microscope

Episode Description:

Welcome to another intriguing episode from our AMA series, where we're diving deep into the realms of cell biology, cognitive aging, and neurodegenerative disease, all through the lens of zebrafish!

We're delighted to have Dr. Liz Haynes, a cell biologist and post-doctoral fellow, as our special guest. A proud advocate for open-source tools and publishing, Dr. Haynes wields a microscope and an unyielding curiosity for the brain's smallest defenders, the microglia.

She embarked on her scientific journey at UNC-Chapel Hill, studying the fascinating actin dynamics and then plunging into the intricate world of kinesin-1’s cargo-binding subunits. But it was the world of zebrafish that stole her heart and honed her research focus.

Dr. Haynes utilizes her expertise in multiscale microscopy, specifically 2-photon and light sheet microscopy, to elucidate the role of microglia in cognitive aging and neurodegenerative diseases in zebrafish. The aim? To unravel the complex behaviors of cells in a 3D environment.

Currently, as a Morgridge Post-Doctoral Fellow working with the Eliceiri and Ulland labs, Dr. Haynes continues to innovate strategies for longitudinal light sheet and multiphoton microscopy. Her work promises new insights into microglia's part in the progression of neurodegenerative diseases.

Join us as we discuss zebrafish, microglia, and the incredible world of cell biology with Dr. Haynes. Prepare to be amazed at what we can learn from the unassuming zebrafish and how they can teach us about cognitive aging and neurodegenerative disease.

Today’s AMA is featuring Dr. Liz Haynes. You can follow her Sci Find Profile here (https://scifind.io/profiles/liz-haynes-j07bjmkz6uukura) to see some of her posts and her Twitter handle is @actin_crazy (https://twitter.com/actin_crazy). Check out her posts: https://scifind.io/posts/tissue-clearing-part-2-mounting-where-theres-a-will-theres-a-way-30puv6hnt5qratg and https://scifind.io/posts/tissue-clearing-part-1-how-i-learned-to-stop-worrying-and-love-r-p3p45h5yjb45iko

Gorden Tallis & Ben Dobbin jump in with plenty of action from the NRL as the Knights shock the Storm, Roosters keep their season alive & are they Eels set to miss the 8?

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🕛 New Footy Talk episode everyday at lunchtime

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If you could put a lock of your hair under a microscope, what would it contain? DNA certainly, but here in dg nanouk okpik’s poem, the hair also contains memory, smell, location, disease, dreams, and medicine.

dg nanouk okpik is Iñupiat-Inuit from Alaska. Her first book, Corpse Whale (University of Arizona Press, 2012), won the American Book Award and May Sarton Award. okpik was long-listed for the PEN American Award for Blood Snow (Wave Books, 2022). She is a Lannan Fellow with the Institute of American Indian Arts. okpik resides in Santa Fe, NM.

Find the transcript for this show at onbeing.org.

We’re pleased to offer dg nanouk okpik’s poem, and invite you to connect with Poetry Unbound throughout this season.

Join us as we speak to Jack Mershon, Applications Specialist for Tescan USA Inc., about SEM advancements and the TESCAN Essence™ 3D Collision Model.

YouTube: 

Bruker Detectors https://youtu.be/4iHCLUG7RGw 

Website:  

Bruker Detectors https://www.bruker.com/en/products-and-solutions/elemental-analyzers/eds-wds-ebsd-SEM-Micro-XRF.html 

Essence™ 3D Collision Model – Tescan https://www.tescan.com/product/sem-for-materials-science-tescan-vega/ 

App Notes application notes:

Essence™ 3D Collision Model – Tescan flyer https://mbna.bruker.com/acton/attachment/15240/f-151ee2e2-f12c-4aa7-9864-7bb93c3f36b8/1/-/-/-/-/Tescan%20-%20Essence%203D%20collision%20model.pdf 

Contact Us:

 Info.BNA@bruker.com 

+1 800-234-XRAY(9729)

Recently Dr. Meiken Falke the Global Product Manager for EDS on TEM and SEM with Bruker Nano Analytics presented the topic "Colorful Quantities of Matter" during a larger formatted program. 

We are going to share her portion here so you can gain insights from her talk. Her presentation is on adding color to electron microscope data using spectroscopy and diffraction. Talking about not just coloring in each type of atom but counting  them one by one and studying their geometric arrangement in complex structures. 

You hear dermatologists talk about the importance of cytology. But, how do you become confident about your collection technique? 

Learn how to master this important derm diagnostic. You will become an expert in no time with these tips!

You always hear me mention "cytology everything"! But, how do you actually collect a diagnostic cytology sample?

Cytology is the minimum database of any dermatology case. So, it is important to find 2-3 techniques you feel comfortable with and become a PRO at them. From direct impression to tape to toothpick samples, get a step-by-step guide on the difference collection methods. 

Don't forget to check out The Derm Nerds which includes a cytology collection PDF and RACE approved cytology presentation!  https://thedermvet.com/the-derm-nerds

„Když pečete bábovku a dáte do ní moc rozinek, může vám prasknout. Stejné je to i s materiálem. Když máte mnoho nečistot na jednom místě, může prasknout – třeba křídlo letadla. Nečistoty ale můžou být tak zákeřné, že mají rozměry desítek atomů. My je umíme díky elektronovým mikroskopům najít, zobrazit, pochopit a vymyslet, jak materiál vyrobit nepoškozený, abychom si mohli bezpečně a v klidu do toho letadla sednout.“

Před necelými sto lety spatřil světlo světa první elektronový mikroskop. Zatímco optický mikroskop ukazoval stěží buňku, technologická novinka dokázala jít na úroveň atomů. Šlo o stejný upgrade, jako byste vyměnili starou televizi za obrazovku s rozlišením 4K, díky kterému vidíte i nedokonalosti pleti herce v seriálu. Když absolvent strojní fakulty VUT Ondřej Sháněl před lety nastupoval do Thermo Fisher Scientific, nevěřil, že se ještě na poli elektronových mikroskopů dá moc vymýšlet. Dnes tyto superstroje umožňují vyrábět mikročipy, ale také třeba pozorovat mutující koronaviry nebo buňky napadené Parkinsonovou či Alzheimerovou chorobou. Nikde jinde na světě se nevyrábí takové množství elektronových mikroskopů jako v Brně.

Psalm 50

As God takes Israel through a dry run in their coming judgment, we learn some fantastic lessons about how to prepare as God's covenant people for the judgment. Yesterday, we learned to fear God. Today, Andrew and Edwin talk to us about mirrors, microscopes, logs, and specks.

Read the written devo that goes along with this episode by clicking here.

Let us know what you are learning or any questions you have. Email us at TextTalk@ChristiansMeetHere.org.

Join the Facebook community and join the conversation by clicking here.

We'd love to meet you. Be a guest among the Christians who meet on Livingston Avenue. Click here to find out more.

Michael Eldridge sang all four parts of our theme song. Find more from him by clicking here.
 
Thanks for talking about the text with us today.

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If the hyperlinks do not work, copy the following addresses and paste them into the URL bar of your web browser:

Daily Written Devo: https://readthebiblemakedisciples.wordpress.com/?p=7089

The Christians Who Meet on Livingston Avenue: http://www.christiansmeethere.org/

Facebook Page: https://www.facebook.com/LivingstonChristians

Michael Eldridge: https://acapeldridge.com/ 

On this week’s The Sci-Files, your hosts Chelsie and Danny interview Erika Buhk. Due to the current COVID-19 Pandemic, many Americans are wearing masks in public to slow the spread. Many people question whether the masks actually do anything. Erika researched how the fabric of disposable masks breaks down with use by placing them under a high-level microscope (scanning electron microscope). She used the pictures taken on the microscope and research on how face masks work to show how important it is to be taking care of masks properly in order to prevent getting, or spreading, illnesses like COVID-19. If you’re interested in talking about your MSU research on the radio or nominating a student, please email Chelsie and Danny at scifiles@impact89fm.org. Check The Sci-Files out on Twitter, Facebook, Instagram, LinkedIn, and YouTube!

In today's episode, we'll be taking a closer look at papers published in March 2021, studying amyloid and tau PET targets in Alzheimer's Disease, as well as some new PET targets.  Topics covered include but are not limited to: butyryrlcholinesterase targeting, PET image processing, and animal models.  

Sections in this episode: 

Amyloid/Tau PET Targets  

Tau pathology (1:08)  

PET image processing and data analysis (6:45)  

Animal models (11:53)  

Miscellaneous (14:47)  

Other PET Targets  

Butyrylcholinesterase (17:50)  

Miscellaneous (20:43) 

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To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:

https://drive.google.com/drive/folders/1N1zx_itPkCDNYE1yFGZzQxDDR-NiRx3p?usp=sharing

You can also join our mailing list to receive a newsletter once per month by filling this form. 

Or tweet at us: @AMiNDR_podcast  

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Please help us by spreading the word about AMiNDR to your friends, colleagues, and networks! Another way you can help us reach more researchers is by leaving us a review on Apple Podcasts. 

We would like to thank our amazing team for all of the work that goes into every episode of AMiNDR. Today's episode was scripted and hosted by Alexandra Pavel, reviewed by Judy Cheng, and edited by Alexandra Pavel. The bibliography was created by Satish Kumar and the wordcloud was generated by Sarah Louadi (www.wordart.com). Big thanks to the sorting team for sorting all the papers published in March into themes for our episodes, and to our management team, which includes Sarah Louadi, Ellen Koch, Naila Kuhlmann, Elyn Rowe, Anusha Kamesh, and Jacques Ferreira, for keeping everything running smoothly.

Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic.   

https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w   

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If you are interested in joining the team, send us your CV by email. We are specifically looking for help with sorting abstracts by topic, abstract summaries and hosting, creating bibliographies, and promotions. However, if you are interested in helping in other ways, don't hesitate to apply anyways.  

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*About AMiNDR: *  

Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!" 

This COVID-19 pandemic is the first one for 102 years. In 1918-1920 we had an influenza pandemic, which we now refer to as the Spanish Flu. Back then we didn’t know about a thing called a ‘virus’, so in 1918 no-one knew what was killing people. But we did know about germs.

Ever wonder what skin looks like under a microscope? How about hair? Or snowflakes, or sand?! This week, Christine and JJ examine award-winning photographs taken through microscopes, and describe a few clickbait closeups, too!

Ricardo "Kikas" Correia is a PhD Physicist. Smart work, a never settle for less mentality, and a childlike fascination with what's outside his experience took him from Maputo all the way to Harvard and the in-betweens are nothing less than inspirational. What a guy, what a story, and can you believe he wanted to be a professional footballer! We talk about his incredible journey from "a praceta do rei dos frangos" to the Kirchhausen Lab at Harvard Medical School. 

You can also watch this episode on our YouTube channel, don't forget to subscribe.

Links:

Phoqus project (Kikas' PhD program, 2014-2017. A total of 200 candidates, 13 were chosen for this project) - https://sites.dundee.ac.uk/phoqus/members/

https://sites.dundee.ac.uk/phoqus/the-project/ricardo-filipe-bango-da-cuhna-correia/

Marie Curie - Actions - European Union Webpage (info about the Marie Curie fellowships) - 

https://ec.europa.eu/research/mariecurieactions/funded-projects/initial-training-networks_en
 

Prof. Kees Weijer Lab webpage, Kikas' PhD boss (2014-2017) - https://www.lifesci.dundee.ac.uk/people/kees-weijer
 

Prof. Ernst Stelzer Lab, Stelzer was the first "revolutionizing" 3D imaging with Lighsheet microscopy. Kikas worked in this Lab in collaboration (from October/2015 - January/2016), designing a microscope that he would eventually build at the end of his PhD in Dundee - https://www.physikalischebiologie.de/
 

In 2016 Kikas attended this conference, and after submitting an abstract about his work he was able to win a slot to talk about his scientific developments with Lightsheet, on Day 2 - https://www.lsfm2016.org/files/2114/7195/6037/full_lsfm_programme_23_August.pdf
 

Kikas was at i3s, in Porto working at this facility. Paula Sampaio was his boss - https://www.i3s.up.pt/scientific-platform?v=63

Prof. Tom Kirchhausen Lab webpage - https://kirchhausen.hms.harvard.edu/

Janelia Research Farm - HHMI - https://www.rvapc.com/works/howard-hughes-medical-institute-janelia-research-campus/

Janelia Research Farm - HHMI (Eric Betzig Lab, Nobel Laureate 2014), Kikas was in his lab to receive training on how to build the new MOSAIC, from April/2019 - December/2019) - https://www.janelia.org/lab/betzig-lab

The microscope behind Kikas in our YouTube video, at this moment there are only 4 functioning on planet Earth - https://www.janelia.org/node/46947/#mosaic

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If you are working with immunohistochemistry (IHC) you know how challenging it can sometimes be to optimize all the steps in the process to obtain a high-quality stain. It often takes testing different antibodies, antibody concentrations, antigen retrieval methods, and incubation times.

What if there was a way to produce an IHC stain virtually, without antibodies or even the need to step into the lab?

Today's episode's guest is Victor Dillard, the commercial operation director of Owkin.
Owkin is a company leveraging artificial intelligence and machine learning for medical image analysis and its offering includes virtual immunohistochemistry staining.  We talk about how it was developed, how it works, and how it can be deployed at interested institutions.

To learn more about Owkin visit https://owkin.com/

This episodes resources:
 Deep learning-based classification of mesothelioma improves prediction of patient outcome

Become a Digital Pathology Trailblazer and See you inside the club: Digital Pathology Club Membership

Who loves cytology more than a veterinary dermatologist? A clinical pathologist! This episode features Dr. Kate Baker, DVM, MS, Dip ACVP talking all things cytology. You know we had a ton of fun! Not only are we both vet moms of two little ones... we LOVE looking under the microscope!

Dr. Baker shares tips regarding aspirate submissions and cells you can feel comfortable identifying in general practice. This is a fun, practical episode! I hope you enjoy listening to it as much as we loved recording it!