Explore "mass spectrometry" with insightful episodes like "The Metabolomist - Robert Ahrends", "The State of What Is - A Lesson in Mass Spectrometry with Michelle Dubuke, Ph.D.", "Fireside Chat with Christopher Rose on Single Cell Proteomics", "Bootstrapping mass spectrometry, featuring Mazdak Taghioskoui of Trace Matters" and "14. The caramel tree" from podcasts like ""The Metabolomist podcast", "New Matter: Inside the Minds of SLAS Scientists", "MSACL", "Tough Tech Today with Meyen and Miller" and "Botanic Garden Chemistry Audio Tour"" and more!
We're joined by Mass Spectrometry (Mass Spec) expert, Michelle Dubuke, Ph.D., to learn all about mass spec! From learning the practical applications of mass spec to how researchers are using the tool to discover new insight into biological aging and cancer development, Dubuke breaks it all down to showcase how expansive mass spec is.
About Michelle Dubuke:
Michelle Dubuke is currently the Manager, Field Application Scientist at Seer. Dubuke is a mass spectrometrist and protein biochemist focused on translational Precision Medicine workflows. Her previous experience was in varied areas of mass spectrometry, including small molecule LC-MS/MS, targeted and untargeted proteomics, DESI imaging, and intact protein analysis in an academic core facility. She has an established publication record in protein biochemistry, bottom-up proteomics, and targeted metabolomics.
About SLAS:
SLAS (Society for Laboratory Automation and Screening) is an international professional society of academic, industry and government life sciences researchers and the developers and providers of laboratory automation technology. The SLAS mission is to bring together researchers in academia, industry and government to advance life sciences discovery and technology via education, knowledge exchange and global community building. For more information about SLAS, visit www.slas.org.
SLAS publishes two peer-reviewed and MEDLINE-indexed scientific journals, SLAS Discovery and SLAS Technology. For more information about SLAS and its journals, visit www.slas.org/publications.
Upcoming SLAS Events:
SLAS Building Biology in 3D Symposium
SLAS Europe 2024 Conference and Exhibition
He built a mass spectrometer from scratch and reinvented it in the process!
Bearing a smile, Mazdak “Maz” Taghioskoui says he immigrated to the United States from Iran for a good education and same-day shipping, two key features that have supported his focus on building – from scratch – a sophisticated next-generation analytical tool: the Trace Matters SPion mass spectrometer.
Maz is the Founder and CEO/CTO of Trace Matters, and we sat down with him for show-and-tell to discuss how he and his company is reinventing the mass spectrometer to save lives here on Earth and to advance our scientific understanding of the cosmos beyond our planet.
00:54 A lesson in high school chemistry
03:44 History and benefits of mass spectrometry for space and medical applications
04:53 Screening newborn babies’ blood for disease mitigation
06:18 Instrumentation Startup: A tiny company in a world of corporates
07:15 Creating a mass spectrometer… from scratch
08:56 The fallacy of“if your system is complex and it’s working, you don’t change it”
10:11 How I built this
12:16 A case study in the 10,000 Hour Rule and brute force science
13:38 Seeing years of work finally come to fruition
17:24 Seeing SPion and the frog
18:53 Expediting mass spectrometry-assisted brain surgery
23:36 Show-and-tell in Maz’s lab
24:48 Inventing a lab-scale fabrication process
28:20 Following a vision or a wandering path?
30:08 Getting addicted to solving challenges
32:01 Immigrating to the United States for a great education and… quick shipping
33:26 The resources at Massachusetts’ Greentown Labs
34:37 Bootstrapping a scientific instrument company
37:32 A shift in how we build instruments?
39:36 Who could be first to benefit from next-generation mass spectrometry?
40:52 Integrating learnings into a tech roadmap
41:23 The Harvard Rapid Acceleration of Diagnostics (RADx) program and COVID-19
42:12 Advice to a younger self: persistence, love, and remembering to eat
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