miniaturization

In this enlightening episode, Adrian La Porta, Technical Director at Bryden Wood, dives deep into the evolving landscape of pharmaceutical manufacturing, focusing on the critical role of Small Molecule Active Pharmaceutical Ingredients (APIs) in modern medicine. As the backbone of the world's most essential medications, the development and production of APIs stand at a crossroads, challenged by the increasing demand for more complex, potent, and targeted molecules. Adrian unveils the limitations of traditional batch chemistry in API manufacturing and explores the revolutionary shift towards miniaturisation, process intensification, and automation. 

Join Adrian as he dissects the groundbreaking technologies reshaping R&D, highlights the inefficiencies of current manufacturing networks, and proposes a new paradigm that promises lean, agile, and environmentally sustainable drug production. He examines the potential of continuous processing and other intensification strategies to enhance chemistry, reduce waste, and improve quality, all while addressing the financial and environmental costs associated with conventional large-scale manufacturing.

This episode is a must-listen for anyone interested in the future of pharmaceuticals, from industry professionals and researchers to healthcare providers and patients. 

Discover how discarding outdated methodologies in favour of innovative, modular manufacturing systems can transform the production of life-saving drugs, making them faster, safer, and more accessible to patients worldwide. 

To learn more about Bryden Wood's Design to Value philosophy, visit www.brydenwood.com. You can also follow Bryden Wood on LinkedIn and Twitter.

Doing something complex and meaningful in a new way requires thinking and acting a bit differently. This is the case with how Dr. Joey Azofeifa, from Arpeggio Bio, is using systems biology to discover new drug candidates.

Join us in this Season 2 kickoff episode where we dive headlong into transcriptomics, systems biology, machine learning, and learn how they’re being used to innovate drug discovery. We learn about 3’-end mRNA barcoding and in-cell reverse transcription methods that allow the pooling of up to 1,536 samples so that only a single library preparation is required while still allowing the deconvolution of RNAseq results. This reduces their RNAseq costs by up to 400-fold, which enables them to generate enormous transcriptomic data sets. We also learn about how they’re using generative adversarial AI networks to use this transcriptomics data to design potential drug candidates. We even hear how one of their drug candidates, which targets iron homeostasis pathways, has progress to successful testing in mice.

To access the transcript for download, please visit - https://www.thermofisher.com/us/en/home/brands/invitrogen/molecular-biology-technologies/speaking-of-mol-bio-podcast.html

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Speaking of Mol Bio Podcast | Thermo Fisher Scientific - US

Visit the Invitrogen School of Molecular Biology to access helpful molecular biology resources and educational content, and please share this resource with anyone you know working in molecular biology. 

Space is a fascinating and mysterious place that often redefines science as we know it. And this couldn’t be more true than with the asteroid Bennu.  

As the spacecraft OSIRIS-REx got close to this ancient interstellar object, they noticed something strange happening. Listen to this episode to hear why scientists think this peculiar event is happening. 

To take a deeper dive into the incredible mission in this episode, please follow the links below:

OSIRIS-REx Mission Overview

Mission Website

Photos of OSIRIS-REx

Video about OSIRIS-REx

How OSIRIS-REx is Returning an Asteroid Sample to Earth

Credits:

Space Makers is a production of Lockheed Martin Space. 

Episode guests were Dante Lauretta from the University of Arizona, and Beau Bierhaus, Sandy Freund, and Joe Landon from Lockheed Martin. And they are Space Makers.

It's executive produced by Pavan Desai.

Senior producer is Lauren Cole. 

Senior producer, writer, and host is Benjamin Dinsmore. 

Associate producers and writers are Kaitlin Benz and Audrey Dods. 

Sound designed and audio mastered by Julian Giraldo.

Graphic design by Tim Roesch.

Marketing and recruiting by Joe Portnoy, Shannon Myers, and Stephanie Dixon.

These stories would not be possible without the support from our space communications professionals Tracy Weise, Natalya Oleksik, Gary Napier, Lauren Duda, and Dani Hauf. 

We're bringing you a story about a groundbreaking mission named Lucy, set to launch in October of 2021. This mission will visit and study a record number of Trojan asteroids that are some of the oldest objects in our solar system.  

It takes an incredible amount of work to plan a mission to one location in deep space, but planning a mission to visit seven Trojan asteroids is a once-in-a-lifetime event.  

We take you behind the scenes with the engineers and scientists leading this mission and then "flash forward" to advanced mission designing and what possibilities we can accomplish next. 

To dig deeper into the incredible mission referenced in today’s episode, please follow these links:

NASA’s Lucy Mission

NASA - Lucy: The First Mission to the Trojan Asteroids

Lucy Mission: Our First Close-Up Look at Jupiter’s Trojan Asteroids

NASA's Lucy Spacecraft Begins Launch Preparations

Credits:

Space Makers is a production of Lockheed Martin Space. 

Episode guests were Cathy Olkin from the Southwest Research Institute, Jacob Englander, who was at NASA Goddard Spaceflight Center at the time of this interview,  and Brian Sutter and Tim Linn from Lockheed Martin. And they are Space Makers.

It's executive produced by Pavan Desai.

Senior producer is Lauren Cole. 

Senior producer, writer, and host is Benjamin Dinsmore. 

Associate producers and writers are Kaitlin Benz and Audrey Dods. 

Sound designed and audio mastered by Julian Giraldo.

Graphic design by Tim Roesch.

Marketing and recruiting by Joe Portnoy, Shannon Myers, and Stephanie Dixon.

These stories would not be possible without the support from our space communications professionals Tracy Weise, Natalya Oleksik, Gary Napier, Lauren Duda, and Dani Hauf. 

In Part II, OSIRIS-Rex continues its incredible mission of collecting a sample from Bennu, an asteroid sailing through space more than 200 miles away.  

With our expert, we'll take a deeper dive to into what the future may look like because of OSIRIS-REx, and what it will take to have sustained colonies on the Moon—and even Mars. 

To dig deeper into the incredible mission referenced in today’s episode, please follow these links:

OSIRIS-REx Mission Overview

Mission Website

Photos of OSIRIS-REx

Video about OSIRIS-REx

How OSIRIS-REx is Returning an Asteroid Sample to Earth

Credits:

Space Makers is a production of Lockheed Martin Space. 

Episode guests were Dante Lauretta from the University of Arizona, and Beau Bierhaus, Sandy Freund, and Joe Landon from Lockheed Martin. And they are Space Makers.

It's executive produced by Pavan Desai.

Senior producer is Lauren Cole. 

Senior producer, writer, and host is Benjamin Dinsmore. 

Associate producers and writers are Kaitlin Benz and Audrey Dods. 

Sound designed and audio mastered by Julian Giraldo.

Graphic design by Tim Roesch.

Marketing and recruiting by Joe Portnoy, Shannon Myers, and Stephanie Dixon.

These stories would not be possible without the support from our space communications professionals Tracy Weise, Natalya Oleksik, Gary Napier, Lauren Duda, and Dani Hauf. 

In this episode, we dive into an unexpectedly rocky relationship between an asteroid named Bennu and a cutting-edge spacecraft named OSIRIS-REx.  

Bennu, an asteroid larger than the Empire State Building, is an ancient relic of our solar system with more than 4.5 billion years of history to share. OSIRIS-REx, a cutting-edge spacecraft built by Lockheed Martin, launched in 2016 on a mission to meet Bennu for an extraterrestrial rendezvous and bring Bennu samples back to Earth.  

Stick around for our "flash forward" with experts discussing what it will take to "untether" humans from Earth in the future.

To dig deeper into the incredible mission referenced in today’s episode, please follow these links:

OSIRIS-REx Mission Overview

Mission Website

Photos of OSIRIS-REx

Video about OSIRIS-REx

How OSIRIS-REx is Returning an Asteroid Sample to Earth

Credits:

Space Makers is a production of Lockheed Martin Space. 

Episode guests were Dante Lauretta from the University of Arizona, and Beau Bierhaus and Sandy Freund from Lockheed Martin. And they are Space Makers.

It's executive produced by Pavan Desai.

Senior producer is Lauren Cole. 

Senior producer, writer, and host is Benjamin Dinsmore. 

Associate producers and writers are Kaitlin Benz and Audrey Dods. 

Sound designed and audio mastered by Julian Giraldo.

Graphic design by Tim Roesch.

Marketing and recruiting by Joe Portnoy, Shannon Myers, and Stephanie Dixon.

These stories would not be possible without the support from our space communications professionals Tracy Weise, Natalya Oleksik, Gary Napier, Lauren Duda, and Dani Hauf.