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    Angel Invest Boston

    In the Decade of Biotech when there will be myriad opportunities to invest in angel-scale biotech startups. After decades of angel investing, I am focusing on the life science side of my portfolio and invite other angels to do the same. Here's why: https://www.labcoatventures.com/why-we-are-focused-on-early-stage-biotech/ I’m Sal Daher, host of the Angel Invest Boston Podcast. After immigrating to Boston as a child and attending Belmont High School, I studied engineering at MIT and Stanford. Decades of work in international finance followed. During that time, I invested in a handful of ventures founded by friends and acquaintances. Now, I’m a member of Walnut Ventures and MIT Angels and spend most of my time as an angel investor. Startups in my portfolio include: SQZ Biotech, Gelesis, Akili Interactive, Vedanta Biosciences, FineTune Learning, Concrete Sensors, Squadle, doDoc, Pixability, Mavrck, Viral Gains, Streamroot, XMOS, Alice's Table and others. Exits include: Exos (Microsoft), Rifiniti (KKR) and PIKA Energy (Generac).
    enSal Daher312 Episodes

    Episodes (312)

    Stephanie Culler PhD - Cancer & the Gut Biome - Co-founder of VC-Backed Persephone Microbiome

    Stephanie Culler PhD - Cancer & the Gut Biome - Co-founder of VC-Backed Persephone Microbiome

    The loss of two grandmothers to cancer propelled the daughter of an entrepreneurial family, Stephanie Culler, to a Ph.D. at Caltech and eventually to founding Persephone Microbiome. The VC-funded startup seeks to use gut bacteria to increase the success of cancer therapies. Persephone is also launching a probiotic for infants. Fascinating chat with a brilliant and articulate scientific founder.

    Highlights:

    • ·       Sal Daher Introduces Stephanie Culler, Ph.D. Co-Founder of Persephone Microbiome
    • ·       Persephone’s Business Model Is to Partner with Big Pharma to Develop Products Based on Its Platform
    • ·       A Probiotic for Babies and Infants Is Coming in Early 2024
    • ·       Results from the Largest Study in the US of Infant Gut Microbiome Were Unsettling
    • ·       Causes of Insufficiencies in the Gut Biome of Babies
    • ·       “Upwards of 80% of cells of our immune system is in our gut.”
    • ·       “...if you have a good microbiome, you're much more likely to respond to treatment.”
    • ·       “We are wet lab and in silico.”
    • ·       How Persephone Got Funded
    • ·       The Importance of Enrolling Populations Previously Under-represented in Studies
    • ·       The Promise of Population-Scale Data Sets
    • ·       Scanning Large Patient Populations Unencumbered by Animal Studies
    • ·       Why You Should Help This Podcast Get Found
    • ·       Stephanie Culler, Ph.D.’s Entrepreneurial Journey
    • ·       Entrepreneurial Family that Lost Two Grandmothers to Cancer
    • ·       Sal’s Appreciation of Articulate Chemical Engineers Like Stephanie
    • ·       Stephanie’s Experience at Y Combinator
    • ·       How Stephanie Culler Connected with Leen Kawas
    • ·       Stephanie’s Parting Thoughts on Biotech Winter
    • Topics: biotech, robotics / AI, venture funding, discovering entrepreneurship

     

    Angel Invest Boston
    enApril 26, 2023

    Fiza Shaukat - Patient First.AI

    Fiza Shaukat - Patient First.AI

    Angel Scale Biotech: Learn More

     

    Fiza Shaukat founded Patient First.AI to make a difference in the healthcare systems in areas outside the US, such as Pakistan. She decided to create a platform which would allow patients to keep their healthcare data on a digital health card. This card would make the check-in process much faster and efficient.

     

    Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.

     

    Highlights:

     

    • Sal Daher Introduces Fiza Shaukat
    • "...How PatientFirst.AI is creating value for patients in places where right now there's no really easy way except for a wad of notes, a notebook, to keep track from visit to visit..."
    • "... You see all the digitization happening over there, but why don't you have the same seamless experience within healthcare? That's what we want to enable with this digital health card. They'll go at a clinic and they scan their digital health card or a QR code, and as soon as they scan that in, they basically are checked in..."
    • The Patient First Business Model
    • Next Steps for Patient  First
    • Fiza's Entrepreneurial Journey
    • Familial Role Models for Entrepreneurship
    • "... Somehow a brother and sister you have known each other for your whole life, so chances are you're going to get along more or less. Whereas husband and wife sometimes it can be you've known each other for three years and the stress of founding a company together can be very painful..."

     

    Topics: discovering entrepreneurship, robotics/AI, founding story

    Angel Invest Boston
    enApril 19, 2023

    Yousof Naderi, PhD - Deep Charge

    Yousof Naderi, PhD - Deep Charge

    Angel Scale Biotech: Learn More

     

    Yousof Naderi, professor at Northeastern University, is co-founder of DeepCharge, which is commercializing a new technology for charging batteries without cables. Intriguing look at how our lives could change as our devices are untethered.

     

    Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.

     

    Highlights:

     

    • Sal Daher Introduces Yousof Naderi
    • What DeepCharge is Solving
    • "... In a case of the wireless charging, DeepCharge has selected and carefully from the beginning are working in a non-radiative technology, which means it's just coil by coil..."
    • How DeepCharge Came About
    • "... Also, there is this piece of sustainability that we can't go through all that, but we think that working with enterprise is really going to help us in our mission, also, to build a wire-free sustainable future..."
    • "... Now, to go to the next level, we feel that this is a right timing to look at the strategic investor and partner that can stay, share our vision, and be able to provide resources and help to make this success for everybody..."
    • The Future of DeepCharge
    • Yousof's Immigrant Story
    • Why Yousof Started DeepCharge
    • Advice to the Audience
    • "... I think one of the biggest pivots was just that type of technology that they use..."

     

    Topics: discovering entrepreneurship, founding story, product

    Angel Invest Boston
    enApril 12, 2023

    Carolina Alarco - Biotech and Inclusion

    Carolina Alarco - Biotech and Inclusion

    Angel Scale Biotech: Learn More

     

    The deep experience Carolina Alarco has gained in the biotech industry now informs her work as an advisor to startups and as an angel investor. Her incisive contributions at Walnut Ventures made me eager to learn more about her story and approach. 

     

    Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.

     

    Highlights:

    • Sal Daher Introduces Carolina Alarco
    • SYTE.bio and What it is Solving
    • SYTE.bio Founders' Backgrounds
    • Why Invest in SYTE.bio?
    • Verbina
    • Latinos in Bio
    • "... I do want to say that Latinos in Bio will be raising awareness of some lack of representation of Latinos in the industry..."
    • Carolina's Background
    • "... I came up in the '90s. I came to study a graduate degree in International Management Harvard..."
    • Advice to the Audience

     

    Topics: angel investing strategies, biotech, discovering entrepreneurship

    Angel Invest Boston
    enApril 05, 2023

    Chris Selland - Squark.AI

    Chris Selland - Squark.AI

    Angel Scale Biotech: Learn More

     

    Chris Selland works at Squark.AI, a startup company that uses AI and machine learning with customer data from things such as games and delivery services to help with predictions of delivery time.

     

    Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.

     

    Highlights:

    • Sal Daher Introduces Chris Selland

    • Squark AI and What It's Solving

    • "... All of those types of predictions is essentially what we do with the model. Now, we do have some other customers using us for other purposes. For instance, a very large package delivery firm is using us, actually, for prediction of packages that might be late..."

    • "... This, I think, highlights really the importance of networking and staying in touch with people that you've worked with successfully. Make sure that you stay in touch with them because you will have that twice annual conversation that you might have with someone that you worked two companies back with..."

    • Squark in the Gaming Industry

    • The Future of Squark

    • Advice to the Audience

     

    Topics: discovering entrepreneurship, founding story, robotics/AI

     

    Angel Invest Boston
    enMarch 29, 2023

    Mike Nolan - Fighter Jets and Machine Learning

    Mike Nolan - Fighter Jets and Machine Learning

    Angel Scale Biotech: Learn More

     

    Mike Nolan is an angel investor specializing in machine learning. As an officer in the Air Force he trained fighter pilots on F-15s. Mike relates the opportunities offered by graduate work at MIT both professionally and in investing. Fun chat with a buddy from Walnut and a listener to the podcast.

     

    Highlights:

    • Sal Daher Introduces Mike Nolan
    • Piction Health and Machine Learning
    • "... we don't frequently see companies that are on the bleeding edge of the academic research or the bleeding edge of what's going on and the top presentations at conferences and so forth, but that's okay..."
    • The Capabilities of Machine Learning In the Health Field
    • Mike Nolan's Background
    • "... You got to picture this beautiful country, the White Sands, New Mexico, close by, and so forth, and here's this chimp running away from this 10-mile-long sled track..."
    • "... They're highly creative people in a highly regimented situation. They are people who think in very creative ways, and so forth, and they have big personalities ... I suspect that there is a lot of room for creativity with fighter pilots..."
    • "... Yes, things can go wrong, whether you're a founder or a pilot..."
    • Advice to the Audience

     

    Topics: angel investing strategies, biotech, robotics/AI

    Angel Invest Boston
    enMarch 22, 2023

    SVB's Failure - Historical Perspective for Founders & Investors

    SVB's Failure - Historical Perspective for Founders & Investors

    What founders and investors in startups need to know about the history of bankruns and how to protect themselves from them in the future.

    Here's the text on which my talk was based:

    Historical Perspective on SVB’s Failure for Investors & Founders 

    This is Sal Daher of the Angel Invest Boston podcast. Prior to becoming an investor in tech startups, I spent decades as a banker and trader involved with the distressed debt of countries. My experience came in handy recently in allowing me to reassure the startups in my portfolio with deposits at SVB that the FDIC would have no option but to make all depositors whole. 

    This piece aims to explain why the business model of banks and past government decisions precluded any other options. It also points to ways that founders can manage deposit risk. While it bothers me to see well-off people bailed out by the taxpayer, it is the necessary if imperfect course of action until we make structural changes to hold bank management more accountable.

    Why was I so certain in my assurances? Because financial authorities in the US and other countries had learned a hard lesson back when Lehman Brothers (not a deposit-taking bank) was allowed to fail in September of 2008. Lehman’s bankruptcy set off an inevitable chain of events that led to the meltdown of the market for credit risk insurance.  This revealed pervasive rot in financial instruments widely held by institutions starved for yields. Thus began the Sub-Prime Crisis that ruined millions and blighted the career of so many of my colleagues in finance for nearly a decade. 

    The hard lesson learned was that when a financial panic gets going it’s impossible to tell where it will stop. The term contagion is apt. Financial authorities understood the need to take prompt steps to reassure investors not to make irrational moves that could impoverish us all. Back in 2008 they ended up taking over banks which created lasting distortions, some of which are still with us today. 

    While the circumstances of SVB’s failure are different from Lehman’s, the fundamental lesson of maintaining the orderly functioning of financial markets still applies. If the FDIC had stuck strictly to its $250K deposit insurance limit (which BTW had been $100K until the Lehman event) chaos would have ensued. Depositors everywhere would have immediately started spreading any holding in excess of $250K to other banks to avoid the possibility of loss and could have melted down the entire banking system. An impaired banking system would have resulted in hundreds of thousands of companies going under and millions of people losing their jobs. So, preventing financial panic is a public service for the entire population. It’s comparable to the fire department. Fire brigades were set up to prevent individual house fires from spreading and burning down entire neighborhoods.

    There is a fundamental flaw in the business model of banks. Banks lend long and borrow short. Borrowers want to repay banks months or years into the future. Depositors usually are not willing to tie up their money for more than a few months. This creates a mismatch between the maturity of loans made by banks (assets) and deposits taken by banks (liabilities). The delicate balance between assets and liabilities is hard to achieve. This is why banks keep cash reserves on hand, i.e., they don’t lend out all their deposits. They also have short-term borrowing lines with other banks or the Federal Reserve to make sure they have cash meet all their obligations. 

    But if enough depositors decide that a bank is impaired, even the soundest bank would not be able to meet the demand for immediate payment without outside help. This is the role the FDIC has come to play. A role with which I am not entirely comfortable, but as we have seen, is essential as things stand. 

    Many argue that unlimited deposit guarantee removes the incentive from depositors to vet a banks’ books. In the absence of this vetting there is a natural temptation for banks to take all the risk possible with depositor’s money because if things go well the bank’s shares will go up and the management will get bonuses. This moral hazard of deposit guarantees is supposedly mitigated by regulations that limit how much a bank can lend and impose minimum capital requirements.  

    Unfortunately, the regulations failed in the case of SVB. The bank appeared to meet its capital requirements but when depositors started to draw out money, it started to sell its reserves. This prompted changes as to how assets were valued and put it suddenly in default of capital requirements. This led to a failed attempt to raise more equity in the stock market.

    One moment SVB seemed fine, the next moment it was on the rocks. Bank books are complicated beyond the ability of even the most sophisticated depositor to figure out. The idea of savvy depositors keeping banks honest is fanciful. The only parties who have any hope of knowing enough about what’s going on in the bank are its management and its board of directors. I support making bank directors and senior management personally liable if a federal rescue is needed. 

    So, what’s a founder to do when holding more than $250,000 in cash? One thing to consider is to have the funds in more than one bank, if only to avoid a sleepless weekend as so many founders experienced recently. But that only gets you up to protecting $500,000 or $750,000. Another option to consider is putting funds into money market funds held by Fidelity, Schwab or Vanguard. Funds held in custody for a beneficiary are legally protected from claims against the entity. This does not mean that there is no risk. Even safe money market instruments may lose value in times of stress, but the exposure to any one entity is much less concentrated. There’s always the risk of fraud or unauthorized trades but those are not usually system-wide and the entities usually make good on those.

    Founders are in the business of sailing in uncharted waters. However, many of the risks that threaten a startup are known to accountants and board members. My advice is to bring up the matter of risk with your CFO and your board. If you don’t have one it’s time you found at least a fractional CFO and functioning board. 

    If found this brief piece useful I invite you to follow Angel Invest Boston on your podcast app. Thanks for listening. This is Sal Daher.

     

    Angel Invest Boston
    enMarch 17, 2023

    Rick McMullen- Physical Therapy That Works

    Rick McMullen- Physical Therapy That Works

    A common sports injury left Rick McMullen incapacitated. His search for recovery led to the founding of Alleviate, a platform for physical therapy that is finding a lot of satisfied users. Thanks to Bryanne Leeming for introducing Rick to me.

    • ·      Sal Daher Explains Why He Came Off the Sidelines to Invest in Alleviate
    • ·      Rick McMullen, Co-Founder of Alleviate, Has the Ideal Background to Build Such a Company
    • ·      Investing from a Self-Directed IRA Is High-Burden
    • ·      The Problem Alleviate Is Solving
    • ·      People Often Quit Before Physical Therapy Begins to Work
    • ·      College Athletes Have a Lot of Support; When They Graduate There’s Nobody to Advise them on Recovering from Injuries
    • ·      Alleviate Aims to Fill the Gap in the Delivery of Physical Therapy in the US
    • ·      “With all of these conditions, you’ve got to do the work [to get better].”
    • ·      Atomic Habits by James Clear
    • ·      Alleviate Is Getting Traction
    • ·      Alleviate’s Revenue Is Cash-Flow Positive
    • ·      Product Returns Are Learning Opportunities
    • ·      Clayton Christensen’s The Innovator's Dilemma
    • ·      “...the specific subset of musculoskeletal pathologies that we serve. You can call it a niche, but it's like a $10 billion niche.”
    • ·      Rick McMullen’s Journey to Founding a Startup
    • ·      “...this central idea that the golden rule is the most economically rational thing.”
    • ·      Why Rick McMullen Is Focused on Capital Efficiency
    • ·      Parting Thought from Rick McMullen

    Topics: product, management, discovering entrepreneurship

    Title: Physical Therapy That Works

    Angel Invest Boston
    enMarch 14, 2023

    Aidan Yeaw, Founder & Angel

    Aidan Yeaw, Founder & Angel

    Fintech founder and angel Aidan Yeaw discusses building and investing in companies such as NODE40 and Unruly Studios. Great chat with a Walnut colleague.

    Highlights:

          Sal Daher Introduces Aidan Yeaw

          NODE40

          NODE40 Founding Story

          Unruly Studios

          "... The other component to it is that they're programming, but they're doing physical movement, physical exercise, large motor, physical exercise, running around, jumping up and down, and so forth because kids are too sedentary..."

          How Aidan Came to Angel Investing

          "... There's an ecosystem of small-scale venture capitalists that are growing, but the opportunities are so numerous, and the venture capitalists are so few, that they're an excess of opportunities, and a lack of funding, a lack of capacity to address this..."

          CoolSculpting

          Aidan's Career Journey in Fintech

          Advice to the Audience

    Topics: fin tech, angel investing strategies, crypto

    Title: Founder & Angel

    Angel Invest Boston
    enMarch 08, 2023

    Jay DeVivo - A Keen Eye for Risk

    Jay DeVivo - A Keen Eye for Risk

    Angel Scale Biotech: Learn More

     

    Jay DeVivo’s angel investing ranges far from his insurance background. Here we discuss his involvement with startups such as Hubly Surgical, FleetNurse, and ApprentiScope. Fun chat with a lively guest.

     

    Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.

     

    Highlights:

     

    • Sal Daher Introduces Jay DeVivo
    • Hubly Surgical
    • "... The advantage for Hubly is that doctors don't need to learn any new skills. It's pressing a button and in fact, there'll be a wider swath of clinicians that'll be able to use it than can use the current hand crank drill..."
    • FleetNurse
    • "... See, that's the thing with Angel investors. They may be new to Angel Investing, they're not new to business..."
    • ApprentiScope
    • How Jay DeVivo Came to Angel Investing
    • "... It's really tough as an investor because you're not controlling things. You're along for the ride..."
    • Jay's Career Journey
    • "... Later on, I did some strategy work for larger companies as well. I started that business right before business school and then I consulted all through business school and things were good, so I did it for two years after business school..."
    • "... It's like in the third ring out from there is where the jobs live. Basically, what you need to do is talk to a lot of people and do informational conversations, low pressure, just talk and you say, 'Hey, this is what I used to do. This is what I'm interested in'..."
    • Advice to the Audience

     

    Topics: angel investing strategies, biotech, product

    Angel Invest Boston
    enMarch 01, 2023

    Leen Kawas - The Microbiome of Babies

    Leen Kawas - The Microbiome of Babies

    Angel Scale Biotech: Learn More

     

    Leen Kawas PhD, managing general partner at Propel Bio Partners, invests in life science companies such as Persephone Biosciences and Inherent Bio that promise immediate benefits for humanity. An uplifting chat with a dynamic VC and founder.

     

    Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.

     

    Highlights:

    • Sal Daher Introduces Leen Kawas
    • What Propel Bio Partners Does
    • Persephone Biosciences
    • "... It's a pipeline for probiotics. They're starting with infant probiotics..."
    • "... is anybody else working in the space of microbiome for babies? I haven't seen this..."
    • Inherent Bio
    • "... That's what Inherent is working on. They have identified an epigenetic signature that has the ability to better predict pregnancy outcome with men..."
    • "...What is the profile of the kind of company that you find attractive in public markets now...?"
    • Advice to the Audience
    • Leen Kawas' Immigrant Story
    • "... I want to tell entrepreneurs that are out there, no is typically not no. Just keep that in mind..."
    • "... I just want to tell the entrepreneurs out there, you tell your own story, you work on your mission, you define your why. Keep going and you'll be successful..."

    Topics: building wealth, management, raising money

    Angel Invest Boston
    enFebruary 22, 2023

    K. Woodman-Maynard - The Business of Being an Artist

    K. Woodman-Maynard - The Business of Being an Artist

    Artist K. Woodman-Maynard discusses her gorgeous graphic novel interpretation of The Great Gatsby, the business of being a graphic artist and other engrossing matters. A delightfully different interview with a charming guest.

    Highlights include:

    • Sal Introduces K. Woodman-Maynard, Creator of The Great Gatsby Graphic Novel
    • “Color is gorgeous. The drawings are extremely expressive and interesting… the style of the period is displayed.”
    • “…I think it's a good way to get people who might not otherwise read The Great Gatsby, the prose book, interested.”
    • Cashflow from a Graphic Novel Is Inconsistent – Good to Have Steady Income from Graphic Design
    • “…it was very painful for me to cut out specific lines, because I love those lines.”
    • “I'm in complete agreement that you shouldn't dismiss somebody's whole life's work just based on certain philosophies. It's a balance.”
    • “…it started by a very intense deep reading of the text…”
    • “The whole book took about 1500 hours. That's actively time tracked hours.”
    • “…the first thing for a beginner that they need to know is that they can do it. You can make a living as a graphic artist.”
    • “I was encouraged to go into architecture because that was considered to be more stable for artists. I'm so glad I didn't, because I graduated college in 2008.”
    • “One thing that's been key for me has been diversifying my income. I have income from graphic novels. I have income from graphic design work, from illustration.”
    • “I think it's an important thing for yourself as a graphic artist to be able to pivot and to be able to work in different ways.”
    • “…finding good mentors. That's something that I would encourage your niece to do.”
    • “Going to Harvard has really helped me with asking stupid questions.”
    • “You can be a good business person and also be good at your craft.”
    • The Great Gatsby was a commercial flop at the time that it was published.”
    • “He was making a huge amount. He would just spend it before he even got it, which is the direct opposite of me.”
    • “…a captive audience of troops who read The Great Gatsby and then returned and spread the word about it.”
    • “I'm wondering what's going to happen once the vaccine is out. Will we experience another Roaring Twenties in a different way?”
    • “I do the Pomodoro method. …You work for 25 minutes; you take 5 minutes off. Then every two hours, you take a half an hour break.”
    • “In high school, we had to take career placement tests. I had equal likelihood artist and military officer.”
    • The Importance of Story Telling
    • Addressing Mental Health Issues with Kids via Comics: TKAMI.org
    • “I decided not to go into architecture because it wasn't my calling. Also, because I could see that it wouldn't be good for my mental health.”
    • “It's just gorgeous. I highly recommend this work.”
    Angel Invest Boston
    enFebruary 15, 2023

    Paul Hartung - Secrets of Biotech Funding

    Paul Hartung - Secrets of Biotech Funding

    Angel Scale Biotech: Learn More

     

    Paul Hartung returns to talk about how to fund promising biotech and life science companies. He continues his conversation from his previous episode discussing his past experience with angel investing.

     

    Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.

     

    Highlights:

    • Sal Daher Introduces Paul Hartung
    • "... Tell me the story of the first syndicated angel funding here in New England..."
    • "'... there's a bunch of guys like you and me who've been successful in business, who are starting to get together.' He said, 'I just joined a group called Launchpad...'"
    • "... I was CEO from the start and chairman, the president and secretary and [laughter] and all the offices..."
    • "... The story here is that technologies are coming out of labs that are amazing, that are just astonishing, that could do things that couldn't be done 10 years ago by any stretch of the imagination. It's not one-off, they're multiplying. The cost of developing this technology is a coming down..."
    • "... how do I support angels? Due diligence I think is part of it, creating due diligence, and I think part of it is also syndication..."
    • "... What is the end game? Who would be the strategic partners that might end up acquirers or might license the technology...?"
    • Pros and Cons of Grant Funding
    • ".. the timing of strategics is not the timing of startups..."
    • "... I think there's a lot of room for Angel-friendly venture funds that will work with Angels and will help bring Angels over from software investing into the life sciences, perhaps initially for digital health, but eventually, in wet lab..."
    • Advice to the Audience
    • "...Don't just have a purely science team. You need to have someone who's going to be your business representative if you will..."

    Topics: angel investing strategies, biotech, building wealth

    Angel Invest Boston
    enFebruary 08, 2023

    Small Rockets, Big Promise - bluShift Aerospace

    Small Rockets, Big Promise - bluShift Aerospace

    Sascha Deri and Lindsay Becker were interviewed by co-host Ben Littauer and me about the equity crowdfunding campaign this fascinating rocket company based in Brunswick, Maine is doing on WeFunder. They are targeting the a growing niche of sending small non-human payload into space. They are doing this with a non-toxic rocket fuel that is friendly to the envidonment. As of this writing they had already passed the million dollar mark at WeFunder. Check them out here: https://wefunder.com/blushiftaerospace

    Natalie Park and Saumya Rawat - Automation for Better Prescription Outcomes

    Natalie Park and Saumya Rawat - Automation for Better Prescription Outcomes

    Angel Scale Biotech: Learn More

     

    What if automation could help patients better follow their prescriptions? Natalie Park and Saumya Rawat met at MIT and are co-founders of Pharmesol which seeks to do this.

     

    Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.

     

    Highlights:

    • Martin Aboitiz Introduces Natalie Park and Saumya Rawat
    • What Problem Pharmesol is Solving
    • Pharmesol's Product and What it Does
    • Pharmesol's Business Model
    • Fee-For-Service vs. Value-Based Payments
    • What Makes Pharmesol Marketable?
    • "... I think ideal profile of a customer would be an integrated delivery network. What that means is that they have both a health system as well as a health plan..."
    • Why Not AI?
    • "... Pharmesol is a clinical automation company, and we're solving the problem of lack of clinical capacity and challenges with workforces at provider organizations..."
    • "... These people, they know what they're talking about. They're trained. Graduate degree, they're a doctor of pharmacy. Underutilized resource..."

    Topics: co-founders, discovering entrepreneurship, founding story

    Angel Invest Boston
    enFebruary 01, 2023

    CL Tian - A Better Way to Sterilize

    CL Tian - A Better Way to Sterilize

    Angel Scale Biotech: Learn More

     

    Finding a less noxious way to sterilize medical devices is the goal of CL Tian, winner as MedTech Innovator ’22. She founded Phiex to commercialize a sterilant that allows devices to sterilize themselves in the presence of light. Industry is listening to this compelling founder.

     

    Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.

     

    Highlights:

    • Sal Daher Introduces CL Tian
    • What Problem Phiex is Solving
    • "... The moat is how do you deliver it without using capital equipment, with plastic packaging material as the delivery system, and how do you deliver it when it's activated by light? Our materials, once they see ambient light, start to release a sterilant..."
    • “... I don't think I mentioned, but the amount of devices that are sterilized with this cancer-causing technology's half of the industry. That's 20 billion devices in the US a year. There's no alternative for most of those devices…”
    • CL Tian's Background
    • How CL Tian Came to the Issue of Sterilization
    • Message to the Audience

    Topics: biotech, discovering entrepreneurship, founding story, product

    Angel Invest Boston
    enJanuary 25, 2023

    Paul Hartung - The Frontiers of Medtech

    Paul Hartung - The Frontiers of Medtech

    Angel Scale Biotech: Learn More

     

    Paul Hartung is an angel investor involved in the life sciences field. Here, he discusses how he helps build companies such as Leuko, Clairways, Verisense, and others in the MedTech space.

     

    Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.

     

    Highlights:

    • Sal Daher Introduces Paul Hartung
    • Leuko Labs
    • "... Something dark goes through, that's a red blood. Something light goes through, that's a white blood cell. Then they count that, and then it can come up with immunocompromised, or low leukocyte count, or normal leukocyte count..."
    • Upcoming Milestones for Leuko
    • Clairways
    • "... That's an area of great interest for me is academic founders in the life sciences, taking their technology from the lab into the clinic, or into the market. It requires understanding the technology, and it also requires understanding the market..."
    • Verisense
    • Xander
    • "... Well, he's basically creating a software that interprets the voice of the person who's speaking to the wearer of the glasses, and creates a caption, which projected on the lens. You can caption what people are saying to you..."
    • Paul's Backstory
    • How Paul Got Into Life Sciences
    • 3Com
    • "... The whole premise of the technology was that you could take people who were suspect of the disease, and rather than immediately going in for really expensive brain imaging tests, which actually involve exposure to radiation and you can only do them very infrequently, this is something that could be done in a general practitioner's office, doesn't even have to be done in a hospital...:
    • Sonivance
    • Advice to the Audience

     

    Topics: angel investing strategies, product, venture capital

    Angel Invest Boston
    enJanuary 18, 2023

    Richard Lane - The Promise of Age Tech

    Richard Lane - The Promise of Age Tech

    Angel Scale Biotech: Learn More

     

    Founder, entrepreneur, and angel, Richard Lane, explains his experience investing in companies such as Alice’s Table and The Jitterbug phone.

     

    Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.

     

    Highlights:

    • Sal Daher Introduces Richard Lane
    • "... The founder is in the business of discovering new territory, terra incognita. The angels and the board members are in the business of making sure that she doesn't run aground on well-known shoals..."
    • Alice's Table
    • "... She was helping women who were very much into floral arrangements to teach in-person classes in floral arrangement, and how to make a really beautiful floral arrangement. What her business did-- basically, she helped these women to run events. The women would use those tools in their network..."
    • "... As an angel investor board member, I go in and I say, "Are you on schedule? Great. Everything's good? I don't care about that. I'll look at that later. Tell me what is keeping you up at night. What is the first stumbling block?"
    • Richard's Entrepreneurial Career
    • "... One of the driving things I had since my childhood was, what happens when you die?"
    • Telephone Companies
    • "... It's a business that didn't exist. Before that, landlines were everything. It was everything, that was telephony was a landline..."
    • Pacific Telephone Company
    • The Jitterbug
    • "... A couple of things worth noting, a device around older people, needs to be looking at their user’s expectations. We're hardwired by the time we're 65 to think certain ways, to do certain traits..."
    • LifePod
    • Parting Thoughts to the Audience

    Topics: angel investing strategies, founding story, product

    Angel Invest Boston
    enJanuary 11, 2023

    Alex Westner, Sound Technologist & Founder - Augmented Reality for Hearing Loss

    Alex Westner, Sound Technologist & Founder - Augmented Reality for Hearing Loss

    MIT Media Lab alum Alex Westner has glasses that show captions to hearing-impaired people during real-time conversations. His approach is to refine existing technologies to deliver an excellent experience in one use case. Loved the focus and his dedication to detail.

    Highlights:

    • Sal Introduces Alex Westner, Sound Technologist & Founder of Xander – Glasses with Captions for the Hearing-Impaired
    • Xander Seeks to Assemble Existing Technology into a Great User Experience
    • XanderGlasses Are Great on Privacy Because Nothing Is Recorded
    • Xander’s Speech Recognition Is Built on Kaldi, the same Opensource Platform Alexa Uses
    • Xander Trims Features of Augmented Reality Devices to Focus on It Use Case
    • Maybe There’s an Annual $200 Million Market for XanderGlasses
    • XanderGlasses Are Certainly Cooler than Hearing Aids (Faint Praise!)
    • Xander’s Go to Market Approach
    • What If Google Gets into the Business?
    • Alex Westner’s Entrepreneurial Journey
    • An Easter Egg for Raul
    • Alex Westner’s Parting Thoughts

    Topics: software, product

    Title: Augmented Reality for Hearing Loss

     

    Angel Invest Boston
    enJanuary 04, 2023

    Stanford's Startup Prof - Chuck Eesley, Founder & Scholar

    Stanford's Startup Prof - Chuck Eesley, Founder & Scholar

    Which Founding Teams Succeed? Are Founders Born or Made? Can Innovation Be Crowdsourced? How Many Jobs Do MIT & Stanford Add to the Economy? Blockchain for the Supply Chain? Chuck Eesley, Stanford's Startup Prof Addresses These Questions and More.

    This timeless interview is being relaunched to make available the wise and affable words of Professor Chuck Eesley.

    HIGHLIGHTS INCLUDE:

    • Introduction

    • Professor Charles Eesley Bio

    • The Traumatic Founding Experience

    • Shivang Dave, PlenOptika & Entrepreneurs in Poor Countries

    • How Chuck Eesley Ended Up at MIT Studying with Ed Roberts

    • The Economic Impact of MIT & Stanford: Millions of Jobs Created & Trillions in Economic Activity

    • “And the other big takeaway is that we had been looking at the impact of these universities in too narrow of a way previously.”

    • Robust Finding: Larger Teams Do Better; Startups Tend to Have Teams that Are Too Small

    • Chuck Gets a Great Idea for Research While Hiking with a Friend

    • Cooperative vs. Competitive Commercialization

    • “…, if the industry is high in the effectiveness of patent protection, and high in the importance of complementary assets ... you're motivated to go and talk to the big guys, because you need their complementary assets…”

    • “…low effectiveness of patent protection, low importance of complementary assets, that's where you tend to get competitive commercialization…”

    • “Are You Experienced, or Are You Talented?”

    • Sal Talks About the Impact of Portfolio Company Concrete Sensors

    • Evidence-based Entrepreneurship

    • Blockchain to Make it Easier to Finance Supply Chains

    • “And with that additional data, then we can also start to optimize more and more of the startup process, and do a better job of picking which ventures to invest in, and to devote resources towards.”

    • The Value of Thrift in Life and in Entrepreneurship

    • Chuck & Family Plan to Give Their Money to the Universities that Made Their Success Possible

    • “So, I think it [thrift] is an underappreciated value. And definitely in Silicon Valley…”

    • Early Google Investor David Cheriton Is a Role Model for Chuck

    • Chuck’s Parting Thoughts: (1) Entrepreneurs Can Change Their Luck, (2) If Chuck’s Projects Interest You, Reach Out, and (3) Be Frugal in Life and in Entrepreneurship.

    Angel Invest Boston
    enDecember 28, 2022