immunohistochemistry

In this podcast episode, Samuel Klempner, MD, and Gregory Botta, MD, PhD, provide expert commentary on the rationale and development of novel agents under investigation for targeting claudin 18.2 in gastric and gastroesophageal cancers, with topics including:

• Expression patterns and function of the claudin family of proteins in normal gastric tissues
• Biologic rationale for utility of claudin 18.2 as an actionable therapeutic target in oncology
• Prognostic implications of claudin 18.2 overexpression in gastric and gastroesophageal cancers
• Laboratory methodology involved in claudin 18.2 scoring as a potential predictive biomarker for patient selection
• Future directions for clinical development of agents targeting claudin 18.2, including monoclonal antibodies, bispecific antibodies, antibody‒drug conjugates, and CAR T-cell constructs

Presenters:

Samuel Klempner, MD
Associate Professor
Department of Medicine
Division of Hematology-Oncology
Mass General Cancer Center
Harvard Medical School
Boston, Massachusetts

Gregory Botta, MD, PhD
Clinical Professor of Medicine
Department of Medicine
Division of Hematology & Oncology
University of California San Diego
La Jolla, California

Content for this program was supported by educational grants from Astellas and Bristol Myers Squibb.

Link to the full program, including a CME-certified text module, downloadable slideset, and ClinicalThought (coming soon!):
bit.ly/3lQxPrq

In this podcast episode, Conor Ernst Steuer, MD, a medical oncologist; Frank Schneider, MD, a pathologist; and Elise Hitron, MSN, FNP-C, a phase I clinical trials nurse practitioner, engage in a multidisciplinary discussion of the latest management strategies for EGFR-mutated NSCLC. Topics include:

• Testing for targetable biomarkers
• Talking with patients about biomarker testing
• Frontline therapy for EGFR-positive NSCLC
• Resistance to front-line osimertinib
• Treatment of EGFR TKI–resistant disease, including the emerging antibody–drug conjugate patritumab deruxtecan
• HER3 protein testing
• Pathology considerations
• Nursing considerations
• Interdisciplinary communication

Presenters:

Conor Ernst Steuer, MD
Assistant Professor
Department of Medical Oncology
Winship Cancer Institute
Emory University
Atlanta, Georgia

Frank Schneider, MD
Associate Professor of Pathology
Department of Pathology and Laboratory Medicine
Director, Cancer Tissue and Pathology Shared Resource
Winship Cancer Institute
Emory University
Atlanta, Georgia

Elise Hitron, MSN, FNP-C
Adjunct Instructor
School of Nursing
Phase I Clinical Trials Nurse Practitioner
Winship Cancer Institute
Emory University
Atlanta, Georgia

Supported by an educational grant from Daiichi Sankyo, Inc.

Link to full program, including a series of short interactive virtual presentations with downloadable slidesets on EGFR-mutated advanced NSCLC, including the evolving role of HER3 in the setting of EGFR TKI resistance:
https://bit.ly/3G32Jkm

In this episode, George D. Demetri, MD, and Alexander Drilon, MD, discuss the biologic rationale behind testing for NTRK fusions in patients with various solid tumors, along with clinical strategies for testing. Topics include:

• Differences between NTRK fusions vs gene mutations
• Frequency of NTRK fusions by age and tumor type
• When to test patients for NTRK fusions and interpreting reports
• Methods of testing: multiplex gene testing, next-generation sequencing of DNA vs RNA, immunohistochemistry, and liquid biopsy

Presenters:

George D. Demetri, MD
Professor of Medicine
Harvard Medical School
Harvard University
Co-Director, Ludwig Center at Harvard
Senior Vice President for Experimental Therapeutics
Director, Sarcoma Center
Dana-Farber Cancer Institute
Boston, Massachusetts

Alexander Drilon, MD
Chief, Early Drug Development
Attending, Thoracic
Memorial Sloan Kettering Cancer Center
New York, New York

Link to full program:
https://bit.ly/2YFIPfr

Link to slideset based on this podcast:
https://bit.ly/3amgU6w

In this episode, Nathan Pennell, MD, PhD, and Laura J. Tafe, MD, provide medical oncology and pathology perspectives, respectively, when answering questions from a clinician audience on topics including:

• Next steps in patient care after identifying a biomarker: selecting treatment, getting insurance approval, arranging for financial assistance
• Performing biomarker testing on cytology vs surgical or anatomic pathology specimens
• Factors affecting turnaround time when testing liquid biopsy vs tissue specimens
• Choice of a targeted agent vs chemotherapy plus immunotherapy for first-line treatment of patients with RET fusions, BRAF mutations, or MET exon 14 skipping
• Concordance between IHC and FISH or NGS for ALK rearrangements
• Use of fluid cytology specimens when testing for fusions in RET or NTRK and MET amplification
• Cost considerations with performing multiple single-gene assays vs upfront NGS
• Testing for driver mutations in early-stage NSCLC
• Developing institutional workflows to enable pathologists to order reflex molecular testing panels

Presenters:

Nathan Pennell, MD, PhD
Professor
Director, Cleveland Clinic Lung Cancer Medical Oncology Program
Department of Hematology and Medical Oncology
Cleveland Clinic Taussig Cancer Institute
Cleveland, Ohio

Laura J. Tafe, MD
Associate Professor of Pathology and Laboratory Medicine
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire
The Geisel School of Medicine at Dartmouth
Hanover, New Hampshire

Content supported by an educational grant from Lilly.

Link to full program, including an associated Podcast Pearls PDF, downloadable slidesets, and on-demand Webcasts:
http://bit.ly/3a3e1Xs

Emma Cannell and Sally van der Meer discuss highlights from the June issue: a prospective pilot study assessing the role of stellate-ganglion block to treat hot flushes in survivors of breast cancer; also discussed is a Personal View about cancer of unknown primary (CUP), and the Leading Edge on public confidence in Merck's HPV vaccine.

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