metastatic melanoma

The Oncology Journal Club - Delivering Oncology News Differently

The Oncology Podcast, brought to you by Oncology News Australia, is proud to present Episode 29 in our series The Oncology Journal Club.

Changing the landscape with neoadjuvant therapy in metastatic melanoma with Georgina Long plus integrative genomic profiling, clinical trial eligibility criteria, oncology randomised clinical trials from LMICs and much more...

This week's episode is in our usual format featuring some fascinating papers, quirky quick bites and an MBS Update. Hans also interviews Professor Georgina Long on a recent publication in Nature Medicine on pathological response and survival with neoadjuvant therapy in melanoma – it’s a very passionate and engaging interview so this is a must-listen segment. 

With the usual top quality banter, papers you won’t hear of anywhere else and expert analysis from our Hosts, you are in for another great episode of The Oncology Journal Club!

Full bios and the list of all papers discussed are available on our website.

For the latest oncology news visit www.oncologynews.com.au and for regular oncology updates for healthcare professionals, subscribe for free to get the weekly The Oncology Newsletter.

The Oncology Podcast - An Australian Oncology Perspective

Jenny speaks to Rita Catolino, health and wellness expert, cover-model, and co-author of an upcoming 12-Week Health Revolution guidebook. We learn about Rita’s emotional journey with infertility, and her discovery of stage 2 melanoma in 2019. Rita also reveals how training and moving her body, has always been her constant, and how she listens and respects her body above all else. Rita’s inspirational words teach as that even in the face of adversity, finding your strong is about showing up and being the version of yourself. 

If you enjoyed this episode, make sure and give us a five star rating  and leave us a review on iTunes, Podcast Addict, Podchaser and Castbox.

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DISCLAIMER: The opinions, beliefs, and viewpoints expressed by the hosts and guests on this podcast do not necessarily represent or reflect the official policy, opinions, beliefs, and viewpoints of Disenyo.co LLC and its employees.

If you or a loved one have recently been diagnosed with skin caner, you don't want to miss this episode. We welcome back board certified dermatologist, Dr. Jonathan Crane to discuss modern treatment modalities for basal cell, squamous cell and melanoma skin cancers, along with the factors that could influence treatment options. Both Dr. Crane and our show's host Dr. Kamran Goudarzi, have seen their respective areas of medical specialties undergo quite an evolution in recent years which has lead to an increasing number of positive patient outcomes. During their conversation, Dr. Crane sheds light on inspiring stories of hope for skin cancer patients, including those with advanced metastatic melanoma.

Later in the episode, Dr. Crane shares his predictions for what could be on the horizon for skin cancer treatment options (hint: it could involve a simple pill). Dr. Kamran and Dr. Crane also discuss the rapid innovation underway in the race to resolve the COVID-19 epidemic and how we could continue to see additional advancements in medicine as a positive ripple effect.

About our guest:

Dr. Jonathan Crane has a practice in Wilmington North Carolina called Atlantic Dermatology and he’s a fellow of the American Academy of Dermatology and the American Osteopathic College of Dermatology. He has published more than 100 research articles in the field of dermatology, serving as principal investigator on many of them.

Dr. Crane, practices general, surgical, and cosmetic dermatology and is the Program Director at Sampson Regional Medical Center for Dermatology Residency Program with Campbell University School of Osteopathic Medicine where he is the Dermatology Co-Course Director.

See omnystudio.com/listener for privacy information.

Episode Notes

Kevin completed his Ph.D. studies at the Université catholique de Louvain (Belgium) in 2010 and since then has held research roles at universities in the USA and Kazakhstan.He is currently a Reader in Medicinal Chemistry, based at the University of Greenwich, at their Chatham (UK) campus – where we recorded this episode. 

You will hear the following terms used during the interview.  I’ve included some descriptions and links to deeper reading. 

• Electrochemistry - https://en.wikipedia.org/wiki/Electrochemistry
• Organic electrochemistry (electrosynthesis) - Organic electrochemistry is the use of electrical current through a reaction to activate organic molecules by means of the addition or removal of electrons.  Organic molecules are, broadly speaking, those containing one or more carbon atoms covalently linked to other atoms.
• Organic Synthesis – Any chemical or biochemical method used to make organic substances.
• Flow (electro)chemistry – for more information on flow chemistry, I suggest that you check out episode 2 of the Modern Chemistry Podcast with Russell Taylor.  Flow Electrochemistry is a technique whereby the components of a reaction are passed between typical electrochemistry electrodes.
• Positron Emmission Tomography – An imaging technique, also referred to as PET, often used in medical diagnosis. https://en.wikipedia.org/wiki/Positron_emission_tomography
• C11 (Carbon 11) – A radio active isotope of carbon.  Typically made in a cyclotron, one of the main uses for Carbon 11 is as a tracing agent in PET scans.
• Cylotron – A particle accelerator, often used to prepare riadionuclides for use in nuclear medicine applications - such as PET. https://en.wikipedia.org/wiki/Cyclotron
• Metastatic Melanoma.Melanoma is a type of cancer that develops from pigment-containing cells (melanocytes) typically found in the skin.Metastatic Melanoma occurs when the initial cancer spreads to other locations in the body.
• Organometallic drug - A drug which contains carbon atoms directly bonded to metals or metalloids.
• Chloraquine – A medicine used to treat malaria.
• Electron Transfer – This process occurs when an electron relocates from an atom or molecule to another such chemical entity. ET is a mechanistic description of a redox reaction, wherein the oxidation state of reactant and product changes

If you want to connect with Kevin, or find out more about his lab, you can find:

Kevin’s lab group page at http://www.lamresearchgroup.com/

Kevin on LinkedIn at https://www.linkedin.com/in/kevin-lam-8b163420/

On Twitter, Kevin is at https://twitter.com/klchemistry (@KLchemistry)

Our theme music is "Wholesome" by Kevin MacLeod (https://incompetech.com)

Music from https://filmmusic.io

License: CC BY (http://creativecommons.org/licenses/by/4.0/)

Connect with me (Paul) at https://www.linkedin.com/in/paulorange/

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