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    david sinclair

    Explore "david sinclair" with insightful episodes like "#136 David Sinclair: Reversing the Aging Process" and "#27 - David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging" from podcasts like ""The Knowledge Project with Shane Parrish" and "The Peter Attia Drive"" and more!

    Episodes (2)

    #136 David Sinclair: Reversing the Aging Process

    #136 David Sinclair: Reversing the Aging Process
    Biologist and genetics expert Dr. David Sinclair is out to prove he can live past 100 years old, and he thinks you can too. On this episode Sinclair goes in-depth on the process of aging and the techniques you can incorporate into your life that help you live a longer, healthier life, including optimizing your diet, the benefits of exercise, the role of a positive attitude, the importance of sleep, the three supplements he takes every day, why it’s never too late to slow the process of aging, and so much more.
     
    Dr. Sinclair is a professor of genetics and co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, and he is best known for his research on aging, with a focus on epigenetics. He’s been called one of the 100 Most Influential People in the World by Time, and in 2019 he released the New York Times bestselling book, Lifespan: Why We Age – and Why We Don't Have To.
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    #27 - David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging

    #27 - David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging

    In this episode, David A. Sinclair, Ph.D., a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging, provides insight into why we age and how to slow its effects based on his remarkable work on the role of sirtuins and NAD in health and diseases. He also presents the case that stabilizing the epigenetic landscape may be the linchpin in counteracting aging and disease. 

    We discuss:

    • How and why David moved from Australia to Leonard Guarente’s lab at MIT [7:30];
    • Sirtuins and aging [15:00];
    • A series of experiments elucidating the mechanisms of sirtuins [20:45];
    • How are sirtuins activated? [25:30];
    • NAD and sirtuin activation [31:00];
    • Nicotinamide, sirtuin inhibition, andPNC1 [39:00];
    • Resveratrol [43:00];
    • The NIH/ITP studies on resveratrol [55:45];
    • Does David take any compounds for longevity? [1:00:15];
    • NAD precursors (NR, NMN) and pterostilbene [1:02:45];
    • Female fertility and NAD precursors [1:14:45];
    • A unifying theory of aging [1:20:30];
    • Waddington’s epigenetic landscape [1:23:00];
    • If David had unlimited resources, what is the experiment he would do? [1:28:25];
    • Testing combinations to extend lifespan [1:31:30];
    • What made David aware of his mortality at such a young age? [01:33:45];
    • What is David’s book going to cover? [01:37:15]; and
    • More.

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