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    Using Salt to Optimize Mental & Physical Performance

    enMarch 14, 2022
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    Podcast Summary

    • The Impact of Salt and Hidden Sugars on Our Health and Performance.Being aware of the effects of salt and hidden sugars in processed foods can help optimize mental, physical health, and athletic performance. Scientists are making groundbreaking discoveries about the role of neuro pod cells in our cravings for sugary foods.

      Salt not only regulates blood pressure but also our appetite for salt and sugar intake, affecting our health and performance in athletics and cognition. The gut also senses sugars through neurons called neuro pod cells, which promote the seeking and consumption of sugary foods subconsciously. Therefore, understanding salt intake and hidden sugars in processed foods can lead to optimizing mental, physical health, and performance. Presale tickets for two live events by Andrew Huberman, a neurobiology and ophthalmology professor at Stanford School of Medicine, are available at hubermanlab.com/tour. Scientists like Diego Bohorquez at Duke University are making incredible discoveries of neuro pod cells and their role in how we crave and consume sugary foods at both conscious and subconscious levels.

    • Understanding the Role of Neuro Pod Cell in Our Gut and Artificial SweetenersOur gut can differentiate between sugar and artificial sweeteners, impacting our cravings. While the effects on insulin responses are unclear, we should be aware of how artificial sweeteners impact our gut and brain, and consider natural alternatives like Stevia.

      Our gut has a sensor cell known as neuro pod cell that can differentiate between sweet things containing calories like sugar and those without calories like artificial sweeteners. This subconscious ability impacts our cravings and is important to understand. Though the insulin response from artificial sweeteners in humans is still unexplored, we need to comprehend how they affect the brain's functioning and register at the gut level. We also need to study how food manufacturers put artificial sweeteners in foods to make us crave sweet foods more. Many consumers are curious about artificial sweeteners and consume them in small amounts. But we should be aware that non-caloric sweeteners can disrupt the gut microbiome, and some might find natural sweeteners like Stevia more appealing.

    • The Role of Salt in Regulating Fluid Balance and Nutrient Appetite in the BodyOur brain has small sets of neurons that interact with the body in context to regulate fluid balance and appetite for nutrients like salt, sugar, and carbohydrates. While table salt does not always equate to sodium in grams, a blood-brain barrier around the brain is essential to protect it from harmful substances since neurons do not regenerate much after injury.

      Salt plays a critical role in regulating fluid balance, salt appetite, and appetite for other nutrients like sugar and carbohydrates. The brain harbors small sets of neurons that sense the levels of salt in our body and interact with the body in the context of salt. Salt also regulates the appetite for other nutrients, but it is important to note that table salt in grams does not always equate to sodium in grams. The blood-brain barrier is a particular fence that protects the brain and other organs such as the ovaries and testes from harmful substances. The neurons you are born with are the ones that you are going to use most of your life, and the brain does not regenerate much after injury. Therefore, having a blood-brain barrier around the brain is essential to protect it.

    • The LVL T: A Circumventricular Organ with a Key Role in Fluid Balance.The LVL T is a vital structure in the brain that helps to regulate fluid balance and blood pressure, and its dysfunction can have severe consequences for health.

      The ovaries and testes have a barrier from the blood to prevent mutation and protect the genetic material. The brain has a blood-brain barrier that makes it difficult for substances to pass through, but there are weaker fences in some regions. O V L T is a circumventricular organ, which has a limited barrier, and it monitors salt balance, as well as the level of blood pressure. The neurons in O V L T can detect changes in the bloodstream and set off certain events within your brain and body that make you either want to drink more fluid or stop drinking fluid. It is critical for life because the failure of LVL T to function correctly can result in death.

    • Understanding the Two Categories of ThirstRecognizing the difference between osmotic and hypovolemic thirst can help us understand our body's needs and make healthier choices for our hydration.

      There are two categories of thirst, osmotic and hypovolemic. Osmotic thirst is caused by high salt concentration in the blood, which activates specific neurons in the OVO LT that send electrical signals to other brain areas. This signaling eventually leads to the release of vasopressin, or antidiuretic hormone, which restricts urine secretion. Hypovolemic thirst occurs when there is a drop in blood pressure. The OLT senses this reduction in blood pressure due to the presence of Beryl receptors and activates thirst through various pathways, including the secretion of Renon and activation of angiotensin two. Understanding the mechanisms behind thirst can help us make healthier choices about what we drink.

    • The Complexities of Thirst and Kidney FunctionSodium and water are vital for regulating fluid balance in the body, and understanding the role of the kidney in retaining or releasing substances, such as salt, is important for maintaining proper hydration.

      Thirst is not just about seeking water, but also seeking to balance osmolarity by seeking salty fluids or foods. Sodium and water work together to generate thirst and regulate fluid balance in the body. Understanding the kidney, which is responsible for retaining or releasing various substances from the body including salt, is key to understanding fluid balance. The kidney responds to hormonal signals like vasopressin to either hold onto or release more fluids. Most people don't realize that urine is filtered blood and the kidney is a complex organ responsible for filtering out certain substances. Increase in osmolarity, or concentration of salt, will be detected by the OVLT and signal cascades through the superoptic nucleus.

    • Vasopressin and its Functions in the BodyVasopressin, a hormone responsible for preventing excess water release in the kidneys, plays a significant role in regulating sexual behavior and mating. Its use in nasal sprays should be done with caution due to its potent effects on the body.

      The hormone vasopressin acts on the kidneys to prevent the release of excess water, which may cause the need to urinate. It does this by increasing the permeability of tubes in the kidney so that the fluid that would otherwise go to the bladder never makes it there. Vasopressin is also involved in sexual behavior and mating. While vasopressin nasal sprays are available, caution is advised in their recreational use as they have powerful effects on the brain and body. The kidney uses sodium to conserve water, and where there is concentrated sodium, water tends to follow and be held onto.

    • Understanding the Complex Relationship between Hormones, Salt and FluidOptimal salt intake varies greatly based on personal factors such as blood pressure, hormone levels, and exercise. It is important to work with a healthcare professional to determine the appropriate salt and fluid intake for overall health and brain function.

      The relationship between hormones, salt, and fluid is complex, and there is no simple formula to determine the optimal salt intake. Personal factors, such as blood pressure, hormone levels, and exercise, will affect the body's response to salt and water retention. High salt intake can be harmful to the body, including the brain, but a low salt intake can also lead to poor brain function and overall health. It is essential to monitor blood pressure and work with a healthcare professional to determine the appropriate salt and fluid intake for each individual.

    • The Importance of Moderation in Salt Intake for Brain and Heart HealthMaintaining a moderate salt intake is crucial for overall health. High salt intake combined with other unhealthy eating habits can lead to dangerous health complications, while a lower salt diet can reduce such events. It is important to evaluate research and make informed decisions about salt intake.

      Moderation is key when it comes to salt intake for overall brain and heart health. Too high or too low salt diet can be detrimental for health. Studies have shown that high salt intake coupled with other unhealthy diet elements like high levels of carbohydrates and fats can lead to hazardous events such as cardiovascular events and stroke. It is important to note that a low, not truly low, but lower salt diet can reduce the number of these events. According to a study published in the journal of the American medical association, the ideal sodium excretion for optimum health is about 4-5 grams of salt per day. It is important to evaluate the literature and make informed health choices.

    • The Complex Relationship Between Sodium Intake and HealthWhile processed foods are high in sodium, consuming more than the recommended intake may not always be harmful. Individual evaluation and doctor consultation should be prioritized, especially for those with low blood pressure conditions. Always prioritize safe and proper evaluation before making any changes.

      Processed foods contain high amounts of sodium, and the recommended cutoff for ingestion of sodium is 2.3 grams per day. Ingesting 4-5 grams of sodium is associated with low incidents of hazardous outcomes for some people, indicating that more sodium intake might actually be beneficial for them. However, such decisions must be made with caution and only after consulting a doctor or evaluating individual context. Blood pressure is regulated partly by sodium intake, and low blood pressure conditions like orthostatic disorders may benefit from increasing sodium intake. The focus should be on knowing your blood pressure and addressing whether an increase in sodium intake would relieve symptoms in a safe context, after proper evaluation. However, never play games with blood sugar or blood osmolarity that could lead to negative events.

    • Context Matters When it Comes to Salt IntakeThe ideal amount of salt consumption varies from person to person, depending on their health and lifestyle. Paying attention to cravings and balancing salt and fluid intake is essential for overall well-being.

      Context is vital when it comes to salt intake. People with high blood pressure may need to limit their salt intake, while those with postural orthostatic syndromes may require higher amounts of salt. For most people, a moderate increase in salt intake is not harmful, as long as they consume enough fluids, particularly water. The body can store sodium, but excess storage is not good for long-term health. Salt and hunger/thirst for salt are regulated, so paying attention to your cravings can be beneficial, provided you're eating healthy, non-processed foods. Sweating excessively, being in a cold, dry, or hot environment, and exercising a lot are all reasons to ensure sufficient salt and fluid intake.

    • The Importance of Hydration and Electrolytes for Optimal PerformanceTo perform at our best, we should start exercise hydrated with electrolytes, drink fluids every 15 minutes based on our body weight, and ensure we stay hydrated during cognitive or physical activities to avoid fatigue.

      The Galpin equation states that we should start exercise hydrated with electrolytes, not just with water, as losing one to five pounds of water per hour can impact our mental and physical performance. The equation suggests that we should drink fluid every 15 minutes based on our body weight in pounds divided by 30, which may be more fluid than we usually consume. Additionally, it is essential to ensure that our body is hydrated sufficiently while performing any cognitive or physical activity and that we hydrate regularly. Most people are probably under hydrating, not just from the perspective of water intake, but also lack of electrolytes such as sodium, potassium, and magnesium, which can cause tiredness and crashes.

    • The Importance of Salt in Regulating the BodySalt plays a crucial role in regulating the body's water balance and hormonal systems, and too little salt can cause problems with the nervous system. Sea salt contains beneficial minerals for human health.

      Salt plays a crucial role in regulating the body's water balance and hormonal systems. Glucocorticoids and aldosterone are two hormones that help regulate metabolism and sodium excretion from the kidneys. The body adapts to a certain amount of salt intake over time, making salt appetite not the best indication of how much salt one should ingest. Sodium and water have a close relationship, and the body regulates its salt and water balance by retaining or releasing water. Salt was a valuable commodity throughout human history. Excess salt can be harmful, but too little salt can also cause problems, especially concerning the nervous system. Sea salt contains many minerals that can be beneficial to human health.

    • The Impact of Adrenal Glands on Fluid Balance and Salinity CravingsProper sodium intake can help counteract stress and anxiety, and a little bit of sea salt can help stabilize blood pressure and increase resilience to challenges.

      The adrenal glands produce hormones that directly impact our fluid balance and regulate our craving and tolerance for salty solutions. Eliminating the glucocorticoid system through adrenalectomy shifts the threshold for what is considered too salty. Low dietary sodium can exacerbate anxiety in animals and humans. Stress actually activates the immune system in the short term, and bringing sodium into the body can counteract or resist stressors, including infection. Adding a little bit of sea salt or salting one's food can stabilize blood pressure and increase one's ability to lean into stressors and challenges.

    • The Importance of Sodium, Magnesium, and Potassium in DietProper sodium, potassium, and magnesium intake through diet is essential for regulating stress responses, muscle soreness reduction, sleep promotion, cognitive function, and longevity. The context of one's diet plays a significant role in determining the right intake.

      Sodium intake can help suppress anxiety responses during stress, and the body craves salty foods during stress due to a primitive mechanism of preparing for additional challenges. Magnesium is important, and while some people get enough through their diet, others may need to supplement it. Different forms of magnesium can promote muscle soreness reduction, sleep promotion, cognitive function, and longevity. Potassium and sodium work together closely in regulating sodium balance in the body and brain. Low carbohydrate diets increase the need for sodium and potassium intake, while carbohydrate-rich diets may require less. Overall, the context of one's diet plays a significant role in determining proper sodium, potassium, and magnesium intake.

    • Avoid Dehydration while Intermittent Fasting with CaffeineDrink 1.5 times more water than caffeinated drinks and add a tiny pinch of sodium to replenish fluids and electrolytes, as recommended in 'The Salt Fix.' Consider individual salt intake and caveats for pre-hypertension and hypertension.

      Drinking caffeine or tea while intermittent fasting can cause the excretion of fluids from the body, including sodium and potassium, leading to dehydration. It is important to replenish fluids, salt, and potassium, especially if exercising while fasted. For every ounce of caffeinated coffee/tea, drink 1.5 times as much water, and add a tiny pinch of sodium (quarter teaspoon = excessive salt intake). The book 'The Salt Fix' by Dr. James DiNicolantonio provides useful recommendations based on individual situations and emphasizes the positive effects of salt on health outcomes. His recommended salt intake is anywhere from 8 to 12 grams a day, but appropriate caveats must be considered for pre-hypertension and hypertension.

    • The Connection Between Salt and Sugar IntakeUnderstanding the role of salt and sugar receptors in our taste system can help us manage our intake of both and make healthier dietary choices. Regularly consuming high levels of salt can increase health risks, while balanced intake can enhance the taste of food without compromising health.

      The recommended daily sodium intake for most people is 2.3 grams, but it can be as high as 4.8 grams depending on certain factors. However, very high salt intake increases health risks. The relationship between salt intake and sugar consumption is also important. We have salt receptors in our body that signal to the brain when we consume salty substances, affecting our perception of salt and our desire for it. This is similar to how sweet and bitter receptors work in the body. Parallel pathways in the taste system allow us to perceive different components of the foods we eat. Understanding these pathways can help us regulate our salt and sugar intake and make informed decisions about our diet.

    • Understanding the Relationship between Taste and Overconsumption.Our brain's perception of taste is based on comparison, which can lead to overconsumption when taste is masked or hidden in processed food. Pay attention to the intake of unprocessed food for optimal health benefits.

      Our nervous system evaluates absolute levels of anything in the context of perception only by comparison. Sweet and salty taste have a homeostatic balance and masking either taste can lead to overconsumption of food. Food manufacturers exploit the way our brain represents the pure form of tastes and their combinations by putting hidden sugars into processed foods, which can activate the neurons that signal the brain to release more dopamine and make us crave more of that food. To explore increasing or decreasing sodium intake for health benefits, it is useful to do that in the context of unprocessed food intake background.

    • The Role of Sodium in Neuronal Function and Salt CravingsConsuming unprocessed foods can help regulate sodium and reduce sugar cravings. Sodium plays a crucial role in neural communication by allowing for electrical activity and creating a positive charge outside neurons.

      Consuming foods in their basic form and taste can help hone in on specific salt needs. Blood pressure is an important metric to monitor when determining appropriate sodium intake, but ingesting salty or sweet foods can skew results. Increasing salt intake in a backdrop of unprocessed foods can reduce sugar cravings, given the way that neuronal pathways for salty and sweet interact. Sodium plays a crucial role in neuronal function, allowing neurons to engage in electrical activity through the action potential, which is fundamental in neural communication. Sodium carries a positive charge, which helps create a positive charge outside neurons when necessary, allowing for the firing of action potentials and the release of chemicals that inspire or suppress action potentials in other neurons.

    • The Role of Sodium in Neurological FunctionMaintaining proper salt intake is crucial for optimal brain and nervous system function. Adjusting fluid and electrolyte intake during exercise or hot environments is important and overdoing salt intake can disrupt kidney function.

      Sodium plays a crucial role in neuron communication through action potentials. Without sufficient sodium levels, neurons won't function as well, and in extreme cases, dehydration can lead to confusion, dizziness, and a lack of coordination. Drinking too much water without sufficient electrolytes, especially sodium, can also disrupt the balance of sodium and potassium and hinder the brain's ability to function. It's important to maintain a proper salt intake depending on individual health parameters and context, and to adjust fluid and electrolyte intake accordingly during exercise or hot environments. Ingesting sufficient salt allows the brain and nervous system to function optimally, but overdoing it can lead to hypernatremia and disrupt kidney function.

    • The Role and Importance of Salt Intake in Our Health.Individuals should not universally increase or decrease their salt intake without considering various factors like health status and diet. Salt plays a crucial role in our mental and physical health, but excessive intake can lead to unhealthy cravings. Consultation with a doctor and moderation is essential.

      Salt intake cannot be universally recommended for all individuals as it depends on various factors such as fluid and caffeine intake, diet, health status and electrolyte balance. Increasing salt intake may be beneficial for people experiencing low blood pressure and postural syndromes, but must be done healthily and under the guidance of a doctor. The perception of salty and sweet tastes can influence sugar intake and increase processed food cravings, which should be avoided. Salt plays a critical role in the nervous system, and is important for mental and physical health, cognitive function, and performance. The development of an app or tool to determine individual salt intake may be useful in the future. Overall, salt is an incredible substance that our physiology depends on, and its regulation is essential for maintaining a healthy body.

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    In this episode, my guest is Dr. Layne Norton, Ph.D., one of the world’s top experts in nutrition and training for physical fitness. We discuss how to evaluate scientific evidence and the validity of different practices aimed at achieving fat loss, muscle strength and hypertrophy, microbiome health, vitality, and longevity. We explore many hotly debated topics, including fasting, seed oils, saturated fats, sugar, red meat, artificial/low-calorie sweeteners, and GLP-1 agonists (e.g., Ozempic). Additionally, we delve into the timing of protein and carbohydrate intake relative to fasting and exercise, fat loss and sleep, and the benefits of dietary protein and fiber on overall health. We also discuss how to accelerate hypertrophy and fat loss, improve strength, whether we need to train to “failure,” how to enhance exercise recovery, and how to manage pain. We cover training before versus after age 50, whether metabolism changes with age, and the connection between muscle health and longevity. We also address why certain behaviors and supplements might work for some people but not others. Listeners to this episode will benefit greatly from Layne’s science-based expertise on a wide range of topics, including health, nutrition, and fitness. Access the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Mateina: https://drinkmateina.com/huberman Eight Sleep: https://www.eightsleep.com/huberman Maui Nui: https://mauinuivenison.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Dr. Layne Norton 00:01:49 Sponsors: Mateina, Eight Sleep, Maui Nui 00:06:39 Science-Based Evidence, Mechanism vs. Outcome 00:14:31 Meta-analysis, Methods, Evidence Quality 00:22:45 Evidence Hierarchy, Randomized Controlled Trials, Cohort Data 00:33:53 Sponsor: AG1 00:35:05 “Don’t Turn Your Brain Off”; Protein Synthesis 00:42:01 Protein Synthesis, Refractory Response; Resistance Training   00:46:05 Protein Intake, Intermittent Fasting & Training 00:54:52 Tool: Total Protein Intake, Distribution & Protein Synthesis 01:00:25 Muscle Quality, Protein Remodeling, Muscle Growth 01:05:34 Sponsor: LMNT 01:06:46 Early vs. Late Time-Restricted Eating; Fasting Blood Glucose & HbA1c 01:10:30 Carbohydrate Timing, Individual Response, Placebo; Tool: Tracking Diet 01:19:50 “The Norton Method”; Tool: Consistency 01:25:16 Resistance & Cardiovascular Training; Competition; Immune System & Rest 01:33:50 Mind & Body Effects, Stress; Belief Effects 01:41:30 Training to Failure, Reps in Reserve, Hypertrophy & Strength Training 01:50:24 Fatigue & Training to Failure, Speed, Strength Training 01:59:06 Tool: Training After 50, Consistency 02:09:12 Fat Cells, Diabetes, Exercise 02:16:50 Metabolism & Age-Related Changes?, Appetite 02:23:17 Ozempic, Mounjaro, GLP-1 Agonists, Lean Mass, “Food Noise” 02:33:42 GLP-1 Agonists, Judgement & Obesity 02:40:19 Sugar, Excess Calories, Body Weight 02:49:16 Satiety, Sugar & Calorie Budget 02:54:56 Tool: Individualization, Context & Diet Psychology 02:57:22 Seed Oils, Butter, Olive Oil 03:06:56 Red Meat, Carcinogenic?; Simple Diet; Fiber Benefits 03:13:43 Saturated Fat, Cholesterol; Seed Oils 03:18:41 Artificial & Low-Calorie Sweeteners, Insulin, Appetite 03:29:06 Artificial & Low-Calorie Sweeteners, Gut Microbiome; Cancer 03:37:58 Tools: Training Recovery, Glycogen Replenishment; Stress & Activity 03:45:56 Collagen Supplementation, Skin & Nails, Whey Protein 03:57:00 Evidence-Based Approach 04:01:41 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures
    Huberman Lab
    enAugust 12, 2024

    Dr. Martha Beck: Access Your Best Self With Mind-Body Practices, Belief Testing & Imagination

    Dr. Martha Beck: Access Your Best Self With Mind-Body Practices, Belief Testing & Imagination
    In this episode, my guest is Dr. Martha Beck, Ph.D., a Harvard-trained sociologist, bestselling author, and one of the world’s foremost experts on personal exploration and development.  Dr. Beck shares specific frameworks and practices to tap into your unique and deepest desires, core truths, and best life direction—all elements that comprise your authentic self. She also explains how to align your work and relationships of all kinds with your true self and how to embrace the discomfort and process of leaving unhealthy relationships. We discuss how to deal with negative thoughts and emotions, grapple with societal norms, and improve body awareness to gauge your inner truth. We also discuss codependency and self-abandonment - and how to exit and recover from these experiences.  By the end of the episode, you will have learned numerous practical tools to access your best self and live a richly fulfilling life.  Access the full show notes for this episode at hubermanlab.com. Dr. Beck's Wayfinder Life Coach Training: https://marthabeck.com/life-coach-training Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Helix Sleep: https://helixsleep.com/huberman LMNT: https://drinklmnt.com/huberman Waking Up: https://wakingup.com/huberman Timestamps 00:00:00 Dr. Martha Beck 00:01:34 Sponsors: BetterHelp, Helix Sleep & LMNT 00:05:34 Tool: Perfect Day Exercise 00:15:31 “Clear Eyed”, Male vs. Female 00:23:31 Family & Work; Directed Attention & Miracles 00:30:21 Sponsor: AG1 00:32:10 Unease, Restlessness & Guilt; Life Worth, Fear 00:37:22 Accessing the Subconscious; Compassionate Witness Self 00:46:16 Finding Self, Suffering, Anxiety; Tool: “KIST”, Self-Parenting 00:54:01 Self, Radiance, Death; Awakening 00:59:14 Suffering & Compassionate Attention 01:02:10 Challenging Internal Thoughts, Understanding Truth, Body & Mind; 01:08:44 Sponsor: Waking Up 01:10:20 Western Society & Pressure 01:18:30 Tool: Sensing Truth in Body; Meditation, “Stopping the World” 01:25:02 Energy, Magnetoreception, Pet’s Death 01:33:49 Lying to Ourselves, Addiction 01:38:18 Tool: “Integrity Cleanse”, Lies; The Light 01:47:32 Relationship with Loss; Love, Self-Abandonment & Codependency 01:55:10 Romantic Relationships; Jobs & Family 02:02:06 Hurting Others, Relationship Imbalance 02:06:55 Tool: True Empathy 02:11:26 “Happiness is an Inside Job”, Codependency 02:18:58 Live Your Joy, Western Society 02:24:41 Relationships, Love & Integrity, “Feeling Good By Looking Weird” 02:30:42 “I Like It!”, Punk Rock Music, Love 02:34:24 Honesty & Essential Self; Helping People & Healers 02:42:12 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures
    Huberman Lab
    enAugust 05, 2024

    AMA #18: Cold Therapy Advice, Skin Health Tips, Motivation, Learning Strategies & More

    AMA #18: Cold Therapy Advice, Skin Health Tips, Motivation, Learning Strategies & More
    Welcome to a special edition of the 18th Ask Me Anything (AMA) episode, part of Huberman Lab Premium. This episode is a recording of the live stream AMA, exclusive to our Premium members. We've decided to make the full-length version available to everyone, including non-members of Huberman Lab Premium. Huberman Lab Premium was launched for two main reasons. First, it was launched in order to raise support for the main Huberman Lab podcast — which will continue to come out every Monday at zero-cost. Second, it was launched as a means to raise funds for important scientific research. A significant portion of proceeds from the Huberman Lab Premium subscription will fund human research (not animal models) selected by Dr. Huberman, with a dollar-for-dollar match from the Tiny Foundation and other donors. If you're not yet a member but enjoyed this full-length livestream AMA, we invite you to join Huberman Lab Premium. By subscribing, you'll gain access to exclusive benefits including our regular monthly full-length AMA episodes, AMA transcripts, podcast episode transcripts, early access to live events and more. Additionally, a significant portion of your membership proceeds contributes to advancing human scientific research. You can learn more about the research we were able to support in our Annual Letter 2023. If you're a Huberman Lab Premium member, you can access the transcript for this AMA episode here. Timestamps 00:00 Introduction & Announcements 00:15 Supporting Mental & Physical Health Research 01:56 Exciting New Research Initiatives 03:39 Skin Health & Appearance 14:46 Cold Therapy Benefits & Guidelines 21:18 Self-Motivation Strategies 27:05 Understanding REM Sleep 28:45 Morning Routine: Exercise & Cold Exposure 29:17 The Importance of REM Sleep 29:49 Non-Sleep Deep Rest (NSDR) Protocols 31:27 REM Sleep Rebound & Compensation 32:55 Impactful School Strategies for Learning 34:19 Meditation & Micro Gaps in Learning 39:13 Physical Activity & Learning 41:01 Exploring Shilajit & Testosterone 47:51 Writing Process & Overcoming Obstacles 51:32 Addiction & Recovery Resources 53:47 Closing Remarks & Gratitude Disclaimer & Disclosures
    Huberman Lab
    enAugust 02, 2024

    Dr. Peter Attia: Supplements for Longevity & Their Efficacy

    Dr. Peter Attia: Supplements for Longevity & Their Efficacy
    In this episode, my guest is Dr. Peter Attia, M.D., a Stanford and Johns Hopkins School of Medicine-trained physician expert in improving human healthspan and lifespan. Dr. Attia is also the host of The Drive podcast and author of the best-selling book Outlive.  We discuss the NAD pathway in human cells and its possible links to aging and health. We evaluate how supplementation can augment molecules in the NAD pathway; we compare NAD, NMN, and NR, different routes of administration, their safety, and bioavailability. Then, we discuss the broader research and clinical literature on longevity to decide if supplementation with NAD, NR, NMN, rapamycin, or resveratrol can indeed extend lifespan.  Finally, we each describe our supplement regimens and compare the role of supplementation to behaviors such as sleep, nutrition, and exercise for longevity. We also discuss whether tests of biological age are true indicators of aging and whether normal radiation levels increase cancer risk.  Listeners of this episode will learn if supplements purported to improve lifespan show any efficacy and the behaviors and other factors that can prevent disease and extend lifespan. Access the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman Levels: https://levels.link/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps 00:00:00 Dr. Peter Attia, NAD Pathway 00:02:31 Sponsors: LMNT, Levels & Eight Sleep 00:06:38 Categories of Longevity Approaches 00:17:22 Peter’s Supplements; Rapamycin & Research Data 00:25:01 NAD Pathway: Energy & DNA Repair; Knock-Out & Knock-In, Klotho 00:30:35 Sponsor: AG1 00:32:25 Yeast, Sirtuins, Caloric Restriction & Lifespan 00:38:56 Sirtuins, Transgenic Mice, Gender & Lifespan 00:43:42 DNA Repair, Sirtuins, Cancer; Resveratrol 00:53:31 Perform with Dr. Andy Galpin Podcast 00:54:18 NAD & NADH, Reactive Oxygen Species (ROS), Mitochondrial Health 01:02:17 NAD vs NR vs NMN Supplementation; IV & Oral Routes 01:11:33 NR vs. NMN, Doses, Side Effects; Interventions Testing Program 01:17:43 Fatty Liver Disease & NR; NMN & Glucose; Clinical Significance 01:25:17 Safety & FDA, NMN & NR Supplementation; Skin Cancer Benefits 01:30:38 Longevity, NR & NMN Supplementation, Inflammation 01:41:00 Rapamycin & Immune Function 01:44:37 Biological Aging Tests, Chronologic & Biologic Age; Vigor  01:55:24 Radiation & Cancer Risk 01:58:12 Tool: Self-Care in 50s-70s & Aging; Energy Decline 02:07:12 Tool: Exercise Timing & Energy Levels 02:11:22 Peter’s Supplements 02:18:46 Andrew’s Supplements 02:24:34 Tool: Supplement Use vs. Critical Behaviors; Titanic Analogy  02:26:52 NAD Pathway Supplementation for Longevity? 02:28:52 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter Disclaimer
    Huberman Lab
    enJuly 29, 2024

    Dr. Stacy Sims: Female-Specific Exercise & Nutrition for Health, Performance & Longevity

    Dr. Stacy Sims: Female-Specific Exercise & Nutrition for Health, Performance & Longevity
    In this episode, my guest is Dr. Stacy Sims, Ph.D., an exercise physiologist, nutrition scientist, and expert in female-specific nutrition and training for health, performance, and longevity. We discuss which exercise and nutrition protocols are ideal for women based on their age and particular goals. We discuss whether women should train fasted, when and what to eat pre- and post-training, and how the menstrual cycle impacts training and nutrition needs. We also explain how to use a combination of resistance, high-intensity, and sprint interval training to effectively improve body composition, hormones, and cardiometabolic health, offset cognitive decline, and promote longevity.  We also discuss supplements and caffeine, the unique sleep needs of women based on age, whether women should use deliberate cold exposure, and how saunas can improve symptoms of hot flashes and benefit athletic performance. Dr. Sims challenges common misconceptions about women’s health and fitness and explains why certain types of cardio, caloric restriction, and low-protein diets can be harmful to women’s metabolic health. Listeners will learn a wealth of actionable information on how to improve their training and nutrition to enhance their health and how to age with greater ability, mobility, and vitality. Access the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Maui Nui Venison: https://mauinuivenison.com/huberman  Eight Sleep: https://eightsleep.com/huberman   Waking Up: https://wakingup.com/huberman  Timestamps 00:00:00 Dr. Stacy Sims 00:02:24 Sponsors: Maui Nui, Eight Sleep & Waking Up 00:07:03 Intermittent Fasting, Exercise & Women 00:12:50 Cortisol & Circadian Rhythm, Caffeine & Training 00:17:25 Reps in Reserve, Rate of Perceived Exertion (RPE); Age & Women 00:21:06 Pre-Training Meal & Brain, Kisspeptin 00:26:45 Post-Training Meal & Recovery Window 00:29:59 Sponsor: AG1 00:31:48 Hormones, Calories & Women 00:34:24 Women, Strength Improvements & Resistance Training 00:39:10 Tool: Women & Training Goals by Age Range 00:44:16 Women, Perimenopause, Training & Longevity 00:47:14 Women & Training for Longevity, Cardio, Zone 2 00:51:42 Tools: How to Start Resistance Training, Machines; Polarized Training 00:58:23 Perform with Dr. Andy Galpin Podcast 00:59:10 Menstrual Cycle & Training, Tool: Tracking & Individual Variability 01:04:31 Tool: 10-Minute Rule; High-Intensity Training & Menstrual Cycle 01:08:36 “Train Hard & Eat Well”; Appetite, Nutrition & Menstrual Cycle 01:12:22 Oral Contraception, Hormones, Athletic Performance; IUD 01:20:57 Evaluating Menstrual Blood, PCOS; Hormones & Female Athletes 01:26:31 Iron, Fatigue; Blood Testing & Menstrual Cycle 01:29:33 Caffeine & Perimenopause; Nicotine, Schisandra 01:34:24 Deliberate Cold Exposure & Women, Endometriosis; Tool: Sauna & Hot Flashes 01:42:19 Tools: “Sims’ Protocol”: Post-Training Sauna & Performance; “Track Stack” 01:49:37 Women, Hormones & Sleep, Perimenopause & Sleep Hygiene 01:52:54 Supplements: Creatine, Water Weight, Hair Loss; Vitamin D3 01:57:21 Protein Powder; Adaptogens & Timing 02:00:11 Pregnancy & Training; Cold & Hot Exposure 02:06:19 Tool: Women in 50s & Older, Training & Nutrition for Longevity 02:09:38 Tool: Women in 20s-40s & Training, Lactate 02:12:18 Tool: What is High-Intensity Training?, Cardiovascular Sets & Recovery 02:17:22 Training for Longevity, Cellular & Metabolic Changes 02:19:30 Nutrition, 80/20 Rule 02:23:30 Listening to Self 02:26:00 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter  Disclaimer & Disclosures
    Huberman Lab
    enJuly 22, 2024

    Dr. Stuart McGill: Build a Strong, Pain-Proof Back

    Dr. Stuart McGill: Build a Strong, Pain-Proof Back
    In this episode, my guest is Dr. Stuart McGill, Ph.D., a distinguished professor emeritus of spine biomechanics at the University of Waterloo and a world expert on spine anatomy and physiology, back pain, and rehabilitation. We discuss the most common sources of back pain, how back pain can be assessed (including self-assessment techniques), and how to design a personalized recovery plan to reduce back pain. We discuss how to train for lifelong fitness, reduce injury risk, and protect your back and joints based on your age and personal goals. We also discuss how to prevent back pain, build core stability, and explain how “McGill’s Big 3” exercises protect and strengthen the back. Dr. McGill, who is exceptionally fit in his late 60s, describes his low-time investment, personal training routine, and the specific exercises he uses for mobility, strength, and cardiovascular fitness. We also discuss controversial issues in the back pain and rehabilitation field, including how pain originates, the biopsychosocial model of pain, and treatments such as platelet-rich plasma (PRP). This episode provides clear, actionable tools to strengthen, prevent, and remedy back pain and injury so you can be pain-free while enjoying sports, exercise, and daily activities at any age. Access the full show notes for this episode at hubermanlab.com. Watch the clip on back pain relief and spine anatomy that accompanies this episode. Demonstration of The McGill Method Thank you to our sponsors AG1: https://drinkag1.com/huberman Helix Sleep: https://helixsleep.com/huberman BetterHelp: https://betterhelp.com/huberman Waking Up: https://wakingup.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Dr. Stuart McGill 00:02:33 Sponsors: Helix Sleep, BetterHelp & Waking Up 00:06:23 What Causes Back Pain?; Genetics, Dog Breed Analogy 00:12:55 Tool: Skeleton & Body Type; Spine Flexibility & Discs 00:20:25 Flexibility & Exercises; Discs & Collagen 00:25:43 Sponsor: AG1 00:27:32 Stress & Tipping Point; Athletic Tradeoffs, Triathletes 00:36:17 Back Pain, Goals & Training Program 00:45:57 Spine Hygiene, Back Pain, Powerlifting 00:53:33 Genetics & Running 00:59:34 Sponsor: LMNT 01:00:46 Rehabilitation & Reducing Volume; Injury 01:07:42 Tool: Training for Lifelong Fitness, Injury & Joints 01:17:40 Pain Types, Biopsychosocial Model of Pain 01:26:15 Coaching, Explosivity & Endurance 01:32:43 Virtual Surgery & Rest, Pain Recovery 01:41:25 Tool: McGill’s Big 3; Building Back Strength & Stability 01:46:39 Inversion Tables & Spine Deloading, Disc Bulge, Tool: Lumbar Support 01:51:09 Tool: Daily Walking; Sitting 01:55:33 Deadlift & Bone Density, Glute-Ham Raise 02:06:20 Training & Age, Osteoporosis, Tool: Deadlift Alternatives 02:16:47 Tools: Biblical Training Week; Spine Stability & McGill’s Big 3; Shrinking & Age 02:24:16 Platelet-Rich Plasma (PRP); Disc Damage 02:27:56 Tools: Biblical Training Week & Strength Exercises, Neck Strength 02:35:24 Tools: Sword Play, Distal Limb Loading, Training for Symmetry 02:42:38 Tools: Biblical Training Week, Mobility & Cardiovascular Exercises, Athletic Panel 02:49:22 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures
    Huberman Lab
    enJuly 15, 2024

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