interdisciplinary collaboration

In this episode, my guests are Mark Zuckerberg, CEO of Meta (formerly Facebook, Inc.), and his wife, Dr. Priscilla Chan, M.D., co-founder and co-CEO of the Chan Zuckerberg Initiative (CZI). We discuss how CZI plans to cure all human diseases by the end of this century by funding transformative projects and technologies at the intersection of biology, engineering, and artificial intelligence (AI). They describe their funding and development of Biohubs and the progress already underway to accelerate the understanding of cell function, pathways, and disease. Then, Mark discusses social media, its impact on mental health, and new tools for online experiences. We also discuss Meta’s virtual reality (VR), augmented and mixed reality tech, and how AI will soon completely transform our online and physical life experiences. This episode ought to interest anyone curious about biology, medicine, mental health, AI, and the future of technology and humanity. For the full show notes, including the episode transcript (available exclusively to Huberman Lab Premium members), please visit hubermanlab.com. The Brain Body Contract Tickets: https://www.hubermanlab.com/events Pre-sale password: HUBERMAN Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman LMNT: https://drinklmnt.com/huberman InsideTracker: https://insidetracker.com/huberman Momentous: https://livemomentous.com/huberman The Brain Body Contract Tickets: https://www.hubermanlab.com/events Timestamps (00:00:00) Mark Zuckerberg & Dr. Priscilla Chan (00:02:15) Sponsors: Eight Sleep & LMNT; The Brain Body Contract (00:05:35) Chan Zuckerberg Initiative (CZI) & Human Disease Research (00:08:51) Innovation & Discovery, Science & Engineering (00:12:53) Funding, Building Tools & Imaging (00:17:57) Healthy vs. Diseased Cells, Human Cell Atlas & AI, Virtual Cells (00:21:59) Single Cell Methods & Disease; CELLxGENE Tool  (00:28:22) Sponsor: AG1 (00:29:53) AI & Hypothesis Generation; Long-term Projects & Collaboration (00:35:14) Large Language Models (LLMs), In Silico Experiments (00:42:11) CZI Biohubs, Chicago, New York (00:50:52) Universities & Biohubs; Therapeutics & Rare Diseases (00:57:23) Optimism; Children & Families (01:06:21) Sponsor: InsideTracker (01:07:25) Technology & Health, Positive & Negative Interactions (01:13:17) Algorithms, Clickbait News, Individual Experience (01:19:17) Parental Controls, Meta Social Media Tools & Tailoring Experience (01:24:51) Time, Usage & Technology, Parental Tools (01:28:55) Virtual Reality (VR), Mixed Reality Experiences & Smart Glasses (01:36:09) Physical Exercise & Virtual Product Development (01:44:19) Virtual Futures for Creativity & Social Interactions (01:49:31) Ray-Ban Meta Smart Glasses: Potential, Privacy & Risks (02:00:20) Visual System & Smart Glasses, Augmented Reality (02:06:42) AI Assistants & Creators, Identity Protection (02:13:26) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

In this episode, Siddhartha Mukherjee, oncologist, researcher, and author of the Pulitzer Prize-winning book “The Emperor of All Maladies: A Biography of Cancer,” discusses his writing process, his thoughts about medicine, cancer, immunotherapy, and his recent collaboration on a study combining a ketogenic diet with a drug in mice that provided remarkable and encouraging results.

We discuss:

• Sid’s background [5:00];
• How Sid and Peter met [6:00];
• Sid’s Pulitzer Prize-winning book: The Emperor of All Maladies [8:00];
• Sid’s writing process: the tenets of writing [12:30];
• Our struggle to find preventable, human, chemical carcinogens of substantial impact [23:30];
• The three laws of medicine — Law #1: A strong intuition is much more powerful than a weak test [26:30];
• Law #2 of medicine: “Normals” teach us rules; “outliers” teach us laws [32:00];
• Law #3 of medicine: For every perfect medical experiment, there is a perfect human bias [35:00];
• The excitement around immunotherapy [38:15];
• The story of Gleevec [46:00];
• How does the body's metabolic state affect cancer? [49:30];
• Can a nutritional state be exploited and/or a drug sensitivity be exploited through a nutritional intervention? [52:00];
• How does Sid balance his family, writing, research, laboratory, and patients? [1:00:30]; and
• More.

Learn more at www.PeterAttiaMD.com

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