antibody library screening

Creative Biolabs offers clients a novel bispecific antibody (BsAb) format, the dual variable domain IgG (DVD-IgG), for many diverse studies in antibody engineering. We aim to provide the reliable, efficient services to meet our customer’s individual requirements.
https://www.creativebiolabs.net/Dual-variable-domain-IgG-DVD-IgG.htm

Creative Biolabs offers clients a novel bispecific antibody (BsAb) format, the dual variable domain IgG (DVD-IgG), for many diverse studies in antibody engineering. We aim to provide the reliable, efficient services to meet our customer’s individual requirements.
https://www.creativebiolabs.net/dual-variable-domain-igg-dvd-igg.htm

DVD-IgG is one type of bispecific antibody format, which is generated from two parental mAbs by placing two variable domains from one parental antibody onto the heavy chain and the light chain of another parental antibody, instead of one variable domain. The variable domain pairs can be derived from whole human, mouse or rat mAbs with phage/yeast display libraries. And the short peptides derived from the N-termini of CH1 or CL link the outer variable domain (VD1) and the inner variable domain (VD2) together. The DVD-IgG retains the antigen-binding specificity, affinity, and biologic activities from its both parental antibodies, therefore, all of its four variable domains are functional. Many different DVD-IgGs have been designed and manufactured for treating complex diseases with multiple mediators contributing to overall disease pathogenesis.
https://www.creativebiolabs.net/dual-variable-domain-igg-dvd-igg.htm

Creative Biolabs is professional in producing Fab fragment antibodies using well established methods. We provide the most comprehensive list of Fab fragment antibodies.
https://www.creativebiolabs.net/Fab-Fragment-Antibodies_24.htm

Because of its high binding capability and easy production character, tandem scFv-Fc bispecific antibody (BsAb) is one of the leading candidates for antibody drug development. Creative Biolabs elaborately integrates its multiple platforms to provide customers a desired tandem scFv-Fc BsAb with high affinity and low immunogenicity for both academic and clinical purposes.

https://www.creativebiolabs.net/tandem-scfv-fc-bispecific-antibody-bsab.htm

At Creative Biolabs, the proprietary protocol and tailored biopanning strategy allow the increase of candidates with higher affinity and desired specificity (e.g. binders recognize conformational epitope rather than linear epitope). In general, by conducting four rounds library screening, our scientists can select scFv/Fab antibodies with the affinity of 10-7. Through constructing serial sub-libraries of the isolated scFv/Fab antibodies, we can increase the affinity from 10-8 to 10-9. Moreover, Creative Biolabs has successfully obtained a scFv antibody with an extremely high affinity of 10-12.
https://www.creative-biolabs.com/phage-display-library-screening.html

Phage display technology is one of the major approaches employed in various protein interaction studies, especially in the discovery of specific antibodies, scaffolds or ligands. While binders with the desired specificity generally exist at low frequencies in the constructed libraries. In this way, phage display library screening has become an effective technique for the enrichment and identification of binders with high affinity and specificity from interested libraries.
https://www.creative-biolabs.com/phage-display-library-screening.html

Phage display technology is one of the major approaches employed in various protein interaction studies, especially in the discovery of specific antibodies, scaffolds or ligands. While binders with the desired specificity generally exist at low frequencies in the constructed libraries. In this way, phage display library screening has become an effective technique for the enrichment and identification of binders with high affinity and specificity from interested libraries.
https://www.creative-biolabs.com/phage-display-library-screening.html

Phage display technology is one of the major approaches employed in various protein interaction studies, especially in the discovery of specific antibodies, scaffolds or ligands. While binders with the desired specificity generally exist at low frequencies in the constructed libraries. In this way, phage display library screening has become an effective technique for the enrichment and identification of binders with high affinity and specificity from interested libraries.
https://www.creative-biolabs.com/phage-display-library-screening.html

At Creative Biolabs, the proprietary protocol and tailored biopanning strategy allow the increase of candidates with higher affinity and desired specificity (e.g. binders recognize conformational epitope rather than linear epitope). In general, by conducting four rounds library screening, our scientists can select scFv/Fab antibodies with the affinity of 10-7. Through constructing serial sub-libraries of the isolated scFv/Fab antibodies, we can increase the affinity from 10-8 to 10-9. Moreover, Creative Biolabs has successfully obtained a scFv antibody with an extremely high affinity of 10-12.
https://www.creative-biolabs.com/phage-display-library-screening.html