gastroenterology and hepatology

Host: Jennifer Caudle, DO
Guest: Manpreet Mundi, MD

Enteral nutrition intolerance is quite prevalent as it can be seen in up to 40 percent of patients who are tube fed. Due to the significant consequences of intolerance, there’s an urgency to manage patients symptoms, and one option that’s been shown to help is peptide-based tube feeding formulas. Joining Dr. Jennifer Caudle to talk about the management of enteral feeding intolerance with peptide-based tube feeding formulas is Dr. Manpreet Mundi, Professor of Medicine in the Department of Endocrinology at the Mayo Clinic College of Medicine and Science in Rochester, Minnesota.

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Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Kalpesh Thakkar, MD, MSCR

Cow’s milk protein allergy is the most common food allergy in infants. And overall, it’s important to know that in general, the incidence of allergy is increasing worldwide. To take a deep dive, join Dr. Charles Turck as he speaks with Dr. Kalpesh Thakkar, Pediatric Gastroenterologist at Memorial Hermann Medical Group in Sugarland, Texas.

All trademarks are owned by Société des Produits Nestlé S.A., Vevey, Switzerland. ©2023 Nestlé

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Kalpesh Thakkar, MD, MSCR

Cow’s milk protein allergy is the most common food allergy in infants. And overall, it’s important to know that in general, the incidence of allergy is increasing worldwide. To take a deep dive, join Dr. Charles Turck as he speaks with Dr. Kalpesh Thakkar, Pediatric Gastroenterologist at Memorial Hermann Medical Group in Sugarland, Texas.

All trademarks are owned by Société des Produits Nestlé S.A., Vevey, Switzerland. ©2023 Nestlé

Host: Jennifer Caudle, DO
Guest: Katherine Bennett, MPH, RD, CLEC

Caregivers and children often face challenges when trying to find a formula that’s well-tolerated, and the burden of feeding intolerance extends to the healthcare system as well. Find out how blenderized whole food tube feeding whole food tube feeding formulas like Compleat Organic Blends can help address those challenges and benefit pediatric patients with Dr. Jennifer Caudle and Ms. Katherine Bennett, a registered dietitian at the Children’s Hospital of Orange County in California.

All trademarks are owned by Société des Produits Nestlé S.A., Vevey, Switzerland. ©2023 Nestlé

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Suijit Janardhan, MD, PhD

Diabetic patients have a significant risk for developing more advanced liver disease, and the disease that they’re particularly at risk for is steatotic liver disease. Dive into this episode to learn more with Dr. Charles Turck and Dr. Sujit Janardhan, Assistant Professor in the Department of Internal Medicine, Division of Digestive Diseases and Nutrition, and the Department of Transplant Surgery at Rush University Medical Center in Chicago.

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Gil Melmed, MD, MS

The inflammation biosimilar development process uses a stepwise approach with increasing certainty to generate the totality of evidence, which demonstrates the safety, purity, and potency in one or more appropriate conditions of use for which the reference product is licensed.^1,2 Dive further into the role of totality of evidence in the inflammation biosimilar development and approval process with Dr. Gil Melmed, Director of Inflammatory Bowel Disease Clinical Research at the Cedars-Sinai and Professor of Medicine at Cedars-Sinai and at the David Geffen School of Medicine at University of California, Los Angeles. Dr. Melmed was compensated for participating in this program.

References:

1. US Food and Drug Administration. Quality Considerations in Demonstrating Biosimilarity of a Therapeutic Protein Product to a Reference Product Guidance for Industry. Published online April 2015. Accessed March 22, 2023. https://www.fda.gov/media/135612/download

2. US Food and Drug Administration. Scientific Considerations in Demonstrating Biosimilarity to a Reference Product Guidance for Industry. Published online April 2015. Accessed March 22, 2023. https://www.fda.gov/media/82647/download

©2023 Amgen Inc. All rights reserved. USA-CBU-81605 5/23

Host: Peter Buch, MD, FACG, AGAF, FACP
Guest: Marianna Arvanitakis, MD, PhD

Consuming ultra-processed foods can pose many risks to your health that go beyond the GI system. Explore the risks associated with ultra-processed foods with Dr. Peter Buch and Dr. Marianna Arvanitakis, Associate Clinical Professor in the Department of Gastroenterology, Hepatopancreatology, and Digestive Oncology from the HUB Erasme Hospital in Brussels, Belgium.

Host: Mary Katherine Cheeley, PharmD, BCPS, CLS, FNLA
Guest: Shelby Yaceczko, MS, RDN-AP, CNSC

The burden of malnutrition across the globe is very high, with hospitals and care teams being directly impacted. Here with Dr. Mary Katherine Cheeley to share what we need to know about the relationship between nutritional deficiencies and health economics in the hospital is Ms. Shelby Yaceczko, an Assistant Clinical Professor in the Department of Nutrition at the University of the Pacific in Sacramento, California.

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Dejan Micic, MD

Early intervention is key when it comes to optimizing outcomes among patients suffering from malnutrition. Explore best practices for identifying and treating adult malnutrition with Dr. Charles Turck and Dr. Dejan Micic, Associate Professor of Medicine at UChicago Medicine.

Guest: Dawn W. Adams, MD, MS, CNSC

Discover best practices for taking a collaborative, multidisciplinary approach to nutritional care with Dr. Dawn Adams, Medical Director for the Center for Human Nutrition at Vanderbilt University Medical Center.

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Carolyn Newberry, MD

Commercially blenderized and standard tube feeding formulas are both ways we can deliver food to our patients requiring home enteral nutrition. So how do these two types of formulas stack up against one another? Find out with Dr. Charles Turck as he discusses the latest literature findings and other key considerations with Dr. Carolyn Newberry, Director of GI Nutrition at Weill Cornell Medical Center’s Division of Gastroenterology.

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Anna Nowak-Wegrzyn, MD

Cow’s milk protein allergy is one of the most common food allergies in childhood and can have a heavy burden on our young patients and their families. That’s why Dr. Charles Turck speaks with Dr. Anna Nowak-Wegrzyn, Director of the Pediatric Allergy Program at Hassenfeld Children’s Hospital NYU Langone, about how we can better manage these patients and address their unmet needs.

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Osman Mohamed Elfadil, MD

Food allergies and malabsorptive conditions limit food options for patients and can lead to malnutrition if alternative sources of nutrition aren’t found. So how might peptide-based formulations fit into our management approach for these GI-compromised patients? Joining Dr. Charles Turck to break down how peptide-based formulations work to improve GI tolerance, who might benefit from them, and the latest data from clinical trials is Dr. Osman Mohamed Elfadil, Senior Research Fellow in the Division of Endocrinology, Diabetes, Metabolism, and Nutrition at the Mayo Clinic in Rochester, Minnesota.

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Osman Mohamed Elfadil, MD

Food allergies and malabsorptive conditions limit food options for patients and can lead to malnutrition if alternative sources of nutrition aren’t found. So how might peptide-based formulations fit into our management approach for these GI-compromised patients? Joining Dr. Charles Turck to break down how peptide-based formulations work to improve GI tolerance, who might benefit from them, and the latest data from clinical trials is Dr. Osman Mohamed Elfadil, Senior Research Fellow in the Division of Endocrinology, Diabetes, Metabolism, and Nutrition at the Mayo Clinic in Rochester, Minnesota.

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Anna Nowak-Wegrzyn, MD

Cow’s milk protein allergy is one of the most common food allergies in childhood and can have a heavy burden on our young patients and their families. That’s why Dr. Charles Turck speaks with Dr. Anna Nowak-Wegrzyn, Director of the Pediatric Allergy Program at Hassenfeld Children’s Hospital NYU Langone, about how we can better manage these patients and address their unmet needs.

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: W. Frank Peacock, MD

For patients with opioid-induced constipation (OIC), can Narcan play a role in finding a new treatment option? Dr. Charles Turck is joined by Dr. Frank Peacock from the Baylor College of Medicine to explore key data on the role of methylnaltrexone in the treatment of OIC.

Host: Peter Buch, MD, FACG, AGAF, FACP
Guest: Sarah McGill, MD, MSc

Alpha-gal allergy is a recently identified food allergy to red meat and other products made by mammals. So what more do we need to know about this new allergy, and which of our patients are at risk for anaphylaxis? To dive into this topic, Dr. Peter Buch is joined by Dr. Sarah McGill, Associate Professor of Medicine at the University of North Carolina, to discuss her recent research on alpha-gal allergy.

Host: Peter Buch, MD, FACG, AGAF, FACP
Guest: Frances Onyimba, MD

Over the last two decades, up to 20 percent of the population in industrialized nations have reported an abnormal physical response to food ingestion, also known as an adverse reaction to food. So what key information do we need to know about food allergies and intolerances amid this recent rise around the world? To find out, Dr. Peter Buch is joined by Dr. Frances Onyimba, Assistant Professor of Medicine at the University of Maryland School of Medicine. Together, they’ll discuss how we can better identify and diagnose food allergies and intolerances.

Host: Esteban Figueroa, MD

Exploring the ACE Index in Acute Ulcerative Colitis

Rebecca K Grant, Gareth-Rhys Jones, Nikolas Plevris, Ruairi W Lynch, Philip W Jenkinson, Charlie W Lees, Thomas A Manship, Fiona A M Jagger, William M Brindle, Mrithula Shivakumar, Jack Satsangi, Ian D R Arnott

Background: Intravenous (IV) steroids remain the first-line treatment for patients with acute ulcerative colitis (UC). However, 30% of patients do not respond to steroids, requiring second-line therapy and/or surgery. There are no existing indices that allow physicians to predict steroid nonresponse at admission. We aimed to determine if admission biochemical and endoscopic values could predict response to IV steroids.

Methods: All admissions for acute UC (ICD-10 K51) between November 1, 2011, and October 31, 2016 were identified. Case note review confirmed diagnosis; clinical, endoscopic, and laboratory data were collected. Steroid response was defined as discharge home with no further therapy for active UC. Nonresponse was defined as requirement for second-line therapy or surgery. Univariate and binary logistic regression analyses were employed to identify factors associated with steroid nonresponse.

Results: Two hundred and thirty-five acute UC admissions were identified, comprising both acute severe and acute nonsevere UC; 155 of the 235 patients (66.0%) …

Host: Neilanjan Nandi, MD
Guest: Monica Schwartzman, MD, MS

It's estimated that 50 percent of patients with IBD experience arthralgia, with the most common form being peripheral arthritis. What screening strategies are available to help us identify those patients with peripheral discomforts? Tune in to hear multidisciplinary perspectives on peripheral arthritis in IBD from gastroenterologist Dr. Neil Nandi and rheumatologist Dr. Monica Schwartzman.