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    The Brain Health Revolution Podcast

    Join award-winning neurologists and researchers, Drs. Dean and Ayesha Sherzai, for a fun, innovative and inspirational approach to brain health and all matters concerning the remarkable human mind. This is the century of the brain, a time when our insights into this incredible organ are exploding at an unprecedented pace. Explore ways to take control of your own brain health, avoid chronic diseases that are devastating communities worldwide, and expand your mind's capacity beyond anything you can imagine.
    enDean and Ayesha Sherzai81 Episodes

    Episodes (81)

    The Most Common Neurological Disorder Among Young Adults - Multiple Sclerosis

    The Most Common Neurological Disorder Among Young Adults - Multiple Sclerosis

    This episode is an in depth review of Multiple Sclerosis, The most common neurological disorder among young adults.

    Multiple Sclerosis is an autoimmune disease of the central nervous system and is one of the most common conditions that is addressed in the field of neurology. Despite the advances in medicine and the emergence of tools to help with diagnosis, it is one of the most common conditions that is misdiagnosed because of its highly variable expression and findings. This can create a unique set of issues for patients, and the goal of this podcast episode is to shed light on the advances in our knowledge of MS, busts some myths regarding the management of MS, which unfortunately is quite common in the wellness space, and to recognize that there are medications, therapies, coping strategies, and support groups to help address these problems. If you or anyone you know is experiencing any of the symptoms, it is important that they speak with a physician,or a nurse or call the National MS Society at 1-800-344-4867.

     

    This episode was a live recording for our NEURO Academy members.  NEURO Academy is a membership based online environment where you’ll have access to resources to achieve optimal health, a better, sharper memory, and prevent cognitive decline, with on demand courses with CE and CME credits and a thriving community. Learn more by visiting NEUROacademy.com.

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    Website: TheBrainDocs.com

     

    The Often Invisible Syndrome: Traumatic Brain Injury

    The Often Invisible Syndrome: Traumatic Brain Injury

    This episode was part of a live discussion for members in NEURO Academy. We discussed brain injuries and concussion, and expanded on their definitions, classification, presentation, signs and symptoms, management and treatment.

    NEURO Academy is a membership based online environment where you’ll have access to resources to achieve optimal health, a better, sharper memory, and prevent cognitive decline. The platform provides the opportunity to connect with us and an empowering community and participate in weekly live Q&A sessions, live cooking sessions, live podcasts and Q&A with remarkable health leaders, have access to on demand courses on prevention of neurological diseases, expanding the course to evidence based nutrition and cooking,  anxiety, and many others on various topics related to brain health. We just released a comprehensive course of evidence based nutrition in  brain health, along with a complete cooking course that will help you learn the basics of healthy eating and how you can apply all the knowledge by improving what’s on your plate. You will be able to get CE or CME credits if you’re interested, and also receive certification after taking the course. Join us by visiting NEUROacademy.com.

     

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    Laxatives "Cause" Dementia? A Discussion and Review of The Latest Research

    Laxatives "Cause" Dementia? A Discussion and Review of The Latest Research

    This episode was part of a live discussion in the Science Club of the NEURO Academy. We discussed the recent article that showed an association between laxative intake and dementia, and critically analzed the methodology and the results for the audience. We then answered their questions. 

    Reference:

    Feng, J., Zheng, N., Fan, X., Li, S., Jiang, Y., Yi, X., & Yang, H. (2023). Association of laxatives use with incident dementia and modifying effect of genetic susceptibility: a population-based cohort study with propensity score matching. BMC geriatrics, 23(1), 1-12.

    NEURO Academy is a membership based online environment where you’ll have access to resources to achieve optimal health, a better, sharper memory, and prevent cognitive decline. The platform provides the opportunity to connect with us and an empowering community and participate in weekly live Q&A sessions, live cooking sessions, live podcasts and Q&A with remarkable health leaders, have access to on demand courses on prevention of neurological diseases, expanding the course to evidence based nutrition and cooking,  anxiety, and many others on various topics related to brain health. We just released a comprehensive course of evidence based nutrition in  brain health, along with a complete cooking course that will help you learn the basics of healthy eating and how you can apply all the knowledge by improving what’s on your plate. You will be able to get CE or CME credits if you’re interested, and also receive certification after taking the course. Join us by visiting NEUROacademy.com.

    Follow us:

    Join the NEURO Academy: NEUROacademy.com

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    Instagram: The Brain Docs @thebraindocs

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    Website: TheBrainDocs.com

     

    Ethics in The Era of Artificial Intelligence with Erin Sharoni

    Ethics in The Era of Artificial Intelligence with Erin Sharoni

    Our guest for this episode is Erin Sharoni, who is a Master of Bioethics degree candidate (‘23) at Harvard Medical School and a seasoned biotechnology executive with expertise in longevity, epigenetics, and Artificial Intelligence (AI). We discussed the incredibly important value of ethics in the field of AI, and explored the reasons why at this most pivotal of times in human history, there hasn't been enough conversations around this subject. 

    Erin has over 15 years of experience building products and brands in molecular health, media, and finance. She has held roles at top financial institutions like Bridgewater Associates, biotech startups like InsideTracker, and worked as an anchor and commentator on national television. Erin sits on the Advisory Board of Animal Save Movement, a global animal rights organization that aims to end animal exploitation through the act of bearing witness and through her work, is passionate about developing animal-free research technologies. Erin holds an additional master’s degree in the field of Biology from Harvard, and a BA with Honors in Studio Art from Wesleyan University. She is currently a researcher for the NIH's AI program, Bridge2AI, where she focuses on the ethics of AI in three-dimensional cell mapping for disease prediction.

     
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    Frontotemporal Lobe Dementia - A Review

    Frontotemporal Lobe Dementia - A Review

    In this episode, we discuss Frontotemporal Lobe Dementia (FTD). FTD is a type of dementia that usually occurs in younger individuals and is progressive. We discuss:

    • Signs and symptoms
    • The different types of FTD
    • The case of Phineas Gage
    • Diagnosis
    • Treatment and management
    • Current research on FTD and implications

    This episode was conducted live for our NEURO Academy audience. 

    Join us at NEURO Academy,  a membership based online environment where you’ll have access to resources to achieve optimal health, a better, sharper memory, and prevent cognitive decline. The platform provides the opportunity to connect with us and an empowering community and participate in weekly live Q&A sessions, live cooking sessions, live podcasts and Q&A with remarkable health leaders, have access to on demand courses on prevention of neurological diseases, expanding the course to evidence based nutrition and cooking,  anxiety, and many others on various topics related to brain health. We just released a comprehensive course of evidence based nutrition in  brain health, along with a complete cooking course that will help you learn the basics of healthy eating and how you can apply all the knowledge by improving what’s on your plate. You will be able to get CE or CME credits if you’re interested, and also receive certification after taking the course. If you join today and until March 5, you will have a chance to get three months off! 

    Join the NEURO Academy: https://neuroacademy.com/
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    The Addictions of Our Lives with Dr. Howard J. Rankin, PhD

    The Addictions of Our Lives with Dr. Howard J. Rankin, PhD

    Our guest for this episode is Dr. Howard Rankin, who has has extensive expertise and knowledge in the areas of psychology, neuroscience, behavior change and neurotechnology. He has worked extensively in the addictions space, running both inpatient and outpatient programs. Along with a career in academics and research, he is also an experienced speaker, coach and best-selling and award-winning author. Dr. Rankin has written 12 books in his own name, co-written another 12, and ghostwritten 30 others, all nonfiction. Howard has also published more than 30 scientific articles on addiction and behavior change, and been a consultant to the NIH and WHO. His latest books include I Think Therefore I Am Wrong: A Guide to Bias, Political Correctness, Fake News and the Future of Mankind which explores the default setting of the mind and how that can lead us astray, Falling to Grace: The Art and Science of Redemption was released on April 15, 2022 and was featured in Psychology Today magazine (May 2022 issue).  Dr. Rankin is also a Psychology Today blogger, the creator and host of the How Not To Think podcast and a consultant to Sapien Labs and Science Director at IntualityAI.

    https://www.drhowardjrankin.com/

    Join us at NEURO Academy, a membership based online environment where you’ll have access to resources to achieve optimal health, a better, sharper memory, and prevent cognitive decline. The platform provides the opportunity to connect with us and an empowering community and participate in weekly live Q&A sessions, live cooking sessions, live podcasts and Q&A with remarkable health leaders, have access to on demand courses on prevention of neurological diseases, expanding the course to evidence based nutrition and cooking,  anxiety, and many others on various topics related to brain health. We just released a comprehensive course of evidence based nutrition in  brain health, along with a complete cooking course that will help you learn the basics of healthy eating and how you can apply all the knowledge by improving what’s on your plate. You will be able to get CE or CME credits if you’re interested, and also receive certification after taking the course. If you join today and until Feb 28th, you will have a chance to get three months off! 

    Join the NEURO Academy: https://neuroacademy.com/

    Follow us:

    Instagram: The Brain Docs @thebraindocs
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    The ONLY Way to Change The Dire Trajectory of Brain Health

    The ONLY Way to Change The Dire Trajectory of Brain Health

    In this episode, we will be speaking about what we believe to be one of the most important aspects and the biggest contributor to brain health - our communities - and each individuals relationship within their community. Based on our experience and the data supporting this theory, brain diseases such has stroke, Alzheimer’s and other dementia are most  consequentially affected at the level of the community. We will discuss the nuances and how community ownership and mobilization is the most important aspect of addressing and preventing devastating neurological diseases such as Alzheimer’s, stroke and other dementia. 

     

    Our Better Brain Nutition and Cooking Course is Live!  Check it out on NEUROAcademy.com

    If you join the NEURO Academy annual plan by February 28th at 11:59 PM Eastern, you’ll get three months free!

    NEURO Academy is a membership based online environment where you’ll have access to resources to achieve optimal health, a better, sharper memory, and prevent cognitive decline. The platform provides the opportunity to connect with us and an empowering community and participate in weekly live Q&A sessions, live cooking sessions, live podcasts and Q&A with remarkable health leaders, have access to on demand courses on prevention of neurological diseases, expanding the course to evidence based nutrition and cooking, Neuro coaching, anxiety, and many others on various topics related to brain health. You will be able to get CE or CME credits if you’re interested, and also receive certification after taking the course.

     

    Join us by visiting NEUROacademy.com.

     

    Follow us on social media:

    Instagram: The Brain Docs @thebraindocs

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    Website: TheBrainDocs.com

    A Review of the Current Evidence-based Nutrition with Dr. Matthew Nagra, ND

    A Review of the Current Evidence-based Nutrition with Dr. Matthew Nagra, ND

    This episode’s guest is Dr. Matthew Nagra, ND. Dr. Nagra is a Naturopathic Doctor devoted to bringing the most up-to-date evidence-based nutrition information to his patients at his clinic in Vancouver and to the public through his social media channels. He has been a contributing author on multiple textbooks from Professional Health Systems, including their Nutrition textbook. He is also a public speaker, and is well-known for his content across multiple social media platforms, where he often tackles misinformation around diet and dives deep into the latest nutrition research. 

    We reviewed the latest evidence on some of the most debated and controversial topics in nutrition. Our conversation revolved around topics such as the data on dietary protein source and quality, fats, low carbohydrate diets, lectins and other anti-nutrients, artificial sweeteners, and many other topics.

     

    References:

    Carb quality:

    - https://pubmed.ncbi.nlm.nih.gov/30638909/ 

     

    Food groups and mortality:

    - https://pubmed.ncbi.nlm.nih.gov/28446499/ 

     

    Low carb/keto:

    - https://pubmed.ncbi.nlm.nih.gov/24500611/ 

    - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001988/ 

     

    Antinutrients:

    - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600777/ 

     

    Protein: 

    - https://pubmed.ncbi.nlm.nih.gov/29722584/ 

    - https://pubmed.ncbi.nlm.nih.gov/33599941/ 

    - https://pubmed.ncbi.nlm.nih.gov/25628520/ 

    - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358922/ 

    - https://pubmed.ncbi.nlm.nih.gov/33261645/ 

    - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698202/ 

     

    Saturated fat vs other fats:

    - https://apps.who.int/iris/handle/10665/246104

    - https://pubmed.ncbi.nlm.nih.gov/28444290/

    - https://www.gov.uk/government/publications/saturated-fats-and-health-sacn-report

     

    Alcohol guidelines:

    - https://ccsa.ca/canadas-guidance-alcohol-and-health



    Join the FREE 5-Day Better Brain Nutrition Challenge!

    BetterBrainNutritionChallenge.com



    Link to Dr. Nagra’s website: https://drmatthewnagra.com

    Dr. Nagra’s Social media:

    Instagram: https://www.instagram.com/dr.matthewnagra/

    Facebook: https://www.facebook.com/dr.matthewnagra/



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    Website: TheBrainDocs.com



    Gluten, Grain and Brain - Separating The Wheat from The Chaff

    Gluten, Grain and Brain - Separating The Wheat from The Chaff

    This episode is dedicated to the science behind the consumption of  gluten and brain health. There is a notion that gluten is bad for our health and especially for our brain, but does that stem from valid scientific sources, or is it just a food fashion statement? Dean and Ayesha go through a case report of celiac disease, describe what gluten is, the science behind it, and explore the evidence for and against gluten for different populations. 

    Ayesha is leading a FREE 5-day, Better Brain Nutrition Challenge beginning Saturday, Feb 4th that will teach the basics of brain-healthy eating and give you specific meals you can make for yourself and your family. She will go live each day of the challenge to cook, alongside you, a brain-healthy breakfast, lunch, dinner, and snacks so that you can see how delicious and simple healthy nutrition can be.

    LINK: https://betterbrainnutritionchallenge.mn.co 

    References:

    Wang, Yiqing, et al. "Long-term intake of gluten and cognitive function among US women." JAMA network open 4.5 (2021): e2113020-e2113020. PMID: PMID: 34019084

    Wang, Kanran, et al. "High consumption of whole grain foods decreases the risk of dementia and Alzheimer's disease: Framingham Offspring Cohort." Psychiatry and Clinical Neurosciences (2022). PMID: PMID: 36382854

    Lebwohl, Benjamin, et al. "Long term gluten consumption in adults without celiac disease and risk of coronary heart disease: prospective cohort study." bmj 357 (2017). PMID: PMID: 28465308

     

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    Year 2022 Review: Exciting Findings in the Field of Neurology and Neuroscience

    Year 2022 Review: Exciting Findings in the Field of Neurology and Neuroscience

    In this episode, we covered some of the interesting research findings from the year 2022, and neuroscientifically let our hair down a bit and had fun. We discussed the following: 

    - Napping and dementia

    - Canabis use and cognitive impairment

    - Some people who are in coma may be concious 

    - Falsification of data around amyloid hypothesis

    - The new Alzheimer's medication: Lecanemab

    - The discovery of the Mutliple Sclerosis Gene

    - Brain "reading" devices help paralyzed people move, talk, and touch

    - People may pick friends that smell like them!

     

    NEURO Academy is a membership based online environment where you’ll have access to resources to achieve optimal health, a better, sharper memory, and prevent cognitive decline. The platform provides the opportunity to connect with us and an empowering community and participate in weekly live Q&A sessions, live cooking sessions, live podcasts and Q&A with remarkable health leaders, have access to on demand courses on prevention of neurological diseases, expanding the course to evidence based nutrition and cooking, Neuro coaching, anxiety, and many others on various topics related to brain health. You will be able to get CE or CME credits if you’re interested, and also receive certification after taking the course. Join us by visiting NEUROacademy.com.

    Follow us:

    Join the NEURO Academy: NEUROacademy.com

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    Website: TheBrainDocs.com



     

    How Artificial Intelligence Will Unrecognizably Change Our World with Gianluca Mauro

    How Artificial Intelligence Will Unrecognizably Change Our World with Gianluca Mauro

    In this episode, we sat down with Gianluca Mauro, and had a conversation about the biggest revolution in the history of mankind, Artificial Intelligence (AI). Gianluca is an expert in the field - he is the founder of AI Academy, author of “Zero to AI” and producer of Tech.Pizza, a weekly tech newsletter. His mission is to empower people to build the future with Artificial Intelligence and have more impactful, inspiring, and fulfilling careers. He has taught AI to thousands of people, from Harvard classes to corporate boardrooms and high schools.

    Our conversation revolved around the exciting and potentially frightening future of this unbound technology, how we all need to learn more and get involved, as it will affect every aspect of our lives. 

    Link to Gianluca's website: http://ai-academy.com

    His newsletter http://tech.pizza

     

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    The Good Life with Marc Shulz, PhD

    The Good Life with Marc Shulz, PhD

    In this episode, we had a conversation with Dr. Marc Schulz, PhD, Associate Director of the Harvard Study of Adult Development. The Harvard Study of Adult Development is the longest scientific study of happiness ever conducted. Radical for its time in 1938, the first-of-its-kind Study is now in its 84th year, going strong with an 84% retention rate. 

    In his new book,  THE GOOD LIFE co authored by Dr. Robert Waldinger, Dr. Schulz explores the findings of the study so far, and shares how we  can proactively create happiness by focusing on what keeps us healthy rather than what makes us sick. By coupling Harvard case studies with the latest psychological research, Dr. Schulz illuminates:

    ●     The most common misconceptions about happiness.

    ●     What social fitness is and how to exercise it.

    ●     How to understand the influence of our childhood on our adult relationships.

    ●     What we’re likely getting wrong about achievement and 

    ●    Steps we can take if we want to live a good life. 

    Link for purchasing the book, THE GOOD LIFE:

    https://www.simonandschuster.com/books/The-Good-Life/Robert-Waldinger/9781982166694

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    Autism, Behavior and Science Miscommunication with Ben Rein, PhD

    Autism, Behavior and Science Miscommunication with Ben Rein, PhD

    In this episode, we sat down with Dr. Ben Rein, a neuroscientist and postdoctoral researcher at Stanford University and a science communicator on social media. Ben’s thesis research focused on autism spectrum disorder and identified key systems in the brain that regulate social behavior. His current research is focused on the neural basis of empathy and mechanisms by which empathic behaviors can be enhanced. 

    Outside of the lab, Ben creates educational science videos on social media, which is so impressive. In his videos, he summarizes recent research papers, teaches fundamental science principles, and debunks "viral" videos containing misinformation. Ben's science communication has been recognized with awards from Stanford University, the American Association for the Advancement of Science, the Mind Science Foundation and many more.

    We spoke about our current understanding of autism, the advances in the field, the misinformation in the realm of neuroscience and brain and more. We hope you enjoy this conversation. 

    Dr. Rein's website: https://www.benrein.com

    Dr. Rein's social media: 

    Instagram: @doctor.brein

    TikTok: @dr.brein

     

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    Diet For a New America with John Robbins

    Diet For a New America with John Robbins

    In this episode, we had the great pelasure of interviewing the legendary John Robbins. 

    The only son of the founder of the Baskin-Robbins ice cream empire, John Robbins was groomed to follow in his father’s footsteps, but chose to walk away from Baskin-Robbins and the immense wealth it represented to “…pursue the deeper American Dream…the dream of a society at peace with its conscience because it respects and lives in harmony with all life forms. A dream of a society that is truly healthy, practicing a wise and compassionate stewardship of a balanced ecosystem.”

    Considered by many to be one of the most eloquent and powerful spokespersons in the world for a sane, ethical and sustainable future, John has been a featured and keynote speaker at major conferences sponsored by Physicians for Social Responsibility, Beyond War, Oxfam, the Sierra Club, the Humane Society of the United States, the United Nations Environmental Program, UNICEF, and many other organizations dedicated to creating a healthy, just, and sustainable way of life. He is the recipient of the Rachel Carson Award, the Albert Schweitzer Humanitarian Award, the Peace Abbey’s Courage of Conscience Award, and lifetime achievement awards from groups including Green America. The widespread media attention he has received has included numerous appearances on national shows including Oprah, Donahue and Geraldo. When John spoke at the United Nations, he received a standing ovation.

    John is the Co-Founder and President of the Food Revolution Network. The Food Revolution Network is committed to healthy, sustainable, humane, and conscious food for all. Guided by John and Ocean Robbins, with more than 600,000 members and with the collaboration of many of the top food revolutionary leaders of our times, the Food Revolution Network aims to empower individuals, build community, and transform food systems to support healthy people and a healthy planet.

    Books by John Robbins: 

    https://bit.ly/3BEGdyH

    This episode was broadcasted live to the NEURO Academy members. NEURO Academy is a membership based online environment with access to resources for optimal health, a better, sharper memory, and prevent cognitive decline. You will have access to monthly live Q&A sessions, Live cooking sessions, Live podcasts such as this one and Q&A with remarkable health leaders, ongoing on demand courses on prevention of neurological diseases, expanding the course to evidence based nutrition and cooking, NEURO coaching, anxiety, and many courses on various topics related to brain health. You will be able to get CE or CME credits if you’re interested, and also receive certification after taking the course. Join us by visiting NEUROacademy.com

    Join the NEURO Academy: NEUROacademy.com

    Follow us on social media:

    Instagram: The Brain Docs @thebraindocs

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    Website: TheBrainDocs.com

    Demystifying the Relationship Between Diet and Mental Health with Dr. Nicole Lipman-Barile, PhD

    Demystifying the Relationship Between Diet and Mental Health with Dr. Nicole Lipman-Barile, PhD

    Our guest is Dr. Nicole Lipman Barile, PhD, Clinical Psychologist and Nutrition Therapy Practitioner with over 10 years of experience working with patients. She specializes in Cognitive Behavioral Therapy (CBT), and uses her incredible social media platform ‘Feed Your Mental’ to disperse evidence-based information on mental health. What we most love about her is her stance against the exhausting amount of pseudoscience in our shared field of neuroscience and psychology. Not only does she break down the latest evidence into palatable information, but she also points out why some influencers are inclined to share misinformation on social media, and what we can do to identify and avoid them. In this episode, we speak about the role of diet in depression, her work with OCD patients and how to navigate through social media while avoiding pseudoscience. 

    Follow Dr. Lipman-Barile:

    IG: @feedyourmental

    TikTok: @feedyourmental

    Website: https://www.feedyourmental.com

     

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    How To Create Amazing Experiences, with Paul Zak, PhD

    How To Create Amazing Experiences, with Paul Zak, PhD

     In this episode, we virtually sat down with our friend and one of the most insightful scientists, thinkers, writers in the field of human behavior, Dr. Paul J. Zak, PhD, who is a professor of economics, psychology, and management at Claremont Graduate University. He is ranked in the top 0.3 percent of most-cited scientists with over 170 published papers. He helped start several interdisciplinary fields, including neuroeconomics, neuromanagement, and neuromarketing, and is a regular TED speaker, four-time tech entrepreneur, and corporate consultant.

    His work has been ground breaking in the academic, public, and now in business and healthcare settings. In his new book, Immersion: The Science of the Extraordinary and the Source of Happiness, Paul discusses how the world is rapidly transforming into an experience economy as people increasingly crave extraordinary experiences and that his research shows that there’s a scientific formula to consistently create extraordinary experiences. We hope you enjoy the conversation.

    Dr. Zak's book is available for purchase: https://amzn.to/3DBUzRY

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    Dispelling Brain Health Misunderstandings: A Response to Joe Rogan and Max Lugavere

    Dispelling Brain Health Misunderstandings: A Response to Joe Rogan and Max Lugavere

    This episode is dedicated to clarification of a podcast between Joe Rogan and Max Lugavere, two popular influencers that have a large audience. They discussed Alzheimer’s disease and brain health in general and some of the information that was shared was not accurate, which can be really harmful.

    This is by no means an attack on Rogan or Lugavere. After listening to the conversation, we think Lugavere may not be quite familiar with the data regarding brain health, and it would be important to set the record straight and share the evidence with people and let them decide what’s best for them. Having seen thousands of patients with dementia, whether it’s Alzheimer’s disease, frontotemporal lobe dementia, Lewy Body Dementia and others, we feel it’s our responsibility to share evidence based data as opposed to feel-good, self confirming anecdotes.

    Relevant references:

    Ketogenic Diet:
    Phillips, M. C et al. (2021). Randomized crossover trial of a modified ketogenic diet in Alzheimer’s disease. Alzheimer's research & therapy, 13(1), 1-12.

    Lilamand, M et al. (2022). Efficacy and Safety of Ketone Supplementation or Ketogenic Diets for Alzheimer's Disease: A Mini Review. Frontiers in Nutrition, 1324.

    Włodarek, D. (2021). Food for thought: the emerging role of a ketogenic diet in Alzheimer’s disease management. Expert Review of Neurotherapeutics, 21(7), 727-730.

    Cronjé, H et al. (2021). Ketogenic therapies in mild cognitive impairment and dementia. Current Opinion in Lipidology, 32(5), 330-332.

    LDL Cholesterol metabolism and risk of Alzheimer’s:
    Andrews, S et al., collaborators of the Alzheimer's Disease Genetics Consortium. (2021). Causal associations between modifiable risk factors and the Alzheimer's phenome. Annals of neurology, 89(1), 54-65.

    Olmastroni, E et al. (2022). Statin use and risk of dementia or Alzheimer’s disease: a systematic review and meta-analysis of observational studies. European Journal of Preventive Cardiology, 29(5), 804-814.

    Iwagami, M et al. (2021). Blood cholesterol and risk of dementia in more than 1· 8 million people over two decades: a retrospective cohort study. The Lancet Healthy Longevity, 2(8), e498-e506.

    Tan, Z. S et al. (2003). Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study. Archives of Internal Medicine, 163(9), 1053-1057.

    Kivipelto, M et al. (2002). Apolipoprotein E ε4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease. Annals of internal medicine, 137(3), 149-155.

    Zhou, Z et al. (2020). Low-density lipoprotein cholesterol and Alzheimer's disease: a systematic review and meta-analysis. Frontiers in aging neuroscience, 12, 5.

    Sáiz-Vazquez, O et al. (2020). Cholesterol and Alzheimer’s disease risk: a meta-meta-analysis. Brain sciences, 10(6), 386.

    Wingo, A. P et al. (2022). LDL cholesterol is associated with higher AD neuropathology burden independent of APOE. Journal of Neurology, Neurosurgery & Psychiatry, 93(9), 930-938.

    The Nigerian Paradox Study:
    Hall, K et al. (2006). Cholesterol, APOE genotype, and Alzheimer disease: an epidemiologic study of Nigerian Yoruba. Neurology, 66(2), 223-227.

    Vascular health and Alzheimer’s disease:
    Levit, A et al. (2020). Neurovascular unit dysregulation, white matter disease, and executive dysfunction: the shared triad of vascular cognitive impairment and Alzheimer disease. Geroscience, 42(2), 445-465.

    The Effect of Lifestyle on Alzheimer’s Risk:
    Dhana, K et al. (2020). Healthy lifestyle and the risk of Alzheimer dementia: Findings from 2 longitudinal studies. Neurology, 95(4), e374-e383. 

    Risk Reduction of Cognitive Decline and Dementia: WHO Guidelines. Geneva, Switzerland: World Health Organization; 2019.  https://apps.who.int/iris/bitstream/handle/10665/312180/9789241550543-eng.pdf. Accessed December 4, 2019.


    MIND Diet:
    Morris, M. C et al. (2015). MIND diet associated with reduced incidence of Alzheimer's disease. Alzheimer's & Dementia, 11(9), 1007-1014.

    Morris, M. C et al. (2015). MIND diet slows cognitive decline with aging. Alzheimer's & dementia, 11(9), 1015-1022.

    van den Brink, A. C et al. (2019). The Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diets are associated with less cognitive decline and a lower risk of Alzheimer's disease—a review. Advances in Nutrition, 10(6), 1040-1065.

    Kheirouri, S., & Alizadeh, M. (2021). MIND diet and cognitive performance in older adults: a systematic review. Critical Reviews in Food Science and Nutrition, 1-19.

    Hosking, D. E et al. (2019). MIND not Mediterranean diet related to 12-year incidence of cognitive impairment in an Australian longitudinal cohort study. Alzheimer's & Dementia, 15(4), 581-589.

    Melo van Lent, D et al. (2021). Mind diet adherence and cognitive performance in the Framingham heart study. Journal of Alzheimer's Disease, 82(2), 827-839.
    Dhana, K et al. (2021). MIND diet, common brain pathologies, and cognition in community-dwelling older adults. Journal of Alzheimer's Disease, 83(2), 683-692.

    Thomas, A et al. (2022). Association of a MIND Diet with Brain Structure and Dementia in a French Population. The Journal of Prevention of Alzheimer's Disease, 1-10.

    Arjmand, G et al. (2022). Effect of MIND diet intervention on cognitive performance and brain structure in healthy obese women: a randomized controlled trial. Scientific Reports, 12(1), 1-14.


    Nutrition and Dementia Prevention:
    Yassine, H. N et al. (2022). Nutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group. The Lancet Healthy Longevity, 3(7), e501-e512.

    Scarmeas, N et al. (2018). Nutrition and prevention of cognitive impairment. The Lancet Neurology, 17(11), 1006-1015.

     

    Publications by Lugavere’s mentor, Dr. Richard Isaacson:
    Isaacson, R. S et al. (2019). Individualized clinical management of patients at risk for Alzheimer's dementia. Alzheimer's & Dementia, 15(12), 1588-1602.

    Amini, Y., Saif, N., Greer, C., Hristov, H., & Isaacson, R. (2020). The role of nutrition in individualized Alzheimer’s risk reduction. Current nutrition reports, 9(2), 55-63. 

    Isaacson, R. S. (2019). Advances in early diagnosis and treatment strategies in the management of Alzheimer’s disease. Journal of Managed Care Medicine, 22(4), 17-21.

    Berkowitz, C. L., Mosconi, L., Rahman, A., Scheyer, O., Hristov, H., & Isaacson, R. S. (2018). Clinical application of APOE in Alzheimer’s prevention: a precision medicine approach. The journal of prevention of Alzheimer's disease, 5(4), 245-252.

    BOOK: The Alzheimer's Prevention & Treatment Diet: Using Nutrition to Combat the Effects of Alzheimer’s Disease. Isaacson, R. S., & Ochner, C. N. (2016). Square One Publishers, Inc.


    Podcast episodes mentioned:

    The Proof with Simon Hill: The carnivore diet, veganism and nutrition misinformation | Dr Alan Flanagan. 

    The Proof with Simon Hill: Debate: Seed Oils And Heart Disease | Tucker Goodrich And Dr Matthew Nagra

     

    Our publications relevant to this topic:

    Sherzai, A., Edland, S. D., Masliah, E., Hansen, L., Pizzo, D. P., Sherzai, A., & Corey-Bloom, J. (2013). Spongiform change in dementia with Lewy bodies and Alzheimer disease. Alzheimer Disease & Associated Disorders, 27(2), 157-161.

    Whitehair, D. C., Sherzai, A., Emond, J., Raman, R., Aisen, P. S., Petersen, R. C., & Fleisher, A. S. (2010). Influence of apolipoprotein E ɛ4 on rates of cognitive and functional decline in mild cognitive impairment. Alzheimer's & Dementia, 6(5), 412-419.

    Lazar, E., Sherzai, A., Adeghate, J., & Sherzai, D. (2021). Gut dysbiosis, insulin resistance and Alzheimer’s disease: review of a novel approach to neurodegeneration. Frontiers in Bioscience-Scholar, 13(1), 17-29.

    Sherzai, D., & Sherzai, A. (2019). Preventing Alzheimer’s: Our most urgent health care priority. American journal of lifestyle medicine, 13(5), 451-461.

    Sherzai, A. Z., Sherzai, A. N., & Sherzai, D. (2022). A Systematic Review of Omega-3 Consumption and Neuroprotective Cognitive Outcomes. American Journal of Lifestyle Medicine, 15598276221117102.

    Sherzai, D., Sherzai, A., & Sherzai, A. (2022). Lifestyle Intervention and Alzheimer Disease. The Journal of Family Practice, 71(1 Suppl Lifestyle), eS83-eS89.

    Sherzai, D., Sherzai, A., Lui, K., Pan, D., Chiou, D., Bazargan, M., & Shaheen, M. (2016). The association between diabetes and dementia among elderly individuals: a nationwide inpatient sample analysis. Journal of Geriatric Psychiatry and Neurology, 29(3), 120-125.

    Sherzai, A., Sherzai, D., Pilot, M., & Ovbiagele, B. (2016). Prevalence of the Diagnoses of Alzheimer's Dementia, Non-Alzheimer's Dementia and Vascular Dementia Among Hospitalized Stroke Patients: A National Inpatient Sample Analysis, 1999-2012 (P1. 125).

     

    Follow us on social media:

    Instagram: The Brain Docs @thebraindocs

    Facebook: The Brain Docs

    Website: TheBrainDocs.com

    Brain Inflammation: Definition, Causes and Management

    Brain Inflammation: Definition, Causes and Management

    In this episode, we discuss brain inflammation. We start with a case presentation, discuss the different cells and chemicals that are involved in the process, different neurological conditions that demonstrate a neuroinflammatory response, such as traumatic brain injuries, encephalopathies, MS, neurodegernative conditions like Alzheimer's and Parkinson's, and others, potential treatments in the horizon and what we can do to prevent it. 

    NEURO Academy is a membership based online environment where You’ll have access to resources to achieve optimal health, a better, sharper memory, and prevent cognitive decline. you will have access to monthly live Q&A sessions, Live cooking sessions, Live podcasts such as this one and Q&A with remarkable health leaders, ongoing on demand courses on prevention of neurological diseases, expanding the course to evidence based nutrition and cooking, NEURO coaching, anxiety, and many courses on various topics related to brain health. You will be able to get CE or CME credits if you’re interested, and also receive certification after taking the course. Join us by visiting NEUROacademy.com

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    Website: TheBrainDocs.com

    Catastrophic Brain Bleeds - Part 3

    Catastrophic Brain Bleeds - Part 3

    In part 3 of the neurovascular series, we take a deep dive on the topic of brain bleeds or hemmorhagic strokes. We discussed its epidemiology, subtypes, pathology, clinical presentation, some treatments and what can be done to avoid these devastating outcomes.

    To learn more about brain health, please check out NEURO Academy, a membership based online environment outside of social media where you will have access to multiple evidence-based on-demand courses and engage with a thriving and supportive community of people on a journey towards better brain health. We offer CE/CME credits and certification after taking the course.  

    NEUROacademy.com

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    Website: TheBrainDocs.com

    The Silent Epidemic of Vascular Dementia - Part 2

    The Silent Epidemic of Vascular Dementia - Part 2

    In this episode, we discuss vascular cognitive impairment and vascular dementia, how it presents, its pathophysiology, subtypes, eidemiology, risk factors, treatment and prevention. For more reading, please refer to the following references:

    Iadecola, et al, (2019). Vascular cognitive impairment and dementia: JACC scientific expert panel. Journal of the American College of Cardiology, 73(25), 3326-3344.

    Zotin, et al, (2021). Cerebral small vessel disease and vascular cognitive impairment: from diagnosis to management. Current Opinion in Neurology, 34(2), 246.

    This episode was broadcasted Live to our NEURO Academy audience, and we had a Live Q&A session at the end. NEURO Academy is a membership based online environment outside of social media where you will have access to multiple evidence-based on-demand courses and engage with a thriving and supportive community of people on a journey towards better brain health.

    You will have access to Live cooking sessions, Live podcasts, Q&As with remarkable health leaders, ongoing on demand courses on lifestyle, nutrition and cooking, coaching, anxiety, and many courses on various topics related to brain health.

    We offer CE/CME credits and certification after taking the course.  

    NEUROacademy.com

    Follow us on social media:

    Instagram: The Brain Docs @thebraindocs

    Facebook: The Brain Docs

    Website: TheBrainDocs.com