Sleep Architecture and Neurotransmitters of Sleep

Catatonia is a neuropsychiatric condition characterized by disturbances in psychomotor function, stemming from various disorders impacting brain function. And while catatonia is not specifically related to schizophrenia alone, it’s important to know how to recognize and treat schizophrenic patients with catatonic symptoms. That’s why psychiatric nurse practitioner Ashley Baker speaks with Dr. Stanley Caroff about his research focusing on the management of schizophrenia with catatonic symptoms. Dr. Caroff is an Emeritus Professor of Psychiatry at the University of Pennsylvania Perelman School of Medicine.

Cerebral amyloid angiopathy (CAA) is a common neurological change that frequently coexists with other pathologies like Alzheimer's disease and Lewy body dementia, which led a team of researchers to investigate the risk factors and prevalence of CAA. The study found that not only is age a risk factor for CAA, but CAA is also seen in patients with Lew body pathology alone and in patients with both Alzheimer's disease and Lewy body pathology. Dive further into the findings with Dr. Charles Turck and Dr. Jagan Pillai, a behavioral neurologist at Cleveland Clinic Lou Ruvo Center for Brain Health.

Cognitive rehabilitation in patients with multiple sclerosis started about 20 to 25 years ago when it transitioned from predominantly patients with traumatic brain injury to other patient populations including multiple sclerosis. And over that period of time, the number of studies that have examined the efficacy of cognitive rehabilitation in MS has grown substantially. However, gaps remain and further research is needed. Dive into to learn more about cognitive rehabilitation trials for MS with Dr. Nancy Chiaravalloti, Director of the Center for Neuropsychology and Neuroscience Research and the Center for Traumatic Brain Injury Research at Kessler Foundation, who also presented a session on this topic at the ACTRIMS 2024 Forum.

Adaptive optics is a promising tool for studying MS-related changes in the retina at a cellular level, providing valuable insights into the disease's progression and potential treatments. Dive further into this line of research with Dr. Daniel Harrison, an Associate Professor of Neurology and the Director of the Division of Multiple Sclerosis and Neuroimmunology at the University of Maryland who presented this research at the 2024 ACTRIMS Forum.

The prevalence of multiple sclerosis seems to be increasing in patients, and the majority of those patients are diagnosed with MS around the peak family planning age. So family planning should be an integral part of comprehensive patient-centered MS care. Learn more with Psychiatric Nurse Practitioner Ashey Baker as she speaks with Dr. Anna Shah, Assistant Professor of Neurology and the Director of Neurology Outpatient Patient Safety & Experience at the University of Colorado Anschutz School of Medicine.

Rehabilitation training for multiple sclerosis patients aims to improve mobility, cognitive function, and quality of life. But one of the largest barriers to having more high-quality randomized control trials of rehabilitation in MS is that most researchers could not be following a stage of different research approaches. So addressing the unmet needs in rehabilitation research is needed to make MS interventions more powerful. You’ll learn more in this episode with Dr. Robert Motl, Professor in the Department of Kinesiology and Nutrition with a secondary appointment in the Department of Rehabilitation Sciences at the University of Illinois Chicago.

A crucial aspect of epilepsy care that often goes underappreciated is the intersection of epilepsy and depression. Join Drs. Munger Clary and Salpekar, leading experts in the field, as they raise awareness about the high prevalence of comorbid mental health disorders, particularly depression, among epilepsy patients. Together, they explore the bidirectional relationship between epilepsy and depression, emphasizing the importance of early detection and comprehensive treatment. They’ll also cover implantable therapies, specifically vagal nerve stimulation devices, as potential tools to manage both epilepsy and depression.

The amount of patients being diagnosed with neurological conditions and multiple sclerosis (MS) is a growing number, which causes a need for more neurologists, MS specialists, and better access to care. A potential advantage of using technology in MS care would be to break down the geographic barrier. To learn more about telehealth in MS care, tune in with Dr. Marisa McGinley, Assistant Professor of Neurology at the Cleveland Clinic Lerner College of Medicine, who also presented this topic at the ACTRIMS Forum 2024.

Chronological age is the biggest early driver of disease progression in patients with multiple sclerosis (MS). That’s why a team of researchers wanted to explore whether biomarkers like p16 and the epigenetic clock can be used to assess biological aging in patients with MS. They found that while patients with MS are aging faster than people without MS based on the epigenetic clock biomarker, no chronological age correlation in p16 expression has been identified in patients with MS. Dive further into these findings with Dr. Yinan Zhang, an Assistant Professor of Neurology at Ohio State University who presented this research at the 2024 ACTRIMS Forum.

Death induced by survival gene elimination (DISE) is a cell death mechanism mediated by short RNAs. And according to a recent study, there may be a correlation between toxic DISE, DNA damage, and neuronal cell death in patients with Alzheimer’s disease. Learn more about the study’s findings and potential implications with Dr. Andrew Wilner and Dr. Marcus Peter, Professor of Medicine in the Division of Hematology and Oncology as well as a Professor of Biochemistry and Molecular Genetics at Northwestern University Feinberg School of Medicine in Chicago.