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    • Discovering Solutions for Weight Loss and Monkeypox PreventionInvest in telehealth services, consider FDA-approved weight loss meds, buy high-quality bedding, and avoid close contact with infected individuals to prevent monkeypox.

      There are solutions available for those struggling with weight loss, such as PlushCare's telehealth services and FDA-approved weight loss medications. Additionally, investing in high-quality bedding, like Boll and Branch's organic cotton sheets, can contribute to better sleep. This Mother's Day, consider gifting exquisite jewelry from Blue Nile to express love and appreciation. During this in-studio discussion on monkeypox, experts shared essential information and answered questions. To summarize, monkeypox is a viral infection that spreads through close contact with an infected person or their contaminated items. Symptoms include fever, rash, and swollen lymph nodes. While there's no specific treatment, isolation and supportive care can help manage symptoms. Monkeypox is preventable through avoiding close contact with infected individuals and their contaminated items. Stay informed and prioritize your health and well-being.

    • Monkeypox Declared a Public Health EmergencyMonkeypox, a virus similar to smallpox but less severe, has been declared a public health emergency by the WHO due to rising cases and concerns about its presentation. Experts believe it could become a pandemic. The virus is difficult to track, necessitating escalated responses. The WHO's declaration unlocks resources and directs communication.

      Monkeypox is a virus within the orthopoxvirus family, similar to smallpox but less severe. The World Health Organization has declared it a public health emergency of international concern due to rising cases and concerns about its presentation. While it hasn't been declared a pandemic yet, experts believe it could be headed in that direction. Monkeypox is presenting in various places around the world, including San Francisco, where emergency room doctor Graham has seen over a dozen cases. The virus is difficult to track, making escalated responses necessary. The experts in the discussion agree that the WHO's decision to declare it a public health emergency was appropriate, as it unlocks resources and directs communication.

    • Monkeypox primarily spreading among gay men through close contactMonkeypox is currently spreading among gay men through close contact, but can also be transmitted through other means like sharing bedding or cuddling. The current strain causes genital, anal, and mouth lesions, and symptoms like fever and body aches are less common. Asymptomatic or presymptomatic transmission may be occurring.

      Monkeypox, a virus that has been around since the 1950s, is currently spreading primarily among gay men through close, prolonged skin-to-skin contact, including sexual encounters. However, it's important to note that transmission can also occur through other means like sharing bedding, cuddling, or even kissing. The current strain of monkeypox is different from past descriptions in that the pox are more commonly found on the genitals, anus, and mouth, rather than the face, and systemic symptoms like fever, body aches, and fatigue are less common. Additionally, there is concern that asymptomatic or presymptomatic transmission may be occurring, as people may not get tested until they develop a rash, which is required for diagnosis. Overall, while the trajectory of monkeypox has not drastically changed, there is still much to learn about this virus and how it manifests.

    • Understanding Monkeypox Transmission: Asymptomatic and Presymptomatic CasesStudies show asymptomatic and presymptomatic individuals can carry similar viral loads as those with symptoms, but the actual transmission through oral route is uncertain. Innovative testing methods like salivary tests are being explored to expand capacity, but a commercially available test is still in development.

      The ongoing monkeypox outbreak is raising questions about the role of asymptomatic and presymptomatic transmission, as a study found a 4% positive rate among those without symptoms at a sex clinic. However, the viral loads in the mouth of these individuals were similar to those with symptoms, suggesting similar contagiousness. Yet, the actual transmission through the oral route is uncertain, as another study showed much higher viral loads in the lesions themselves. Regarding testing, the process has been slow and challenging, with bottlenecks in sample turnaround times. Innovative methods like salivary tests are being explored to expand testing capacity beyond laboratory-based confirmation. However, the development of a commercially available salivary test is still a long way off. PCR tests, which look for the genetic material of the virus, have been used since 1982, but the testing process remains complicated, and it's unclear why obtaining and distributing primers for these tests has been difficult. Overall, the ongoing monkeypox outbreak highlights the need for improved testing and a better understanding of transmission dynamics.

    • Smallpox-centric approach complicating monkeypox responseDespite having the knowledge and resources to address monkeypox effectively, the smallpox-centric approach is causing logistical issues in managing vaccine supplies and defining the target population for vaccination, requiring more testing for atypical presentations and cases in non-traditional high-risk populations.

      The current response to the monkeypox outbreak is facing challenges due to our past focus on preparing for a smallpox attack. This has led to logistical issues in managing vaccine supplies and defining the target population for vaccination. While it's clear how to identify and diagnose monkeypox in typical cases, there's a need for more testing for atypical presentations and cases in populations not traditionally considered high risk. The case of a cashier in Georgia who tested positive despite no known risk factors highlights this need. The frustration lies in the fact that we had the knowledge and resources to address monkeypox effectively, but the smallpox-centric approach has caused unnecessary complications.

    • Importance of Thorough Testing and Moving Beyond Contact TracingThe monkeypox outbreak underscores the need for comprehensive testing and the importance of investing in digital transformation to enhance public health systems' ability to manage and respond to outbreaks effectively.

      The ongoing monkeypox outbreak highlights the importance of thorough testing and the need to move beyond relying on contact tracing for identification and containment. The discussion also touched upon the underfunding and digital transformation needs of the public health system to better manage and respond to outbreaks. The speakers expressed disappointment with the overall rollout of testing, vaccines, and treatment for monkeypox, and while they acknowledged the challenges faced by public health systems, they emphasized the need for a more proactive and prepared approach to outbreaks. The conversation also suggested the creation of a national stockpile for tests and resources to prevent and respond to outbreaks effectively.

    • The Need for a Proactive Approach to Public HealthInvest in preventative measures like surveillance, support public health institutions, and work together globally to address outbreaks early and contain their spread.

      We need to adopt a more proactive and global approach to public health, especially when it comes to infectious diseases. The discussion highlighted the lack of preparedness and response in the early stages of outbreaks, using the examples of COVID-19 and monkeypox. It's crucial to invest in preventative measures, such as surveillance, and support public health institutions, rather than reacting after an outbreak has spread. Additionally, the global community needs to work together to address outbreaks as they are no longer confined to specific regions. The ease of travel makes it essential to take action as soon as possible to prevent the spread and contain the outbreak. Overall, a more collaborative and proactive approach to public health is necessary to protect individuals and communities worldwide.

    • Monkeypox Outbreak Affects Gay Community, Address StigmatizationThe monkeypox outbreak disproportionately affects the gay community, but it's crucial to address this issue without stigmatizing. The community's openness to sexual health discussions makes them more responsive to public health messages. Equitable vaccine and healthcare access is essential for all, including marginalized communities.

      The current monkeypox outbreak disproportionately affects the gay community, and it's crucial to address this issue without stigmatizing the community. The gay community's openness and willingness to discuss sexual health issues make them more responsive to public health messages and vaccination efforts. However, it's essential to ensure equitable access to vaccines and healthcare for all, including marginalized communities who have historically been overlooked during health crises. The highest risk group for monkeypox is behavior-based, not based on sexual orientation. The affordability and ease of at-home manicure kits from companies like Olive and June can help people achieve salon-quality nails quickly and conveniently.

    • Prioritizing vaccinations based on risk behaviorsEffective vaccination strategies adapt to new information and prioritize high-risk groups, while clear communication is essential to build trust and confidence.

      Effective vaccination strategies require careful consideration and adaptability. Houston and the Netherlands have successfully prioritized vaccinations based on risk behaviors rather than sexual orientation. However, it's crucial to understand the efficacy and evolving nature of the vaccine. The challenge lies in communicating these changes to the public, as people may be skeptical of shifting messages. The HPV approach, focusing on specific age groups and high-risk networks, could be a potential solution to reach everyone. Recently, the FDA authorized a new method of delivering the Jynneos vaccine, which could increase the number of doses per vial, potentially leading to significant progress. Yet, the effectiveness of this method is still uncertain. The key is to continue learning and adapting, while ensuring clear and transparent communication to build trust and confidence in the vaccination process.

    • Exploring new approaches to monkeypox treatmentWhile intradermal smallpox vaccine and tecovirimat show promise for monkeypox, further research is necessary to ensure their efficacy, effectiveness, and safety for immunocompromised individuals.

      While the intradermal administration of the smallpox vaccine for monkeypox shows promise, it's essential to conduct further research to ensure its efficacy, effectiveness, and safety, particularly for immunocompromised individuals. The intradermal approach may not provide a robust enough response for those with weakened immune systems. Tpox or tecovirimat, a drug used to treat monkeypox, has shown impressive results in animal studies and case series, but more research is needed to understand its effectiveness in real-world situations and appropriate dosing for immunocompromised individuals. The animal studies suggest that tecovirimat can prevent severe outcomes when given in high doses, but we lack information on the counterfactual - how the lesions would heal without the drug. Overall, while these developments are promising, it's crucial to approach them with caution and continue researching to ensure the best possible outcomes for those affected by monkeypox.

    • New challenges with Monkeypox virus: Reinfection and Asymptomatic spreadDespite falling scabs, there's a risk of reinfection. Asymptomatic spread is possible, but mechanisms and extent are unclear. Intense pain from lesions may limit spread through sexual contact.

      The monkeypox virus, while similar to smallpox, continues to present new challenges and uncertainties. While the scabs on infected individuals are no longer infectious, there have been cases of reinfection even after the scabs have fallen off. This has led to revised counseling for patients regarding resuming normal activities and skin-to-skin contact. Additionally, while the majority of cases have been symptomatic, there is a possibility of asymptomatic or presymptomatic spread. The exact extent and mechanisms of these transmissions are still under investigation. The pain associated with monkeypox lesions can be intense, particularly in sensitive areas, and may contribute to limiting the spread through sexual contact. The CDC acknowledges that asymptomatic transmission is not yet fully understood and is an active area of investigation.

    • Monkeypox transmission through surfaces is not a major concernWhile cleaning surfaces is important, focusing excessively on it may distract from proven methods of prevention like vaccination and avoiding close contact with infected individuals.

      While there is a possibility of Monkeypox transmission through surfaces or fomites, it is not a major route of transmission based on current evidence. The risk of transmission depends on various factors such as contact with infected lesions, duration of contact, and personal hygiene. People's anxiety about the virus may lead them to focus excessively on fomites, but it is important to remember that most people already know how to assess risk and engage in basic hygiene practices. While it is still important to clean surfaces, it should not overshadow other proven methods of prevention such as vaccination and avoiding close contact with infected individuals. The ongoing pandemic has brought back fears and uncertainties, but it is crucial to separate myths from facts and prioritize evidence-based information.

    • Addressing the history of mistrust between the medical community and LGBTQ+ communityEducation and nudges, rather than bans or shaming, are more effective in changing behaviors. It's important to address the historical mistrust between the medical community and LGBTQ+ community while offering outreach and open conversations.

      While it's important to be cautious about potential health risks, banning or shaming behaviors doesn't necessarily stop them from happening. Instead, education and nudges in the right direction have been shown to be more effective. This was discussed in relation to the Folsom Street Fair in San Francisco, which is known for its fetish and leather celebrations. The history of how the medical community has treated the LGBTQ+ community in the past has left a scar and mistrust, making open and realistic conversations necessary. It's crucial to address this history while also recognizing opportunities for outreach to these communities. The speaker also acknowledged his discomfort discussing the topic but emphasized the importance of addressing it.

    • Collaborating with communities during public health crisesDuring public health crises, organizations should engage with communities and provide resources and education instead of just telling them to cancel events. Effective strategies include partnering with local clinics and using innovative channels like social media to reach high-risk populations.

      During public health crises, it's essential for organizations to meet communities halfway and find opportunities to provide resources and education rather than simply telling them to cancel events. This approach was discussed in relation to the Folsom Street Fair and the ongoing monkeypox outbreak. The CDC could be more effective by directly engaging with local clinics and targeting high-risk populations through innovative channels like social media. The reproductive number of a virus or pathogen is both a biological and societal feature, and the high reproductive number in a subset of the MSM community underscores the importance of targeted interventions. However, more research is needed to understand the current context and reach of this population. Overall, the conversation highlighted the importance of collaboration, innovation, and targeted approaches in addressing public health crises.

    • Understanding the complexities of monkeypox data and renaming it to reduce stigmaLimited and messy data collection complicates predicting monkeypox's spread and assessing risk. Renaming it to reduce stigma could make it sound more objective.

      The ongoing monkeypox outbreak is complex and understanding its spread is challenging due to limited and messy data collection, especially in certain communities. As a result, predicting the virus's reproductive number and assessing the risk of other communities contracting it is difficult. Additionally, the name of the virus, monkeypox, has been suggested to be changed to reduce stigma and make it sound more technical and objective. The World Health Organization (WHO) has considered renaming it, but no consensus has been reached yet. The discussion also touched upon the importance of removing stigma from virus names, as seen with COVID-19, and the potential benefits of simple, objective names.

    • WHO's naming system for new diseases gaining acceptanceFollow reliable sources like @agramwalker, insidemedicine.bulletin.com, @neurofoyer, and @doctor_neuro for COVID-19 and monkeypox info. Stay informed, seek professional advice, and consider UnitedHealthcare's Health ProtectorGuard for managing medical costs.

      The use of Greek letters by the World Health Organization (WHO) to name new diseases, such as monkeypox, is gaining acceptance and effectiveness in the medical community. During the COVID-19 pandemic, the WHO's naming system was met with skepticism, but it has proven to be a clear and efficient way to communicate about new health threats. Three experts in the field, Graham Snyder, Jeremy Faust, and Neel Shah, discussed the importance of following reliable sources for COVID-19 and monkeypox information, such as Graham's Twitter account (@agramwalker) for frontline insights, Jeremy's Inside Medicine newsletter (insidemedicine.bulletin.com), and Neel's social media channels (@neurofoyer on Twitter and Twitch, @doctor_neuro on Twitch). The experts also acknowledged the contributions of other experts, including Jason Kindichuk, Oguma Tapanji, Joe Osmonson, and Collezzo Makofane. The podcast emphasized the importance of staying informed about health concerns and seeking professional advice for individual health needs. UnitedHealthcare's Health ProtectorGuard fixed indemnity insurance plans were also mentioned as a helpful resource for managing out-of-pocket medical costs.

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