adenocarcinoma

In this episode, Ryan D. Gentzler, MD, MS, and Jonathan Riess, MD, MS, answer audience questions on managing EGFR-mutated non-small-cell lung cancer (NSCLC) from a live meeting series. The episode includes expert insights on:

• Identifying patients who may benefit the most from adjuvant osimertinib  

• Testing for EGFR mutations in early-stage NSCLC

• Critical importance of getting molecular test results before starting immunotherapy

• Monitoring cardiac toxicity in patients receiving osimertinib

• Key ongoing trials in EGFR-mutated NSCLC for patients with newly diagnosed disease and following progression on osimertinib

Presenters:

Ryan D. Gentzler, MD, MS
Associate Professor
Division of Hematology/Oncology
Department of Medicine
University of Virginia
Thoracic Medical Oncologist
University of Virginia Comprehensive Cancer Center
Charlottesville, Virginia

Jonathan Riess, MD, MS
Associate Professor
Department of Internal Medicine/Hematology-Oncology
University of California, Davis
Medical Director, Thoracic Oncology
University of California, Davis Comprehensive Cancer Center
Sacramento, California

Link to full program: 
https://bit.ly/3DZGzSO 

It’s been a while! I think we will call this the second season as it seems fitting as I head into another season of battling cancer. 

Devastated and angry are just two of the words that come to mind. But also with that come to surrender and faith. 

Thank you for being on the journey with me so far. Tag along as I fight cancer again.

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DISCLAIMER: The opinions, beliefs, and viewpoints expressed by the hosts and guests on this podcast do not necessarily represent or reflect the official policy, opinions, beliefs, and viewpoints of Disenyo.co LLC and its employees.

In this episode, Nathan Pennell, MD, PhD; Jamie E. Chaft, MD; and Stephen V. Liu, MD, answer questions asked by an audience of healthcare professionals during a live CCO webinar on biomarker-driven therapies for NSCLC. Topics include:

• Choosing between immune checkpoint inhibitor monotherapy and combination therapy with an immune checkpoint inhibitor plus chemotherapy for newly diagnosed NSCLC
• Incorporating newly approved immunotherapies into practice
• Evolving guidelines and recommendations for biomarker testing  
• RNA- vs DNA-based next-generation sequencing
• Interpretation of NGS results
• Use of frontline TKI therapy for patients with CNS metastases
• Future role of KRAS inhibitors in the treatment of advanced NSCLC
• Improving rates of biomarker testing in lung cancer

Presenters:

Nathan Pennell, MD, PhD
Professor
Director, Cleveland Clinic Lung Cancer Medical Oncology Program
Department of Hematology and Medical Oncology
Cleveland Clinic Taussig Cancer Institute
Cleveland, Ohio

Jamie E. Chaft, MD
Associate Attending Physician
Thoracic Oncology Service
Memorial Sloan Kettering Cancer Center
New York, New York

Stephen V. Liu, MD
Associate Professor of Medicine
Department of Medical Oncology
Lombardi Comprehensive Cancer Center
Georgetown University
Washington, DC

Supported by educational grants from Amgen; Lilly; Regeneron Pharmaceuticals, Inc.; and Sanofi Genzyme. For further information concerning Lilly grant funding, visit www.lillygrantoffice.com.

Link to full program, including an downloadable slidesets and an on-demand webcast:
https://bit.ly/3npjyyb

[00:02:52] So that's when I knew that if I survived. Actually, I believe that either way, I was going to survive because I was going to live forever with the God. So if I survived, I was going to do something to help others. [00:03:04][11.8]

[00:03:26] Yes, we're all about education, so not just the physicians, but the public, especially the public, because they you just don't know. You only know what you hear, what you read on the Internet, what's what's your oncologist says. And so it's really important to get the best information you can. Same is true for the alternative doctors because we want to make sure that they have the best therapies available, not necessarily the latest and greatest something that has a lot of experience behind it, science behind it or even anecdotal. I mean, it's there's nothing wrong with anecdotal. [00:04:00][34.8]

[00:05:10] And I can't I don't think I said this, but I said I also learned that they distorted the DNA of your healthy cells, which actually made the healthy cells precancerous. And so if if you get a recurrence, there's nothing left to fight. Is that correct? And she said, yes. I said, why would I want to do that? [00:05:27][16.8]

[00:08:00] In my opinion, the biggest missing link is mind, body and spirit. I think people don't pay enough attention to the stinking thinking. You know, it's one of my favorite phrases, the stinking thinking, you know it cancer loves the stink and think and it loves the negatives and loves the trauma, drama, anger, bitterness, resentment, loves all that stuff. So, yeah, I think that's actually the biggest missing link. And doctors are not trained to look there. So it's the it's the unusual doctor who examines that connection. [00:08:38][37.3]

[00:13:14] And that's about twenty five to thirty minutes. At that point, they deliver just a tenth of the dose of whatever medication it is. So if it's not cancer and they're treating like pneumonia, they would deliver the dose for pneumonia. If it's cancer, they're going to deliver chemo or another anticancer substance and then cancer loves. [00:13:31][17.6]

[00:14:49] Yeah, well, most people, almost all people don't lose their hair. You know, I think a lot of that is is in in the mind too. You expect to look like that cancer patient that I've seen very few people over the last 19 years lose their hair so you don't get sick, you don't lose your hair because, again, your healthy cells are not involved if you get the blood sugar to the proper level. So to make sure those healthy cells are snoozing, sleeping. [00:15:14][25.0]

[00:19:10] And they they think they are giving you at doing a such a favor to give you those two months. And then also with all the pain and suffering, I mean, how how you're feeling as you're as you're doing that those sorts of life. [00:19:25][15.1]

[00:20:04] So it plays a role and you have to recognize when it's the appropriate time to use it. And so is having that wisdom. But also then recognize, like you're saying, your doctor said that this is all we got. So you have to recognize that this is all they can offer because that is all they got. [00:20:24][19.2]

[00:22:51] And and also with the more of the holistic or integrative alternative, whichever name that you that you use, I mean, by this time we've had millions of people use these kind of therapies millions upon millions. [00:23:05][14.7]

[00:25:54] It's been. Thank you. That's a great question. It's been revolutionary. So we started out when I found it in 2006, it was just IBT. There really wasn't much out there. And I think even. That next year was when we first found out about the benefit of certain nutraceuticals and then. High dose vitamin C, I think, was more two thousand eight, but then all of a sudden it just mushroomed. We had ozone come in, ozone came in in 09 and it just blew the doors off for a lot of people. So all of a sudden, I had I had invited one vendor to the two thousand seven conference. I don't think I had any in 2006, our first conference was 2006 and 2007 conference. [00:26:44][49.4]

[00:01:19] Yeah. So you were given three months left to live. And what when were you diagnosed with at that time?

[00:01:25] It was in stage 4 adenocarcinoma in the breast. They found it also in my lymph. My brain and my lungs.

[00:02:30] They said six months to a wheelchair and less than two years to live. And they were wrong both of those times. And so when they gave me the three months in 2001, I thought, well, OK, they've been wrong before.

[00:03:28] There was like die a little bit of diet, detox, you know, God, oh, God. Mind, body. But there weren't any like there wasn't high dose vitamin C that I could find. So there just wasn't a lot there. So in two thousand two, I'd been alive a year...

[00:04:33] And now you had you just had incredible results or incredible event where you have some of the outside leading be leading integrative cancer experts throughout the world. Come. And this is what you're facilitating now as a response to to what you were faced with and the lack of information and therapies that existed when you were diagnosed. 

[00:05:39] And that's intentional on my part, because as a patient, you know, I want to I want to help others that that were like me, that didn't have a lot of money. And so when you approached me, I thought, oh, my gosh, this guy's just like me. He just wants to raise awareness. I act like what you're doing. 

For more information about products and services discussed in this podcast, please visit www.integrativecancersolutions.com. To learn more about the cutting-edge integrative cancer therapies Dr. Karlfeldt offer at his center, please visit www.TheKarlfeldtCenter.com

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