drug screening

Dr. Mitchell Lee, Ph.D. is the Chief Executive Officer of Ora Biomedical ( https://orabiomedical.com/ ), a biotech company developing small molecule therapeutics that extend lifespan and delay chronic illness by targeting the underlying molecular mechanisms of aging. Dr. Lee’s research interests are focused on identifying healthy aging therapeutics, understanding the connections between aging and age-related disease, and investigating how natural genetic variation modifies disease and therapeutics efficacy. He has earned awards for science communication, multiple NIH training grants, and in 2015 was awarded a Howard Hughes Medical Institute (HHMI) Gilliam Fellowship for Advanced Study. Dr. Lee has centered his career around leading and managing scientists. During graduate and postdoctoral studies, he mentored over 45 trainee researchers ranging from high schoolers, community college and university undergraduates, to post-baccalaureates and grad students. In recognition of his research mentorship, Dr. Lee was awarded a UW Undergraduate Research Mentor Award in 2018. Dr. Lee was the founding Chair of the American Aging Association (AGE) Trainee Chapter and served on the Executive Committee and Board of Directors for AGE. During this time, Dr. Lee established standing leadership committees, founded and managed the GeroScience Peer Review Training Program, and organized multiple research conferences. Dr. Lee received a B.S. in Biology and a B.A. in Philosophy from Western Washington University in 2010. He remained at WWU and completed an M.S. in Biology in 2012. He received his PhD in Experimental Pathology from the University of Washington School of Medicine in 2018. Most recently, Dr. Lee completed a certificate in Biotechnology Project Management from UW/UCSD in 2022. 

Background Screening Packages... so many options

At a bare minimum the social security number trace and national criminal database search are the typical starting point for most screening packages.  The national criminal database has obvious flaws, but this search also covers high level government watch lists and sex offender registries, so it is something that employers are comfortable with as a foundation for their background report.

So, once you have the SSN trace and national criminal covered the next question becomes the county criminal searches.  There are a few flavors of this search

LISTEN TO THIS EPISODE TO LEARN MORE.

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For decades the pharmaceutical industry has synthesized millions of molecular entities in the pursuit of novel biological activities. These huge compound libraries have always been considered a treasure trove of potential new drugs for a plethora of new therapeutic targets. With the huge progress in laboratory automation and high-throughput technology over the last decade, library screening remains a key drug discovery strategy. The size of these libraries and their handling present however multiple challenges, starting from the synthesis and screening speed, storage space, and annotation required when working with Singleton compounds. A clever alternative finds inspiration from biology and leverages the DNA information storage power. This is known as DNA Encoded Libraries, or DELs. Dr. Katelyn Billings is a pioneer of this technology that offers a number of advantages, starting from the possibility of working on the nanoscale in as little as a few microliters to make and screen millions of molecules as a pool. In this episode we learn about how DELs work and discuss their advantages, challenges and the promise of combining data from DEL screens with machine learning to disrupt modern drug discovery.

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About Your Host

Paolo Braiuca grew up in the North-East of Italy and holds a PhD in Pharmaceutical Sciences from nearby esteemed University of Trieste, Italy.  He developed expertise in biocatalysis during his years of post-doctoral research in Italy and the UK, where he co-founded a startup company. With this new venture, Paolo’s career shifted from R&D to business development, taking on roles in commercial, product management, and marketing. He has worked in the specialty chemicals, biotechnology, and pharmaceutical markets in Germany and the UK, where he presently resides.

He is currently the Director of Global Market Development in the Laboratory Chemicals Division  at Thermo Fisher Scientific™ which put him in the host chair of the Bringing Chemistry to Life podcast. A busy father of four, in what little free time he has, you’ll find him inventing electronic devices with the help of his loyal 3D-printer and soldering iron. And if you ask him, he’ll call himself a “maker” at heart. 

Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help!  

Joseph tells you about more papers on drugs in development from June 2020.   These studies encompass those done in vitro or using computational models, but not animal testing. Here, you will hear about approaches with multiple targets: cholinesterase, amyloid-beta, tau, oxidative stress...  If you're interested in hearing more about treatments for AD, you should also check out our episodes on pre-clinical and clinical testing. 

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Today's episode was scripted and hosted by Joseph Len Liang-Lee, edited by Sarah Louadi, and made possible by an entire team of volunteers behind the scenes.  

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