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    Ozempic Expert: Ozempic Increases This Disease By A Factor Of 9! They're Lying To You About Ozempic Side Effects & What It's Doing To Our Brains! - Johann Hari

    enApril 29, 2024

    Podcast Summary

    • New weight loss drug Ozempic offers significant weight loss but potential risksOzempic, a new weight loss drug, leads to substantial weight loss but raises concerns about muscle mass loss, increased health risks, and potential suicidal feelings. A sustainable solution is uncertain as users often regain weight once they stop taking it.

      The use of the new weight loss drug Ozempic, which is currently gaining popularity, presents both extraordinary benefits and disturbing risks. The drug, which is a type 2 diabetes medication, has been found to significantly reduce hunger and lead to substantial weight loss for many users. In fact, the average person using this drug loses 15% of their body weight in a year, and the next generation of drugs promises even more weight loss. However, there are concerns about the drug's potential risks, including the loss of muscle mass, increased risk of certain conditions, and even suicidal feelings. Additionally, the drug may not be a sustainable solution as users often regain the weight once they stop taking it. The speaker, who was surprised to find that many people around him were using the drug, expressed deep conflict about its use due to its potential risks. Ultimately, while the drug offers a promising solution for those struggling with obesity and related health issues, it is important to be aware of its risks and consider other options as well.

    • The author's personal journey with Azempic and its implicationsThe author tried Azempic, experienced weight loss, but remains conflicted due to concerns about cost, side effects, and societal implications.

      The author, while intrigued by the potential of the weight loss drug Azempic, was deeply conflicted due to past experiences with miracle diet drugs and concerns about side effects, cultural implications, and the impact on people with eating disorders. During his research for his book, he personally tried the drug and experienced a significant reduction in appetite, leading to weight loss. However, the cost, which varies greatly depending on the location, remains a significant barrier for many. Despite gaining a better understanding of the benefits and risks, the author remains conflicted about the drug and its implications for society.

    • GLP-1 drugs mimic a natural hormone for extended appetite suppressionGLP-1 drugs can lead to weight loss by mimicking a natural hormone, but may cause side effects and loss of appetite some find unbearable.

      GLP-1 drugs, which have been used to manage diabetes for nearly 20 years and are relatively new for obesity treatment, work by mimicking a natural hormone in the body called GLP-1. This hormone signals to the brain that a person has had enough to eat and should stop. However, the drugs keep this hormone in the system for a week instead of just a few minutes, making people feel full for a longer period. While this can lead to significant weight loss, there are also risks and downsides. Some people may find the loss of appetite and pleasure in food unbearable, and the drugs can have side effects that make it difficult for some to continue taking them. It's important to consider both the benefits and risks when considering GLP-1 drugs for weight loss.

    • Ozempic's Effect on Food Intake and BrainOzempic, a diabetes drug, impacts the brain and affects food intake and preferences, potentially influencing motivation and pleasure, with further research needed on implications for addiction and depression.

      Ozempic, a medication used to manage type 2 diabetes, not only affects the gut but also the brain, leading to potential impacts on food intake and preferences. The speaker shared their personal experience of using Ozempic, which made it difficult for them to stuff themselves and led to more enjoyment of food. The drug's impact on the brain is still a subject of scientific debate, but research suggests that GLP-1, the active ingredient in Ozempic, can be produced in the brain and affects the reward system, influencing motivation and pleasure. The speaker also shared anecdotal evidence of altered food preferences and cravings after taking the drug. The potential implications of these findings for addiction and depression are significant, but further research is needed to fully understand the brain's response to these drugs.

    • Drugs and Food Preferences: Impacts on Reward and Satiety SystemsSome drugs, like those for weight loss, may alter brain reward and satiety systems, potentially leading to unhealthy food choices and risks such as depression or suicidal thoughts. The debate continues on whether these drugs reset preferences to healthier levels or contribute to addiction.

      Certain drugs, including those used for weight loss, may impact the reward and satiety systems in the brain, leading to changes in food preferences and potential risks such as depression or suicidal feelings. An ongoing debate exists regarding the accuracy of these concerns, with some scientists suggesting these drugs reset preferences to healthier levels instead. Additionally, the satiety system, which signals the feeling of having had enough, is crucial to understanding these drugs and the implications for addiction and our diets. The experiment conducted by professor Paul Kenny, a neuroscientist, helps explain how sugar consumption might lead to increased intake and the obesity epidemic.

    • Impact of Food on Satiety Signals and Eating HabitsThe modern food system disrupts natural nutritional wisdom and satiety signals, leading individuals to ignore negative consequences and overconsume unhealthy foods, contributing to obesity.

      The food we consume can significantly impact our ability to recognize satiety signals and regulate our eating habits. This was demonstrated in an experiment involving rats, where they became obsessed with junk food to the point of neglecting their natural diet and becoming obese. The researchers concluded that the desire for junk food is so strong that individuals will ignore negative consequences to continue consuming it. This phenomenon is not unique to rats, as many humans also struggle with overeating unhealthy foods. The root cause of this issue lies in the modern food system, which disrupts our natural nutritional wisdom and satiety signals. Therefore, addressing the food system and promoting healthier food choices is crucial for preventing and managing obesity. Additionally, drugs that restore a sense of satiety can be seen as an artificial solution to an artificial problem created by the food system.

    • Address immediate health needs while working towards long-term solutionsFocus on both short-term improvements and long-term solutions to maintain overall health and well-being

      While it's essential to address the root causes of health issues, such as environmental factors contributing to breast cancer or obesity, individuals also need to prioritize their immediate health and well-being. Using the analogy of a house on fire, it's crucial first to put out the fire before focusing on building fire-resistant houses. Similarly, people battling health issues, like cancer or obesity, should not overlook the importance of taking necessary measures, such as medication or diets, to improve their health in the present while working towards long-term solutions. It's a delicate balance between addressing the root causes and taking care of immediate health needs.

    • Our bodies are not designed for long-term weight lossBiological changes make it hard to maintain weight loss, focusing on lifestyle changes may be more effective

      While diets may lead to weight loss in the short term, most people regain the weight back after just a few months. This is due to biological changes that occur as we gain weight, which make it harder for us to maintain weight loss. These changes include a rise in our body's set point, which causes our metabolism to slow down, our energy levels to decrease, and our cravings for sweet and salty foods to increase. This is a result of our evolutionary history, where humans did not evolve in environments with abundant calories for their entire lives, but rather faced frequent periods of food scarcity. Therefore, our bodies are not well-equipped to maintain weight loss in a world of abundant food. Instead, focusing on sustainable lifestyle changes, such as increasing physical activity and making long-term adjustments to our eating habits, may be more effective for achieving and maintaining a healthy weight.

    • Our instinct to gain and hold onto weightUnderstanding our evolutionary history and modern stressors can help us approach weight management with a sustainable perspective, focusing on emotional and environmental factors instead of just caloric intake.

      Our biological makeup, including the instinct to gain and hold onto weight, can make dieting challenging. This instinct is driven by our evolutionary history and the potential for future food scarcity. Furthermore, modern life's stressors and distractions can weaken our willpower and make it harder to maintain a healthy diet. Some weight loss drugs may help reset our biological set point, but they can also have unintended consequences, such as reducing our ability to comfort eat. Ultimately, a sustainable approach to weight management may involve addressing the underlying causes of overeating, including emotional and environmental factors, rather than just focusing on caloric intake.

    • Obesity drugs vs bariatric surgery: Improvements and risksObesity drugs and bariatric surgery can lead to impressive health improvements but also carry psychological risks, including new addictions and depression.

      While obesity drugs can lead to significant weight loss and improved physical health, they can also have negative psychological consequences. The comparison to bariatric surgery is illuminating, as both methods can result in impressive health improvements but also carry risks. The surgery, for instance, can lead to increased happiness for some but depression and even suicide for others due to the loss of comfort eating. Similarly, obesity drugs can disrupt underlying psychological reasons for overeating, leading some people to develop new addictions. It's essential to consider these potential risks when weighing the benefits of such treatments.

    • The link between trauma and comfort eating60% of severely obese women gained weight after trauma, revealing comfort eating as a coping mechanism. Deprivation can resurface past traumas, requiring sensitivity and honesty.

      The relationship between comfort eating and trauma is complex and deeply interconnected. Dr. Vincent Felitti's research in the 1980s, as shared in the discussion, revealed that 60% of severely obese women in his study had gained weight in the aftermath of sexual abuse or assault. This finding suggests that for some individuals, excessive comfort seeking through food may serve as a coping mechanism for past traumas. The complexity of this issue is further emphasized by the fact that deprivation of comfort eating, whether due to illness or medication, can bring these traumas to the surface, making it essential to approach this topic with honesty and sensitivity. The relationship between trauma and comfort eating is just one aspect of the intricate web of causes and effects surrounding our relationship with food and eating.

    • Living in an obesogenic environmentDespite challenges, progress towards healthier food choices is possible, as seen in countries like Japan with low obesity rates.

      We live in an obesogenic environment that makes it difficult to maintain a healthy weight due to the easy access and promotion of unhealthy food. Processed food, in particular, contributes to an average consumption of 500 extra calories per day. However, change is possible, as seen in countries like Japan that have successfully transformed their diets to have very low obesity rates. Although it may seem challenging, the transformation towards healthier food options has already happened with smoking, and the same progress can be made with processed foods. The government acknowledges the risks associated with these foods, and it's essential for individuals and governments to take action to make healthy choices more accessible and affordable.

    • Japan's Successful Efforts to Keep Obesity Rates LowJapan's low obesity rates aren't due to genetics but deliberate efforts but rather cultural norms and policies promoting healthy eating and physical activity since the 1920s.

      Japan's success in staying slim despite becoming a wealthy country is not due to genetics but rather deliberate efforts to transform their food culture. The Japanese government recognized the importance of a healthy population for their military strength in the 1920s and took conscious steps to improve their diet. Today, Japanese schools employ professional nutritionists to prepare and educate children about healthy eating, with a focus on eating until only 80% full. The absence of processed food in schools and the practice of children walking to and from school contribute to their physical activity levels. These policies, implemented decades ago, have resulted in Japan having one of the lowest obesity rates in the world. This example shows that with conscious efforts and cultural norms, it's possible to prevent obesity even in wealthy countries.

    • Cultural differences in eating habits and food educationJapan's emphasis on nutritionally balanced meals and slow eating leads to low childhood obesity, while some Western cultures' trend towards using drugs for weight loss can lead to health risks

      There are significant cultural differences in eating habits and food education that contribute to better health outcomes. For instance, in Japan, people are taught from a young age to eat a nutritionally balanced meal with a variety of ingredients, and they eat slowly, allowing their bodies to fully digest and absorb the nutrients. This system results in a population with low childhood obesity. On the other hand, in some Western cultures, there's a growing trend towards using drugs like semaglutide (marketed as Ozempic or Wegovy) for weight loss, which can lead to eating disorders and other health risks. These drugs are easily accessible online without a prescription, making them a concerning issue for health experts. Overall, the way we approach food and eating can have a significant impact on our health and wellbeing, and cultural differences and trends should be considered when making choices about our diets.

    • Virtual doctor consultations and GLP-1 replicas: Convenience with risksGLP-1 replicas offer benefits for diabetes and weight loss, but only after in-person consultation with eating disorder experts due to risks, particularly for young women and those with eating disorders. Potential side effects include pancreatitis and thyroid cancer.

      While virtual doctor consultations and the availability of weight loss drugs like GLP-1 replicas offer convenience, they also come with significant risks, particularly for young women and those with eating disorders. Experts recommend that these drugs should only be prescribed after an in-person consultation with a doctor trained in detecting and managing eating disorders. The discovery of GLP-1 replicas began with the study of insulin production in the 1980s, leading to significant benefits for diabetics. However, the appetite-suppressing effects were later discovered, and the drugs have since shown to reduce the risk of heart attacks and strokes for those with a higher BMI. Despite these benefits, there are potential risks and side effects, including pancreatitis and thyroid cancer, which warrant careful consideration before use.

    • Semaglutide drugs linked to higher risk of thyroid cancer and pancreatitisDiabetics taking semaglutide drugs like Ozempic and Wegovy for 3 years had a 50-75% increased risk of thyroid cancer and a known risk of pancreatitis.

      The use of semaglutide drugs like Ozempic and Wegovy, which are commonly prescribed for diabetes and obesity, has been linked to an increased risk of thyroid cancer and pancreatitis. Professor Fahey's research found that diabetics who took these drugs for three years between 2006 and 2015 had a 50 to 75% higher risk of thyroid cancer. Although this doesn't mean that every user will develop thyroid cancer, it is a significant concern given the large number of people taking these drugs worldwide. Additionally, pancreatitis, a rare but painful condition, is a known side effect of these drugs. The risk is low, but the condition can be excruciating, as Michelle Stesniak's experience demonstrates. It's essential to be aware of these risks and discuss them with your healthcare provider before starting these medications.

    • New weight loss drugs target gut hormones for appetite suppression and fullnessNew drugs like Wegovy, Ozempic, Munjaro, and Triple G stimulate feelings of fullness and suppress appetite through gut hormones, leading to significant weight loss. However, potential side effects include muscle mass loss and debated links to increased suicidality, anxiety, and depression.

      The new class of weight loss drugs, such as Wegovy, Ozempic, Munjaro, and the upcoming Triple G, work by targeting gut hormones to stimulate feelings of fullness and suppress appetite. These drugs have shown significant weight loss results, with Munjaro causing an average of 21% loss and Triple G causing 24.2%. However, a potential concern is muscle mass loss as a side effect, which is a natural consequence of weight loss but can lead to serious health issues like sarcopenia in older adults. Another debated issue is the potential link between these drugs and increased suicidality, anxiety, and depression, which may be due to underlying mental health conditions or a separate side effect. Overall, these new drugs represent a promising development in weight loss treatment, but they come with potential risks that need to be carefully considered.

    • The complex link between weight loss drugs and suicidalityScientific consensus on the connection between weight loss drugs and suicidality is unclear, and historical examples of diet drugs with serious side effects highlight the need for caution and continued research.

      The connection between weight loss drugs and suicidality is complex and not fully understood. Some scientists argue there isn't enough evidence to link the drugs to suicidality, while others worry about the potential impact on the brain's reward system. Additionally, the psychological effects of weight loss, such as unmet expectations, can lead to significant psychological discomfort. The history of diet drugs is filled with examples of promising treatments that turned out to have serious side effects, from Dinitrophenol's explosive properties to amphetamines' addictive nature and Fen-phen's link to heart valve problems. These examples underscore the importance of continued research and caution in the development and use of weight loss drugs.

    • Fen-Phen: Incredible Short-Term Weight Loss, Serious Long-Term RisksFen-Phen, a once popular weight loss drug combo, had short-term success but long-term risks like primary pulmonary hypertension, heart damage, and unknown effects on memory, taste, and gut motility. Drug companies hid these risks. Ongoing research is vital for understanding long-term impacts.

      Fen-Phen, a once popular weight loss drug combination, had incredible short-term results but was later linked to serious health risks, including primary pulmonary hypertension and heart damage. The drug companies knew about these risks but failed to warn the public. The long-term effects, including unknown unknowns, are still a concern, particularly since these drugs affect key parts of the brain related to memory, taste, and gut motility. While obesity also poses significant health risks, the long-term risks of these drugs are not fully understood. A comparison can be drawn to antipsychotics, which were considered safe for decades before being linked to increased risk of Alzheimer's disease and other forms of dementia. The potential risks and benefits of these drugs should be carefully weighed, and ongoing research is crucial to understanding their long-term effects.

    • Considering the Risks and Trade-offs of Drugs like OzempicWhile Ozempic and similar drugs offer health benefits, it's crucial to be aware of potential risks and make informed decisions based on personal circumstances and potential downsides.

      While some drugs like Ozempic can offer significant health benefits, it's essential to consider the potential risks and trade-offs. And, as with many things in life, there's often no such thing as a completely risk-free solution. Dr. Max Pemberton, a doctor and friend of the speaker, emphasizes that if given a choice between becoming HIV positive with proper medical treatment or developing diabetes, he'd choose HIV every time due to diabetes's severe health complications and shorter life expectancy. However, personal circumstances, such as family history or concerns about muscle mass, may influence the decision. The speaker acknowledges that these drugs can save lives for some people, but he believes in the importance of being aware of potential downsides and making informed judgments. He encourages everyone to carefully weigh the pros and cons before deciding to take these drugs. The speaker also draws parallels to other seemingly miraculous solutions, like productivity-enhancing drugs, which may come with hidden costs. Ultimately, it's crucial to remember that there's always a trade-off in life, and being aware of the potential consequences is key to making the best decision for one's unique situation.

    • Considering the personal, ethical, and societal dilemmas of weight loss drugsWeight loss drugs like Ozempic have potential benefits and costs, leading to complex personal, ethical, and societal implications. Easy access to these drugs could change industries and create societal divides.

      The use of weight loss drugs like Ozempic is a complex issue with potential significant personal and social implications. While some people may see the benefits of these drugs as outweighing the costs, others may view them with skepticism. The widespread adoption of these drugs could lead to various unpredictable effects, some positive and some negative, such as changes in the food industry, healthcare sectors, and even airline industries. As more people gain easier access to these drugs, there might be a divide between those who use them and those who don't, potentially leading to societal implications. It's essential to consider the personal, ethical, and societal dilemmas surrounding the use of these drugs as they continue to evolve and become more accessible. Additionally, managing stress is crucial for overall well-being, and tools like Whoop's stress monitor can help individuals identify and cope with stressors in their daily lives.

    • A society divided by weight loss drugsThe use of weight loss drugs like Ozempic could lead to a future where only those who can afford them maintain a slim body, while others are left behind, potentially leading to serious health consequences. To avoid this dystopian future, it's crucial to address the root causes of obesity and ensure healthy food is accessible to all.

      The widespread use of weight loss drugs like Ozempic could lead to a society divided between those who can afford to use the drugs and maintain a slim body, and those who cannot. This could result in a dystopian future where drugs become the norm for weight loss, with potentially serious side effects and health consequences. However, there is hope for a more optimistic future if governments and societies take action to address the root causes of obesity, such as regulating the food industry and making healthy food accessible to all. The conversation also touched upon the potential for drugs to alter people's taste preferences, making unhealthy food less appealing. It's important to consider the long-term effects of these drugs and the potential risks to public health if they become widely used without proper regulation.

    • Improving public health through reformulation and regulationGovernments and companies can reduce health issues like strokes by regulating salt in food and implementing weight loss plans, but cultural differences must be considered.

      Governments and companies have the power to make significant improvements to public health through reformulation and regulation. For instance, reducing salt in bread led to a substantial decrease in strokes in Britain, saving thousands of lives each year. This approach can be applied to other foods and health issues. However, cultural differences and challenges must be considered. For example, Japan's Metabo law, which requires companies to weigh their employees annually and implement weight loss plans, would not be feasible in cultures where such practices are unacceptable. Nevertheless, learning from countries like Japan, which has the longest life expectancy in the world, can provide valuable insights into how to tackle obesity and improve overall health and wellbeing. Ultimately, recognizing the root causes of the obesity crisis and taking action to address them is crucial for the health of current and future generations.

    • Societal pressures and external factors impact weight gain and maintenanceIndividuals have personal responsibility for their health choices, but societal pressures and external factors significantly influence weight gain and maintenance. A holistic approach to weight management acknowledges both personal responsibility and external influences.

      While individuals have responsibility for their own health choices, the external factors influencing weight gain and maintenance are significant. The speaker shares their personal experience of weight fluctuations throughout their life and the societal pressures that contribute to it. They express concerns about the long-term effects of weight loss drugs, such as Ozempic, on metabolism and potential development of tolerance. Additionally, the speaker raises awareness of the eating disorder epidemic, particularly among teenage girls, and the potential dangers of diet drugs falling into the wrong hands. The speaker calls for a holistic approach to weight management that acknowledges both personal responsibility and external influences. The historical example of amphetamine-based diet drugs and their devastating impact on young women serves as a cautionary tale.

    • Dangers of Diet Drugs and Disordered EatingThe combination of diet drugs and eating disorders can lead to severe health consequences and societal pressures normalizing rapid weight loss contribute to disordered eating.

      The combination of diet drugs and eating disorders can lead to devastating consequences. A personal anecdote shared involved a woman who obtained diet drugs and died of a heart attack, while her niece, influenced by the weight loss, asked for the same drug despite being a healthy weight. The speaker expressed concern about the potential normalization of rapid weight loss in the entertainment industry, particularly for women, who face more scrutiny for their bodies. The speaker also touched upon the historical association of obesity with sin and the admiration of weight loss through suffering. Overall, the discussion highlights the importance of addressing the potential dangers of diet drugs and the societal pressures that contribute to disordered eating.

    • Societal Attitudes Towards Weight Loss: Shame, Jealousy, and AngerSociety's focus on individual weight loss rather than addressing systemic issues can lead to negative emotions and blame towards those who lose weight. Instead, we should promote collective action and understanding to tackle the root causes of obesity.

      Our societal attitudes towards weight loss, as illustrated by shows like The Biggest Loser, can lead to feelings of shame, jealousy, and anger towards those who manage to lose weight. This stems from the fact that many people put in great effort to be thin, while others may resort to unconventional methods or appear to "cheat" the system. However, it's essential to recognize that the root cause of the issue is not individuals but the food industry and societal norms that contribute to obesity. We should focus on collective action and understanding rather than engaging in toxic conversations and blaming individuals. The rapid increase in obesity in recent decades, as evidenced by historical photos, highlights the shared crisis we face. Additionally, people's reactions to public figures like Adele or Rebel Wilson losing weight demonstrate the deep-rooted shame and feelings of betrayal some individuals experience when confronted with weight loss. To move forward, we need to address the systemic issues and foster a more compassionate and supportive environment for those struggling with weight and body image issues.

    • Exploring the Emotional Impact and Addiction Potential of Weight Loss Drugs like OzempicOzempic's emotional impact and potential for helping with addiction is a subject of ongoing research. Animal studies suggest it may dampen the desire for unhealthy substances, but more research is needed in humans.

      The use of weight loss drugs like Ozempic can bring up deep-rooted emotions and self-doubt, stemming from past experiences of pain and betrayal. Meanwhile, the drug's impact on addiction is still a subject of debate in scientific communities. Animal studies have shown promising results, with rats and mice reducing their consumption of alcohol, heroin, fentanyl, and cocaine after being given GLP-1 agonists. The theory suggests that these drugs may selectively dampen the desire for unhealthy substances while leaving healthy choices unaffected. However, more research is needed to confirm these findings in humans. Anecdotal evidence includes stories of individuals overcoming various addictions after using Ozempic. While the early human studies are mixed, the potential for these drugs to help with addiction is an intriguing area of ongoing research.

    • Ozempic: A Diabetes Drug with Weight Loss BenefitsOzempic, a diabetes drug, shows potential for appetite suppression and weight loss. Animal studies suggest it enhances self-control and reduces heavy compulsive use. Users report significant weight loss, but common side effects include nausea. Notable figures like Oprah Winfrey have shared success stories.

      Ozempic, a drug primarily used for diabetes treatment, has shown promising results in appetite regulation and weight loss. Some researchers argue that it doesn't just cause appetite suppression but enhances self-control across various aspects. Animal studies suggest it reduces heavy compulsive use, making it unique among other drugs. Personally, users have reported significant weight loss, with one individual losing 3 stone (approximately 42 pounds) in a year. However, side effects like nausea are common, but they usually subside over time. Notable figures like Oprah Winfrey have publicly shared their success stories using Ozempic for weight loss despite the risks and controversies surrounding its use. The complexity of these drugs warrants a truthful and nuanced understanding, acknowledging both the potential benefits and risks.

    • Considering the Risks of Weight Loss DrugsWeight loss drugs may lead to decreased exercise, negatively impact mental health, and may not be necessary for those not overweight or obese. Careful consideration and individual circumstances are key.

      The use of weight loss drugs, while potentially effective in the short term, comes with significant risks and unintended consequences. The drugs may lead to decreased exercise, which can negatively impact mental health and overall well-being. Additionally, the drugs may not be necessary for those who are not overweight or obese, as they incur the risks without the benefits. The decision to use weight loss drugs should be carefully considered, taking into account individual circumstances and potential risks and benefits. The benefits of exercise, which extend beyond weight loss, should also be kept in mind. It's important to remember that magic, or quick fixes, may not always provide the expected results and may come with unintended consequences.

    • The Shortage of Weight Loss Drugs and Prioritizing Those in NeedThe demand for weight loss drugs like Ozempic has caused a shortage, prioritizing those with the greatest need, such as diabetics, is suggested, and the benefits and risks of these drugs should be considered for informed decisions.

      The demand for weight loss drugs like Ozempic has led to a shortage for those who truly need them, such as diabetics. The author, Johan Harstad, who has written a book about the topic, expressed his regret for contributing to this issue by using the drug himself. He suggests implementing a rationing system to prioritize those with the greatest need. Harstad also commended the author of this podcast for giving him a chance early in his career and for his nuanced approach to the subject in his book, "Magic Pill." The book presents both the benefits and risks of these drugs, allowing readers to make informed decisions for themselves. Harstad's storytelling ability and remarkable writing have influenced the podcast host and many readers. "Magic Pill" is due to be released on May 2nd, 2024, and is highly recommended for those interested in the topic of weight loss drugs.

    • The Power of Human CompassionRob's story of survival and dedication to helping homeless survivors in Las Vegas tunnels highlights the importance of human connection and empathy in overcoming adversity.

      Power of human compassion and the importance of helping others, even those who have made mistakes or are facing difficult circumstances. The story of Rob, a former homeless man in Las Vegas who survived an ax attack and then dedicated his life to helping others still living in the tunnels beneath the city, illustrates this idea. Despite the risks and challenges, Rob and his friend Paul continue to return to the tunnels to provide essential supplies and support to those in need. Their selfless actions serve as a reminder that human connection and empathy are valuable reasons for humanity to continue existing.

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    Simon Sinek: "Strong Thigh Muscles = More friends", This Is Why You Can't Make Friends!

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    Moment 166: What Men & Women NEED To Know About The Menstrual Cycle: Dr Mindy Pelz

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    The Menopause Doctor: This Diet Delays Menopause! They're Lying To You About Menopause! Menopause Is Shrinking Your Brain! - Dr Lisa Mosconi

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    Meet the woman behind the scientific research revolution that could change the lives of 50% of the world’s population Dr Lisa Mosconi is the associate professor of neurology and radiology at Weill Cornell Medicine and director of Women’s Brain Initiative and Alzheimer’s Prevention Program. She is also the author of the books, ‘The XX Brain’, ‘Brain Food’, and ‘The Menopause Brain’. In this conversation Lisa and Steven discuss topics such as, how the menopause impacts the brain, the link between menopause and Alzheimer’s, why sex hormones are essential for brain health, and the truth about hormone therapy. 00:00 Intro 02:05 Why People Should Listen To This Conversation 04:10 What People Need To Know About Menopause And The Impact On The Brain 06:21 Who Is Lisa Misconi? 08:08 Why Hasn't There Been Research And Investment Into Menopause? 14:28 What Is Menopause And Signs 15:54 Menopause Stages Start Before You Think! 19:07 What's The Youngest Person With Menopause 22:35 Perimenopause Transition 29:54 Menopause Brain Scans 33:09 Some Women Have More Shocking Brain Scans Than Others 34:28 Behavioural Changes From Menopause 38:05 How Many Women Experience Brain Fog? 39:53 Menopause Rewires The Brain 41:11 Symptoms As A Result Of Brain Change 43:57 Isn't The Cure Simple? 51:50 What Age Should We Think About Treating/Preventing Symptoms 52:50 Going Deeper Into The Stages Of Menopause 58:34 Link Between Suicides And Menopause In Women 01:02:55 Brain Fog Over Time With Menopause 01:07:28 The Benefits Of Exercise 01:11:04 Link Between Exercise And Alzheimer's 01:14:11 Caffeine, Sleep And Menopause 01:18:08 Is Alcohol Bad For Menopause? 01:20:52 What Toxins Should We Be Aware Of? 01:22:40 Specific Foods That Help Stave Off The Menopause 01:25:42 Are Supplements Needed In Our Diet? 01:30:06 What Is The Evolutionary Reason For Menopause? 01:37:14 Does Menopause Make You Sad? 01:40:11 Surgical Menopause 01:45:17 Isn't It Just Ageing? 01:53:07 When Will I Go Through Menopause? 01:56:48 Last Guest Question You can get in contact with Lisa’s team to discuss enrolling in her studies, here: https://neurology.weill.cornell.edu/research/womens-brain-initiative You can access the results from Lisa’s research on brain changes during the menopause, here: http://drlisamosconi.tiiny.co/ You can access a time lapse video of changes to the menopause brain, here: http://brain-shrinking-video.tiiny.co/ You purchase Lisa's most recent book, ‘The Menopause Brain: The New Science Empowering Women to Navigate Midlife with Knowledge and Confidence’, here: https://amzn.to/3VncZgS  Follow Lisa: Twitter - https://bit.ly/3XeTpWM  Instagram - https://bit.ly/4ek0Ulh  Watch the episodes on Youtube - https://g2ul0.app.link/3kxINCANKsb My new book! 'The 33 Laws Of Business & Life' is out now - https://smarturl.it/DOACbook Follow me: https://beacons.ai/diaryofaceo Sponsors: PerfectTed - perfectted.com- Code: DIARY10 at checkout for 10% off  Colgate - https://www.colgate.com/en-gb/colgate-total Uber: https://p.uber.com/creditsterms Learn more about your ad choices. Visit podcastchoices.com/adchoices

    Simon Cowell Opens Up About His Heartbreaking Loss, "losing them was the hardest thing that happened to me"!

    Simon Cowell Opens Up About His Heartbreaking Loss, "losing them was the hardest thing that happened to me"!
    From working in the post room in a record label to becoming the world’s best known music mogul, this is the Simon Cowell you don’t see on TV. Simon Cowell is a world-renowned record producer, talent scout, and music mogul. He is best known for being a judge on some of the world’s most popular TV shows including, ‘The X Factor’, ‘Britain’s Got Talent’, ‘Pop Idol’, and ‘American Idol’.  In this episode, Simon and Steven discuss topics such as, being bankrupt at 30, working his way up from the bottom, his life threatening accident, how his son’s birth changed his life, and his one and only regret about One Direction.  (00:00) Intro (00:52) Early Context (02:38) Your Parents (03:53) Your Work Ethic, Where Does That Come From (06:41) The Importance of Respect (10:23) Making the Decision to Pursue Entertainment (15:45) Working in the Post Room at a Record Label (19:24) Making His Way Up in the Music Industry (23:21) Starting a Record Label with Your Boss (28:40) Creating Your First Smash Hit Record (31:58) I Don't Know How Music Is Made, Staying in the Mind of the Consumer (39:40) Going Broke Right After Creating Your First Smash Hit (46:39) Meeting Pete Waterman, a Moment That Changed Everything (50:37) Being an Early Adopter of TV (59:50) Following Your Gut Regardless of the Criticism (01:06:30) Finding Westlife (01:09:30) Your Father Passing Away (01:17:37) Your Life Changing After Your Son, Eric, Was Born (01:23:09) Loyalty, Why It's So Important to Me (01:25:35) Setting New Work Boundaries in My New Life (01:29:15) Advice for a Young Simon Cowell (01:32:03) The Importance of Hard Work (01:34:30) Your Accident, Breaking Your Back in 3 Places (01:39:39) Going to Therapy (01:45:56) Foundational Advice for Anyone Starting Out in Their Career (01:49:39) The Importance of Legacy (01:53:02) The Rise of Bullying (01:55:02) One Direction (01:58:11) Searching for a New Boy Band (02:03:33) Harry Styles (02:05:54) AI Within the Music Industry (02:09:48) Will One Direction Get Back Together? (02:11:14) The Last Guest's Question Follow Simon:  Instagram - https://bit.ly/4c5bKK0  Twitter - https://bit.ly/3yKu9xg  Simon Cowell Launches Nationwide Hunt For Next UK Boyband Phenomenon Audition, sign up here - https://g2ul0.app.link/WnrZDXcwjKb Watch the episodes on Youtube - https://g2ul0.app.link/3kxINCANKsb   My new book! 'The 33 Laws Of Business & Life' is out now - https://smarturl.it/DOACbook  Sponsors: Linkedin Jobs: https://www.linkedin.com/doac Colgate - https://www.colgate.com/en-gb/colgate-total Uber: https://p.uber.com/creditsterms Learn more about your ad choices. Visit podcastchoices.com/adchoices

    Moment 165: This Exercise Enhances Mood, Memory & Concentration: David Raichlen

    Moment 165: This Exercise Enhances Mood, Memory & Concentration: David Raichlen
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    Secret Agent: Send Your Children To A Village! How To Detect A Lie Instantly! The Eye Contact Trick I Learnt From 12 Years As A Secret Service Agent! - Evy Poumpouras

    Secret Agent: Send Your Children To A Village! How To Detect A Lie Instantly! The Eye Contact Trick I Learnt From 12 Years As A Secret Service Agent! - Evy Poumpouras
    She was the last line of defence and ready to die for the most important person on earth, here are the secret skills she’s learned defending 4 U.S. Presidents.  Evy Poumpouras is a former U.S. Secret Service Special Agent and multi-media journalist. She is also the co-host of Bravo TV's series ‘Spy Games’ and author of the best-selling memoir, ‘Becoming Bulletproof’. In this episode, Evy and Steven discuss topics such as, Evy’s close encounter with death on 9/11, how to gain control over anyone, her biggest lessons from working for Obama and Bush, and the best way to tell if someone is lying to you.   00:00 Intro 02:05 My Mission To Unlock People's Potential 05:05 How You Became A Secret Service Officer 10:43 How To Get Someone To Do What You Want Them To 13:10 When You Listen To Someone They Like You More 14:34 You Need To Know About Them And Then You Can Start Asking The Right Questions 18:18 How To Get Others To Respect You 22:59 Is It Your Ego Or Have Your Boundaries Being Broken? 26:49 How To Build Confidence 29:34 The Different Versions Of Ourselves We Create 32:49 What I Learnt About Leadership From Working With 4 US Presidents 35:47 I Was In The Room When US Presidents Would Make Tough Decisions 38:36 My First Day Working For George Bush 41:07 Secret Service Training: Only 1% Make It Through 44:16 The 1% Of People That Became Part Of The Secret Service 46:06 How Can You Tell If Someone Is Lying To You? 48:16 Who's The Biggest Liar You've Met? 50:54 Signs They're Lying To You 52:59 What Your Body Language Reveals About You 01:00:19 Do Men Struggle With Strong Women? 01:01:00 What Advice Would You Give Your Daughter Become A Resilient Person 01:04:37 What Do You Work Out Your Mind And Body 01:07:19 What Was The Scariest Day Of Your Career? 01:12:28 How Was Your Mental Health During Your Career? 01:17:48 Discrimination In The Secret Service 01:19:39 How To Be Heard And Respected 01:25:51 Why You Need To Take Personal Responsibility 01:33:48 The Addiction To Being A Victim 01:35:02 Identifying Victims That Don't Want To Change 01:39:47 Undercover Missions 01:45:24 Discrimination In The Job 01:50:58 Labelling Yourself Can Affect The Way You See Yourself You can purchase Evy’s book, ‘Becoming Bulletproof’, here: https://amzn.to/3RhDtz9  Follow Evy:  Instagram - https://bit.ly/4aN4q4D  Twitter - https://bit.ly/4c4TErD  Watch the episodes on Youtube - https://g2ul0.app.link/3kxINCANKsb My new book! 'The 33 Laws Of Business & Life' is out now - https://smarturl.it/DOACbook Follow me: https://beacons.ai/diaryofaceo   Sponsors: PerfectTed: bit.ly/PerfectTed-DOAC with an exclusive code DIARY10 for 10% off ZOE: http://joinzoe.com with an exclusive code CEO10 for 10% off Learn more about your ad choices. Visit podcastchoices.com/adchoices

    The Pregnancy Doctor: Pregnancy Halves Every Year After 32! If You Want 2+ Children, You Need To Know This! If You Experience This Pain, Go See A Doctor!

    The Pregnancy Doctor: Pregnancy Halves Every Year After 32! If You Want 2+ Children, You Need To Know This! If You Experience This Pain, Go See A Doctor!
    Where have all the babies gone? Dr Natalie breaks down everything you need to know about fertility.  Dr Natalie Crawford is a double board-certified fertility doctor. She is also the co-founder of Fora Fertility clinic and Pinnacle Conference, a leadership conference for women in medicine. In this conversation, Dr Natalie and Steven discuss topics such as, how plastic and pollution affect your fertility, the surprising condition that’s affecting 1 in 4 women, the best time to have sex for pregnancy, and the impact of phones and hot baths on sperm count.  00:00 Intro 02:05 You Need To Look After Your Fertility Even Before You Want Children 04:31 We're Struggling More Than Ever To Have Children 07:00 Are We Having Less Sex? 07:47 Sperm Count Is Declining At Scary Risk 10:38 I Had 4 Pregnancy Losses And It's Devastating 13:36 The Stigma Of Infertility 16:15 Infertility Is Not Just A Female Issue, Men Are Affected Too 18:49 Understanding The Basics Of Fertility 22:26 Environmental Factors Affecting Male And Female Fertility 26:32 Are Phones And Laptops Bad For Fertility? 29:40 Heat And Infertility 30:15 What Testosterone Replacement Therapy Does To Your Sperm 31:45 The Egg Vault 35:25 Egg Production And Anomalies 42:41 Regret, Hindsight Of Patients And What You Can Do 47:16 What Has Changed Since Our Parents 49:06 The Effects Of An Unhealthy Lifestyle 54:07 Sleep Is Crucial In Your Reproductive Hormone System 55:07 How Stress Impacts Fertility 57:14 The Best Diets For Good Fertility 59:11 How Dairy Impacts Your Fertility 01:01:05 You Need To Understand The Reproductive Cycle To Know How Exercise Impacts It 01:10:58 Menstrual Irregularities And What's Normal 01:16:57 How Long Does It Take To Get Pregnant? 01:17:50 When Trying To Have Children Sex Can Become A Chore 01:21:43 Purchasing Sperm From The Black Market 01:24:48 PCOS Explained 01:30:59 PCOS Diagnosis 01:33:50 Link Between PCOS & Endometrial Cancer 01:37:02 What Is Endometriosis & How Do You Know You Have It 01:43:55 What Happens When You Come Off The Pill And Want To Have Children 01:46:25 Advice For People With Endometriosis And PCOS, If They Want To Have Children 01:49:36 Getting Started With Freezing Eggs And Embryos And Success Rate 01:55:15 The Cost Of Fertility Procedures 01:56:40 IVF Stigma 01:58:42 Ads 01:59:32 When To Think About Fertility Treatment 02:01:54 Dummies Guide To IVF 02:06:38 Myths Of Conception 02:08:54 Best Sex Position To Get Pregnant 02:10:33 Is Birth Control Healthy? 02:13:36 What Can People Do If They Struggle With Infertility? 02:15:40 Last Guest Question Follow Natalie:  Instagram - https://bit.ly/3yIQJ9L  Twitter - https://bit.ly/3wLxtb6  YouTube - https://bit.ly/4551ZZY  Watch the episodes on Youtube - https://g2ul0.app.link/3kxINCANKsb My new book! 'The 33 Laws Of Business & Life' is out now - https://smarturl.it/DOACbook Follow me: https://beacons.ai/diaryofaceo   Sponsors: Colgate: https://www.colgate.com/en-gb/colgate-total Shopify: http://shopify.com/bartlett Learn more about your ad choices. Visit podcastchoices.com/adchoices

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    🎙️Follow The Business of Wellness on Apple Podcasts & leave a 5-star rating & review 

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    References used in this podcast episode:

    1.The Natural Medicine’s Database: Berberine (Professional Monograph) https://info.trchealthcare.com/natmed-ppc

    2.Zhang Y, Gu Y, Ren H, et al. Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study). Nat Commun. 2020;11(1):5015.

    3.Habtemariam S. Berberine pharmacology and the gut microbiota: A hidden therapeutic link. Pharmacol Res. 2020;155:104722.

    4.Zhang L, Wu X, Yang R, et al. Effects of Berberine on the Gastrointestinal Microbiota. Front Cell Infect Microbiol. 2020;10:588517.

    5.Och A, Och M, Nowak R, Podgorska D, Podgorski R. Berberine, a Herbal Metabolite in the Metabolic Syndrome: The Risk Factors, Course, and Consequences of the Disease. Molecules. 2022;27(4).

    6.Cao RY, Zheng Y, Zhang Y, et al. Berberine on the Prevention and Management of Cardiometabolic Disease: Clinical Applications and Mechanisms of Action. Am J Chin Med. 2021;49(7):1645-1666.

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