immunological

Join Yvonne Brandenburg, RVT, VTS SAIM and Jordan Porter RVT, LVT, VTS SAIM as we talk about:

• We are going back to basics again! This time, we are diving into the immune system; our one true love. We are getting down and dirty with how the immune system should normally work, so we can further discuss what is happening when the immune system is not functioning properly. 

 

Question of the Week

• Do you have a love for the immune system, or still a slight fear from lack of true understanding? 
• • Leave a comment at https://imfpp.org/episode50 

 Resources We Mentioned in the Show 

• Merck Veterinary Manual: Immunologic Diseases:
• • https://www.merckvetmanual.com/immune-system/immunologic-diseases/immunologic-diseases-in-animals
  • https://www.merckvetmanual.com/immune-system
• Internal Medicine for Pet Parents
• • https://www.internalmedicineforpetparents.com/immunology.html
  • https://www.internalmedicineforpetparents.com/blog/topic-of-the-week-treating-immune-mediated-diseases
• UC Davis: Vaccination Guidelines: 
• • https://www.vetmed.ucdavis.edu/hospital/animal-health-topics/vaccination-guidelines
• Wiley: Immunomodulatory drugs and their application to the management of canine immune‐mediated disease
• • https://onlinelibrary.wiley.com/doi/full/10.1111/j.1748-5827.2011.01024.x
• Veterinary Clinics Small Animal Practice. Immunomodulating Agents. Cecil P. Moore, DVM, MS
• • http://www.geac.ufv.br/agentesimunomoduladores.pdf
• Linda Merrill, L. V. (2012). Small Animal Internal Medicine for Veterinary Technicians and Nurses. Ames: Wiley-Blackwell.
• Bassert, T. C. (2002). Clinical Anatomy and Physiology for Veterinary Technicians. St. Louis: Mosby, Inc.

 

 

Thanks so much for tuning in. Join us again next week for another episode! 

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Thanks for listening! 

– Yvonne and Jordan 

Cytotoxic T cells use Flower power

In order to efficiently kill multiple target cells, cytotoxic T lymphocytes must endocytose and recycle cytotoxic granule membrane components from the immunological synapse. Chang et al. reveal that a protein called Flower facilitates granule endocytosis in a calcium-dependent manner. This biosights episode presents the paper by Chang et al. from the February 5th, 2018, issue of the Journal of Cell Biology and includes an interview with one of the paper's senior authors, Jens Rettig (Saarland University, Saarbrücken, Germany). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.

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Darwin College Lecture Series 2007 "Immunological Self" by Philippa Marrack