Clonal Expansion of Blood Stem Cells in Aging and Leukemia with Leonard Zon - Sanford Stem Cell Symposium 2023

Cancer has a major impact on our society with approximately 1 in 3 adults in the U.S. diagnosed during their lifetimes. This program looks at the role of exercise and physical activity and their benefits for cancer patients. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 39647]

E-cigarettes were first sold in the United States in 2007. These battery-operated devices heat a liquid made of chemicals, including some with high levels of nicotine, to make an aerosol that users inhale into their lungs. This program discusses the numerous health concerns related with e-cigarette usage. Series: "Excerpts" [Health and Medicine] [Show ID: 39593]

In this UC Santa Barbara GRIT talk, Dr. Meghan Morrissey discusses her work to get immune cells to eat cancer. Her goal is to uncover fundamental principles of macrophage signaling and tune macrophage function in the tumor microenvironment. Series: "GRIT Talks" [Health and Medicine] [Show ID: 39441]

A diagnosis of prostate cancer can be scary. In this program, Dr. Matthew Cooperberg with the UCSF Helen Diller Family Comprehensive Cancer Center explains what prostate cancer is and what treatments options are available for newly diagnosed patients including active surveillance, surgery (prostatectomy), radiation therapy, and focal therapy. [Health and Medicine] [Show ID: 39376]

Ronald DePinho, M.D., explains how telomerase, typically linked to telomere maintenance, serves as a transcriptional co-activator in the brain. Epigenetic repression of TERT, the gene for telomerase, occurs with aging, contributing to aging hallmarks like cellular senescence and inflammation. DePinho's team developed a compound that reactivates TERT, which, when administered to mice, reverses age-related changes. It restores cognitive function, reduces amyloid plaque, and alleviates inflammation. This suggests that maintaining TERT levels can counteract age-related cognitive decline and neurodegeneration, offering potential for treating neurodegenerative diseases like Alzheimer's. DePinho's work expands our understanding of telomerase's multifaceted role in aging and neurodegeneration, holding promise for interventions against these age-related processes. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39071]

Leonard Zon, M.D., discusses cutting-edge research on the intricate relationship between macrophages, stem cells, and the development of leukemia using the zebrafish model. He delves into the fascinating interactions between these cell types, highlighting the role of a "don't eat me" signal and the influence of the leukemic niche. Through cellular barcoding and single-cell RNA sequencing, he unveils a potential therapeutic target which may offer promising insights into treating leukemia by disrupting the stromal activities that support it. Zon showcases the power of zebrafish models in advancing our understanding of hematopoiesis and cancer, promising new avenues for research and treatment. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39064]

Aparna Bhaduri, Ph.D., shares insights into human brain development and its intricate processes. Explore the intriguing reappearance of developmental cell elements in brain cancers like glioblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38329]

In this inspiring video, Elena Martinez, Ph.D., shares her journey as a first-generation student from Mexico who dedicated herself to a career in cancer epidemiology, prevention, and disparities. Dr. Martinez emphasizes the transformative power of education as a means of empowerment and opportunity. She candidly discusses the cultural and societal barriers she faced and the unwavering support from her family that fueled her determination to succeed. Dr. Martinez also underscores the significance of representation and diversity in the scientific community, emphasizing the need to break down barriers and create more opportunities for underrepresented individuals in STEM fields. Series: "Education Channel" [Health and Medicine] [Education] [Show ID: 38746]

Paul A. Northcott, Ph.D., St. Jude Children's Research Hospital, shares his work in multi-omic bulk and single-cell approaches to decipher molecular landscapes and developmental origins of medulloblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38889]

Join expert Dr. Judith Walsh as she discusses cancer screening and prevention strategies. Walsh talks about the significance of family history, genetic testing, and personalized risk assessment in making informed healthcare decisions. From the nuances of colorectal cancer screening to the complexities of breast cancer detection, you’ll gain a comprehensive understanding of modern screening techniques and their implications. Learn why it's crucial to use radiologic procedures judiciously and understand the potential risks of radiation exposure. Walsh also explores the challenges of pancreatic cancer detection and discusses specialized screening approaches for high-risk individuals. Stay informed and empowered with expert recommendations for effective cancer prevention strategies. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 38792]