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    Can A 100-Year-Old Treatment Help Save Us From Superbugs?

    en-usJanuary 16, 2020

    Podcast Summary

    • The Power of Information and InspirationA real-life example of the BBC's role in delivering valuable information and inspiration is the story of Stephanie Strath and her husband Tom Patterson, who were saved by a century-old treatment after Tom contracted a superbug in Egypt. This story underscores the importance of access to knowledge and perseverance in overcoming challenges.

      The BBC provides valuable information and inspiration through storytelling, encouraging us to think deeply about the world. A real-life example of this comes from the story of Stephanie Strath and her husband Tom Patterson. While traveling in Egypt in 2015, Tom became seriously ill with a superbug, Acinetobacter baumannii, which was resistant to all antibiotics. The couple never pinpointed the exact source of Tom's infection, but they knew it came from an Egyptian stream. Tom's condition worsened, and he was on the brink of death. Stephanie refused to give up and turned to the scientific community for help. This led to the discovery of a century-old treatment that saved Tom's life. This story highlights the importance of information and inspiration in overcoming challenges, and the BBC's role in delivering such content.

    • A wife's determination leads to a life-saving discovery through phage therapyStaying informed and actively seeking resources during health crises can lead to life-saving discoveries. Phage therapy, using viruses to attack bacteria, is an example of ongoing scientific advancements.

      When faced with a health crisis, determination and the power of knowledge can lead to life-saving discoveries. Stephanie's story illustrates this as she tirelessly researched online to find a potential solution for her husband's life-threatening condition. Through her search on PubMed, she discovered phage therapy, a method using viruses called bacteriophages to attack and kill bacteria. These viruses, which naturally occur and are abundant, can be harnessed to target specific bacteria. Stephanie's experience underscores the importance of staying informed and actively seeking out resources during challenging times. Additionally, this discussion highlights the ongoing advancements in science and technology, as Amgen continues to pioneer new treatments for various diseases. Apple Card also offers a practical solution for managing finances, providing daily cash rewards on purchases.

    • A woman's search for a life-saving phageBacteriophages, or viruses that kill bacteria, could be an alternative to antibiotics. Internet and scientific collaboration can help find the right phage to treat specific bacterial infections.

      Bacteriophages, or viruses that infect bacteria, have the ability to kill harmful bacteria by injecting their own DNA and forcing the cell to produce more viruses until it bursts. This process releases new viruses to infect other cells. Phages have been used for decades in the former Soviet Union to treat bacterial infections, but their use in the West has been experimental due to a lack of clinical studies and trials. When faced with her husband's life-threatening bacterial infection, a woman turned to the Internet to find scientists studying the specific phage that could match the bacteria. She reached out to a lab at Texas A&M, and they became a "command center" in the search for the right phage to save her husband's life. This story highlights the potential of phages as an alternative to antibiotics in treating bacterial infections and the importance of scientific collaboration in medical emergencies.

    • Collaborative effort to find phages for antibiotic-resistant Acinetobacter infectionsScientists found a cocktail of four phages to combat antibiotic-resistant Acinetobacter infections by using a multi-faceted approach involving collaboration between various scientific communities and regulatory bodies.

      A team of scientists, including a doctor and researchers from academia and the military, collaborated to find bacteriophages, or phages, in environmental samples like sewage and barnyard poop to combat antibiotic-resistant Acinetobacter infections. They isolated thousands of samples and found four matching phages for a cocktail treatment. This approach is crucial because bacteria and phages have been co-evolving for billions of years, and bacteria can develop resistance quickly to a single phage. By using a cocktail of phages targeting different components of the bacteria, the bacteria's ability to develop resistance is reduced. This collaborative effort between various scientific communities and regulatory bodies demonstrates the importance of a multi-faceted approach to combating antibiotic-resistant bacteria.

    • Phage therapy: A promising solution with challengesPhage therapy using viruses to fight bacterial infections holds promise but faces hurdles like bacterial resistance, difficulty delivering phages, and lack of clinical trial data for wider acceptance in US.

      Phage therapy, which involves using viruses to fight bacterial infections, can be a promising solution, but it still faces challenges in becoming a common treatment option in the US. A notable success story is that of Tom, who recovered from a severe infection using a combination of Texas and Navy phages. However, the process took several months, and there are challenges such as bacterial resistance to phages and the difficulty of delivering phages to the exact site of infection. The most significant hurdle for phage therapy is the lack of clinical trial data to demonstrate its efficacy on a larger scale. The National Institute of Health is funding the first phage therapy trial, which will help gather the necessary data and potentially lead to FDA licensing of phage therapy alongside antibiotics.

    • A complex journey of a scientist, wife, and caregiver during her husband's battle with a rare infectionThrough the chaos of being a scientist, wife, and caregiver during her husband's rare bacterial infection, Stephanie Strathie found hope and healing through phage therapy, turning their experience into a movie based on her book.

      Stephanie Strathie's experience as a scientist, wife, and caregiver during her husband's battle with a rare bacterial infection was a complex and chaotic journey, much like looking through a kaleidoscope with its ever-changing patterns. Strathie, who is the codirector of the Center For Innovative Phage Applications and Therapeutics at UC San Diego School of Medicine, went through a rollercoaster of emotions and identities. She was not only a wife to a sick husband but also a scientist trying to find a solution to his condition. Adding to this complexity was the fact that she and her family were also suffering from PTSD. However, when her husband recovered through phage therapy, it was like the pieces of the kaleidoscope coming together to form a beautiful mosaic. Strathie's story is not unique, as many lives have been saved through phage therapy, some directly related to her husband's case. It's a privilege for Strathhe to witness such transformations, and her experience is now being turned into a movie based on her book, "The Perfect Predator."

    • Navigating Investing Challenges: Insights from Larry Fink of BlackRockInvestors face challenges in retirement and adapting to a rapidly changing economic and geopolitical landscape. A long-term strategy, staying informed, and having a trusted partner can help navigate these challenges.

      Learning from the latest episode of The Bid featuring Larry Fink, the chairman and CEO of BlackRock, is that investors are facing numerous challenges, particularly in the areas of retirement and other situations where global capital markets can provide solutions. Fink discussed these issues in depth on the podcast, providing valuable insights for those seeking to navigate the complex world of investing. For those planning for retirement, Fink emphasized the importance of having a long-term investment strategy and being prepared for market volatility. He also highlighted the role that technology and innovation will play in shaping the retirement landscape in the years to come. Beyond retirement, Fink touched on other challenges facing investors, including the need to adapt to a rapidly changing economic and geopolitical landscape. He emphasized the importance of staying informed and being agile in order to make the most of opportunities as they arise. Throughout the conversation, Fink underscored the value of having a trusted partner like BlackRock to help investors navigate these challenges and make informed decisions. He encouraged listeners to tune in to The Bid for more insights from BlackRock's thought leaders and to subscribe for ongoing market analysis and commentary.

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