Live Long and Master Aging

Could we one day cheat death? Are we hurtling towards a time when science will be so advanced that aging can be prevented or halted in its tracks? Nobel laureate Venki Ramakrishnan takes a skeptical view in a fascinating exploration of longevity research. In Why We Die: The New Science of Aging and the Quest for Immortality, the acclaimed scientist delves into the complexities of aging and the pursuit of extending healthy lifespan.

A former president of the Royal Society in London, Ramakrishnan is a group leader at the Medical Research Council's Laboratory of Molecular Biology in Cambridge, England.  He shared the Nobel Prize in Chemistry in 2009 for his work uncovering the structure and function of tiny cellular particles called ribosomes and was knighted in 2012.

In this interview with Peter Bowes, the molecular biologist provides a critical perspective on the dilemmas of aging research; questions the hype and financial interests linked to some aspects of longevity science; delves into the concept of compressed morbidity and its challenges, and explains his belief that dramatic life extension is not imminent.

Read a transcript:  LLAMA podcast website
Photo credit: Kate Joyce and Sante Fe Institute

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Affiliation disclosure: This podcast receives a small commission when you use the code LLAMA for purchases from companies below which support our mission.   It helps to cover production costs and ensures that our interviews, sharing information about human longevity, remain free for all to listen.
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▸ Movement & resistance training have long been associated with living a long, healthy life - along with a balanced diet and good sleep. Which is why we're delighted to be working with Hampton Fitness to provide a 15% discount on essential workout gear. Use code: llamapodcast15 at checkout
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Listen on: Apple Podcasts   Spotify

Time-line

Mitopure (a highly pure form of Urolithin A) boosts the health of our mitochondria – the battery packs of our cells – and improves muscle strength. Time-line is offering LLAMA listeners a 10% discount on its range of products – Mitopure powders, softgels & skin creams.  Use the code LLAMA at checkout
-

FlexBeam red light therapy

Recharge Health is offering LLAMA listeners a discount on the purchase of FlexBeam, the wearable red light therapy device which targets key parts of the body to improve sleep, treat injuries and sooth aches and pains associated with aging. Discounts vary - see details of the current offer here

The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Ron Kastner experienced what he called a "mortality moment" in his late 50s. A new dad, with two young daughters, it was a "profound realization" that he was entering the third act of his life and that to make the most of it, he had to make significant changes. 

A businessman who drank too much and was challenged by the stresses of the corporate world, Ron embarked on a journey to discover the life he wanted to live. He embraced new practices for health and longevity and discovered that it was possible to be fitter, stronger, more energetic, more grounded and happier than ever before. Now in his mid 70s, he says: "The feeling of being alive is just so visceral and so joyous....the wonder, that is our bodies, is just like a ceaseless source of amazement for me."

Ron shares his story in the book, A Life Yet to Live: Finding Health, Vitality and Joy. 

In this interview he reveals the backstory to his transformation - becoming a father at an older age, significant lifestyle changes, such as exercising regularly, adopting a healthier diet, abstaining from alcohol, and an holistic approach to longevity that encompasses both physical and emotional health. 

Read a transcript:  LLAMA podcast website

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Affiliation disclosure: This podcast receives a small commission when you use the code LLAMA for purchases from companies below which support our mission.   It helps to cover production costs and ensures that our interviews, sharing information about human longevity, remain free for all to listen.
-
Hampton Fitness

Movement & resistance training have long been associated with living a long, healthy life - along with a balanced diet and good sleep. Which is why we're delighted to be working with Hampton Fitness to provide a 15% discount on essential workout gear. Use code: llamapodcast15 at checkout
-

Listen on: Apple Podcasts   Spotify

Time-line

Mitopure (a highly pure form of Urolithin A) boosts the health of our mitochondria – the battery packs of our cells – and improves muscle strength. Time-line is offering LLAMA listeners a 10% discount on its range of products – Mitopure powders, softgels & skin creams.  Use the code LLAMA at checkout
-

FlexBeam red light therapy

Recharge Health is offering LLAMA listeners a discount on the purchase of FlexBeam, the wearable red light therapy device which targets key parts of the body to improve sleep, treat injuries and sooth aches and pains associated with aging. Discounts vary - see details of the current offer here

The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

By Peter Bowes

I lost a dear friend last week. In fact the UK, my home country, lost a national treasure.

Steve Wright was much more than a DJ on the radio. He was a wonderful communicator, entertainer and soul-mate. He was everyone's pal during more than four decades on the air and was the best at what he did. Millions tuned in to his shows but it was Steve's kindness away from the studio and his friendship over the past 30 years that I will forever cherish.

This is a podcast about living as long as possible while enjoying the best life we can. Steve's death, at the age of 69, was sudden and has been hard to come to terms with.

This episode is devoted to his memory.

Joining me, once again, is Peter Allison. We were friends at school in North East England 50 years ago. Mid-life we lost touch but thanks to social media we now talk regularly and for the past few months have been sharing our thoughts about life, fitness and aging through this podcast.

We share a common interest in the science behind human longevity and the lifestyle interventions that could help us live longer and better. We review the latest research, media stories and personal hacks in pursuit of a long healthspan.

Peter has also suffered a recent bereavement, with the loss of his mother, just before Christmas. My sincere condolences to Peter and his family.

In this conversation we reflect on the loss of loved ones, in the context of this podcast, which at its core, is about living a long, purposeful and fulfilling life. 

Peter spent much of his life working as a professor of geology in London.  He is an experienced diver and keen to optimize his health and vitality to continue with his physically demanding pastime. 

The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Coleen T. Murphy, a professor at Princeton University, specializes in genomics and molecular biology and is the author of How We Age: The Science of Longevity. 

In this wide-ranging interview we discuss the significance of declining cellular repair mechanisms that over time lead to visible signs of aging. Prof. Murphy has a particular interest in reproductive aging and cognitive function during aging, considering the former as an often overlooked aspect that begins midlife. 

Prof. Murphy also expresses concern about the way longevity science is portrayed and criticizes some researchers for failing accurately to describe the true implications of their work. She says there is a need for honesty and realism from scientists to maintain public trust, especially in the field of aging and longevity where bold claims can often outpace reality. Researchers, she insists, should not over-promise results that science cannot yet deliver. 

We also address the potential for 'exercise in a pill' while Prof. Murphy argues that without taking care of our planet and its inhabitants, the quest for longevity loses much of its significance.

Discounts & Affiliation disclosure: This podcast is supported by sponsorship and affiliate arrangements with a select number of companies. The income helps to cover production costs and ensures that our interviews, sharing information about human longevity, remain free for all to listen
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Listen on: Apple Podcasts   Spotify

Time-line

Mitopure (a highly pure form of Urolithin A) boosts the health of our mitochondria – the battery packs of our cells – and improves muscle strength. Time-line is offering LLAMA listeners a 10% discount on its range of products – Mitopure powders, softgels & skin creams.  Use the code LLAMA at checkout
-

FlexBeam red light therapy

Recharge Health is offering LLAMA listeners a discount on the purchase of FlexBeam, the wearable red light therapy device which targets key parts of the body to improve sleep, treat injuries and sooth aches and pains associated with aging. Discounts vary - see details of the current offer here

The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Are you annoyed by the use of acronyms in longevity science?  Does conflicting advice about diet and exercise drive you crazy?  No wonder we're confused about the best ways to live longer and healthier, when much of the information we receive is contradictory or overly complicated.

Brad Inman, founder of Inman News, has spent much of his career staging world class events, focussing on real estate. But now, at the age of 71, the award winning journalist and businessman is turning his attention to health and longevity. 

Motivated by a desire to continue his enjoyable and fulfilling life - along with a frustration about a lack of accessible information - Inman is launching a new event to try to demystify longevity science. The Live Long and Master Aging podcast will join some of the world's leading experts at the two-day summit in Palm Beach, Florida, in March. 

In this interview, a co-production with Livelong Media™, we unravel Inman's mission to bring transparency and simplicity to the longevity space. How should we explain complex research findings, so that everyone can benefit from it? And who can we trust?

The Livelong Summit will take place at the Palm Beach Convention Center in West Palm Beach, Fl., on March 15th and 16th.  The event is open to everyone, offering in-person access to leading experts, with the goal of challenging and explaining the latest innovations. 

Our conversation ventures beyond his personal journey and grapples with the complexities of credible information about aging research.  We explore how Brad's mission, at the heart of the Live Long Summit, could herald an era where longevity science echoes in every household, emboldening people from all walks of life to stay healthy for longer.

The Livelong Summit will take place at the Palm Beach Convention Center in West Palm Beach, Fl. , on March 15th and 16th. 

The event is open to everyone, offering in-person access to leading experts, with the goal of challenging and explaining the

Listen on: Apple Podcasts   Spotify

Time-line

Mitopure (a highly pure form of Urolithin A) boosts the health of our mitochondria – the battery packs of our cells – and improves muscle strength. Time-line is offering LLAMA listeners a 10% discount on its range of products – Mitopure powders, softgels & skin creams.  Use the code LLAMA at checkout
-

FlexBeam red light therapy

Recharge Health is offering LLAMA listeners a discount on the purchase of FlexBeam, the wearable red light therapy device which targets key parts of the body to improve sleep, treat injuries and sooth aches and pains associated with aging. Discounts vary - see details of the current offer here

The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Deborah Maragopoulos, a nurse practitioner and self-described intuitive healer, believes health and longevity starts with the hypothalamus region of the brain. In her book, the Hypothalamus Handbook, she bridges the gap between traditional medicine and complementary therapies, revealing how a blend of botanicals, nutraceuticals, and intuition not only works alongside evidence-based medicine but can profoundly impact our health. 

Deborah, a past president of the California Association of Nurse Practitioners, is the founder of Genesis Health Products, Inc. and creator of the nutraceutical supplement, Genesis Gold®. 

In this interview, we travel through the body's complex systems, controlled by the hypothalamus, and explore the role this part of the brain plays in every day health and wellbeing.

Deborah discusses the power of targeted nutrients and her own botanical formulations, for rebalancing our body's systems. She recounts patient stories, emphasizing the importance of early detection of hypothalamic imbalances that could be the key to longevity and a 'harmonious life.' 

Check out Genesis Health products, here

Watch the interview at YouTube

Listen on: Apple Podcasts   Spotify

Time-line

Mitopure (a highly pure form of Urolithin A) boosts the health of our mitochondria – the battery packs of our cells – and improves muscle strength. Time-line is offering LLAMA listeners a 10% discount on its range of products – Mitopure powders, softgels & skin creams.  Use the code LLAMA at checkout
-

FlexBeam red light therapy

Recharge Health is offering LLAMA listeners a discount on the purchase of FlexBeam, the wearable red light therapy device which targets key parts of the body to improve sleep, treat injuries and sooth aches and pains associated with aging. Discounts vary - see details of the current offer here

The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

It is that time of the year when we are all acutely aware of the importance of our immune system. But it's about more than catching a winter cold. The health of our natural defense system is crucial to long-term health.

Dr. Nicola Vannini is a researcher in the Department of Oncology at the University of Lausanne, in Switzerland. 

In this conversation we discuss new research that suggests dietary supplementation with Urolithin A could help boost the immune system. The study (in mice) suggests the compound, which targets mitochondria, is able to reverse the decline in hematopoietic stem cells, which play an essential role in blood health.

Could these findings offer hope to older adults as they experience a decline in the efficiency of their immune system?

READ THE PAPER
Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems (Nature Aging)

Watch the interview at YouTube

This interview includes: 

• Recap of urolithin A and its role in promoting metabolic fitness and reducing the accumulation of waste in the cells. 
• Discussion of hematopoietic stem cells and their decline in function with age. 
• Description of Vannini's research on urolithin A and its effects on hematopoietic stem cells in two sets of experiments: ex-vivo and in mice. 
• "Astonishing" results of the experiments, showing that urolithin A treatment improved the function of old hematopoietic stem cells to match that of young stem cells, and enhanced immune response in mice. 
• Potential applications of urolithin A in reversing immunosenescence and improving immune function in elderly individuals and cancer patients who have undergone chemotherapy. 
• Broad impact of urolithin A on various organs and diseases due to its effects on the immune system. 
• Discussion on the role of exercise and nutrition in conjunction with urolithin A supplementation for overall metabolic health. 
• Positive response from the scientific community to Vannini's research and the potential of urolithin A. 

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The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

As healthy aging science evolves, researchers are able to focus on the lifestyle interventions that have the biggest impact on our lives.  A good, balanced diet and consistent exercise top of the list of daily must-dos, but paying attention to our cellular health is also essential.  It is a pillar of healthy longevity that has emerged as central to our ability to stave off disease and remain physically strong. Dr. Anurag Singh, Chief Medical Officer at the Swiss life science company, Timeline Nutrition, studies the role of the gut metabolite, Urolithin A, which recent research has shown to have wide benefits, including muscle strength, skin health and a potential to protect our immune systems.  

For this interview, LLAMA host Peter Bowes met Dr. Singh at his office in Lausanne, Switzerland, to learn more about his quest to understand how Urolithin A impacts human health.

Timeline make Mitopure, which is a highly pure form of Urolithin A.

This episode is produced in association with Timeline, with which LLAMA has an affiliate relationship. 

DISCOUNT

Mitopure (a highly pure form of Urolithin A) boosts the health of our mitochondria – the battery packs of our cells – and improves muscle strength. Timeline is offering LLAMA listeners a 10% discount on its range of products – Mitopure powders, softgels & skin creams.  Use the code LLAMA at checkout

In this conversation we cover:

• More than a decade of research to bring a biotech approach to nutrition
• Deconstructing the pomegranate, its juices and extracts
• Distinguishing Urolithin A, from Urolithin B, C and D
• Why Urolithin A outshines other molecules
• Reasons to produce pure Urolithin A
• Anurag's training as a physician and his introduction to the field of biotechnology
• Identifying sources of ellagitannins, the precursors to urolithin A
• Why to some people have gut microbiomes that seem to be incompatible with Urolithin A production.
• Enabling the consumer through precision nutrition
• Trial data and real world stories - understanding how anecdotal evidence seeds new ideas in science
• Dosage levels - the current state of research with Urolothin A recommendations
• Explaining autophagy and mitophagy and why their essential for life
• Is it possible to do harm by overdosing with Urolithin A?
• The multiple ways to boost mitochondrial heath - finding the optimum regime
• Pilars of a healthy lifestyle - diet, exercise and boosting cellular health
• Targeting skin as a longevity organ and the impact of topical Mitopure
• Future research; brain health, cognitive ability and possible supplement combinations
• The intricacies and complexities of conducting clinical trials

Watch the interview at YouTube

Listen on: Apple Podcasts   Spotify

The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

The Next Chapter

Peter Allison and Peter Bowes – school friends 50 years ago - discuss science-based lifestyle interventions as they pursue the next chapter. 

Peter A. has spent much of his life working as a professor of geology in London.  He is a keen diver and keen to optimize his health and vitality to continue with his physically demanding pastime.

Peter B. is a journalist and broadcaster with a longtime interest in the science of healthy aging and the hacks we can employ to live life to the full, for as long as possible.

In regular conversations they review the latest data that could help us achieve a longer healthspan. 

This episode includes:

- A study from the University of Barcelona that found a Mediterranean diet rich in healthy fats was associated with reduced cognitive decline in older adults.
A Mediterranean Diet-Based Metabolomic Score and Cognitive Decline in Older Adults: A Case–Control Analysis Nested within the Three-City Cohort Study
Molecular Nutrition Food Research journal
Published: 24 October 2023
- The study used biomarkers in blood tests to confirm dietary habits, providing more reliable evidence than self-reported diaries.
- Potential systemic bias in self-declarations of exercise and diet habits.

- The impact of positive mindset on healthy aging, referencing a study that found those with positive beliefs about aging lived longer and had lower blood pressure.
People who think positively about getting older often live longer, healthier lives. Here is how to reconsider your perspective.
Published:  20 September, 2023

- And finally: The centenarian sisters who embrace modern technology and emphasize the importance of movement.
Centenarian sisters celebrate life together
Published: 22 November, 2023

Listen on: Apple Podcasts   Spotify

Time-line

Mitopure (a highly pure form of Urolithin A) boosts the health of our mitochondria – the battery packs of our cells – and improves muscle strength. Time-line is offering LLAMA listeners a 10% discount on its range of products – Mitopure powders, softgels & skin creams.  Use the code LLAMA at checkout
-

FlexBeam red light therapy

Recharge Health is offering LLAMA listeners a discount on the purchase of FlexBeam, the wearable red light therapy device which targets key parts of the body to improve sleep, treat injuries and sooth aches and pains associated with aging. Discounts vary - see details of the current offer here

The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

As a teenager Chris Mirabile developed a "humble appreciation of life" that turned into a life-long dedication to biohacking and self-experimentation.   He survived a brain tumor at the age of 16 - an experience that piqued his interest in longevity research and eventually to the launch of NOVOS, a nutraceutical company that targets the biological causes of aging to increase longevity.  An appreciation of science and peer-reviewed research has seen Chris emerge as a leading voice in the pursuit of healthy aging and longevity. 

In this interview we cover:

• Recovering from a brain tumor - Chris's lightbulb moment.
• Evolving interest in human longevity - seminal article Cell - Hallmarks of Aging
• How an invincible attitude as a teenage morphed into a humbling appreciation of life
• Tacking the US Marine Corps benchmark for fitness
• Nurturing an interest in biohacking through citizen science and self experimentation
• The lifestyle interventions to make the biggest impact on health
• The value of strong healthy relationships and social tied to the community
• How our definition of moderation (in everything) is shifting and changing
• The value of recovery over pushing too hard to achieve optimum fitness
• Adding a billion years of healthy life to humanity
• How longevity plays a role in how your look
• Clarifying the differences between biological and chronological age

Read a transcript:  LLAMA podcast website

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Affiliation disclosure: This podcast receives a small commission when you use the code LLAMA for purchases from companies below which support our mission.   It helps to cover production costs and ensures that our interviews, sharing information about human longevity, remain free for all to listen. 
-

Listen on: Apple Podcasts   Spotify

Time-line

Mitopure (a highly pure form of Urolithin A) boosts the health of our mitochondria – the battery packs of our cells – and improves muscle strength. Time-line is offering LLAMA listeners a 10% discount on its range of products – Mitopure powders, softgels & skin creams.  Use the code LLAMA at checkout
-

FlexBeam red light therapy

Recharge Health is offering LLAMA listeners a discount on the purchase of FlexBeam, the wearable red light therapy device which targets key parts of the body to improve sleep, treat injuries and sooth aches and pains associated with aging. Discounts vary - see details of the current offer here

The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

To what extent do genetics play a role in our ability to live a long healthy life? It is one of the many questions that doctors at the Swiss medical spa, Clinique La Prairie (CLP), consider when assessing someone's state of health and potential longevity. 

The clinic adopts a holistic approach to wellbeing - balancing the impact of inherited predispositions to certain conditions, the role of epigenetics - the environment we live in - along with lifestyle factors that also have a powerful impact.

To explore these and other issues, LLAMA's Peter Bowes traveled to Montreux in Switzerland to meet CLP's Medical Director, Dr Adrian Heini. 

YouTube | LLAMA website: transcript & show notes

This episode is produced in association with Clinique La Prairie with whom the LLAMA podcast shares a common goal of helping people pursue a long healthspan.  The pioneering health and wellness destination, nestled on the shores of Lake Geneva in Montreux, Switzerland, combines preventative medicine with bespoke lifestyle and nutrition plans, and offers a holistic approach to living fuller, healthier, and longer lives.

The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Peter Allison and Peter Bowes – school friends 50 years ago, now contemplating the next chapter in life - return with another conversation about the latest science that could help us achieve a longer healthspan.

In this episode we discuss:

• Are our longevity goals too perfectionistic? We reflect on an earlier LLAMA podcast interview with Dr. Thomas Curran
• A National Institutes of Health study, published Oct 13, 2023 in Aging Cell, suggests even a small reduction (12%) in daily calories is beneficial for wellness.  
• Do you have what it takes to live to 100? An article in The Wall Street Journal by Alex Janin suggests, "It's Not Good Habits; Good genes matter more  the older you get."  How does that impact our attitude towards exercise and other lifestyle hacks to try to optimize healthspan? 

Read a transcript:  LLAMA podcast website

-
Affiliation disclosure: This podcast receives a small commission when you use the code LLAMA for purchases from companies below which support our mission.   It helps to cover production costs and ensures that our interviews, sharing information about human longevity, remain free for all to listen. 
-

Listen on: Apple Podcasts   Spotify

Time-line

Mitopure (a highly pure form of Urolithin A) boosts the health of our mitochondria – the battery packs of our cells – and improves muscle strength. Time-line is offering LLAMA listeners a 10% discount on its range of products – Mitopure powders, softgels & skin creams.  Use the code LLAMA at checkout
-

FlexBeam red light therapy

Recharge Health is offering LLAMA listeners a discount on the purchase of FlexBeam, the wearable red light therapy device which targets key parts of the body to improve sleep, treat injuries and sooth aches and pains associated with aging. Discounts vary - see details of the current offer here

The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Should we be striving to live a perfect life or is it more realistic to aim for one that's "good enough?" 

Thomas Curran is an assistant professor of psychology at the London School of Economics and the author of The Perfection Trap: Embracing the Power of Good Enough. He argues that a modern-day pandemic of "perfectionism" is putting people under extreme pressure to be the best they can, at everything. 

Prof. Curran says social pressures have resulted in us losing perspective on what it takes to be happy and fulfilled.  Social media images of people seemingly living perfect lives distort reality and are leading to an unhealthy wave of dissatisfaction with our lives.

In this interview we explore the implications for those of us pursuing a long life, where healthspan is the goal, rather than lifespan.

YouTube | LLAMA website: transcript & show notes

This episode is produced in association with Clinique La Prairie with whom the LLAMA podcast shares a common goal of helping people pursue a long healthspan.  The pioneering health and wellness destination, nestled on the shores of Lake Geneva in Montreux, Switzerland, combines preventative medicine with bespoke lifestyle and nutrition plans, and offers a holistic approach to living fuller, healthier, and longer lives.

You may also like:  Are we trying too hard to live perfect lives - March 4, 2019

The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Peter Allison and Peter Bowes – school friends 50 years ago, now contemplating the next chapter in life - return with another conversation about the latest science that could help us achieve a longer healthspan.

In this episode we discuss:

• New study: Having a lower waist circumference and body mass index is more likely to be associated with exercising between 7 a.m. and 9 a.m. than during midday or evening, according to a new study. 
• Paper: The diurnal pattern of moderate-to-vigorous physical activity and obesity: a cross-sectional analysis
• Journal: Obesity Pub: Sept 4, 2023
• Obesity and physical inactivity is very bad for our health but according to  the US Surgeon General Dr. Vivek H. Murthy the mortality impact of being socially disconnected  - i.e  lonely - is an even greater threat to our longevity.  For some, the LA Times reports, supermarket self-checkouts make it worse.
• Last month the UK's oldest man celebrated his 111th birthday.    John Tinniswood took the opportunity to share some of his rules to live by with healthy aging in mind -  they include "exercising the mind" and "moderation" in all things. 

Read a transcript:  LLAMA podcast website

-
Affiliation disclosure: This podcast receives a small commission when you use the code LLAMA for purchases from companies below which support our mission.   It helps to cover production costs and ensures that our interviews, sharing information about human longevity, remain free for all to listen. 
-

Listen on: Apple Podcasts   Spotify

Time-line

Mitopure (a highly pure form of Urolithin A) boosts the health of our mitochondria – the battery packs of our cells – and improves muscle strength. Time-line is offering LLAMA listeners a 10% discount on its range of products – Mitopure powders, softgels & skin creams.  Use the code LLAMA at checkout
-

FlexBeam red light therapy

Recharge Health is offering LLAMA listeners a discount on the purchase of FlexBeam, the wearable red light therapy device which targets key parts of the body to improve sleep, treat injuries and sooth aches and pains associated with aging. Discounts vary - see details of the current offer here

The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

What does it mean to grow old?  Put another way, what are the hallmarks of aging?  They are questions that have long since intrigued biologists and longevity researchers, with a wide range of theories about what drives the aging process.  We understand the impact of weaker muscles, frailty, cognitive challenges and greying hair, but it is the underlying factors - molecular and cellular mechanisms - that researchers are striving to understand.  Dr. Davide D’Amico, Research and Development Group Leader with the Swiss cellular nutrition brand, Timeline Nutrition, is studying how compounds derived from plants can be used to reverse muscle decline and boost mitochondrial health. 

In this conversation we cover:

- The 'hallmarks of aging,' which refers to the key features of human aging, such as genomic instability and mitochondrial dysfunction.

- How the understanding of aging is not simply a chronological process, but also includes the concept of biological aging and the potential for reversing or slowing down this process.

- The potential benefits of supplementing with Urolithin A, a compound found in certain foods that can improve mitochondrial health and reduce inflammation.

- The importance of muscle strength and physical health in promoting longevity and preventing age-related diseases.

- How the ability to convert the precursor molecules found in plants into beneficial compounds like Urolithin A can vary among individuals and is influenced by the diversity and composition of their gut microbiome.

- The potential benefits of Urolithin A for the immune system, cartilage health, and overall mobility and quality of life in older adults.

- The importance of personalized approaches to health and longevity, with a focus on maintaining quality of life rather than simply extending lifespan.

- The overall goal of preventing age-related diseases, supporting optimal health, and promoting a compressed morbidity, where the period of decline in health near the end of life is relatively short.

- The need for education and awareness about lifestyle interventions for healthy aging, involving doctors, researchers, politicians, and educators.

-

DISCOUNT

Mitopure (a highly pure form of Urolithin A) boosts the health of our mitochondria – the battery packs of our cells – and improves muscle strength. Timeline is offering LLAMA listeners a 10% discount on its range of products – Mitopure powders, softgels & skin creams.  Use the code LLAMA at checkout

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The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

The gut microbiome has a huge impact on the way we live our lives and our ability to stay healthy.  In this final episode of our series on red light therapy, Dr. Zulia Frost, clinical director at Recharge Health, creators of the FlexBean device, discusses how red light can benefit gut health and digestion by stimulating the gut microbiome, promoting the production of antioxidants, improving blood circulation, and reducing muscle spasms. 

Dr. Frost also emphasizes the importance of personalizing diets based on genetic tests and explains that many people suffer from gut-related problems due to stress, pollution and a poor diet.  

We discuss the importance of a multifaceted approach to health optimization - from embracing the sunlight and daily stretching to consuming food with gratitude and sharing positive energy. 

FlexBeam is not intended to diagnose, cure, or prevent specific diseases or medical conditions.

In this conversation we cover:

• How the human gut is often affected by issues related to polluted food, depleted soil, high sugar intake, and stress.
• Stress directly impacts the functioning of the digestive system, causing bowel contractions and hindering proper digestion.
• Pollutants, such as smoking and excessive alcohol consumption, can also negatively affect the gut.
• Electromagnetic pollutants, like static electricity, can debilitate the gut.
• Worries and ambiance can also affect digestion, with relaxing environments promoting better assimilation of food.
• Genetic DNA testing can help determine the best diet for individual needs, as different bodies have varying capabilities to break down certain nutrients.
• Protein is crucial for the body, but the type of protein consumed can affect gut-related issues and stomach pain.
• Red light therapy can benefit gut health by stimulating the microbiome, producing subcellular melatonin, improving blood circulation, and reducing muscular spasms.
• FlexBeam, a targeted red light device, can be used on the stomach to improve digestion.
• Using FlexBeam after meals can help redirect blood flow to the digestive system and address issues like constipation and poor food absorption.
• Red light therapy has a systemic effect on the body, benefiting different cells and tissues, and is a non-invasive and side-effect-free solution for various health concerns.

Affiliation disclosure: This podcast receives a small commission when you use the code LLAMA for purchases from companies below which support our mission.  

Time-line

Mitopure (a highly pure form of Urolithin A) boosts the health of our mitochondria – the battery packs of our cells – and improves muscle strength. Time-line is offering LLAMA listeners a 10% discount on its range of products – Mitopure powders, softgels & skin creams.  Use the code LLAMA at checkout
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FlexBeam red light therapy

Recharge Health is offering LLAMA listeners a discount on the purchase of FlexBeam, the wearable red light therapy device which targets key parts of the body to improve sleep, treat injuries and sooth aches and pains associated with aging. Discounts vary - see details of the current offer here

The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

The art of controlled breathing is a powerful tool in the quest to live a longer, healthier life. 

There is evidence that breath work can help us improve sleep, control physical and mental stress, boost our metabolism and fuel the immune system. Phil Simha is the resident breathing coach at Clinique La Prairie (CLP), the Swiss medical spa that specializes in treatments that nurture our longevity.  An experienced free diving instructor and teacher of yoga and pranayama (the practice of breath regulation), Phil believes slower breathing can help us live better while nurturing our healthspan.

Peter Bowes met Phil in his studio at CLP to learn more about his passion for improving peoples' health; his love of life and the planet and the free spirit that propels his journey of discovery around the world.

This episode is brought to you in association with Clinique La Prairie with whom we share a common goal of helping people pursue a long healthspan.  The pioneering health and wellness destination, nestled on the shores of Lake Geneva in Montreux, Switzerland, combines preventative medicine with bespoke lifestyle and nutrition plans, and offers a holistic approach to living fuller, healthier, and longer lives.
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Photo: ©Franck Seguin

The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Peter Allison and Peter Bowes – school friends 50 years ago, now contemplating the next chapter in life - return with another conversation about the latest science that could help us achieve a longer healthspan.

In this episode

·      A study in the British Journal of Sports Medicine found that wall squats and planks are best at lowering blood pressure, with isometric exercises providing greater benefits than aerobic exercise. 

·      Walking just 3867 steps a day can reduce the risk of dying from any cause, according to research published in the European Journal of Preventive Cardiology.

·      A study suggests that a 10-minute MRI scan could be better at screening for prostate cancer than the traditional PSA test.

·      A nematode worm that survived 46,000 years in permafrost but could the episode highlight broader concerns that the melting permafrost could release potentially harmful organisms and viruses.

References, transcript and additional show notes are available at the LLAMA podcast website

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Affiliation disclosure: This podcast receives a small commission when you use the code LLAMA for purchases from companies below which support our mission.   It helps to cover production costs and ensures that our interviews, sharing information about human longevity, remain free for all to listen. 
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Listen on: Apple Podcasts   Spotify

Time-line

Mitopure (a highly pure form of Urolithin A) boosts the health of our mitochondria – the battery packs of our cells – and improves muscle strength. Time-line is offering LLAMA listeners a 10% discount on its range of products – Mitopure powders, softgels & skin creams.  Use the code LLAMA at checkout
-

FlexBeam red light therapy

Recharge Health is offering LLAMA listeners a discount on the purchase of FlexBeam, the wearable red light therapy device which targets key parts of the body to improve sleep, treat injuries and sooth aches and pains associated with aging. Discounts vary - see details of the current offer here

The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Could red light therapy be used to help us recover faster from sporting injuries and promote better health as we grow older?  In this third installment of our series exploring the technology behind the handheld device, FlexBeam, we discover how red light therapy can help address pain and injuries by improving local circulation and relaxing muscular spasms. Dr. Zulia Frost, clinical director at Recharge Health, creators of FlexBeam, also explains the importance of mitochondrial health for longevity.

In this conversation we cover:

- How red light therapy can help optimize cellular energy production by stimulating mitochondria
- How nitric oxide, which is released during red light therapy, dilates blood vessels and improves circulation.
- How red light therapy can be applied to injuries such as sprained ankles or knee injuries to speed up the healing process.
- Plantar fasciitis treatment by improving the quality and hydration of collagen in the fascia.
- The importance of using red light therapy in combination with other treatments and therapies for optimal results.
- The use of red light therapy by professional athletes, including tennis player Casper Ruud, for injury recovery and prevention.
- The use of red light therapy as a rejuvenation device, optimizing energy reserves in the body and improving performance during workouts.

Affiliation disclosure: This podcast receives a small commission when you use the code LLAMA for purchases from companies below which support our mission.   It helps to cover production costs and ensures that our interviews, sharing information about human longevity, remain free for all to listen. 
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Listen on: Apple Podcasts   Spotify

Time-line

Mitopure (a highly pure form of Urolithin A) boosts the health of our mitochondria – the battery packs of our cells – and improves muscle strength. Time-line is offering LLAMA listeners a 10% discount on its range of products – Mitopure powders, softgels & skin creams.  Use the code LLAMA at checkout
-

FlexBeam red light therapy

Recharge Health is offering LLAMA listeners a discount on the purchase of FlexBeam, the wearable red light therapy device which targets key parts of the body to improve sleep, treat injuries and sooth aches and pains associated with aging. Discounts vary - see details of the current offer here

The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

We cannot see them, but the tiny bugs inside our bodies are crucial to our long-term health.  The problem is, they're becoming extinct.

Martin Blaser, MD and Dr. Gloria Dominguez-Bello are microbiologists from the Center for Advanced Biotechnology and Medicine at Rutgers University in the US state of New Jersey. In the feature documentary, The Invisible Extinction, they investigate the impact antibiotics and other common medical practices have on our microbiome and gut health. Their research highlights compelling evidence that the misuse of antibiotics could be to blame for a rise in food allergies, chronic diseases, and other gut-related health issues including irritable bowel syndrome (IBS).

In this interview Martin and Gloria discuss their work, the importance of eating organic, non-processed foods, along with the essential role of bacteria, fungi and viruses that naturally live in our intestines and stomach.

This episode is brought to you in association with Clinique La Prairie, with whom we share a common goal of helping people pursue a long healthspan.  The award-winning spa clinic and pioneering health and wellness destination, nestled on the shores of Lake Geneva in Montreux, Switzerland,  combines preventative medicine with bespoke lifestyle and nutrition plans, and offers a holistic approach to living fuller, healthier, and longer lives.

Credits: This interview includes clips from The Invisible Extinction  documentary, courtesy of Microbe Media LLC.  Thanks also to Steven Lawrence - the film's co-director and producer - and Paul Clarke from Newsworthy press for their help in the production of this podcast. 
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Affiliation disclosure: This podcast receives a small commission when you use the code LLAMA for purchases from companies below which support our mission.   It helps to cover production costs and ensures that our interviews, sharing information about human longevity, remain free for all to listen. 
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The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.