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    Neuroendocrinology (SEX & GENDER) Mega Encore with Daniel Pfau

    en-usJuly 31, 2024
    What is neuroendocrinology?
    How does Dr. Daniel Bao identify in relation to gender?
    What myths about queer individuals are debunked by Dr. Bao?
    How do animal behaviors challenge traditional gender roles?
    What does recent research say about sex and gender in the brain?

    Podcast Summary

    • Neuroendocrinology and sex differencesEnvironmental signals play a crucial role in shaping sex differences in the brain, and neuroendocrinology helps us understand this complexity. Dr. Bao debunks myths about queer individuals in science and shares their personal journey of coming out and the impact of their upbringing on their research interests.

      Neuroendocrinology, the study of the interaction between the nervous system and hormones, helps us understand the complexities of biological sex and gender. Dr. Daniel Bao, a neuroscientist and non-binary researcher, shares their insights on this topic. They discuss how environmental signals contribute to sex differences in the brain and debunk common myths about queer individuals in the scientific field. Dr. Bao also shares their personal journey of coming out as queer and the impact of their religious upbringing on their scientific interests. The conversation sheds light on the importance of representation and acceptance in science and society.

    • Gender Identity ComplexitiesAccepting and understanding the complexities of gender identity is essential for creating inclusive environments. Use inclusive language, validate gender expressions, and educate yourself on various gender identities.

      Understanding and accepting the complexities of gender identity is crucial for creating inclusive environments. The speaker shared their personal experiences of struggling with their gender identity in a church community and in therapy sessions, where they were given messages that suppressing their unique expression was better. They also discussed the importance of representation and understanding the differences between gender identity, expression, and sex. The speaker emphasized the importance of using inclusive language and being open to the diverse range of gender identities and expressions. They also introduced the concept of intersex individuals and shared examples of various gender identities, including genderqueer, non-binary, and demi-males/females. The speaker encouraged everyone to educate themselves on these topics and normalize the use of inclusive language. By acknowledging and validating the experiences of individuals with non-traditional gender identities, we can create a more inclusive and accepting society.

    • Brain development and gender identityResearch shows that each individual's brain development contributes to their unique gender identity, challenging the notion of rigid gender roles and expectations, and emphasizing the importance of recognizing and respecting the spectrum of gender identities.

      Human sex and gender are more complex than commonly believed. Instead of being monolithic groups defined by chromosomes or hormones, each individual has a unique brain development that contributes to their gender identity. Dr. Daphne Joel's research shows that there is a mosaic of male and female regions in every brain, and individual differences are larger than average differences between sexes. This challenges the notion of rigid gender roles and expectations, and highlights the importance of recognizing and respecting the spectrum of gender identities. A recent study in the journal Science Advances supports this idea, showing that sex and gender are distinct and irreducible to one another in the brain. This research underscores the need to move beyond binary notions of sex and gender and embrace the diversity and complexity of human identity.

    • Pheromones and behaviorLoss of TRPC2 gene affects not only the detection of pheromones but also leads to significant changes in behavior, including decreased maternal aggression in females and less aggression in males

      Pheromones play a significant role in shaping behaviors in animals, including altered sexual and aggressive behaviors in knockout mice lacking the TRPC2 gene. The loss of signals from the vomeronasal organ, which detects pheromones, was initially thought to be the sole cause of these behaviors. However, researchers Daniel and Janet discovered that more robust changes occurred in the brain beyond just the loss of signals. They found that females, which typically show maternal aggression towards intruding males, no longer displayed this behavior when the TRPC2 gene was absent. Similarly, males, which typically exhibit aggression towards other males, became less aggressive. These findings suggest that the role of pheromones in behavior goes beyond just the initial detection and reception of signals, highlighting the complexity of neural processes in animals.

    • Animal gender rolesAnimal gender roles can be more complex than assumed with females exhibiting male traits and vice versa, and chemicals like oxytocin and vasopressin influencing monogamy or polygamy behaviors.

      Animal behavior and sexuality can be more complex and diverse than what we commonly assume. From lionesses growing manes and roaring like males to females having pseudo-phalluses and being in charge in certain hyena species, nature finds ways to adapt and switch up gender roles. Additionally, chemicals like oxytocin and vasopressin play significant roles in controlling monogamy or polygamy behaviors in various species. Another fascinating discovery is the existence of "velvet deer," male deer with low levels of androgen, who exhibit less aggression towards females and reduce aggression towards them. This research challenges our understanding of gender and sexuality, highlighting the intricacy and diversity of nature.

    • Sexual orientation developmentSexual orientations develop through a complex interplay of factors including genetics, hormones, and environment, and are influenced by constant brain changes

      Conversion therapy, a harmful and discredited practice aimed at changing a person's sexual orientation, is not effective or scientifically sound. The idea that humans have always exhibited queer behaviors, as suggested by the loss of the TRPC2 gene 25 million years ago, challenges the notion that heterosexuality and non-heterosexual identities developed separately. Hormones, such as testosterone, may influence attraction, but the development of sexual identities is likely influenced by a complex interplay of various factors, including hormone levels and sensitivity to hormones. The nature versus nurture question is no longer valid, as our brains are influenced by our environment and are constantly changing. There is some evidence suggesting that maternal hormones during pregnancy may play a role in sexual orientation development, but more research is needed. Ultimately, it's important to recognize that sexual orientations exist on a spectrum and that variation is the norm.

    • Complexities of gender and sexualityThe importance of recognizing and accepting the full spectrum of gender and sexual identities beyond binary labels, with a significant increase in younger generations identifying outside the gender binary, and the need for societal acceptance and scientific research to reflect these changes.

      There are more complexities to gender and sexuality than what is traditionally presented or assumed. Dr. Swishita emphasized the importance of considering the full spectrum of experiences and identities beyond binary labels. She also mentioned the significant increase in younger generations identifying outside the gender binary, highlighting the need for scientific research and societal acceptance to reflect this change. Furthermore, the discussion touched upon the historical context of gender reveals and the misconception that revealing a child's sex can determine their future identity. The Marsha P. Johnson Institute was introduced as an organization dedicated to supporting and defending the human rights of black transgender people, emphasizing the importance of recognizing and addressing the exclusion of trans women of color from social justice issues. Overall, the conversation emphasized the need for understanding, acceptance, and representation of diverse gender and sexual identities.

    • Sex development and gender identityThe complexity of sex development and gender identity goes beyond simplistic definitions, as shown by examples like Whiptail lizards and the need for individualization in hormone replacement therapy.

      The complexity of sex development and gender identity goes beyond simplistic definitions based on body parts or chromosomes. The example of Whiptail lizards, which exhibit female-female reproduction, challenges traditional notions of male and female roles. In the realm of hormone replacement therapy (HRT), there's a need for more research and understanding, as individual responses to hormones can vary greatly. Hormones like estrogen and testosterone affect us differently based on our unique biology, and it's crucial to acknowledge this complexity. Furthermore, the benefits of both sexual reproduction and cloning exist in various species, highlighting the intricacy of evolution and the importance of ongoing research in transgender medicine.

    • Hormones and athletic performanceHormones, like progesterone, can impact mental health and athletic performance. The gender unicorn model highlights the complexity of gender identity, expression, sex, and orientation. It's crucial to respect individuals' self-identification and consider the intricacies of the hormonal system in sports.

      Hormones, including progesterone, play a complex role in our bodies and can significantly impact various aspects of our lives, including mental health and athletic performance. The gender identity model, represented by the gender unicorn, highlights the distinction between gender identity, gender expression, sex assigned at birth, and sexual orientation. It's crucial to recognize the complexity and individuality in these areas and to respect each person's self-identification. In the context of sports, focusing solely on testosterone levels may overlook the intricacies of the hormonal system and the diversity of experiences among athletes. It's essential to promote an inclusive environment where individuals can explore their identities and trust their own experiences, while also considering the role of science in understanding and validating these experiences.

    • Trans and non-binary hormonal mental healthHormones, such as testosterone, significantly impact mental health and well-being for trans and non-binary individuals. Consistent use is necessary for equilibrium, while hormonal changes during puberty can contribute to mental health disorders. Authenticity and self-expression are essential for managing anxiety and societal expectations.

      Hormones, including testosterone, play a significant role in mental health and well-being for trans and non-binary individuals. While testosterone does not inherently make people more aggressive, the introduction of hormones can cause behavioral changes due to the body's reaction to a new environment. Consistency in hormone use is essential for maintaining equilibrium. Furthermore, hormonal changes during puberty can contribute to the development of mental health disorders. Authenticity and self-expression are crucial for managing anxiety and navigating societal expectations. The complexity of hormonal interactions and their impact on mental health warrants further research and understanding.

    • Gender identity and body developmentThe disconnect between gender identity and body development can lead to dysphoria, and research suggests supporting transgender individuals can improve their well-being.

      Gender identity and body development are intricately connected, and the disconnect between the two can lead to dysphoria. The brain's associative areas, which connect one's identity to their body, may have weaker connections in some trans individuals. The development of these associations can vary throughout one's life, leading to feelings of comfort or discomfort in different parts of the body. It's essential to create a safe and open environment for individuals to express their gender identity and ensure they feel comfortable discussing these topics. While there's still much to learn, research suggests that supporting transgender individuals can help reduce self-harming behaviors and improve overall well-being. It's crucial for researchers to collaborate with the transgender community to conduct ethical and inclusive studies.

    • Inclusivity in scientific researchScientific researchers should strive to include marginalized communities like the transgender community in their studies and listen to their experiences, rather than making assumptions or relying on limited data.

      Inclusivity and understanding are key in scientific research, especially when it comes to marginalized communities like the transgender community. Researchers should strive to include transgender individuals in their studies and listen to their experiences rather than making assumptions or relying on limited data. Discriminatory attitudes and ignorance should not be barriers to inclusion, and scientists should be open to learning and growing. The importance of empathy and operating from a place of love cannot be overstated. A fascinating example of this is the evolution of the pineal gland, which went from being directly exposed to light in lizards to being embedded in the human brain and receiving light information through the retina. This shift required the pineal gland to adapt, much like how we as individuals and society as a whole must adapt to include and understand marginalized communities.

    • Moments to cherishEmbrace every moment, connect with others, and don't miss out on high-five opportunities. Self-love, acceptance, and respect for all individuals are essential.

      Life's moments, whether joyful or seemingly embarrassing, should be embraced and lived freely. The speaker shared an anecdote from a friend's wedding where he missed a high-five moment due to lack of eye contact. While it may seem insignificant, the speaker expressed hope that it wouldn't be captured in the wedding video. This experience serves as a reminder to make the most of every moment and connect with those around us. The speaker also emphasized the importance of self-love, acceptance, and respect for all individuals, regardless of their relationship status or identity. The episode was edited by a team of friends and featured theme music by Nick Thorburn of the band Islands. The speaker ended by encouraging listeners to be true to themselves and their feelings.

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    Editing by Mercedes Maitland of Maitland Audio Productions and Jacob Chaffee

    Managing Director: Susan Hale

    Scheduling Producer: Noel Dilworth

    Transcripts by Aveline Malek 

    Website by Kelly R. Dwyer

    Theme song by Nick Thorburn

    Ologies with Alie Ward
    en-usJuly 11, 2024