ibrutinib

In this episode, Jeff P. Sharman, MD, Danielle M. Brander, MD, and Nicole Lamanna, MD, answer questions focused on the optimizing BTK inhibitor therapy for previously untreated patients with CLL considering presentation characteristics and drug pharmacology.

Presenters:

Jeff P. Sharman, MD, Program Director
Medical Director
Hematology Research
US Oncology Research
Eugene, Oregon

Danielle M. Brander, MD
Assistant Professor of Medicine
Division of Hematologic Malignancies 
& Cellular Therapy
Department of Medicine
Duke University
Attending Physician, Hematologic Malignancies
Duke University Health System
Durham, North Carolina

Nicole Lamanna, MD
Associate Attending
Leukemia Service
Director of CLL Program
Hematologic Malignancies Section
Department of Medicine
New York-Presbyterian/Columbia University Medical Center 
New York, New York

Content based on an online CME program supported by an educational grant from AstraZeneca.

Link to full program, including associated downloadable slidesets:
https://bit.ly/3hATX0L

In this episode, Jeff P. Sharman, MD, Danielle M. Brander, MD, and Nicole Lamanna, MD, answer audience questions from a live Webinar focused on optimal use of BTK inhibitor therapy in patients with CLL, with topics including:

•           The impact of COVID-19 on CLL treatment decisions

•           The use of anti-CD20 antibodies in combination with BTK inhibitors

•           Considerations when recommending BTK inhibitors

•           MRD testing in patients with CLL

•           The potential impact of targeted therapies on when to start treatment

Presenters:
Jeff P. Sharman, MD, Program Director
Medical Director
Hematology Research
US Oncology Research
Eugene, Oregon

Danielle M. Brander, MD
Assistant Professor of Medicine
Division of Hematologic Malignancies & Cellular Therapy
Department of Medicine
Duke University
Attending Physician, Hematologic Malignancies
Duke University Health System
Durham, North Carolina

Nicole Lamanna, MD
Associate Attending
Leukemia Service
Director of CLL Program
Hematologic Malignancies Section
Department of Medicine
New York-Presbyterian/Columbia University Medical Center 
New York, New York

Content based on an online CME program supported by an educational grant from AstraZeneca.

Link to full program, including associated downloadable slidesets:
 https://bit.ly/3hATX0L    

In this episode, Jeff P. Sharman, MD, Danielle M. Brander, MD, and Nicole Lamanna, MD, answer audience questions from a live Webinar focused on optimal use of BTK inhibitor therapy in patients with CLL, with topics including:

• Rechallenging patients with venetoclax and BTK inhibitors 
• Mechanism by which BTK inhibitors may reduce infusion reactions
• Risk of secondary malignancies with BTK inhibition
• Different cytogenetic findings and adverse event risk

Presenters:

Jeff P. Sharman, MD, Program Director
Medical Director
Hematology Research
US Oncology Research
Eugene, Oregon

Danielle M. Brander, MD
Assistant Professor of Medicine
Division of Hematologic Malignancies 
& Cellular Therapy
Department of Medicine
Duke University
Attending Physician, Hematologic Malignancies
Duke University Health System
Durham, North Carolina

Nicole Lamanna, MD
Associate Attending
Leukemia Service
Director of CLL Program
Hematologic Malignancies Section
Department of Medicine
New York-Presbyterian/Columbia University Medical Center 
New York, New York

Content based on an online CME program supported by an educational grant from AstraZeneca.

Link to full program, including associated downloadable slidesets:
https://bit.ly/3hATX0L

In this episode, Jennifer R. Brown, MD, PhD, and John Allan, MD, discuss recent key clinical trial results in CLL presented at the 2020 annual meetings of the American Society of Clinical Oncology (ASCO) and the European Hematology Association (EHA). Studies and topics include:

• ASCEND: acalabrutinib vs idelalisib plus rituximab or BR
• ACE-CL-001: acalabrutinib long-term efficacy
• CLL14: Venetoclax plus obinutuzumab
• CLARITY: Ibrutinib plus venetoclax
• Measurable residual disease (MRD)
• Complex karyotypes
• Zanubrutinib plus obinutuzumab and venetoclax

Presenters:

Jennifer R. Brown, MD, PhD
Associate Professor of Medicine
Department of Hematologic Malignancies
Dana-Farber Cancer Institute
Harvard Medical School
Director, CLL Center
Department of Medical Oncology
Dana-Farber Cancer Institute
Boston, Massachusetts

John Allan, MD
Assistant Professor of Medicine
Division of Hematology and Medical Oncology
Weill Cornell Medicine
New York, New York

Content based on an online CME program supported by an educational grant from AstraZeneca.

Link to full program: https://bit.ly/3aSfekM