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    Science of Social Bonding in Family, Friendship & Romantic Love

    enDecember 20, 2021

    Podcast Summary

    • The Neural Circuits for Social Bonding: From Infancy to AdulthoodOur nervous system is wired for social bonding, and understanding how our brains form and change these bonds can improve our relationships and overall quality of life. With plasticity within the system, we can rewire our neural circuits in response to experience and navigate different types of social bonds.

      Social bonding, from infancy to death, significantly affects the quality of life. Our nervous system is wired for bonding, with particular wiring diagrams oriented towards the specific bonds that occur between infant and mother, as well as infant and father. Specific brain circuits are activated during social bonding, including friendship and romantic relationships. Breakups with romantic partners, friends, or coworkers are painful, but our neural circuits for social bonding are repurposed and generic for all types of social bonds. There is plasticity within the system, and we can rewire the neural circuits for social bonding in response to experience. Understanding the neural circuits for bonding can help us navigate different types of social bonds, such as introversion, extroversion, trauma bonds, and healthy bonds.

    • The Importance of Social Bonding for Human BeingsSocial bonding is necessary for humans' well-being as it helps maintain social homeostasis, and lack of it can lead to stress, aggressive behavior, and difficulty in forming connections. Seeking social contact is as crucial as basic needs such as hunger, thirst, and temperature regulation.

      Social bonding is crucial for human beings as they have a unique chemical signature for bonding. Lack of social bonding leads to social isolation which elevates stress hormone levels and triggers aggressive and irritable behavior towards others. Chronic social isolation changes the nature of the brain and body, making social connections more challenging. Healthy craving for social contact has a specific brain circuit and neurochemical signature. Social bonding is critical for maintaining social homeostasis, much like hunger, thirst, and temperature regulation. Seeking social contact is crucial for human beings' well-being, and they put in significant efforts to form social bonds that help them regulate and function optimally.

    • The neural circuit behind social bonding.The social homeostasis circuit involves a detector, control center, effector, and prefrontal cortex, working together to maintain and adjust social bonds through behavioral responses and hormonal influence.

      The social homeostasis circuit consists of a detector, control center, effector, and prefrontal cortex, which work together to regulate social bonding. The detector system involves the ACC and the basal lateral amygdala, which help detect healthy and unhealthy social bonds. The control center includes the lateral and peri ventricular hypothalamus, which use hormones like oxytocin to influence social behavior. The effector system drives behavioral responses, such as using social media, texting, or making plans with friends. The prefrontal cortex plays a crucial role in establishing social hierarchies and adjusting them based on subjective understanding. Overall, the neural circuit controlling social homeostasis is highly dynamic and fluid, allowing individuals to maintain and adjust social bonds in different settings with the same people.

    • The Role of Dopamine in Social InteractionDopamine within the dorsal raphe nucleus drives our craving for social interaction, making us seek out social connections. Chronic social isolation can result in negative behavioral changes, highlighting the importance of social interaction for human wellbeing.

      The dorsal raphe nucleus in the brain contains dopamine neurons responsible for mediating social homeostasis, which is the process by which we crave social interaction when we lack it. Dopamine causes us to seek out social interactions of particular kinds, and chronic social isolation can lead to becoming introverted or even antisocial. This is similar to the hormonal mechanisms that make us hungry when we eat regularly and predict food is coming in. However, just as sudden food deprivation would cause us to seek out food through other routes, sudden social deprivation leads us to crave replacement social interaction.

    • Understanding the Social Homeostasis Circuit and Dopamine in Introversion and ExtroversionPersonal response to social interaction and dopamine levels determine introversion or extroversion. Instead of being chatty or quiet, it is important to consider social needs for balance. The prefrontal cortex offers flexibility in social interaction decisions.

      The social homeostasis circuit and dopamine play a crucial role in introversion and extroversion. Introverts release greater dopamine in response to individual social interactions and do not require much social engagement to feel sated. On the other hand, extroverts release less dopamine in response to individual social interactions and require much more social interaction to feel filled up. Therefore, it is useful to think about people in terms of how much social interaction they need to bring the social homeostasis into balance rather than whether they are chatty or quiet. However, the prefrontal cortex affords flexibility in terms of the types of social interactions that one can engage in and whether to spend time with certain people or not.

    • The Neuroscience of Loneliness and Social BehaviorSocial behavior is motivated by dopamine neurons, introverts require fewer interactions to feel fulfilled, and social interactions are crucial for everyone regardless of their position on the introversion/extroversion spectrum.

      Loneliness is the distress that arises from differences between ideal and perceived social relationships. Social behavior is motivated by dopamine neurons in the dorsal Rapha nucleus, which causes individuals to seek out social interactions. Similarly, social hunger is likened to hunger caused by a lack of food intake. Those who identify as introverts require fewer social interactions to feel fulfilled than extroverts. Social seeking and social isolation are influenced by where a person sees themselves in the social hierarchy. At a neural level, the same neurochemicals underlie all these different drives. Ultimately, social interactions are crucial for everyone, regardless of their position on the introversion-extroversion spectrum.

    • The Biological Circuit of Social Interaction and Food CravingsOur need for social interaction, food, and water are homeostatic drives that work together and are controlled by dopamine. Social isolation can increase our craving for food, while falling in love can reduce the craving for food and positively affect our senses.

      Social interaction and food cravings share a common biological circuit that is driven by dopamine. Social isolation increases our craving for social interactions, and when we can't fulfill that through social interactions, we turn to other dopamine-boosting activities like eating comfort food. Similarly, food fasting increases hunger and increases our appetite for social interactions. The importance of social interaction in maintaining our wellbeing is comparable to that of basic necessities like food and water. All these homeostatic drives work in synergy, and dopamine is the final pathway that drives our behavior. Falling in love activates the same circuit as social interaction, reducing the craving for other activities like food and sleep, and positively affecting our senses and interpretation of stimuli.

    • The power of physiological synchronization in social bonding.Physiological synchronization between individuals strengthens social bonds, and engaging in activities that stimulate synchronized responses can improve relationships, even with challenging family members.

      Physiological synchronization can enhance social bonding, as proven in a study where people listening to the same story at different times had synchronized heart rates. The quality and perceived depth of social bonds correlate strongly with physiological synchronization between individuals. The body and brain are reciprocally connected so that what we think, hear and feel drives our physiology and vice versa, influencing our state of mind. This can be leveraged, for example, during the holidays to improve relations with challenging family members, avoiding direct confrontation. Instead, engaging in activities that stimulate synchronized physiological responses, such as listening to the same story or attending a concert together, can enhance the sense of bonding between individuals.

    • The Power of Shared Experiences in Building Stronger Social BondsShared experiences that synchronize physiological responses create stronger social bonds. Childhood attachment experiences also impact adult attachment. Creating these experiences is powerful for challenging interactions or friction in relationships.

      Shared experiences can synchronize heart rates of different individuals, acting as a bridge to establish social bonds. Focusing on external stimuli, such as common narratives, traditions, events, or music that create a physiological response can bond individuals without necessarily shifting their physiologies. The right and left-brained forms of attachment established during childhood also influence adult forms of attachment, underlining the importance of early bonding experiences. Such experiences create subconscious or autonomic nervous system responses that impact adult bonding. Therefore, focusing on creating shared experiences that synchronize physiological responses can establish stronger social bonds. It is a powerful tool for those experiencing challenging interactions or friction in relationships.

    • The Importance of Autonomic System Synchronization for Healthy Social Bonding in Infants.Physical touch and emotional connection between an infant and their primary caretaker, aided by oxytocin release, is vital to establishing healthy social bonds, which require a synchronization of both the right and left brain systems.

      Healthy social bonding between infants and their caretakers relies on the synchronization of the autonomic functions of the right and left brain circuits. The right brain system involves emotional regulation, while the left brain system is more conscious and focused on predictable narratives that offer rewards. The physical contact between an infant and their primary caretaker, typically the mother, coordinates and synchronizes the autonomic nervous systems of both parties. Oxytocin, a peptide hormone, plays a key role in this synchronization process. The more closely related one is to the particular child, the more oxytocin is released and the stronger the bond becomes. As children get older, both the right and left brain systems continue to be important in establishing bonds.

    • The importance of empathy in establishing healthy social bonds.To establish strong social bonds, it is essential to have both emotional and cognitive empathy and strive for synchronization of bodily and cognitive states. Disagreements are also a part of bonding, and empathy forms the foundation of healthy relationships.

      Establishing healthy social bonds requires both emotional empathy, which is feeling what the other person feels, and cognitive empathy, which is understanding how the other person thinks. Synchronization of bodily and cognitive states are essential for establishing deeper bonds with friends and romantic partners. It is not necessary to agree on everything as disagreements are also a part of bonding. Infants and parents establish healthy bonds using both left and right-brain systems, and as people age, the same circuits established in childhood are repurposed for other forms of attachment. An autonomic bond or synchronization of experience is vital for a complete bond with another individual. Empathy is the ability to sense what others are feeling and thinking, and it forms the foundation of strong social bonds.

    • The Power of Oxytocin in Social Bonding and Biological Processes.Oxytocin plays a crucial role in social bonding, from pair bonding to social recognition. Understanding its regulation through attachment can lead to healthy adult attachment. While neurotransmitters act quickly, hormones like oxytocin have long-lasting effects on behaviors and biological processes.

      Oxytocin, a hormone associated with social bonding, is involved in a range of behaviors such as orgasm, social recognition, pair bonding, honesty, and autism. It can be regulated through various pathways, and understanding early forms of attachment can lead to developing healthy adult attachment. Biological processes work on short and long timescales, and while neurotransmitters and neuromodulators are quick, hormones have longer lasting effects. Oxytocin has longstanding effects, such as involving lactation, uterine contraction during childbirth, and sexual response in both males and females. Interactions between individuals that see each other as closely associated release oxytocin at high levels which contributes to social homeostasis.

    • The Science of Bonding: Exploring the Power of Oxytocin and MTMA.Oxytocin plays a vital role in social bonding, intimacy, and trust. The drug, MTMA, being tested in clinical trials, can increase oxytocin levels, further promoting connections between individuals. Variations in oxytocin genes also influence social interactions in the digital sphere.

      Oxytocin is a powerful hormone that promotes bonding and connection between individuals. It can be released through physical contact, as well as just the sight or smell of a loved one, and is associated with feelings of trust and sexual desire. MTMA, a drug being explored in clinical trials, can cause massive increases in the amount of oxytocin released, leading to greater feelings of connection and bonding. Oxytocin receptors and gene polymorphisms can also impact an individual's capacity to feel bonded. Some variations in the oxytocin and oxytocin receptor genes have been linked to increased social media interactions, indicating a potential role in social bonding beyond physical contact.

    • The Role of Oxytocin in Online Social BondingEmotional and cognitive empathy contribute to strong social bonds, introverts and extroverts differ in social interaction needs, and paying attention to external events can deepen social bonds. Understanding oxytocin's role can help establish and reinforce social bonds.

      The oxytocin system plays a crucial role in online social bonding and can actively encourage more social interactions on social media. Emotional empathy and cognitive empathy together make up robust bonds of various kinds. Introverts and extroverts differ not in how much they seek out social interactions per se, but in how much is enough for the given person. It's important to pay attention to external events, such as narrative story, music, or sports, to drive synchrony of autonomic function for establishing and deepening social bonds. By understanding the biological circuitry of social bonding, individuals can identify entry points to establishing and reinforcing social bonds of different kinds.

    • The Science of Social Bonding and the Pain of Breaking UpSocial bonding is complex yet understandable and essential for humans. By recognizing the underlying biology, we can work to strengthen bonds and deal with the social challenges that come with breakups, forming attachments and seeking connections.

      Breakups, whether between friendships or romantic partners, are painful because they involve a breaking of both emotional and cognitive empathy, causing social isolation and devastation to our nervous system. Social bonding is vitally important to us as a species, and there are specific biological, neurochemical and hormonal underpinnings to it. Understanding these can help us strengthen social bonds and establish new ones. It can also provide insight into why we seek out online interactions and help us work with people we feel challenged in forming social bonds with. While social bonding is complex, it is not infinitely so and is tractable. With this knowledge, we can understand the challenges of breaking up, falling in love, forming attachments, and being challenged with attachments.

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    In this episode, my guest is Dr. Mary Claire Haver, M.D., a board-certified OB/GYN and an expert on women’s health and menopause. We discuss the biology and symptoms of perimenopause and menopause and their effects on body composition, cardiometabolic health, mental health, and longevity. She explains the lifestyle factors, including nutrition, resistance training, sleep, and supplements, that can better prepare women for and improve symptoms of both perimenopause and menopause. We also discuss hormone replacement therapy (HRT) and whether HRT impacts the incidence of breast cancer or can affect cardiovascular health. We also discuss contraception, cellulite, polycystic ovary syndrome (PCOS), and how to reduce the risk of osteoporosis. This episode is rich in actionable information related to what is known about menopause and perimenopause and the stages before, allowing women of all ages to best navigate these life stages. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman  AeroPress: https://aeropress.com/huberman  Eight Sleep: https://eightsleep.com/huberman  BetterHelp: https://betterhelp.com/huberman  InsideTracker: https://insidetracker.com/huberman  Timestamps 00:00:00 Dr. Mary Claire Haver 00:02:04 Sponsors: AeroPress, Eight Sleep & BetterHelp 00:06:26 Menopause, Age of Onset 00:09:50 Perimenopause, Hormones & “Zone of Chaos” 00:14:42 Perimenopause, Estrogen & Mental Health 00:20:04 Perimenopause Symptoms; Tool: Lifestyle Factors & Ovarian Health 00:25:26 Early Menopause, Premature Ovarian Failure; Estrogen Therapy 00:29:42 Sponsor: AG1 00:31:31 Contraception, Transdermal, IUDs; Menopause Onset, Freezing Eggs 00:38:18 Women’s Health: Misconceptions & Research 00:45:01 Tool: Diet, Preparing for Peri-/Menopause; Visceral Fat 00:48:31 Tools: Body Composition, Muscle & Menopause, Protein Intake 00:51:42 Menopause: Genetics, Symptoms; Tools: Waist-to-Hip Ratio; Gut Microbiome 00:58:22 Galveston vs. Mediterranean Diet, Fasting, Tool: Building Muscle 01:05:18 Sponsor: InsideTracker 01:06:29 Hot Flashes; Estrogen Hormone Replacement Therapy (HRT), Breast Cancer Risk & Cognition 01:15:36 Estrogen HRT, Cardiovascular Disease, Blood Clotting; “Meno-posse” 01:24:00 Estrogen & Testosterone: Starting HRT & Ranges 01:30:36 Other Hormones, Thyroid & DHEA; Local Treatment, Urinary Symptoms 01:37:57 OB/GYN Medical Education & Menopause 01:41:30 Supplements, Fiber, Tools: Osteoporosis “Prevention Pack” 01:46:53 Collagen, Cellulite, Bone Density 01:51:42 HRT, Vertigo, Tinnitus, Dry Eye; Conditions Precluding HRT  01:55:27 Polycystic Ovary Syndrome (PCOS) & Treatment; GLP-1, Addictive Behaviors 02:01:55 Post-menopause & HRT, Sustained HRT Usage 02:04:58 Mental Health, Perimenopause vs. Menopause; Sleep Disruptions, Alcohol 02:09:09 Male Support; Rekindle Libido 02:12:46 HRT Rash Side-Effect; Acupuncture; Visceral Fat 02:16:24 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Social Media, Neural Network Newsletter Disclaimer
    Huberman Lab
    enJune 03, 2024

    Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

    Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis
    In this episode, my guest is Dr. Diego Bohórquez, PhD, professor of medicine and neurobiology at Duke University and a pioneering researcher into how we use our ‘gut sense.’ He describes how your gut communicates to your brain and the rest of your body through hormones and neural connections to shape your thoughts, emotions, and behaviors. He explains how your gut senses a range of features such as temperature, pH, the macro- and micronutrients in our foods, and much more and signals that information to the brain to affect our food preferences, aversions, and cravings. Dr. Bohórquez describes his early life in the Amazon jungle and how exposure to traditional agriculture inspired his unique expertise combining nutrition, gastrointestinal physiology, and neuroscience. We discuss how the gut and brain integrate sensory cues, leading to our intuitive “gut sense” about food, people, and situations. This episode provides a scientific perspective into your gut sense to help you make better food choices and, indeed, to support better decision-making in all of life. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Joovv: https://joovv.com/huberman LMNT: https://drinklmnt.com/huberman Helix Sleep: https://helixsleep.com/huberman InsideTracker: https://insidetracker.com/huberman Timestamps 00:00:00 Dr. Diego Bohórquez 00:02:37 Sponsors: Joovv, LMNT & Helix Sleep; YouTube, Spotify & Apple Subscribe 00:06:49 Gut-Brain Axis 00:11:35 Gut Sensing, Hormones 00:15:26 Green Fluorescent Protein; Neuropod Cells & Environment Sensing 00:26:57 Brain & Gut Connection, Experimental Tools & Rabies Virus 00:35:28 Sponsor: AG1 00:37:00 Neuropod Cells & Nutrient Sensing 00:43:55 Gastric Bypass Surgery, Cravings & Food Choice 00:51:14 Optogenetics; Sugar Preference & Neuropod Cells 01:00:29 Gut-Brain Disorders, Irritable Bowel Syndrome 01:03:03 Sponsor: InsideTracker 01:04:04 Gut & Behavior; Gastric Bypass, Cravings & Alcohol 01:07:38 GLP-1, Ozempic, Neuropod Cells 01:11:46 Food Preference & Gut-Brain Axis, Protein 01:21:35 Protein & Sugar, Agriculture & ‘Three Sisters’ 01:25:16 Childhood, Military School; Academics, Nutrition & Nervous System 01:36:15 Plant Wisdom, Agriculture, Indigenous People 01:41:48 Evolution of Food Choices; Learning from Plants 01:48:15 Plant-Based Medicines; Amazonia, Guayusa Ritual & Chonta Palm 01:56:58 Yerba Mate, Chocolate, Guayusa 02:00:22 Brain, Gut & Sensory Integration; Variability 02:06:01 Electrical Patterns in Gut & Brain, “Hangry” 02:12:43 Gut Intuition, Food & Bonding; Subconscious & Superstition 02:22:00 Vagus Nerve & Learning, Humming 02:26:46 Digestive System & Memory; Body Sensing 02:32:51 Listening to the Body, Meditation 02:40:12 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Social Media, Neural Network Newsletter Disclaimer
    Huberman Lab
    enMay 27, 2024

    Dr. Gary Steinberg: How to Improve Brain Health & Offset Neurodegeneration

    Dr. Gary Steinberg: How to Improve Brain Health & Offset Neurodegeneration
    In this episode, my guest is Dr. Gary Steinberg, MD, PhD, a neurosurgeon and a professor of neurosciences, neurosurgery, and neurology at Stanford University School of Medicine. We discuss brain health and brain injuries, including concussion, traumatic brain injury (TBI), stroke, aneurysm, and transient ischemic attacks (TIA). We discuss key and lesser-known risk factors for brain health and explain how certain treatments and medications can improve brain health and cognitive function. We also cover novel mechanisms to improve recovery after concussions and brain injury, including the use of stem cells, temperature (mild hypothermia), and vagus nerve stimulation. Dr. Steinberg also describes new advances in neurosurgery and minimally invasive brain augmentation. This episode ought to be of interest to anyone seeking actionable tools to improve their brain health and for those seeking to improve recovery after a brain injury such as concussion, stroke, aneurysm, or TBI. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman ROKA: https://roka.com/huberman AeroPress: https://aeropress.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Dr. Gary Steinberg 00:01:44 Sponsors: Eight Sleep, ROKA & AeroPress; Subscribe on YouTube, Spotify & Apple 00:06:16 Stroke, Hemorrhage & Blood Clot 00:10:25 Blood Clots & Risk Factors, Medications, Smoking, Cholesterol 00:16:19 Heart & Brain Health; Neurosurgery & Brain Function 00:23:27 Current Technology & Neurosurgery, Minimally Invasive Techniques 00:28:13 Transient Ischemic Attacks (TIA); Spinal Cord Strokes 00:33:23 Stroke Risk: Alcohol, Cocaine & Other Drugs 00:38:24 Sponsor: AG1 00:39:55 Traumatic Brain Injury (TBI), Concussion: Sports, Testing & Recovery 00:46:45 Statins; TBI & Aspirin; Caffeine & Stroke Risk 00:48:31 Exploratory MRI: Benefits & Risks 00:51:53 Blood Pressure, Lifestyle Factors; Tool: Feeling Faint, Hydration; Sleep 00:59:52 Sponsor: LMNT 01:01:27 Chiropractic Neck Adjustment & Arterial Obstruction; Inversion Tables 01:05:16 Kids, Tackle Football, Soccer, Boxing; Mild Concussion 01:10:49 Nerve Regeneration, Stem Cells, Stroke Recovery 01:17:36 Stem Cells, Immune System, Activity 01:21:27 Injury & Recovery, Restraint Therapy 01:23:46 Neuroprotection After Injury; Mild Hypothermia 01:34:59 Platelet-Rich Plasma (PRP), Stem Cell Therapy 01:42:27 Scientific Advancements & Clinical Translation, FDA & Industry 01:47:40 Vagal Stimulation 01:53:17 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Social Media, Neural Network Newsletter Disclaimer
    Huberman Lab
    enMay 20, 2024

    LIVE EVENT Q&A: Dr. Andrew Huberman at the ICC Sydney Theatre

    LIVE EVENT Q&A: Dr. Andrew Huberman at the ICC Sydney Theatre
    Recently I had the pleasure of hosting a live event in Sydney, Australia. This event was part of a lecture series called The Brain Body Contract. My favorite part of the evening was the question and answer period, where I had the opportunity to answer questions from the attendees of each event. Included here is the Q&A from our event at the ICC Sydney Theatre. Sign up to get notified about future events: https://www.hubermanlab.com/events Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps 00:00 Introduction 00:15 Live Event Recap: The Brain Body Contract 00:32 Sponsors: AG1 & Eight Sleep 03:30 Q&A Session Begins: Napping and Sleep Quality 06:34 The Power of the Placebo Effect 11:31 Entering Rest and Digest State: Techniques and Tools 15:35 Muscle Growth, Learning & the Brain 20:13 Hallucinogens: Personal Experiences & Clinical Insights 27:28 The Misunderstood Effects of MDMA 27:42 Exploring the Potential of MDMA in Clinical Settings 29:25 The Complex World of Psychedelics & Mental Health 30:07 Ketamine: From Misconception to Medical Use 31:53 The Fascinating Science of DMT 33:11 Supporting Science: Funding & Future Directions 34:48 The Gut-Brain Axis: A Key to Overall Health 40:41 Sleep Patterns and Chronotypes: Personalizing Rest 42:50 Addressing ADHD & Focus in the Modern World 49:27 Closing Remarks & Gratitude Disclaimer
    Huberman Lab
    enMay 17, 2024

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