Logo

    The Spectacular Fall of 23andMe

    enFebruary 13, 2024
    What was the main topic of the podcast episode?
    Summarise the key points discussed in the episode?
    Were there any notable quotes or insights from the speakers?
    Which popular books were mentioned in this episode?
    Were there any points particularly controversial or thought-provoking discussed in the episode?
    Were any current events or trending topics addressed in the episode?

    Podcast Summary

    • The Unpredictable Journey of 23andMeDespite initial success, 23andMe faced numerous challenges leading to layoffs and a decline in stock value, underscoring the risks and uncertainties of entrepreneurship and the importance of adaptability.

      The success story of 23andMe, a DNA testing company, serves as a reminder of the unpredictable nature of business. The company, which gained significant public attention a few years ago for its DNA testing kits, has since faced numerous challenges, resulting in layoffs and a decline in stock value. Founded in 2006 by Linda Avey and Anne Wojcicki, 23andMe aimed to empower individuals to access their own genetic information for personal learning. However, despite initial success and innovative business model, the company faced unforeseen challenges that led to its decline. This story highlights the risks and uncertainties that come with entrepreneurship and the importance of adaptability in the face of adversity.

    • Anne Wojcicki's Charm and Connections Fueled 23andMe's SuccessAnne Wojcicki's unique charm and deep connections in Silicon Valley played crucial roles in 23andMe's success, leading to early investments from Google co-founder Sergey Brin and billionaire Yuri Milner, and enabling the company to lower the price of its DNA kits and reach a broader audience.

      Anne Wojcicki's unique energy, charisma, and deep connections in Silicon Valley played crucial roles in the success of 23andMe. During their first meeting, Wojcicki's quirky charm was evident, even when she wore her sweater backwards. With 23andMe, she saw an opportunity to provide consumers with valuable health information, which could impact their lives significantly. This personal experience drove her to push for genetic testing for her father, leading to the discovery of an important genetic mutation. Moreover, Wojcicki's relationships in Silicon Valley proved invaluable for the company's growth. Her then-boyfriend and Google co-founder, Sergey Brin, was an early investor, providing crucial funding when 23andMe was starting. Later, Wojcicki's neighbor, billionaire Yuri Milner, led a major funding round, enabling the company to lower the price of its kits and reach a broader audience. Despite these achievements, Wojcicki faced challenges, including a power struggle with her co-founder. However, her connections and financial resources ultimately helped her take control of the company and lead it to success. Today, 23andMe invites you to learn more about your health by ordering a DNA kit for just $99.

    • 23andMe's rapid growth fueled by innovative product, effective marketing, and cultural zeitgeist23andMe's success story highlights the importance of a groundbreaking product, strategic marketing, and timing in achieving exponential growth. The company's DNA testing and personal genomics services gained significant attention through media exposure and word-of-mouth, leading to a valuation of over $6 billion when it went public.

      The rapid growth of 23andMe, a DNA testing and personal genomics company, can be attributed to its innovative product, effective marketing, and the cultural zeitgeist of the time. In 2019, the company gained significant attention through various media outlets, including Ellen DeGeneres' holiday giveaway and a Saturday Night Live skit. This exposure, combined with the ease of use and appeal of the product, led to an exponential increase in users. When the company went public in 2021, it reached a valuation of over $6 billion. CEO Anne Wojcicki expressed her satisfaction with the success but acknowledged that challenges lay ahead. The episode also hinted at the company's subsequent business problems, which were not further discussed. Overall, the story illustrates the power of a well-executed product and strategic marketing in driving massive growth.

    • 23andMe shifts focus to health23andMe pivots from ancestry testing to health, launching a subscription service and entering drug development with partnerships.

      23andMe, a genetic testing company, faced scrutiny from investors after going public in 2021 due to concerns about its business model and the saturation of the ancestry testing market. However, the company pivoted its focus towards health, recognizing the larger market potential. This shift included launching a subscription service for personalized health reports and lifestyle advice, as well as entering the drug development field with partnerships like the one with pharmaceutical giant GSK. The company's large database of DNA samples provides valuable opportunities for research, particularly in identifying specific segments of the population for deeper study. Despite initial challenges, 23andMe's move into healthcare shows the company's adaptability and commitment to leveraging genetic data for significant advancements.

    • The hype and virality of a company aren't enough for long-term successA solid business model and profitability are essential for a company's long-term growth, even if it initially gains attention and success through hype and virality.

      While hype and virality can bring attention and initial success, they are not enough for a company's long-term sustainability. The story of 23andMe, a biotech company known for its DNA testing and health subscriptions, illustrates this point. Although the company had a massive database and ambitious plans to develop new drugs and reconnect people, it faced financial struggles due to the lack of significant subscriptions and only two drugs reaching early human trials out of 50. The company's wide focus on various initiatives proved to be expensive and time-consuming. Despite the challenges, 23andMe still has potential, but it will require substantial time and resources to turn a profit. This lesson serves as a reminder that while hype and virality can bring initial success, a solid business model and profitability are crucial for long-term growth.

    • Learning from the Challenges of StartupsFocus on making money as you grow, learn from success stories and failures, and stay informed to succeed in your business journey.

      While it's inspiring to look at successful companies like Amazon and Jeff Bezos, the reality is that most startups are not in their league. Many companies never turn a profit, and it's crucial to focus on making money as you grow. The example discussed in the podcast never managed to do so. So, while it's essential to learn from the success stories, it's equally important to understand the unique challenges and realities of your own business journey. If you're a startup founder, your path may not be as straightforward as Jeff Bezos's, but with determination, hard work, and a solid business strategy, you can still achieve success. Additionally, the podcast emphasizes the importance of staying informed and staying the course. By following shows like this one, you can learn from the experiences of others and apply those lessons to your own business. And, as the hosts remind us, they're out every weekday afternoon with new insights and perspectives. So, keep listening, keep learning, and keep moving forward.

    Recent Episodes from The Journal.

    The Rise of the Tween Shopper

    The Rise of the Tween Shopper
    Tweens, or kids aged 8 to 12, have learned to shop online. Brands are taking note. WSJ’s Chavie Lieber spoke to TikTok-er Demetra Dias and explains the impact of influencers like her on young shoppers and the brands that court them. Further Reading: - Teen Girls Are Spending Big. She Tells Them What to Buy.  - Why Tweens Are Obsessed With This $110 Sweatsuit  Further Listening: - How the Stanley Cup Became the Internet's Favorite Water Bottle  - Teens Are Falling Victim to AI Fake Nudes  Learn more about your ad choices. Visit megaphone.fm/adchoices
    The Journal.
    enSeptember 04, 2024

    What's Behind the Arrest of the Telegram CEO?

    What's Behind the Arrest of the Telegram CEO?
    Pavel Durov, the CEO of the messaging app Telegram, was arrested in France last month. He was charged with a host of crimes, including complicity in distributing child pornography, illegal drugs and hacking software on the app. Matthew Dalton reports on how the charges represent a major escalation by the French government in holding tech executives accountable for the content that appears on their platforms. Further Reading: - Telegram CEO Pavel Durov Charged by French Authorities  - Exclusive | Telegram Founder Pavel Durov Was Wooed and Targeted by Governments  Further Listening: - Is Fighting Misinformation Censorship? The Supreme Court Will Decide.  - What Happens to Privacy in the Age of AI?  - Meta Is Struggling to Boot Pedophiles Off Facebook and Instagram  Learn more about your ad choices. Visit megaphone.fm/adchoices
    The Journal.
    enSeptember 03, 2024

    For Kamala Harris, a Big Interview and a Narrow Lead

    For Kamala Harris, a Big Interview and a Narrow Lead
    Kamala Harris is trying to step out of President Biden’s shadow without distancing herself from thier administration’s policies. Molly Ball breaks down a new WSJ poll that shows Harris has a narrow lead in the presidential election and unpacks the VP’s first big interview. She also takes your questions.   Further Reading: - Harris Has Taken Narrow Lead Over Trump, WSJ Poll Finds  - Race Is On To Reach the Rapidly Shrinking Pool of Undecided Voters  Further Listening: - Is the Trump Campaign Going Off Track?  - Kamala Harris, In Context   Learn more about your ad choices. Visit megaphone.fm/adchoices
    The Journal.
    enAugust 30, 2024

    Private Equity Finally Can Get a Piece of the NFL

    Private Equity Finally Can Get a Piece of the NFL
    The world’s most lucrative sports league is allowing private equity to buy into teams. WSJ’s Andrew Beaton and Miriam Gottfried unpack why the NFL is opening up, and what it could mean for owners and fans. Further Reading: -Private Equity Ownership Is Coming to the NFL  -College Sports Is About to Turn Pro. Private Equity Wants In.  Further Listening: -Why Three Media Giants Are Betting on Sports Streaming  -ESPN’s Big Bet on an F-Bomb-Throwing YouTube Star  Learn more about your ad choices. Visit megaphone.fm/adchoices
    The Journal.
    enAugust 29, 2024

    Why China Is Risking a Trade War

    Why China Is Risking a Trade War
    Faced with stagnating economic growth, Chinese leader Xi Jinping decided to go all in on manufacturing and exporting. But, as Lingling Wei reports, the increase in low-cost Chinese goods is squeezing businesses around the world and raising the specter of a new trade war. Further Listening: - How Xi Jinping's Dream Slowed China's Economy  - The Political Cost of China's Faltering Economy  Further Reading: - Why China Is Starting a New Trade War  - China Revives Socialist Ideas to Fix Its Real-Estate Crisis  Learn more about your ad choices. Visit megaphone.fm/adchoices
    The Journal.
    enAugust 28, 2024

    Lending Elon Musk Money Was A Very Bad Bet

    Lending Elon Musk Money Was A Very Bad Bet
    When Elon Musk bought Twitter in 2022, he borrowed $13 billion dollars from several banks to complete the deal. Now, it looks like the banks may not get all their money back. WSJ’s Alexander Saeedy on what the banks didn’t take into account when they made those loans. Further Reading: -Elon Musk’s Twitter Takeover Is Now the Worst Buyout for Banks Since the Financial Crisis  -Elon Musk’s Hard Turn to Politics, in 300,000 of His Own Words  Further Listening: -Elon Musk and Silicon Valley Turn Towards Trump -Tesla’s Multibillion-Dollar Pay Package for Elon Musk -Why Elon Musk’s Twitter Is Losing Advertisers  Learn more about your ad choices. Visit megaphone.fm/adchoices
    The Journal.
    enAugust 27, 2024

    Etsy: Big Commerce or Crafters' Community?

    Etsy: Big Commerce or Crafters' Community?
    For almost 20 years, Etsy has been a popular website for handmade and specialized goods on the internet. But as the company grew, many current and former sellers say the platform has changed and is now full of mass-produced goods. They’ve also complained about increased seller fees. The CEO, Josh Silverman, responds, saying Etsy is still true to its original mission to keep commerce ‘human.’  Further Listening: - What’s Behind Amazon’s Review Problem  - The Resurrection of Abercrombie & Fitch  Further Reading: - Temu’s U.S. Entry Is an Orange Flag for Etsy  - Etsy to Cut 11% of Marketplace Workforce in Restructuring  Learn more about your ad choices. Visit megaphone.fm/adchoices
    The Journal.
    enAugust 26, 2024

    Hope, Unity (and Some Nerves) at the DNC

    Hope, Unity (and Some Nerves) at the DNC
    Last night, Vice President Kamala Harris formally accepted the Democratic presidential nomination. It capped off a boisterous, speaker-packed week in Chicago as the Harris campaign tries to reach a broad swath of American voters. Molly Ball reports from Chicago.  Further Listening: - Is the Trump Campaign Going Off Track?   - Takeaways from the RNC: Trump Is in Control  Further Reading: - Kamala Harris Defines the Democrats’ New Normal  - Democrats’ Upbeat Convention Has Nancy Pelosi to Thank  Learn more about your ad choices. Visit megaphone.fm/adchoices
    The Journal.
    enAugust 23, 2024

    Outcry at Bank of America Over Dangerous Workloads

    Outcry at Bank of America Over Dangerous Workloads
    In May, an associate at Bank of America died unexpectedly after working long hours on a big acquisition. The death sparked an outcry about the all-nighters and 100-hour weeks that grind down young investment bankers. WSJ’s Alexander Saeedy spoke to over three dozen current and former employees about a pervasive culture of overwork at the bank. Further Reading: -How Bank of America Ignores Its Own Rules Meant to Prevent Dangerous Workloads  -Bank of America Urges Bankers to Sound Alarm on Overwork After WSJ Investigation  Further Listening: -Lewd Photos, Booze and Bullying: Inside the FDIC’s Toxic Culture  -JPMorgan's $75 Million Jeffrey Epstein Settlement  Learn more about your ad choices. Visit megaphone.fm/adchoices
    The Journal.
    enAugust 22, 2024

    The Inside Story of Starbucks’s CEO Drama

    The Inside Story of Starbucks’s CEO Drama
    Last week, Starbucks ousted its CEO Laxman Narasimhan and replaced him with Brian Niccol, the current leader of Chipotle. Lauren Thomas reports on the dramatic leadership change, as Starbucks struggles to turn around its business and contend with activist investors.   Further Listening: - Can Chinese Customers Rescue Starbucks?   - The Underdog Coffee Bean That’s Making a Comeback  Further Reading: - Inside Starbucks’s Surprising CEO Firing and Hiring  Learn more about your ad choices. Visit megaphone.fm/adchoices
    The Journal.
    enAugust 21, 2024

    Related Episodes

    #133 - Updates for Startup School 2019 and Office Hours with Kevin Hale

    #133 - Updates for Startup School 2019 and Office Hours with Kevin Hale

    Kevin Hale is a Partner at YC. Before working at YC he cofounded Wufoo.

    Kevin’s on the podcast today to do some Office Hours and talk about this year’s edition of Startup School.

    If you’d like to sign up or learn more, check out https://StartupSchool.org.

    The YC podcast is hosted by Craig Cannon.

    Y Combinator invests a small amount of money ($150k) in a large number of startups (recently 200), twice a year.

    Learn more about YC and apply for funding here: https://www.ycombinator.com/apply/

    ***

    Topics

    00:00 - Intro

    00:51 - Stats from Startup School 2018

    2:11 - Updates for Startup School 2019

    8:41 - Sign up at StartupSchool.org

    9:16 - Sean Maina asks - In the early days of Wufoo, how did you give a great customer experience?

    11:56 - Design affordances

    14:11 - Sunil Tej asks - How was Wufoo 10x better than the market when they just got started?

    18:11 - Building an audience before a product

    20:41 - Wufoo's growth

    23:56 - Coming up with the idea for Wufoo

    27:56 - Companies pivoting during YC

    29:26 - Building a product in an unsexy space

    32:56 - Sivaraj Ghanesh asks - How do you know if you've achieved product market fit? Or if your product just isn't noticed yet?

    43:56 - Sivaraj Ghanesh asks - How do you gauge the size of a market?

    46:26 - Tips for Startup School success

    50:41 - Advice on vetting cofounders

    54:11 - Sign up at StartupSchool.org

    EP69: Summarise anything in minutes: Hidden Trick Leaked by Digital Marketing Legend

    EP69: Summarise anything in minutes: Hidden Trick Leaked by Digital Marketing Legend
    Visit https://www.spreaker.com/show/digital-marketing-legend-leaks and listen to Legend’s secretive podcast.

    Who is “Srinidhi Ranganathan”?

    Digital Marketing Legend "Srinidhi Ranganathan" is the Director of Digital Marketing at First Look Digital Marketing Solutions (India's First Artificial Intelligence Powered Digital Marketing company) located in Bangalore, India and is one of the top instructors in India who is teaching futuristic marketing-related courses on Udemy. He is a Technologist, Digital Marketing Coach, Author, and Video Creation Specialist with over 12+ years of experience and has worked at top companies in India. Having over 6 Lakh students on Udemy - he has facilitated digital marketing analysis and provided state-of-the-art marketing strategy ideas and tactical execution plans for top marketing companies in India including startups, SMB's and MNC's. This includes strategic brainstorming sessions, Artificial Intelligence-powered market analysis, market research related to digital performance, support of various AIDM marketing initiatives for new product and consumer promotional launches, etc.
    Srinidhi gained popularity through his unique, practical yet engaging training methodologies he utilizes to teach during the training sessions. Some of his training methods include gamified learning experiences conducted by virtual writing and teaching robots like "Aera 2.0" that prompts behavioural changes in students and bring forth a new kind of fascination among the crowd. These robots are virtual humans having super-intelligence capabilities. They can autonomously train anyone on topics ranging from ABC to Rocket Science, without human intervention.
    Srinidhi's passionate fans call him a "Digital Marketing Legend" and he's busy working on creating new virtual and humanoid robots to revolutionize education in India and the world.
    He is deemed to be an innovator in the field of Artificial Intelligence (AI) based Digital Marketing and is someone who has embraced many ideas and has created various environments in which team members are taught the required AI automation tools and resources to challenge the status quo, push boundaries and achieve super-extensive growth. His courses are a testament to where the future is actually heading.

    Legend's YouTube Channel:

    Full Free 11 Hours Digital Marketing Course - https://www.youtube.com/watch?v=-qJWb-Vtbhs&list=PL7iVMyVUvAra2egy90W498ItgO3UUc-Tr&index=1
    Extract Billions of Email’s (Email Marketing Course) - https://www.youtube.com/watch?v=WXLrWdf3f70&list=PL7iVMyVUvAra2egy90W498ItgO3UUc-Tr&index=5&t=269s
    Artificial Intelligence in Digital Marketing (Full Guide for 2021) - https://www.youtube.com/watch?v=acSYPzX0gz8&list=PL7iVMyVUvAra2egy90W498ItgO3UUc-Tr&index=4&t=1s
    Create a Google-like Search Engine in Minutes - https://www.youtube.com/watch?v=kgWY4eVpHNo&list=PL7iVMyVUvAra2egy90W498ItgO3UUc-Tr&index=9&t=86s
    Earn Money Blogging without writing a word in 2021 - https://www.youtube.com/watch?v=ZI6pY0YTHLc&list=PL7iVMyVUvAra2egy90W498ItgO3UUc-Tr&index=6
    Mini-SEO Course 2021 - https://www.youtube.com/watch?v=PDPslvkQyPk&list=PL7iVMyVUvAra2egy90W498ItgO3UUc-Tr&index=10&t=749s
    Ultimate Graphic Design Course (Cloud Photo Editing of the Decade) - https://www.youtube.com/watch?v=jOZaRM2duFE&list=PL7iVMyVUvAra2egy90W498ItgO3UUc-Tr&index=3
    WordPress CMS Full Course 2021 Edition - https://www.youtube.com/watch?v=HR8xRU1vus4&list=PL7iVMyVUvAra2egy90W498ItgO3UUc-Tr&index=13&t=556s
    Create a humanoid Robot Now (Secret Tutorial 2021) - https://www.youtube.com/watch?v=2hgljxLEezA&list=PL7iVMyVUvAra2egy90W498ItgO3UUc-Tr&index=88&t=10s
    Free Mentorship in Artificial Intelligence (AI) Digital Marketing for 2021 - https://www.youtube.com/watch?v=ATuqwMU9kfs&list=PL7iVMyVUvAra2egy90W498ItgO3UUc-Tr&index=11
    Social Media Extreme Hacks Secretive Tutorial 2021 - https://www.youtube.com/watch?v=K7_um4yfHkg&list=PL7iVMyVUvAra2egy90W498ItgO3UUc-Tr&index=83
    Video Backlinks Course Tutorial to Skyrocket Viral Traffic - https://www.youtube.com/watch?v=RCN7a1oQKb8&list=PL7iVMyVUvAra2egy90W498ItgO3UUc-Tr&index=96

    Elevate Your Brand with Gadiel Morantes of Early Growth

    Elevate Your Brand with Gadiel Morantes of Early Growth
    Gadiel Morantes is president at Early Growth. He works closely with early stage entrepreneurs and founders providing them with mentorship, guidance and outsourced accounting, finance, tax, controller & CFO level solutions for their organizations. He works with many of these organizations at different stages of their lifecycle from inception through exit. He is an accomplished executive with 20+ years of sales, marketing and operations experience. He has an ability to strategically build and maintain profitable business relationships with key corporate decision-makers establishing large-volume, high-profit accounts with excellent levels of retention and loyalty.Laurel Mintz, founder and CEO of award-winning marketing agency Elevate My Brand, explores some of the most exciting new and growing brands in Los Angeles and the US at large. Each week, the Elevate Your Brand podcast features an entrepreneurial special guest to discuss the past, present and future of their brand.

    Hair Is Segregated

    Hair Is Segregated
    In this conversation, Karen, Jay, and Dana discuss diversity in hiring and marketing. Dana talks about the challenge of getting white customers to come to a hair salon that is mostly Black. Karen talks about the challenge of persuading Black candidates to join a company that does not have a lot of Black employees: “So the question is not: are they out there? They're out there. I guarantee they're out there. The question is: do we need to spend more time, more energy, and be willing to be patient until we find a good pool of candidates?”