In this week’s episode, we welcome Sune Lehmann, a network and complexity scientist at the Technical University of Denmark. Sune shares insights into his revolutionary work using algorithms to predict health outcomes, income, and mortality, drawing on extensive datasets from Danish citizens. He emphasizes the power of viewing human lives as sequences of events, akin to language, and how this perspective can lead to groundbreaking predictions about individuals' futures. We also get into the ethical considerations and future implications of this research, highlighting the balance between predictive accuracy and the importance of shared risk in insurance. Additionally, he touches on the once-Danish-now-global phenomenon of cold water swimming, illustrating how this practice offers a unique sense of well-being and mental clarity.

What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)

Thanks to our sponsors:

LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST

Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist

InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST

Key Moments
“From a certain perspective, human lives are sequences, right? You're born, you are seen by a doctor. They do some measurements and all of that information can be structured to create, let's say, the sentence of your life.

And so what we did is that we took an enormous dataset and we used the same technology that lies underneath the AI large language models, and we built a kind of general model for human lives.”

“That model, as long as you have training data, can really predict anything about humans. I mean, it might do things with kind of varying quality, but for the things that we've tested it, it performs better than any other algorithm that we can find.”

“So lots of people have kind of contacted me saying let's let's use this for something that's actually meaningful and useful. And I think, you know, what's amazing about what we do is that we also model not just the medical data, but the data around the life that people live.”

Connect with Sune

Artificial intelligence can predict events in people's lives

Personal website

X (twitter)

Transcript

In this week's episode, Dylan Livingston discusses his work with the Alliance for Longevity Initiatives, focusing on advocating for longevity science in the political arena. He emphasizes the importance of aligning with different political perspectives to promote the field's growth and the need for more foundational research and FDA support. Dylan also highlights the economic and health benefits of advancing longevity science and calls for public involvement in political advocacy to drive change in health policy and research funding.

What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)

Thanks to our sponsors:
Fatty15: C15 is the first essential fatty acid to be discovered In 90 years. Fatty15 is on a mission to replenish your C15 levels and restore your long-term health. Get 15% off their 90-day subscription Starter Kit here or enter code: AGEIST at checkout. 

Sundays: Sundays is healthy, fresh dog food made of human-grade ingredients that is easy to store and serve. No synthetic nutrients or artificial ingredients. Just good quality food for your pup. Get 40% off your first order here or enter code: AGEIST at checkout. 

LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST.

Key Moments
“Alliance for Longevity Initiatives is a5001c for nonprofit organization focused on representing the longevity, biotech industry and general movement on Capitol Hill.”

“This is the next generation of health care. And, you know, it's their job as members of Congress to support and spread awareness around this topic and ultimately try to push more resources towards this effort.”

“You know, this is a major driver of economic growth. Right. I'm sure you have seen the longevity dividend argument, which, you know, the latest iteration argues, I think, $37 trillion in GDP gains for one extra healthy year of life expectancy–and even if that's off by, you know, 90%, that's still a, you know, $3.7 trillion is still worth pursuing.”

“So really right now, there are two or three major asks that I know will help the longevity industry and thus I believe, increase healthy lifespan in the U.S. First and foremost, there needs to be more foundational research for this space in geroscience in general from the federal government. I believe in 2023, 0.6% of the budget went to geroscience research at the NIH and aging is responsible for 70% of daily deaths. The second thing we want to get done is we want to help or really we want to help companies better design clinical trials through guidance from the FDA and support through congressional action. So those are the two big wishlist items you know, ultimately what we'd like to see in the long term, maybe medium long term, is a longevity initiatives bill.”

Connect with Dylan

Alliance for Longevity Initiatives

LinkedIn

Transcript

This week, SuperAge explores the world of music and community with John Loken. John, an Executive VP of Marketing for The Recording Academy,  discusses his work with the GRAMMYs, highlighting their role in supporting and celebrating music creators. He emphasizes the academy's purpose-driven nature, focusing on advocacy, education, and crisis support beyond just the glitz of the GRAMMY Awards. John also gets into the power of music when it comes to creating a sense of tribe and belonging, transcending barriers of language, politics, and culture. His insights reveal the profound impact of music in unifying people and fostering a global community.

What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)

Thanks to our sponsors:
InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.

Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist.

DIVI – take back control of your hair and scalp health, and do it with Divi's clean, science-backed ingredients. Listeners get 20% off your first Divi order at diviofficial.com/AGEIST or enter code "AGEIST" at checkout.

Key Moments
“Yes the GRAMMYs are a key part of what we do. That's what we're famous for. But the other 364 days a year, we are in Washington, D.C. advocating for creator rights. We are in schools helping to educate young people. We also have a Health and Human Services operation called MusicCares, which is not just about addiction support, but but really for people in any kind of crisis, economic crisis or otherwise”

“There's something about music and the way that music makes us feel that whether it is a classical artist, a jazz artist, a country artist, a hip hop artist, any EDM artist or rock artist, we're all in this music tribe, and it just really generates an incredible feeling of belonging.”

“We want to make sure we're talking about craft, right? There are plenty of award shows that are about the most streamed artists, or maybe the artists that sold the most tickets or had the most revenue off of their tours or whatever. That's not us. We're a different thing.”

Connect with John
Instagram
LinkedIn
The Recording Academy
Transcript

In this week's episode of The SuperAge Show, Tamsen Fadal, renowned TV journalist and advocate for women's health, shares her insights on the importance of nurturing relationships and community involvement, particularly in later life stages. She discusses practical approaches to reduce social isolation, including reconnecting with old friends and participating in new groups. Tamsen highlights the role of vulnerability in forming genuine bonds and the effective use of digital platforms in cultivating meaningful connections. This episode offers valuable guidance for anyone looking to enhance their social network and create a supportive community environment.

What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)

Thanks to our sponsors:
DIVI – take back control of your hair and scalp health, and do it with Divi's clean, science-backed ingredients. Listeners get 20% off your first Divi order at diviofficial.com/AGEIST or enter code "AGEIST" at checkout.

Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist.

LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST.

Key Moments
But I do think you have to get out there and put yourself out there, not be afraid, because you know what happens to all of us.

There is a place to go. There's something whether it's an activity or a hobby or whatever it is, there's something out there to go to, even no matter how big or small.

I realize now when I have a problem or I'm worried or fretting about something, there are those people that I can text or pick up the phone and talk to that make me feel like it's all going to be okay. And that's what that community is about. That's what that small community is about.

I watch my dad, who is 84. He goes to his gym, he meets people and goes out to restaurants by himself. He is determined to make sure he keeps doing that, even though a lot of his friends have passed away. And so I was like, Oh, he can do that. I should be doing that, because I think it's really, really hard and I think that sense of community is really necessary and really special. And I think that's kind of what we're all here for in the end.

Connect with Tamsen
Website
Podcast
Instagram
Facebook
Youtube

This week on the SuperAge podcast, we dive into the world of integrative and preventive medicine with Dr. Chris Renna. Dr. Renna, with a career spanning over three decades, shares his unique perspective on achieving optimal health and longevity. From discussing the nuances of detoxification and the role of the microbiome to exploring the future of biotech and AI in medicine, Dr. Renna provides a comprehensive look at modern healthcare techniques. He emphasizes the importance of individualized treatment plans and the integration of various modalities like nutrition, sleep, and exercise for overall well-being. The conversation challenges conventional medical thinking and a road map into the future of personal health management.

What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)

Thanks to our sponsors:
InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.

Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist.

LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST.

Key Moments
“The Goldilocks concept is really the goal, but it is really complicated and highly individualized, meaning balance is quite subjective.”

“We're on the verge of developing generative A.I. Now we're considering both the risks and benefits of sentience, and I think that the way our brain works, we are naturally drawn to the risk before we're drawn to the opportunity. And I think that works, you know, like that's kept us here and that's brought us forward in our technologies.”

“If God had a complete understanding of every physiologic system and all of its implications and interactions, what would God recommend we have for supper? Generative A.I. holds that potential. It would only inform us. So I think that, you know, the future is amazingly bright.”

Connect with Dr. Chris Renna
LifeSpan
Contact
Book

This week, we speak with Karl Pfleger, PhD who, after studying Machine Learning at Stanford and working a successful tech career, now does all he can to support longevity research and biotech. Karl discusses the inadequacies of traditional healthcare in addressing the root causes of aging and shares insights on groundbreaking research that can slow down or even reverse aging processes. He emphasizes the significant impact of lifestyle choices on longevity and previews promising future therapies, including stem cell treatments and mitochondrial health interventions.

What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)

Thanks to our sponsors:
InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.

Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist.

AmeriCorps Seniors — Get involved in your community through AmeriCorps Seniors’ volunteer opportunities and change your life. Go to AmeriCorps.gov/YourMoment 

Key Moments
“So the traditional health care and medical practice in our country, in the US and most of the world concerns really considering everyone to be baseline healthy until they get sick to a level where they're very sick and they cross some kind of a threshold for diagnosis of having an actual disease. So even though we call it health care, a lot of people kind of pejoratively describe it as sick care.”

“In short-lived species you can extend lifespans manyfold. One single gene mutation in worms can extend their lifespans by 10X, for example. And even in mice, we have interventions now that can extend their lifespans by 30% or 40% sometimes. And many of these interventions work across multiple species. So we believe they’re likely to work for people as well."

“I wanted them to realize how big [the longevity field] had gotten so that they wouldn't delay getting into it with more serious amounts of money. They didn't realize that they were two years behind given how fast it was growing.”

Connect with Karl Pfleger
X
AgingBiotech.info
LinkedIn

In this week's SuperAge podcast, we delve into Denise Kirtley's vital midlife transformation from overweight and pre-diabetic, to empowered and strong. Denise shares her journey of overcoming common misconceptions about fitness and weight loss in midlife, emphasizing the importance of a tailored approach to nutrition and exercise. She discusses how setting personal goals and dreams played a crucial role in moving beyond societal expectations. Denise also highlights the oft-overlooked impact of physical strength on mental well-being and confidence, inspiring others in similar life stages. The conversation is a testament to the power of self-care and the potential for transformation at any age.

What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)

Thanks to our sponsors:
DIVI – take back control of your hair and scalp health, and do it with Divi's clean, science-backed ingredients. Listeners get 20% off your first Divi order at diviofficial.com/AGEIST or enter code "AGEIST" at checkout.

Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist.

LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST.

Key Moments
“Aesthetics was a goal of mine, but more importantly, as I had gained weight, my health declined. And what did that look like? I became pre-diabetic. I started having joint pain in my knees specifically. Unfortunately, I have 50 stairs from the ground level to my front door. I had to go up and down the stairs every day.”

“Before, I wasn't even very good about getting my blood work done regularly. Now I do it twice a year. That's a huge part of my health regimen. I take supplements based on what my blood work says. And I think you have to be intentional like this if you want to age strong and healthy and vibrant.”

“They see me muscular and in a bikini. And at 53, they say ‘that's not what someone should be doing.’ I do feel there is some of this ageism in those comments. I really do feel that. I also think we're very focused on: ‘well, you were fine before. Why did you do that?' – I wasn't fine. Right. I was pre-diabetic. I woke up exhausted. I felt like crap most days, right? My quality of life was poor. So I think we need to get beyond what we see and realize that this was a health journey.”

Connect with Denise
Rebellion Body
Contact
Instagram

Our first guest of 2024 is Dr. Darshan Shah, a surgeon, longevity expert, and founder of Next Health. In their conversion, David and Dr. Shah take a snapshot of today’s ever-changing health optimization and longevity landscape.The two discuss new diagnostic tools like executive physicals and AI-enabled heart scans, highlighting the power of early detection in combating conditions like Alzheimer’s, heart disease, and cancer. David also takes the opportunity to learn all about up-and-coming treatments like gene therapy from an expert. Dr. Shah also shares his personal journey from surgery to functional medicine, emphasizing the importance of looking beyond traditional Western healthcare to prevent chronic diseases.

What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)

Thanks to our sponsors:
InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.

Science Research Wellness — improve your cellular health. Listeners receive 20% off all products with code AGEIST20 at SRW.co.

LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST. 

Key Moments
“I think there's a lot going on in the world of longevity that unfortunately the FDA is trying to block. But you know, the research continues to go on in other countries and it will continue to flourish and we will be able to do a lot of these things here at some point, whether it be in the United States or outside.”

“I always tell people that we have a few different goals in mind. Our first goal is to optimize along the most common things we need to make sure your nutrition, your exercise and your sleep is perfect, right? And so as close to perfect as we can get it.”

“If Steve Jobs were alive today, and he had an executive physical, he would have been saved from pancreatic cancer."

“I always tell my patients, you need to know what your hemoglobin A1C level is. I should ask you, and you should be able to tell me what it is.”

Connect with Dr. Shah
Website
Next Health
Making the Cut: 10 Things You Should Consider Before Having Plastic Surgery
Instagram

This week, we discuss the importance of setting realistic and sustainable goals. If we can form positive, long-term habits rather than resorting to extreme, short-term “resolutions,” we can get more healthy every day. Reflecting on previous goals, David shares personal anecdotes and lessons learned. Why not take a gradual approach to fitness and nutrition that aligns with one's lifestyle and capabilities? The episode is a blend of practical advice and motivational insights aimed at fostering a healthier, more self-aware approach to personal growth and well-being.

Thank you to our sponsors:
LMNT – our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST.

InsideTracker — the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.

Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist.

Key Moments
“When people think about goals for the new year, they often initially think about things like diets and exercise, fitness, these sort of things. What I have seen, I've seen this multiple times. I have engaged in this myself and I can tell you it does not work.”

“We're looking to establish habits, habits that we can keep for a long period of time. Extreme diets are not a habit. They're sort of a short term occasion, and just a recipe for failure. We want to slightly modify what we're doing so that we can achieve it, so we can pat ourselves on the back and say “great job, reevaluate in three months.”

“So this is an achievable target and it's measurable, which is really key about this.”