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    The bleeding edge, part two

    enMarch 20, 2024
    How do Mercury's services benefit businesses?
    What role does community support play in personal achievements?
    What challenges did Christine and Peter face in their research?
    How does self-belief affect Abby Ayers' journey?
    Why is research on menstrual fluid important for women's health?

    Podcast Summary

    • Simplicity and openness lead to effective outcomesEmbracing simplicity and openness can foster productive environments and lead to significant progress and discoveries

      Simplicity and openness can lead to effective and productive outcomes, even in unexpected situations. Mercury's financial services provide simplicity and control for businesses, allowing them to focus on their goals. Apple Card offers simplicity and growth through daily cashback and savings. At the Feinstein Institutes For Medical Research, openness and acceptance of various responses, including Amber's calm reaction to my joke about menstrual fluid, fostered a comfortable and productive environment for research. This acceptance and focus on simplicity can lead to significant progress and discoveries.

    • Endometriosis research faces stigma surrounding menstrual fluidResearchers aim to detect endometriosis through menstrual fluid, but societal stigma and misconceptions pose challenges, potentially delaying early diagnosis and effective treatment for those affected.

      The stigma surrounding menstrual fluid continues to impact research and the lives of those affected by endometriosis. Researchers Christine Metz and Peter Gregersen, working on the Rose study, aim to detect endometriosis through menstrual fluid due to its high genetic link and the disease's challenging diagnosis process. Despite the potential benefits, the stigma around menstrual fluid has posed challenges, with symptoms often dismissed and underdiagnosed due to societal norms and misconceptions. Endometriosis, a painful disease affecting 1 in 10 menstruators, can severely impact daily life, and early detection is crucial. The Rose study's innovative approach could revolutionize diagnosis and treatment, but it underscores the importance of addressing the lingering stigma surrounding menstruation and menstrual fluid.

    • Studying menstrual fluid for uterus and endometriosis researchResearchers discovered a new way to study the uterus and endometriosis by focusing on menstrual fluid, eliminating the need for invasive procedures and opening up new possibilities for non-invasive diagnostics and therapeutics.

      Researchers Christine and Peter discovered a new way to study the uterus and endometriosis by focusing on menstrual fluid, which had previously been overlooked and considered as waste. This approach eliminates the need for invasive procedures, making it more feasible and accessible for patients. Despite the long-standing identification of the uterus, few studies have examined menstrual blood due to the lack of standardized collection methods. Christine and Peter faced numerous challenges, including figuring out how to collect menstrual fluid from patients with endometriosis and ensuring its safe transportation. They also had to determine which parts of the samples to focus on for their research. This innovative approach not only advances the understanding of the uterus and endometriosis but also opens up new possibilities for non-invasive diagnostic and therapeutic interventions.

    • Overcoming Challenges in Science and SocietyPerseverance, community support, and self-care are crucial for achieving personal and scientific goals. Christine and Peter's determination led to groundbreaking menstrual fluid research, while Abby found empowerment through running and community. Self-care and celebration are emphasized through commercial segments.

      Overcoming scientific and societal challenges is essential for making groundbreaking discoveries. Christine and Peter's research on menstrual fluid faced skepticism from their team, but they persisted and eventually succeeded in collecting samples. Their determination paved the way for answering their original questions. Additionally, the discussion highlights the importance of supporting women and their achievements, whether it's in scientific research or personal goals. Abby Ayers' story in the "Running Sucks" docuseries demonstrates how running helped her regain power and confidence postpartum. Moreover, the importance of self-belief and community support is emphasized. Christine and Peter's team eventually came around to their idea, and Abby found encouragement and solidarity in the running community. Lastly, the commercial segments of the text showcase various products and services that cater to women, emphasizing the importance of self-care and celebration. Whole Foods Market offers Mother's Day deals on body care, flowers, and desserts, while Apple Card rewards women for their everyday purchases. In summary, the discussion highlights the importance of perseverance, community support, and self-care in achieving personal and scientific goals.

    • Identifying cell differences in menstrual fluid for potential endometriosis diagnosisResearchers found cell differences in menstrual fluid samples from endometriosis patients and controls. This could lead to a non-invasive diagnostic test, but requires careful validation and participation of symptomatic, undiagnosed patients.

      Researchers have identified potential differences in cell types and patterns in menstrual fluid samples between endometriosis patients and healthy controls. These findings could lead to the development of a non-invasive diagnostic test for endometriosis. However, the challenge lies in validating the test's accuracy through confirmatory surgeries and ensuring the participation of symptomatic, undiagnosed patients. The ultimate goal is to provide an alternative to invasive diagnostic procedures and improve the current limited treatment options for endometriosis patients. However, the researchers acknowledge that this process is complex and requires careful validation to ensure accuracy.

    • Researching menstrual fluid and uterine tissue holds potential for diagnosing and treating conditions like endometriosis and uterine cancerUnderstanding menstrual fluid and uterine tissue through research can lead to diagnosing and treating conditions, predicting uterine cancer, and studying fibroids. However, societal stigma and funding challenges hinder progress.

      Our lack of understanding about the biology of conditions like endometriosis and uterine cancer hinders the development of effective treatments. Research into menstrual fluid and uterine tissue, such as the work being done by Christine and Peter, has the potential to diagnose and treat these conditions, as well as predict uterine cancer and study fibroids. However, the stigma surrounding menstruation and reproductive health research creates barriers, including funding challenges and societal taboo. It's crucial to acknowledge the potential value of this research and work towards reducing the stigma, allowing for the discovery of potential treasures and advancements in our understanding and treatment of these conditions. If you have endometriosis or are interested in contributing to research, consider participating in the Rose study.

    • Learning More About Endometriosis and Womb HealthCheck out an old podcast episode on endometriosis, read Leah Hazzard's book 'Womb Enough', attend a Q&A session, and support the podcast through reviews or donations.

      There are numerous resources available to learn more about endometriosis and womb health. For instance, listeners can check out an old episode of this podcast dedicated to the topic, which will be linked in the transcript. Additionally, Leah Hazzard's book, "Womb Enough," is highly recommended for its exploration of Christine Metz's work and various research on wombs and womb health. A Q&A session with Leah Hazzard will also be available on the show's website. This episode was produced and reported by Bert Pinkerton, edited by Jorge Just, Brian Resnick, and Meredith Hodnath, with music by Noam Hassenfeld, sound design by Christian Ayala, and fact-checking by Melissa Hirsch. The podcast and all of Vox are free, and listeners can support it by leaving a review or making a donation. If you have thoughts, feelings, or ideas for future episodes, please email unexplainable@vox.com. Unexplainable is part of the Vox Media Podcast Network and will return next week. A fascinating fact mentioned in the episode is that female phalaropes are not only bigger than male ones but also more colorful.

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