Clonal Expansion of Blood Stem Cells in Aging and Leukemia with Leonard Zon - Sanford Stem Cell Symposium 2023

Amander Clark, Ph.D., delves into crafting artificial ovaries for fertility and aging research. She stresses the importance of diversity in stem cell studies to ensure comprehensive findings. By assembling ovarian models from various genetic backgrounds, her team aims for inclusive representation in biomedical research, potentially offering insights into reproductive health and disease. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 38334]

Hanna Mikkola, M.D., Ph.D., shares her work in hematopoietic stem cells (HSCs) and their complex renewal process. Her research aims to unravel these cells' behavior in mice and humans, offering potential insights for future medical advancements. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39258]

Mathew Blurton-Jones presents CRISPR-based interventions for a rare brain disorder in mice by substituting defective brain cells with healthy ones. He details experiments demonstrating the efficacy of corrected cells in mitigating brain pathologies. Blurton-Jones emphasizes the need for cautious translation to human trials, advocating gradual cell replacement to preempt potential adverse effects. Additionally, he delves into the implications of microglia in Alzheimer's disease progression and explores potential interconnections among various neurodegenerative conditions. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 38333]

Anna Beaudin, Ph.D., delves into the intricacies of how prenatal inflammation impacts the immune system's blueprint, shaping its long-term function. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39257]

CIRM-funded Alpha Stem Cell Clinics are a network of California medical centers that specialize in delivering stem cell clinical trials to patients. In this fascinating panel, clinic directors discuss advanced treatments, therapies like gene editing, and sharing knowledge and creating networks across the country for better patient care. Featuring: Geoffrey Lomax, Dr.PH California Institute for Regenerative Medicine Esther and Andrew Schorr Patient Advocates Sandra Dillon Cancer Survivor and Stem Cell Champion Catriona Jamieson, M.D., Ph.D. UC San Diego Mehrdad Abedi, M.D. UC Davis Daniela A. Bota, M.D., Ph.D. UC Irvine Sheila Chari, Ph.D. Cell Press Leo D. Wang, M.D., Ph.D. City of Hope National Medical Center Mark Walters, M.D. University of California, San Francisco Thomas Buchanan, M.D. University of Southern California Michael Lewis, M.D. Cedars Sinai Noah Federman, M.D. UCLA Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 39070]

Experts discuss the immense potential of conducting experiments and manufacturing goods in space. They explore how this could enhance our understanding of health issues, unveil new discoveries, and produce innovative technology for use on Earth. The conversation encompasses collaborations between various industries and scientists, aiming to explore the distinct conditions in space to enhance life for all. Featuring: Catriona Jamieson, M.D., Ph.D. UC San Diego Jana Stoudemire, M.Bio. Axiom Space Alain Berinstain, Ph.D. Space Tango Marc Giulianotti, Ph.D. Sierra Space Kevin Engelbert, M.S.F. NASA Michael Roberts, Ph.D. CASIS Arun Sharma, Ph.D. Cedars Sinai Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39072]

Clive Svendsen, Ph.D., leads groundbreaking experiments using stem cell transplants, uncovering unexpected findings. These trials aimed at improving ALS treatments, revealed higher success with upper motor neuron transplants compared to spinal cord methods. Svendsen's exploration of cortical transplants hints at a potential breakthrough. Moreover, his study of stem cell behavior in space opens doors to exciting medical advancements. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39068]

Hans Clevers, M.D., Ph.D., shares his research at the intersection of medicine and biology. Clevers discusses revolutionary advances in personalized medicine, where patient-specific treatments can be developed by studying small samples of patients' tissues. He explores the role of specialized cells known as "best for cells" in gastrointestinal health, shedding light on how they may help fight infections. Additionally, he highlights how mini-organs, or organoids, grown in the lab help us understand complex cellular functions and diseases. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39066]

Carla Kim, Ph.D., explains how aging impacts lung cell biology and its potential to reshape our understanding of diseases, including lung cancer. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39254]

Siddhartha Jaiswal, M.D., Ph.D., discusses clonal hematopoiesis and its impact on aging and diseases. Jaiswal highlights the role of genetic variations, focusing on a specific gene, TET2, and its link to clonal expansion. He explains that certain genetic variations can slow clonal expansion, potentially offering insights into treatments or interventions to mitigate its effects. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39260]