Pediatrics

Host: Jennifer Caudle, DO
Guest: Victoria A. Statler, MD, MSc

Test-confirmed influenza outcomes provide a specific measure of influenza vaccine effectiveness (VE) and has helped to illustrate the potential benefit of cell-based versus egg-based vaccines.¹ So what data support improved VE from cell-based flu vaccines versus egg-based vaccines? To learn more, join Dr. Jennifer Caudle as she speaks with Dr. Victoria A. Statler, Associate Professor of Pediatrics at the University of Louisville and the Director of the Pediatric Transplant and Immunocompromised Host service at Norton Children’s Hospital.

Reference:

1. Stein AN, Mills C, McGovern, et al. Superior effectiveness of cell-based versus egg-based quadrivalent influenza vaccines against test-confirmed influenza over three consecutive seasons in the United States. Paper presented at: The Ninth European Scientific Working Group Influenza (ESWI) Influenza Conference; September 17-20, 2023: Valencia, Spain.

USA-QIVc-23-0119 01/24

Guest: Stephen I. Pelton, MD

Influenza disproportionately affects adults 65 and older as a result of increased frequency of comorbidities and immunosenescence.^1,2 And it’s also linked to neurologic, cardiovascular, and respiratory complications in high-risk groups, while potentially exacerbating underlying chronic medical conditions.^1,2 So how can adjuvanted vaccines help patients who are affected? Dive in to learn more with Dr. Stephen Pelton, Professor of Pediatrics at Boston University Chobanian and Avedisian School of Medicine.

References:

1. Pelton SI, Nguyen VH, Mould-Quevedo JF. The value of influenza vaccination in the older adult population. A stochastic model estimation of the benefit of vaccination to prevent the severe outcomes in the U.S. Poster presented at: IDWeek 2023; October 11-15; Boston, MA.
2. Pelton SI, Mould-Quevedo JF, Nguyen VH. The impact of adjuvanted influenza vaccine on disease severity in the US: a stochastic model. Vaccines. 2023; 11(10):1525. https://doi.org/10.3390/vaccines11101525

USA-FLUD-23-0011 12/23

Host: Michael J. Thorpy, MD
Guest: Anne Marie Morse, DO

Half of children who develop narcolepsy do so before age 16. However, the majority do not get diagnosed in childhood. In fact, many children are misdiagnosed and, as a result, are medically treated for conditions they do not have. Join Drs. Thorpy and Morse as they delineate the differences between adult and pediatric narcolepsy and offer strategies to optimize treatment adherence and outcomes in children.

Guess what? The CDC's Advisory Committee on Immunization Practices had a unanimous vote in favor of a preferential recommendation of vaccines for the cool adults who are 65 and older—one of these options is adjuvanted influenza vaccines.¹ Talk about a milestone in the world of public health! Now the burning question is why on earth did they decide on adjuvant vaccines? Let's unravel this immunization mystery together, shall we?

Reference:

1. Grohskopf LA, Blanton LH, Ferdinands JM, Chung JR, Broder KR, Talbot HK, Morgan RL, Fry AM. Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices - United States, 2022-23 influenza season. MMWR Recomm Rep. 2022 Aug 26;71(1):1-28. doi: 10.15585/mmwr.rr7101a1

USA-CRP-23-0037 12/23

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Wendy Wright, DNP
Guest: Elias Chahine, PharmD, FCCP, FASCP

While the flu may seem benign to some, it may result in up to 710,000 hospitalizations and up to 52,000 deaths every year.¹ So how are current and concerning trends in declining flu vaccinations being addressed? To hear the latest updates and recommendations, join Dr. Charles Turck as he speaks with Dr. Wendy Wright, Owner and Family Nurse Practitioner at Wright & Associates Family Healthcare in New Hampshire, and Dr. Elias Chahine, Professor of Pharmacy Practice at Palm Beach Atlantic University in West Palm Beach, Florida and Clinical Pharmacy Specialist at Wellington Regional Medical Center.

Reference:

1. Disease Burden of Influenza. Centers for Disease Control and Prevention. https://www.cdc.gov/flu/about/burden/index.html. Updated October 4, 2022. Accessed November 28, 2023.

USA-CRP-23-0043 01/24

Host: Jennifer Caudle, DO
Guest: Manpreet Mundi, MD

Enteral nutrition intolerance is quite prevalent as it can be seen in up to 40 percent of patients who are tube fed. Due to the significant consequences of intolerance, there’s an urgency to manage patients symptoms, and one option that’s been shown to help is peptide-based tube feeding formulas. Joining Dr. Jennifer Caudle to talk about the management of enteral feeding intolerance with peptide-based tube feeding formulas is Dr. Manpreet Mundi, Professor of Medicine in the Department of Endocrinology at the Mayo Clinic College of Medicine and Science in Rochester, Minnesota.

All trademarks are owned by Société des Produits Nestlé S.A., Vevey, Switzerland. ©2023 Nestlé

Host: Stuart Weinzimer, MD

From continuous glocuose monitors to insulin pumps, there have been immense technological advancements for patients with type 1 diabetes. Learn more about how these two tools can be used to treat pediatric patients with type 1 diabetes with Dr. Stuart Weinzimer, Interim Section Chief of Pediatric Endocrinology and Diabetes at Yale School of Medicine.

Several factors impact vaccine effectiveness from year to year. One of them is the phenomenon of strain mismatch which may result from egg adaptation during the egg-based influenza vaccine manufacturing process.¹ So what exactly is the process of egg-adaptation? Gather your esteemed colleagues from far and wide, and tune into this episode of World of Tomorrow to learn more.

Reference:

1. Rajaram S, Boikos C, Gelone DK, Gandhi A. Influenza vaccines: the potential benefits of cell-culture isolation and manufacturing. Ther Adv Vaccines Immunother. 2020;8:1-10.

USA-CRP-23-0021 11/23

Host: Andrew Wilner, MD, FACP, FAAN
Guest: Carri Polick, PhD, RN

Two recent studies linked childhood stress and stressors experienced across the lifespan to the severity of multiple sclerosis (MS) symptoms. In fact, both childhood and adult stressors were associated with MS disability and the so-called invisible symptoms of pain interference and psychiatric morbidity while only adult stressors were related to relapse burden. Joining Dr. Andrew Wilner to discuss these findings and how they may shift our approach to caring for patients with MS is Dr. Carri Polick, a postdoctoral fellow and VA scholar in the Duke National Clinician Scholars Program.

Host: Jennifer Shu, MD, FAAP
Guest: Steven H. Abman, MD

Bronchopulmonary dysplasia is a chronic lung disease that can have significant impacts on a newborn’s overall respiratory health, making it imperative to know how to recognize and treat it. Tune in to hear Dr. Jennifer Shu talk about the symptoms, impacts, and treatment of bronchopulmonary dysplasia with Dr. Steven Abman, a Professor in the Department of Pediatrics at the University of Colorado School of Medicine and the Director of the Pediatric Heart Lung Center at Children’s Hospital Colorado.

Host: Dalmacio Dennis Flores, PhD, ACRN, FAAN

According to a Gallup poll, Generation Z youth identify as LGBTQ more than previous generations. Given this increasing prevalence, clinicians need to know how to foster synergistic relationships between parents and LGBTQ+ youth. Here to discuss this important topic is Dr. Dalmacio Dennis Flores, an Assistant Professor at the University of Pennsylvania School of Nursing. He also spoke about this exact topic at the 2023 Annual ANAC conference in his session, titled “Synergy in Inclusive Sexual Health: Triadic Models Empowering LGBTQ+ Youth, Parents, and Nurses.”

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Kalpesh Thakkar, MD, MSCR

Cow’s milk protein allergy is the most common food allergy in infants. And overall, it’s important to know that in general, the incidence of allergy is increasing worldwide. To take a deep dive, join Dr. Charles Turck as he speaks with Dr. Kalpesh Thakkar, Pediatric Gastroenterologist at Memorial Hermann Medical Group in Sugarland, Texas.

All trademarks are owned by Société des Produits Nestlé S.A., Vevey, Switzerland. ©2023 Nestlé

Guest: Ahmed Abdelhak, MD

The state of research to better detect multiple sclerosis activity is changing rapidly, with emerging assays and other tools seeking to predict the occurrence of MRI lesions or relapses in patients. To dive into the latest biomarker research for MS in children, tune in with Dr. Ahmed Abdelhak, Clinical Instructor of Neurology at the University of California San Francisco School of Medicine.

Host: Jennifer Caudle, DO
Guest: Katherine Bennett, MPH, RD, CLEC

Caregivers and children often face challenges when trying to find a formula that’s well-tolerated, and the burden of feeding intolerance extends to the healthcare system as well. Find out how blenderized whole food tube feeding whole food tube feeding formulas like Compleat Organic Blends can help address those challenges and benefit pediatric patients with Dr. Jennifer Caudle and Ms. Katherine Bennett, a registered dietitian at the Children’s Hospital of Orange County in California.

All trademarks are owned by Société des Produits Nestlé S.A., Vevey, Switzerland. ©2023 Nestlé

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Austin Larson, MD

Thymidine kinase 2 deficiency (TK2d) is a rare, genetic condition with nonspecific symptoms that wouldn’t lead to a definitive etiological diagnosis, underscoring the important role genetic testing plays in diagnosing patients. Learn more about the common clinical manifestations of TK2d and the diagnostic process with Dr. Charles Turck and Dr. Austin Larson, Assistant Professor in the Section of Genetics and Metabolism within the Department of Pediatrics at the University of Colorado School of Medicine.

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Bruce H. Cohen, MD, FAAN

The diagnosis and management of the rare genetic disease thymidine kinase 2 deficiency (TK2d) can come with many challenges. So to help shed light on those challenges and key management strategies, Dr. Charles Turck speaks with Dr. Bruce Cohen about his experiences and approaches to real-world patient cases in TK2d care. Dr. Cohen is the Chair of the NeuroDevelopmental Science Center at Akron Children’s Hospital in Ohio.

Guest: Bruce H. Cohen, MD, FAAN

Thymidine kinase 2 deficiency is a very rare disorder that presents several diagnostic and treatment challenges. Learn more about those challenges along with the clinical manifestations of thymidine kinase 2 deficiency and the importance of taking a multidisciplinary approach to care with Dr. Bruce H. Cohen, Chair of the NeuroDevelopmental Science Center at Akron Children’s Hospital.

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Jill Foster, MD

The clinical and economic burden associated with the flu is particularly heavy for our youngest patients. Learn more about this burden and how influenza vaccines can help reduce it with Dr. Charles Turck and Dr. Jill Foster, Professor in the Department of Pediatrics and the Director of the Division of Pediatric Infectious Diseases at the University of Minnesota Medical School in Minneapolis.

Guest: Kenneth Alexander, MD, PhD
Guest: Noel T. Brewer, PhD

Healthcare providers face challenges in promoting HPV vaccination, which is now recommended for children at age 9. The good news is that there are scientifically validated, effective methods for promoting HPV vaccination. Tune in to learn more about the 3-step Announcement Approach and discover strategies to address parents' hesitation and optimize cancer prevention.

Host: Jennifer Caudle, DO
Guest: Ravi Jhaveri, MD

Influenza vaccines have prevented between 39,000 and 105,000 hospitalizations and between 3,700 and 9,800 deaths each year over the last 10 years in the United States alone.¹ But many challenges still exist in the traditional egg-based influenza vaccine manufacturing process. To explore how cell-based vaccines, an option that uses an alternative manufacturing approach, could help address those challenges and the overall influenza burden, Dr. Jennifer Caudle speaks with Dr. Ravi Jhaveri, Division Head of Pediatric Infectious Diseases at the Ann & Robert H. Lurie Children's Hospital of Chicago.

References:
1. Centers for Disease Control and Prevention. Past seasons estimated influenza disease burden averted by vaccination. https://www.cdc.gov/flu/vaccines-work/past-burden-averted-est.html. Accessed April 8, 2022.

USA-QIVc-23-0038 06/23