In the third episode of the Personalized Medicine Podcast we discuss glycans and their role in personalized medicine with Professor Gordan Lauc. Gordan is a Professor of Biochemistry and Molecular Biology at the University of Zagreb. He is also a Founder and CEO of Genos, one of the few companies in the world capable of high-throughput glycan analysis. In addition to it, Gordan has initiated the Human Glycome Project to facilitate collaboration between laboratories around the world and to encourage more scientists to include glycan analysis in their research.
Together with Gordan we have discussed:
◦ Why most drugs don’t work in most patients
◦ Why glycans can be very precise biomarkers of diseases, aging and inflammation
◦ Challenges in the robust measurement of protein glycosylation
◦ The Human Glycome Project
◦ How individual glycosylation profile can affect treatment outcomes
◦ Glycan-engineering to improve the efficiency of monoclonal antibody therapies
◦ Patient stratification for clinical trials should take advantage of individual protein glycosylation.
◦ Technical challenges of transferring glycan biomarkers from research to clinics
◦ How to assess biological age with glycans using GlycanAge test
◦ Dynamics of antibody (IgG) glycome
◦ Relation between the glycosylation of blood plasma proteins and metabolic diseases
◦ Why every biomedical study should include glycan analysis
◦ The outlook on the role of glycans in personalized medicine
Get in touch with Gordan:
Twitter: @GordanLauc
Web (Human Glycome Project):
https://human-glycome.org/Make sure to download the full show notes with Gordan's bio, links to his most notable research papers and our recommendations for further reads on the topic of the episode at personalizedmedicinemedia.com