AMA #59: Inflammation: its impact on aging and disease risk, and how to identify, prevent, and reduce it

    #301 - AMA #59: Inflammation: its impact on aging and disease risk, and how to identify, prevent, and reduce it

    View the Show Notes Page for This Episode

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    In this “Ask Me Anything” (AMA) episode, Peter delves into the often misunderstood concept of inflammation. He first defines inflammation and differentiates between acute inflammation and chronic inflammation, the latter of which is linked to aging and a plethora of age-related diseases. Peter breaks down the intricate relationship between chronic inflammation, obesity, and metabolic health, and highlights the signs that might suggest someone may be suffering from chronic inflammation. From there, the conversation centers on actionable advice and practical steps one can take to manage and minimize chronic inflammation. He explores how diet plays a crucial role, including the potential benefits of elimination diets, and he examines the impact of lifestyle factors such as exercise, sleep, and stress management. Additionally, he discusses the relevance of food inflammatory tests and concludes by examining the potential benefits and drawbacks of drugs and supplements in managing inflammation.

    If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #59 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.

    We discuss:

    • Defining inflammation (and the cultural impact of Napoleon Dynamite) [1:45];
    • Acute vs chronic inflammation [8:00];
    • The connection between chronic inflammation, aging, and age-related diseases [11:00];
    • The impact of inflammation on metabolic health [18:30];
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    • Factors that contribute to low-level chronic inflammation [28:00];
    • Minimizing inflammation through diet [29:45];
    • The important role of fiber for gut health and inflammation [33:45];
    • A closer look at the impact of trans fats and saturated fats on overall health [34:45];
    • Why Peter prefers dietary fiber from food sources over supplements [38:30];
    • Debunking “superfoods”: emphasizing proven methods over marketing claims for reducing inflammation [39:00];
    • Is there any value in over-the-counter food inflammatory tests? [42:30];
    • Food elimination diets: how they work, symptoms and markers to watch, challenges and limitations [45:15];
    • Identifying dietary triggers for gut-related symptoms through low-FODMAP diets like the “carnivore diet” [51:15];
    • Dairy: the complex role of dairy on inflammation and individual responses [55:00];
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    • How exercise influences inflammation [1:02:00];
    • How sleep quality and duration impacts inflammation [1:07:00];
    • The potential impact of chronic psychological stressors on inflammation [1:13:00];
    • The impact of oral health on inflammation and overall well-being [1:15:00];
    • The role of medications in managing chronic inflammation [1:18:15];
    • Supplements: evaluating the efficacy of various anti-inflammatory supplements [1:22:15];
    • Parting thoughts and takeaways [1:27:00]; and
    • More.

    Connect With Peter on TwitterInstagramFacebook and YouTube

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    #300 - Special episode: Peter on exercise, fasting, nutrition, stem cells, geroprotective drugs, and more — promising interventions or just noise?

    View the Show Notes Page for This Episode

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    In this special edition celebrating 300 episodes of The Drive, Peter discusses a variety of popular topics and health interventions and classifies them based on their level of evidence and relevance using the following categories: proven, promising, fuzzy, noise, and nonsense. Peter first delves into the topic of geroprotective molecules, covering rapamycin, metformin, NAD and its precursors, and resveratrol. Next, he explores the significance of metrics like VO2 max and muscle mass, as well as emerging concepts like blood flow restriction and stem cells. The conversation extends to nutrition, addressing questions surrounding long-term fasting, sugar consumption, sugar substitutes, and the contentious role of red meat in cancer. Peter not only provides his current stance on each topic—most of which have been covered in great detail in the previous 300 episodes—but also reflects on how his opinion may have evolved over the years.

    We discuss:

    • Defining the categories of “proven, promising, fuzzy, noise, and nonsense” [3:15];
    • Rapamycin [9:30];
    • Metformin [17:00];
    • NAD and its precursors [24:30];
    • Resveratrol [32:45];
    • The importance of VO2 max, muscle mass, and muscular strength for lifespan [38:15];
    • Blood flow restriction (BFR) training [44:00];
    • Using stem cells to treat osteoarthritis or injury [51:30];
    • Fasting as a tool for longevity (and why Peter stopped his fasting protocol) [55:45];
    • The energy balance theory [1:06:30];
    • The idea that sugar is poison [1:12:00];
    • The idea that sugar substitutes are dangerous [1:22:15];
    • The debate on red meat and cancer [1:28:45]; and
    • More.

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    Special episode with Dax Shepard: F1 and the 30th anniversary of Ayrton Senna’s death

    Special episode with Dax Shepard: F1 and the 30th anniversary of Ayrton Senna’s death

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    This is a special episode of The Drive with Peter’s friend and fellow car enthusiast Dax Shepard. In this podcast, which commemorates the 30th anniversary of the death of Brazilian Formula One legend Ayrton Senna, Dax sits down with Peter to better understand what made Senna so special and why Peter remains an enormous fan. This conversation focuses on Senna’s life, the circumstances of his death, and his lasting impact and legacy on the sport of F1.

    We discuss:

    • Peter’s interest in motorsports began as a child [2:30];
    • The drama and dangers of F1 [6:00];
    • What made Senna special [13:00];
    • What Senna meant to Brazilians [24:00];
    • The cause of the fatal crash [28:15];
    • Why Peter is obsessed with Senna [40:30];
    • Being the best versus having the best record [43:30];
    • Senna’s unique driving style and incredible intuition about automotive engineering [46:30];
    • Back to the day of the dreadful race [53:00];
    • What Peter believes caused the crash [1:02:45];
    • Views on dying young, in the prime of life [1:13:00];
    • Senna lives on in his foundation and in safety changes adopted by F1 [1:21:00];
    • Statistics aren’t enough for fandom, and why people like who they do [1:24:15];
    • The biggest difference between F1 today and F1 in the 80s [1:28:30];
    • Senna’s driving superpower [1:30:30];
    • The fastest drivers currently in F1 [1:38:30];
    • Current F1 obsessions [1:45:00];
    • How hard it is to do what the top F1 drivers do [1:50:15];
    • Dax’s love of motorcycles and his AMG E63 station wagon [1:52:15];
    • Awesome Senna mementos from Etsy [2:01:15];
    • What makes specialists interesting, and Max’s devotion to F1 [2:10:15];
    • What Senna might have done if he had not died that day [2:14:00];
    • Michael Schumacher and Max Verstappen are also top F1 drivers [2:17:30];
    • Interlagos in Sao Paulo Brazil is always an incredible experience [2:18:45]; and
    • More.

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    #299 ‒ Optimizing muscle protein synthesis: the crucial impact of protein quality and quantity, and the key role of resistance training | Luc van Loon, Ph.D.

    #299 ‒ Optimizing muscle protein synthesis: the crucial impact of protein quality and quantity, and the key role of resistance training | Luc van Loon, Ph.D.

    View the Show Notes Page for This Episode

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    Luc van Loon is an internationally renowned expert in skeletal muscle metabolism. In this episode, Luc starts with an exploration of the roles of insulin and triglycerides in endurance exercise, highlighting their impact on skeletal muscle metabolism, and he offers profound insights into the significance of protein in this context. He elucidates how different protein types and forms influence muscle protein synthesis rates, exploring the nuances of protein absorption, digestibility, amino acid quality, and their implications for performance and recovery. Delving deeper, he differentiates between animal and plant protein sources, unraveling the distinctive properties of various protein types, from the differences between whey and casein to the emerging trends in collagen protein supplementation. Moreover, Luc dissects the intricate connections among physical activity, lean muscle mass, muscle protein synthesis induced by resistance training, and dietary protein.

    We discuss:

    • Luc’s background and insights about fuel selection during exercise [3:30];
    • Fuel utilization during endurance exercise [9:30];
    • Fat metabolism, intramuscular lipids, and the nutritional dynamics of endurance sports [17:15];
    • The optimal window for replenishing intramuscular fat stores and glycogen post-exercise [25:15];
    • Luc’s interest in protein metabolism and exploration of amino acids' dual role as building blocks and signaling molecules in driving muscle protein synthesis [32:15];
    • How protein metabolism differs between sedentary individuals and those engaged in predominantly strength training or endurance training [38:45];
    • The basics of how proteins are digested and absorbed, and how muscle protein synthesis is measured [50:30];
    • How factors like food texture, cooking methods, and protein composition impact muscle protein synthesis, and the importance of protein distribution throughout the day [59:45];
    • Differences in whey and casein proteins, and the ability of ingested protein to stimulate muscle protein synthesis [1:03:30];
    • Dietary protein distribution and quantity for the maximization of muscle protein synthesis [1:09:00];
    • Muscle loss with age and inactivity and the importance of resistance exercise to maintain type II muscle fibers [1:17:15];
    • Differences between whey and casein proteins, and the importance of both quantity and quality of protein sources [1:28:30];
    • Optimizing muscle protein synthesis: exercise, timing of protein intake, protein quality, and more [1:37:00];
    • How to preserve muscle while trying to lose weight [1:46:00];
    • Anabolic resistance and overcoming it with physical activity [1:55:45];
    • Importance of protein intake and physical activity in hospitalized patients [2:06:30];
    • Reviewing the efficacy of collagen supplements [2:13:30];
    • Plant-based diets: how to ensure a balance of amino acids, and other considerations [2:20:30];
    • Future research: understanding protein metabolism in the brain [2:23:45]; and
    • More.

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