chronic hepatitis b

In this episode, Nancy Reau, MD, discusses new data on hepatitis B virus presented at AASLD 2023, including:

• Current therapies
  • Studies 108 and 110: Factors Linked With Lack of Virologic Suppression After 8 Yr of TAF or TDF
  • Kaiser Permanente Northern California: HCC or Death With TDF vs ETV for Chronic Hepatitis B
  • Early vs Late Postpartum Cessation of TDF Initiated for Prevention of Vertical HBV Transmission
• Investigational functional cure strategies
  • B-Together: Sequential Bepirovirsen and PegIFN Added to NA Therapy for Chronic HBV Infection
  • MARCH Part B: VIR-3434 ± VIR-2218 ± PegIFN Added to NA Therapy for Chronic HBV Infection
  • REEF-IT: JNJ-3989 + NA ± JNJ-6379 With PegIFN Add-on Consolidation in Patients With HBeAg-Positive CHB
  • HBV003: VTP-300 + Nivolumab Added to NA Therapy for Chronic HBV Infection
  • CVP-NASVAC: Nasally Administered Therapeutic Vaccine for Chronic HBV Infection

Presenter:
Nancy Reau, MD
Professor of Medicine
Richard B. Capps Chair of Hepatology
Chief, Section of Hepatology
Associate Director, Solid Organ Transplantation
Rush University Medical Center 
Chicago, Illinois

Link to full program: 
https://bit.ly/47XJlU4

In this episode, Joseph Ahn, MD, MS, MBA; Christina Delacruz Leyson, MD; and Alice Chan, a person who experienced pregnancy as a person living with chronic hepatitis B, discuss solutions for overcoming barriers to HBV care in people of childbearing potential and their infants, including:

• HBV screening and vaccination in pregnancy
• Management of pregnant people who are HBsAg positive
• Infant care
• Breastfeeding

Presenters: 

Joseph Ahn, MD, MS, MBA
Professor of Medicine, Section Chief
Division of Gastroenterology and Hepatology
Oregon Health & Science University
Portland, Oregon

Christina Delacruz Leyson, MD
Associate Professor
Medical Director, Liver Transplant Program
Program Director, Hepatology Fellowship
University of Kentucky
Lexington, Kentucky

Alice Chan, person living with chronic hepatitis B

Link to downloadable slides:
https://bit.ly/3rXLTC7

Link to program: 
https://bit.ly/3L3Kz6l

In this episode, Stefan Zeuzem, MD, discusses new data on viral hepatitis presented at EASL 2023, including:

• Hepatitis B virus
  • Durability of response with bepirovirsen
  • HBsAg loss with siRNA VIR-2218 combined with either VIR-3434 (novel monoclonal antibody) or pegIFN-alfa
• Hepatitis delta virus
  • 96-week follow-up of immediate vs delayed bulevirtide
  • Off-treatment response for lonafarnib + ritonavir ± pegIFN-alfa 
  • Safety and efficacy outcomes with siRNA JNJ-3989 + nucleos(t)ide analogue
• Hepatitis C virus
  • Collaborative service at opiate substitution treatment clinic to improve linkage to care in Ireland
  • Nurse-led test-and-treat program to increase screening and diagnosis at female prisons in the United Kingdom
  • FIND-C study using machine learning to improve screening-to-diagnosis ratio using clinical factors and social determinants of health

Presenter:

Stefan Zeuzem, MD
Professor of Medicine 
Chief, Department of Medicine 
JW Goethe University Hospital 
Frankfurt, Germany

Link to full program: 

https://bit.ly/3JQQj3J

In this episode, Robert S. Brown, Jr., MD, MPH; Nancy Reau, MD; and Eric, a person living with chronic hepatitis B, discuss solutions for overcoming barriers to HBV care in older adults, including:

• Awareness of HBV and CHB in older adults
• Updated HBV screening and vaccination recommendations
• Monitoring of renal and bone disease
• Adjustment of monitoring and treatment as a person with HBV ages

Presenters: 
Robert S. Brown, Jr., MD, MPH
Vincent Astor Distinguished 
Professor of Medicine
Chief, Division of Gastroenterology and Hepatology
Weill Cornell Medicine
New York, New York

Nancy Reau, MD
Professor of Medicine
Chief, Section of Hepatology
Associate Director, Solid Organ Transplantation
Richard B. Capps Chair of Hepatology
Rush University Medical Center
Chicago, Illinois

Eric, person living with chronic hepatitis B

Link to downloadable slides: please link to VM404 downloadable slides when ready

Link to program: 
bit.ly/3L3Kz6l

In this episode, Joseph Lim, MD; Mindie H. Nguyen, MD, MAS, AGAF, FAASLD; and Jennifer Wild, MS, BSN, RN, OCN, discuss strategies for overcoming barriers to HBV care in Asian American people, including:

• HBV-related stigma
• Language barriers
• Health insurance navigation

Presenters:

Joseph Lim, MD
Professor of Medicine 
Director, Clinical Hepatology
Vice-Chief, Section of Digestive Diseases
Yale University School of Medicine
New Haven, Connecticut 

Mindie H. Nguyen, MD, MAS, AGAF, FAASLD
Professor of Medicine (GI & Hepatology, Liver Transplant) 
Professor of Epidemiology & Population Health (By Courtesy)
Director of Hepatology Fellowship 
Director of Hepatology Clerkship
Stanford University Medical Center
Palo Alto, California

Jennifer Wild, MS, BSN, RN, OCN 
Clinical Nurse
UCSF Helen Diller Family Comprehensive Cancer Center
GI Medical Oncology, Outpatient Hepatobiliary Program
Oakland, California

Link to downloadable slides: please link to VM401 downloadable slides when ready

Link to program: please link to HEP 2023 HBV Key Communities VM (PRP5676) when ready

In this episode, Essa Mohamed, PhD; Daouda Ndiaye; and Ponni Perumalswami, MD, MS, discuss strategies for overcoming barriers to HBV care in African immigrant people, including:

• HBV awareness and misconceptions
• HBV-related stigma
• Language barriers
• Health insurance navigation

Presenters:  
Essa Mohamed, PhD
Clinical Researcher
Division of Gastroenterology and Hepatology
Mayo Clinic
Rochester, Minnesota

Daouda Ndiaye
Patient Navigator

Ponni Perumalswami, MD, MS
Associate Professor of Internal Medicine
Division of Gastroenterology and Hepatology
University of Michigan
Ann Arbor, Michigan

Link to program: bit.ly/3L3Kz6l

In this episode, Stefan Zeuzem, MD, discusses new viral hepatitis data from AASLD 2022, including:

• Hepatitis B
• Prevention of HBV vertical transmission when HBIg is unavailable
• Therapeutic vaccination for HBV cure
• Antiviral therapy to prevent HCC in patients with CHB in the indeterminate phase
• Hepatitis delta
• HDV prevalence in ethnically diverse, urban, safety-net populations
• Bulevirtide ± pegIFN-α2a for chronic HDV in the French cATU study
• Bulevirtide monotherapy for patients with HDV and compensated cirrhosis in the HEP4Di study
• HDV functional cure with lonafarnib-based therapy
• Hepatitis C
• Integrated community HCV service for PWUD: the ITTREAT study
• Helios-3 study of treatment of people with HCV by specialists or nonspecialists
• Risk of HCC after SVR in patients with HCV

Presenter:

Stefan Zeuzem, MD
Professor of Medicine
Chief, Department of Medicine I 
JW Goethe University Hospital 
Frankfurt, Germany

Follow along with the downloadable slideset at: 
https://bit.ly/3FxIOwZ

Link to full program: 
https://bit.ly/3Y1tD6f

In this episode, Nancy Reau, MD, shares her thoughts on the most practice-changing viral hepatitis data from AASLD 2022, including:

• Novel therapeutics for HBV
• HCV management strategies
• HDV screening and linkage to care
• Fatty liver disease in persons with viral hepatitis
• Use of statins to decrease morbidity and mortality in persons with liver disease

Presenter:

Nancy Reau, MD
Professor of Medicine
Chief, Section of Hepatology
Associate Director
Solid Organ Transplantation
Richard B. Capps Chair of Hepatology
Rush University Medical Center
Chicago, Illinois

Link to full program: 
https://bit.ly/3Y1tD6f

In this episode, Jordan J. Feld, MD, MPH, and Nancy Reau, MD, share lessons learned in the testing and treatment of viral hepatitis in the COVID-19 era, including:

• Global impact of the COVID-19 pandemic on viral hepatitis testing and linkage to care
• Impact of COVID-19 pandemic on testing and treatment in the United States and Canada
• Innovative strategies to improve linkage to care of patients with viral hepatitis during the COVID-19 pandemic

Presenters:

Jordan J. Feld, MD, MPH
Professor of Medicine
University of Toronto
Hepatologist
Toronto Centre for Liver Disease
Sandra Rotman Centre for Global Health
Toronto, Canada

Nancy Reau, MD
Professor of Medicine
Chief, Section of Hepatology
Associate Director, Solid Organ Transplantation
Richard B. Capps Chair of Hepatology
Rush University Medical Center
Chicago, Illinois

Follow along with the slides at:
https://bit.ly/3HQ6dZ5

Link to full program:
https://bit.ly/3Bgyd5I

In this episode, Drs Norah Terrault, MD, MPH, and Grace LH Wong, MD, share lessons learned in the care of patients with hepatitis B virus (HBV) in the COVID-19 era, including:

• HBV cascade of care before vs during the pandemic
• Innovative strategies to improve HBV diagnosis and linkage to care
• Lessons learned in telemedicine
• Elimination through vaccination
• Management of HBV and COVID-19 coinfection
• Management of elevated liver enzymes in COVID-19

Presenters:

Norah Terrault, MD, MPH
Professor of Medicine
Chief of Gastrointestinal and Liver Diseases
University of Southern California
Los Angeles, California

Grace LH Wong, MD
Professor
Director, Medical Data Analytics Centre (MDAC)
Deputy Director, Center for Liver Health 
Assistant Dean (Learning Experience), Faculty of Medicine
The Chinese University of Hong Kong 
Honorary Consultant
Division of Gastroenterology and Hepatology
Department of Medicine and Therapeutics
Prince of Wales Hospital
Hong Kong

Follow along with the slides at:
https://bit.ly/3HQ6dZ5

Link to full program:
https://bit.ly/3Bgyd5I

In this episode, Robert G. Gish, MD, and Pietro Lampertico, MD, PhD, share lessons learned in the care of patients coinfected with hepatitis B virus and hepatitis delta virus (HDV), including:

• Burden of HDV infection
• Chronic HDV infection and comorbidities
• Impact of COVID-19 on care of patients with chronic hepatitis B
• Screening for HDV and which assays to use
• Screening for viral hepatitis at a COVID-19 vaccination site

Presenters:

Robert G. Gish, MD, FAASLD, AGAF, FAST
Professor of Medicine
Loma Linda University
Loma Linda, California
Clinical Professor
University of Nevada Reno School of Medicine
Reno, Nevada
University of California Skaggs School of Pharmacy and Pharmaceutical Sciences
San Diego, California
Medical Director
Hepatitis B Foundation
Washington, DC

Pietro Lampertico, MD, PhD
Professor of Gastroenterology
Director, Division of Gastroenterology and Hepatology
IRCCS Ca Granda Policlinico Hospital
University of Milan
Milan, Italy

Follow along with the slides at:
https://bit.ly/3HQ6dZ5

Link to full program: 
https://bit.ly/3Bgyd5I

In this episode, Stefan Zeuzem, MD, discusses exciting new data on viral hepatitis reported at the virtual EASL 2021, including new findings on treatment of HDV, treatment of HBV and HCV in children, linking patients to care, and new molecules being investigated for HBV cure.

Stefan Zeuzem, MD
Professor of Medicine
Chief, Department of Medicine I
JW Goethe University Hospital 
Frankfurt, Germany

Content based on a CME program supported by educational grants provided by AbbVie, Antios Therapeutics, and Gilead Sciences, Inc.

To follow along, download the slides at:
https://bit.ly/3rl8AeS

Link to full program:
https://bit.ly/3ky46QK

Link to full program: 
https://bit.ly/37bBrce