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    Explore "pharmacology class" with insightful episodes like "Ep 77 B Vitamin Pharmacology Mnemonics", "Ep 75 Eye and Ear Pharmacology Mnemonics in 5 minutes", "Ep 73 Antiarrhythmics Pharmacology Mnemonics", "Ep 72 ABCD Antihypertensive Mnemonics ACEIs ARBs Beta and Calcium Channel Blockers Diuretics" and "Ep 71 Statins and More (gemfibrozil, fenofibrate, niacin, ezetimibe, cholestyramine, PCSK9)" from podcasts like ""Memorizing Pharmacology Podcast: Prefixes, Suffixes, and Side Effects for Pharmacy and Nursing Pharmacology by Body System", "Memorizing Pharmacology Podcast: Prefixes, Suffixes, and Side Effects for Pharmacy and Nursing Pharmacology by Body System", "Memorizing Pharmacology Podcast: Prefixes, Suffixes, and Side Effects for Pharmacy and Nursing Pharmacology by Body System", "Memorizing Pharmacology Podcast: Prefixes, Suffixes, and Side Effects for Pharmacy and Nursing Pharmacology by Body System" and "Memorizing Pharmacology Podcast: Prefixes, Suffixes, and Side Effects for Pharmacy and Nursing Pharmacology by Body System"" and more!

    Episodes (33)

    Ep 77 B Vitamin Pharmacology Mnemonics

    Ep 77 B Vitamin Pharmacology Mnemonics

    B Vitamin Pharmacology Mnemonics

    Find the book here: https://geni.us/iA22iZ 

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to TonyPharmD YouTube Channel here: https://www.youtube.com/c/tonypharmd

    Need more help? You can find many of my mnemonics books on Audible that you might be able to get your first for free if you've never had one before: https://www.audible.com/pd/Memorizing-Pharmacology-Mnemonics-Audiobook/B07DLGC8MP?source_code=AUDFPWS0223189MWT-BK-ACX0-118296&ref=acx_bty_BK_ACX0_118296_rh_us

    Here is the Link to my Pharmacy Residency Coursesresidency.teachable.com

    B vitamins can be hard to remember with skipped numbers and names for each B vitamin. In this video, I go over some ways to help you remember.  

     

    Auto Generated Transcript:

    Welcome to the Memorizing Pharmacology podcast. I’m Tony Guerra, pharmacist and author of the Memorizing Pharmacology book series, bringing you mnemonics, cases, and advice for succeeding in Pharmacology. Sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.com/P/mobile. Let’s get started with the show.

    Alright, today we’re going to go over B vitamin mnemonics. So here we go. First thing of course is that we have water-soluble vitamins versus fat-soluble vitamins. B vitamins are water-soluble as are C vitamins. So here are the names and the trick is how do you remember the number with the name? So B1 is thiamin, B2 is riboflavin, B3 is niacin, B5 is pantothenic acid. Notice there’s a skip between three and five, there is no four. B6 is pyridoxine, B7 is biotin, B9 is folic acid, and B12 it’s cobalamin.

    So let’s kind of move on to the next and what we’ll do is we’ll divide this into thirds. First we’ll take a look at thiamin, riboflavin, and niacin. So the way we’re going to do this is we’re going to go from the bottom up. So we’re going to say that B1 is thiamin looking at this skeleton’s thigh, riboflavin is rib so ‘thi’ from thigh, ‘rib’ from riboflavin and then if you pronounce it I thought it was an Australian accent but it actually comes out more of a South African accent if you say ‘Nick’ rather than ‘neck’ you can get the ‘Nic’ that’s in niacin.

    So again it’s the thigh, the rib and the ‘Nic’. So by the rib and the neck reminds you the B1, B2 and B3 going from the bottom up are thiamine, riboflavin and niacin.

    The next three and we’ll get a little crazy with the picture here but we’re going to have pantothenic acid so pants uh and I have no idea why there was this skeleton with the jeans but it was available for purchase so I was able to get the picture. Pyridoxine think of a pyramid so upside down pyramid the way the rib cage kind of comes down right you guys are old enough to remember Mork and Mindy yeah that was the kind of symbol on the front of Mork uh and then biotin uh the tin hat uh on top of the skeleton.

    So we have B5 is pantothenic acid with pants, B6 is pyridoxine but the pyramid upside down and then biotin is the tin hat okay.

    The last two we’ll use just a forest and a beautiful blue sky so forest for folic acid that’s B9 and then B12 is cobalamin with the cobalt sky. I know this isn’t exactly Cobalt it’s not exactly that blue it’s actually kind of a green but just roll with me here forest and cobalt sky folate and cobalamin are B9 and b12.

    So let’s dive into what they’re good for three at a time so first B1 or thiamin this converts carbs to glucose prevents Wernicke’s encephalopathy in alcoholism or liver disease so a little picture of a beer there and some cirrhotic liver.

    B2 is riboflavin deficiency due to alcoholism vegan vegetarian lifestyle malabsorption just can’t absorb it or lactose intolerance.

    And then B3 niacin is great for high triglycerides where we’re really trying to stabilize that plaque as an add-on for statins where the statins maybe they get the LDL down but just not the triglycerides where you want to be so you can avoid pancreatitis and you would need maybe to give an aspirin 30 minutes before to avoid that flushing effect okay all right let’s move on to the next.

    So B5 pantothenic acid it synthesizes coenzyme A for fatty acid metabolism and you can think of the A in acid and the word acid for coenzyme A and fatty acid metabolism.

    B6 pyridoxine this is for alcoholism and peripheral neuropathy from isoniazid. Isoniazid is one of those drugs for TB okay so again the ripe mnemonic when you have a TB in duration that’s ripe okay so Rifampin isoniazid uh and so forth okay so.

    The XYZ mnemonic is to take the X and Y from pyridoxine and match it up to Z in ice niazid okay and that peripheral neuropathy is really this picture we have this exclamation point and somebody’s really having trouble feeling their fingers uh so fingers and toes That uh, a lot of times for that peripheral neuropathy shows up, it may show up as not being able to button a shirt as well. So it doesn’t necessarily show up as pain, it’s just can’t always just really use your fingers as you’d like to. Biotin that helps enzymes break down carbs, fats and proteins but really skin and hair is where we see it in beauty products especially. So the ‘in’ from Biotin for skin and then the hair again. I just got a picture of someone who’s an athlete, good hair, good skin.

    B9 is folate. This is where we want to prevent those neural tube defects and think of the F in folate and F in defects. Deficiency is a reduced hemoglobin level and really B9 is critical for red blood cell production. To be honest, you need B9, iron and B12 and if you think of a nine iron if you know golf a little bit, a nine iron being used on the 12th hole you can put the nine, the iron and the 12 all together. And there’s a very famous shot on the 18th hole that where someone just yelled out ‘be right’ and the B from ‘be right’ is just you know, be right, be the right shot.

    And so here again we’re using that B so B9 iron on the B12 hole um hopefully that helps you remember that iron B9 and b12 need to go together to really form those red blood cells properly.

    B12 is cobalamin so it’s for macrocytic not microcytic and pernicious anemia so the ‘ma’ in cobalamin for macrocytic, the ‘ni’ in cobalamin for pernicious anemia and then a lot of the letters from anemia are in cobalamin so if you’re somebody that can kind of do those word scrambles I think that’s helpful.

    A lot of those people that have gastric bypass surgery you think oh my gosh that’s so great they you know they don’t aren’t hungry and things like that but really it does cause a lot of problems in terms of B12 um uh Celiac and Crohn’s disease these are two issues that would definitely necessitate adding some B12.

    And then deficiency again just like with B9 and folate I will D equal reduced hemoglobin level for red blood cell production so again both of these really work in tandem to help you know those red blood cells properly form.

    And then this was supposed to be uh the nine iron and the golf course and all of that but it turned out to be just grass and sky but think of a nine iron on the 12th hole and uh I think it’ll be a lot easier to remember.

    Again this is for informational purposes only it is not medical advice so if you’ve got a medical condition consult a medical professional. Thanks for listening to the Memorizing Pharmacology podcast. You can find episodes, cheat sheets, and more at memorizingfarm.com. Again, you can sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.com/P/mobile. Thanks again for listening.

    Like to learn more?

    Find my book here: https://geni.us/iA22iZ

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to my YouTube Channel TonyPharmD here: https://www.youtube.com/c/tonypharmd

    Here is the Link to my Pharmacy Residency Coursesresidency.teachable.com

     

    Ep 75 Eye and Ear Pharmacology Mnemonics in 5 minutes

    Ep 75 Eye and Ear Pharmacology Mnemonics in 5 minutes

    Eye and Ear Pharmacology Mnemonics in 5 minutes 

    Find the book here: https://geni.us/iA22iZ 

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to TonyPharmD YouTube Channel here: https://www.youtube.com/c/tonypharmd

    Need more help? You can find many of my mnemonics books on Audible that you might be able to get your first for free if you've never had one before.  https://www.audible.com/pd/Memorizing-Pharmacology-Mnemonics-Audiobook/B07DLGC8MP?source_code=AUDFPWS0223189MWT-BK-ACX0-118296&ref=acx_bty_BK_ACX0_118296_rh_us

    Here is the Link to my Pharmacy Residency Coursesresidency.teachable.com

    A lot of time, eyes and ears get short shrift, but there are a lot of medications that you can readily remember with a few suffixes in this group. 

    Auto Generated Transcript:

    Welcome to the Memorizing Pharmacology podcast. I’m Tony Guerra, pharmacist and author of the Memorizing Pharmacology book series, bringing you mnemonics, cases, and advice for succeeding in Pharmacology. Sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.com/P/mobile. Let’s get started with the show.

    Hey, welcome to the Memorizing Pharmacology podcast. Today we’re going to go over eye and ear infection pharmacology and some mnemonics that can help you. Let’s get started here with what is maybe better known as swimmer’s ear but external ear infection. So when you have an infection on the outer ear then it actually makes sense to just use drops and put something on it. So you can use something that would be an antibiotic that would take care of the infection but also there’s going to be some inflammation so we’ll use some kind of steroid.

    So the medication that we can use is something like Ciprodex which is a combination of ciprofloxacin and the floxacin ending tells us it’s a fluoroquinolone antibiotic. The FL is for fluoro and then the oxygen is for quinolone and then the dexamethasone, we’ve seen that sewn ending before, that’s a steroid for inflammation. Now you do it a little bit differently for a child versus an adult. A child, you’ll put the head horizontally, pull the earlobe down and then apply the drops. So the word child ends in d and then use that for d for down whereas an adult has a u in it and we go adult up.

    So the head will be again horizontal, we pull the earlobe up and we apply the drop. So child down, adult up. When you have a middle ear infection, the drops aren’t going to be able to get to that infection so we need an oral medication. And I remember my daughter had the tubes put in and a physician said okay well you know what this is our week meeting we’ll give her amoxicillin like well she’s already been on amoxicillin for a whole week. It’s like oh all right well what that means is that it is a beta lactamase producing bacteria that is resistant to Amoxicillin.

    So beta lactamase is an enzyme that the bacteria secretes and it destroys the beta-lactam ring and makes it ineffective in penicillin. So just to be clear, the amoxicillin didn’t work for a week, my daughter still had an infection in her ear and it was because the bacteria made an enzyme that basically broke the amoxicillin ring. So we switched to something a little bit different so we cross off amoxicillin and include amoxicillin with something called clavulanate.

    So Augmentin is just that something that augments amoxicillin by itself and what clavulanate does is it kind of has the bacteria attack it instead of the amoxicillin allowing the amoxicillin to do its job. You can do some work with cephalosporins again cephalosporins tend to begin with CEF or ceph so cephachlor which is seclor and cephyroxine which is sinus F those are both second generation or you might see suffixine which is suprax that’s third generation.

    So what we’re really doing with this middle ear infection is it’s a resistant infection we’re going to give what’s quotation figures a stronger antibiotic now why don’t you want to give clavulanate why don’t you just give that in the first place well you want to reserve it for resistant infections but also it tends to cause a lot of GI upset unlike amoxicillin by itself.

     

    Let’s move on to the eyes. There’s really three big conjunctivitises that you have to deal with. There’s the allergic where we kind of put in an eye drop antihistamine is usually a good way to do it. Something viral, we might have to take an oral medication like oral acyclovir or if it’s bacterial, we have lots and lots of eye drop antibiotics. Fluoroquinolones like we talked about with the ear, Amino glycosides Gentamicin Tobramycin, macrolides like erythromycin and then others will see the kind of neomycin type of thing.

    Alright, well let’s start with the allergy eye drops, the antihistamines. There’s just a number of them and there’s not really as good a stem as this although if you’re familiar with Loratadine which is Claritin, you notice olopatadine which is Pat a day then open which looks a lot like ketoprofen which is a non-steroidal but that’s zaditor and then pheneramine. You may remember the chloropheneramine which is color trimeton from a long time ago that was also an antihistamine which is Opticon A or part of afcon A.

    So again, if the patient has allergy eyes we’re going to try to put an antihistamine drop in there. Usually there’s some water, some redness that’s how allergic conjunctivitis presents. We talk about bacterial conjunctivitis, you’re going to get some crud as it were and you’re going to have eye drops and ointments available. You can use the fluoroquinolones again that’s the floxacin stem ciprofloxacin levofloxacin, aminoglycosides Tobramycin Gentamicin, the macrolides erythromycin and azithromycin.

    So again be careful with that mycin stem, a lot of drugs end in mycin and it just means that the streptomyces bacteria was used to actually make the antibacterial and then the other is like neomycin polymixon B and Bacitracin or polymixon B and trimethoprim. So lots and lots of options when it comes to bacterial conjunctivitis. Viral conjunctivitis actually usually clears up in a week or two maybe three weeks at worst. You’ll probably use an oral medication like oral acyclovir if that’s something we’re going to use.

    Well let’s talk about actually instilling the drop itself so you want to tilt the head back while looking up that’s the first thing and this is kind of a natural thing you kind of look up to the sky you tend not to look down you’re going to pull the lower eyelid down and away foreign drops into that pocket then this is kind of the key is that you’re going to and you’ll probably do this automatically you’ll close the eye okay to get those drops in there so kind of four steps here tilt your head back while looking up pull the lower eyelid down and away squeeze the drops into the pocket and then close the eye.

    Again this information is informational only if you have a medical condition contact a medical professional. Thanks for listening to the Memorizing Pharmacology podcast. You can find episodes cheat sheets and more at memorizingfarm.com. Again you can sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile friendly self-paced online pharmacology review course at residency.teachable.com/P/mobile. Thanks again for listening.

     

    Like to learn more?

    Find my book here: https://geni.us/iA22iZ

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to my YouTube Channel TonyPharmD here: https://www.youtube.com/c/tonypharmd

    Here is the Link to my Pharmacy Residency Coursesresidency.teachable.com

    Ep 73 Antiarrhythmics Pharmacology Mnemonics

    Ep 73 Antiarrhythmics Pharmacology Mnemonics

    Antiarrhythmics Pharmacology Mnemonics

    Find the book here: https://geni.us/iA22iZ 

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to TonyPharmD YouTube Channel here: https://www.youtube.com/c/tonypharmd

    Need more help? You can find many of my mnemonics books on Audible that you might be able to get your first for free if you've never had one before.  https://www.audible.com/pd/Memorizing-Pharmacology-Mnemonics-Audiobook/B07DLGC8MP?source_code=AUDFPWS0223189MWT-BK-ACX0-118296&ref=acx_bty_BK_ACX0_118296_rh_us

    Here is the Link to my Pharmacy Residency Coursesresidency.teachable.com

    Antiarrhythmics are usually more of a "can you figure out which class this drug is in" and I give you a number of mnemonics to put the right drug in the right place. 

     

    Auto Generated Transcript:

    Welcome to the Memorizing Pharmacology podcast. I’m Tony Guerra, pharmacist and author of the Memorizing Pharmacology book series, bringing you mnemonics, cases, and advice for succeeding in Pharmacology. Sign up for the email list at memorizingpharm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.com/P/mobile. Let’s get started with the show.

    Alright, we’re going to go into antiarrhythmics or antidysrhythmics is really more correct pharmacology mnemonics and the first step is really to see where these are. You’re going to hear class one usually with Roman numerals rather than these kind of numbers but class 1 sodium channel blockers. Class 2 is the beta blocker, class 3 are potassium channel blockers, class 4 calcium channel blockers and class 5 are kind of the unknown or extras. Beta blockers and calcium channel blockers may be familiar from hypertension drugs but these other ones might be a little bit new.

    So there’s Vaughn Williams which is how we kind of classify these and usually your questions are going to be in some way you have to know what the sodium channel blockers are or which ones are potassium channel blockers. So we’re going to do a couple of mnemonics to just kind of get you knowing what’s what and then we’ll go from there.

    So, I made up a little story: NAB money in Kansas City, police are mad. A way to remember that number one is NA which is it’s actually for natrium but it’s sodium so sodium channel blockers and then the B in NAB and you can put two B’s here to make it more clear that it’s going to be beta blockers. And then Kansas City represents three and four which are going to be potassium which is calcium or calium that’s the K and then CA are the calcium from calcium channel blockers so NAB KC and then mad. The others that are kind of in this fifth group are magnesium, adenosine, and digoxin.

    That’s kind of one way to do it. Another way is to maybe make a sentence like some block Kings and castles with mad moves. So the sum is for sodium okay and that would be NA plus block would be for beta blockers. K would be for potassium and kings CA from castles would be calcium channel blockers and then mad moves. The Mad represents the Magnesium, adenosine, and digoxin.

    I’ve got a little picture here of a king and a Castle in chess okay so two different ways to remember those but some students have to remember like all of them like a lot of the drugs within the classes so the class ones actually divided up into class one A, one B, and one C.

    Traditional way to remember this is Double Quarter Pounder with lettuce tomato mayo and more fries please so class 1A is disopyramide, quinidine, procainamide that’s the Double Quarter Pounder. The lettuce tomato Mayo is class 1B lidocaine, mexiletine, tocainide and then class 1C more fries please is moricizine, flecainide, propafenone.

    So if you have to remember all of those then hopefully this is helpful and then we kind of add the other ones so a beta blocker. The nice thing is that the endings are the same so it’s like bisoprolol, atenolol, metoprolol ending with the OLOL. I just put the three Bam Bam for bisoprolol atenolol metoprolol you can think of Class 2 because they are they are you know have two B’s in beta blocker to remind you that’s class two.

    Class three is potassium blockers: The sad poets so sad is for sotalol amiodarone dofetilide and The Poets is for potassium to remember that one, class four is the calcium channel blockers with four very dill pickles. So it’s class four and the Very Dill stands for verapamil and diltiazem. Okay, and then the class five, the Mad group is magnesium, adenosine, and digoxin. So if you have to remember all of them, this is a way to do it. So we can do a little quiz here, make sure that you’ve got this down. So on the left I have sodium, beta blockers, potassium, calcium channel blockers, and then the unknown. And then adenosine, procainamide, metoprolol, diltiazem and amiodarone are not in the right order.

    So how do we get the right order? Well we think about our mnemonics here and our sodium again it’s going to be that Double Quarter Pounder so the P from procainamide. The beta blockers end in OLOL so that’s group two and again two B’s to remind you it’s group two. The potassium is going to be that sad poet and the A in sad poet is amiodarone. Then our four very dill pickles are the diltiazem and the verapamil that’s four. And then the Mad group is adenosine so that magnesium adenosine digoxin that’s in our fifth group.

    And so it would look like this if the answers are correct. Okay so let’s just take a look at some of the characteristics of some of these. So for example if you’ve got group 1A procainamide this is the P in the Double Quarter Pounder it’s good for atrial fib supraventricular tachycardia vtac it’s really chemical cardioversion our mechanism is sodium and hypotension is really the big one here can cause a wide QRS but if we have hypotension as an adverse effect we probably don’t want to give it to a hypotensive patient then congestive heart failure second third degree heart block all of these would be contraindications.

    And then what are we going to do? Well we’ll make sure to watch their labs and then an ECG would also be important as well so that’s procainamide. Get to amiodarone now we’re talking about ventricular fibrillation rather than atrial fibrillation resistant v-tac you can give it for atrial and ventricular dysrhythmias but that’s probably where you would put it potassium is our mechanism again this is group three we kind of skipped over the beta blockers.

    And there’s a number of things that you’re going to have with adverse effects you really want to tell the patient about first the hypotension so just get that blood pressure just kind of dropping blue facial hue I couldn’t use the Blue Man Group because those guys are actually a thing so I just found this picture of and I thought it was clever that they’re kind of pacing and waiting in line and they’ve got blue faces and well blue bodies too and then vision changes.

    So while it’s kind of tough to say well what does vision change look like having this rainbow iris just kind of reminds you that vision changes so hypotension blue facial hue and vision changes bradycardia and shock are really contraindications for this one. And then what do we want to monitor? We want to make sure to put cardiac monitor on and modified valsalva maneuver has just proven to be a bit better.

    And then the Valsalva if you aren’t familiar with it it’s where you kind of plug your nose to pop your ears alright so again this is informational purposes only it’s not medical advice if you have a medical condition contact a medical professional.

    Thanks for listening to the Memorizing Pharmacology podcast. You can find episodes cheat sheets and more at memorizingpharm.com. Again you can sign up for the email list at memorizingpharm.com to get your free suffixes cheat sheet or find our mobile friendly self-paced online pharmacology review course at residency.teachable.com/P/mobile. Thanks again for listening.

     

    Like to learn more?

    Find my book here: https://geni.us/iA22iZ

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to my YouTube Channel TonyPharmD here: https://www.youtube.com/c/tonypharmd

    Here is the Link to my Pharmacy Residency Coursesresidency.teachable.com

    Ep 72 ABCD Antihypertensive Mnemonics ACEIs ARBs Beta and Calcium Channel Blockers Diuretics

    Ep 72 ABCD Antihypertensive Mnemonics ACEIs ARBs Beta and Calcium Channel Blockers Diuretics

    ABCD Antihypertensive Mnemonics ACEIs ARBs Beta and Calcium Channel Blockers Diuretics

    Find the book here: https://geni.us/iA22iZ 

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to TonyPharmD YouTube Channel here: https://www.youtube.com/c/tonypharmd

    Need more help; you can find many of my mnemonics books on Audible that you might be able to get your first for free if you've never had one before.  https://www.audible.com/pd/Memorizing-Pharmacology-Mnemonics-Audiobook/B07DLGC8MP?source_code=AUDFPWS0223189MWT-BK-ACX0-118296&ref=acx_bty_BK_ACX0_118296_rh_us

    Here is the Link to my Pharmacy Residency Coursesresidency.teachable.com

    Hypertension treatments are really about a few drug classes: ACEIs and ARBs, Beta Blockers, Calcium Channel Blockers, Diuretics, and a few more. This episode has a few mnemonics and a focus on prefixes and suffixes that will help you remember them. 

     

    Auto Generated Transcript:

    Welcome to the Memorizing Pharmacology podcast. I'm Tony Guerra, a pharmacist and author of the Memorizing Pharmacology book series, bringing you mnemonics, cases, and advice for succeeding in Pharmacology. Sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.com/p/mobile.

     

    Let's get started with the show. I'm going to go over anti-hypertensives in a way that hopefully makes a bit of sense. It's actually easier to compare them side by side with a bunch of these and I'll get into that, but let's start with what the ABCD of hypertension really is. Okay, so it's just talking about the drug classes: ACE, ARBs, the Alpha One blockers, the beta blockers, calcium channel blockers, and diuretics. Let's start with A, B, C, and D and there's going to be some oddball ones that I'll talk about at the end.

     

    The alpha agonists like clonidine, methyl dopa, the dilators that will peripheral vasodilators hydralazine nitropresside and then the direct reading inhibitor Alice Kirin but these are going to be the kind of heart and soul of our anti-hypertensive therapy and what you'll notice is that stems go really well with these. So when I say stems I mean the endings these in these cases they are all suffixes but for Angiotensin converting enzyme Inhibitors it's pril as in lisinopril.

     

    Angiotensin II receptor blockers it's sartan. The Alpha One blocker is as a sin be careful I've seen zosin a lot it's azosin but again that'll get you there too which is a little bit different than tamsulosin we'll talk about the differences in a minute. Beta blockers again be careful first and second Generations have the same stem of olol and that third generation will have something that kind of indicates there is an alpha blocking component uh the alol with labetalol or the dilol for dilation with Carvedilol.

     

    Calcium channel blockers we divide them into dihydropyridines like nifedipine or non-dihydropyridines which are diltiazem and Verapamil. Then the diuretics really furosemide is not for hypertension in general really it's Hydrochlorothiazide that's first line and then the potassium sparing diuretics but Hydrochlorothiazide is definitely preferred.

     

    So when we talk about being able to recognize them that's kind of the first thing you want to be able to do is make sure that as you look at these endings you can recognize all these but what we'll do is we'll kind of cut it down so that makes a little bit easier. I know this seems a little bit busy but soon enough you'll be able to get all of these.

     

    Okay alright well let's just look at what first line is first line are the Angiotensin converting enzyme Inhibitors like lisinopril and the ARBs like losartan. Calcium channel blockers like nifedipine, diltiazem, Verapamil though calcium channel blockers are first line in African Americans because of poor outcomes with ACE inhibitors. Then diuretics Hydrochlorothiazide is certainly first line.

     

    So let's take a look at the renin Angiotensin aldosterone system some people call it renin or the RAS system. The big thing is recognizing what happens here in this pathway and we'll put three of the drugs in here so lisinopril that works here at ACE where Angiotensin one cannot become Angiotensin II if you block this enzyme why does that matter well Angiotensin II is a potent vasoconstrictor and it also acts to release aldosterone which would normally hold on to salt and water so if you block Angiotensin II you vasodilate instead of vasoconstrict and you don't stimulate these release of aldosterone so you're not holding on to salt and water okay increasing blood pressure so the ultimate thing that happens is that you decrease blood pressure okay.

     

    And this happens with lisinopril by blocking this enzyme here or with Losartan which is an Angiotensin II receptor blocker I'm actually blocking the enzyme itself okay or The receptors on the enzyme and then Alice Kiran that blocks renin directly right at the beginning but for whatever reason the outcomes were not what we wanted so this is definitely not a first line drug but the first thing is recognize the medications by their stems recognize they have different mechanisms of action within the RAS system and then we'll combine them to look at them side by side so what I do is I take the one that has something more and put it on the left and I have something that has something less and put it on the right.

    So, with the ACEs and ARBs, when we go through our eye match mnemonic, we see that I have similar indications: hypertension, congestive heart failure, MI. But when we get to the adverse effects, we see that really the taste, some irritation of the throat, the cough, that's really Angiotensin converting enzyme inhibitors, not really so much Angiotensin II receptor blockers. So when you get there, you're like okay well let me cross that one off on the right and so I'm just remembering one set of things and then one difference. And we'll see that this happens over and over again with our ABCD.

     

    So Angiotensin converting enzyme inhibitors, that's the one that causes that taste, the throat, the cough and it sure it causes angioedema, it causes hyperkalemia. But we switch to an ARB because it doesn't have that issue with taste, the irritation of the throat, the cough and those things. So understanding how those work side by side is critical.

     

    Okay when you look at contraindications which you would think if you have other potassium sparing medications like spironolactone diuretic or pregnancy certainly a contraindication as well that's out. And then really it's just letting the patient know hey you know if you get this dry cough don't try to treat it let us know we can give you something that won't cause that and then maybe talking about the foods and other things that might add to the hyperkalemia.

     

    Alpha blockers we talked about before and we'll just kind of go through the three parts of it where in the beginning we talked about the stem, the azosin stem of prazosin doxazosin terazosin all very similar. And we used the prazosin mnemonic using the word prazosin to remind ourselves of the three indications: prazosin - the pr for prostate or BPH; raz to remind us is for Raynaud's which is when your fingers are really cold or your toes are really cold because just not enough blood getting to them; and then hypertension. And we looked at the last s-i-n for that and it does this by relaxing the bladder neck for prostate and by causing vasodilation for Raynaud's and hypertension.

     

    But the adverse effects come from that vasodilation so I have a picture here of somebody who's kind of a little bit shaky that's getting that maybe first dose effect where first time they took it they didn't realize they were supposed to take it right before bed so they don't fall down. I really feel that reflex tachycardia or orthostatic hypotension or first dose syncope or first dose phenomenon but again big mechanism of action here is that vasodilation.

     

    Okay and then you put them side by side and you see that prazosin is actually second line for hypertension because of that adverse effect that they might just drop so we don't want to give something like that so BPH right now it's hypertension those are certainly indications but when you look over on the other side and take something like tamsulosin or alfuzosin that are really only for BPH it's first line for that condition because it's really not going to cause that kind of first dose syncope phenomenon hypotension all that stuff to the same extent.

     

    So what we do is we take the mechanism and we say okay we're going to have the same Alpha One bladder smooth muscle and vasodilation of blood vessels and maybe we darken out that vasodilation of blood vessels to make clear that we're really being a lot more selective okay in both cases. The elderly is a concern coronary artery disease certainly and then we want our patients to be slow to get from sitting to standing okay.

     

    Beta blocker stems we talked about how the first generation affects beta 1 beta 2 again you have one heart so it affects the heart reduces heart rate but also it affects the lungs it may cause some degree of bronchoconstriction. And so Propranolol is a concern with asthmatic but with the second generation it was beta one specific and we have our bam mnemonic where bisoprolol Atenolol metoprolol these are three of those drugs that are in the second generation.

     

    And then third generation was our Carvedilol and our labetalol which are also non-selective but not in the same way as Propranolol because they also have Alpha One activity so that allows for vasodilation okay because what the body is going to do is as soon as it sees heart rates going down it's gonna try to vasoconstrict because it wants to get heart rate back or blood pressure back up. And so Alpha One blocking takes care of that by causing vasodilation again. The dil or dial is in that stem so when you compare them side by side first versus second you see very similar in terms of what they do.

    Hypertension, migraine, and China atrial fibrillation again, beta blockers are an antiarrhythmic. Okay, but again the mechanism is that we block beta 1 and beta 2 receptors so our adverse effect with beta 1 would be bradycardia. Our adverse effect with beta 2 would be bronchoconstriction. Okay, and so we take that bronchoconstriction one and beta 2 away when we get to the second generation. Now again we can cause bradycardia, heart block have are bradycardia, heart block are certainly contraindications but also asthma with first generation not so with second generation. And then they all really do mask those signs and symptoms of hypoglycemia so we want to be careful with our diabetics.

     

    Get to the calcium channel blockers, the C in our ABCD mnemonic here we really need to separate the dihydropyridines from the non-dihydropyridine. So the non-dihydropyridines affect both vasodilation and the heart so diltiazem which is Cardizem and Verapamil which is Calan versus dihydropyridine which is dilation only so the dipine the dilation only the nifedipine or Procardia XL all these D's try to use that to remember that this is just affecting the artery it is not affecting the heart as an antiarrhythmic.

     

    Okay, and so when you put them side by side you would put the non-dihydropyridines here and what you want to do is show that okay hypertension angina they're both good for that but these two are good for atrial fib because it does affect the heart nifedipine is not they both block calcium channels in the smooth muscle but still diltiazem of rap milk are going to have decreased contractility and heart rate both will cause hypotension peripheral edema and constipation but here bradycardia is the issue and here reflex tachycardia is the issue.

     

    So again that vasodilation, the body's not happy with that and it's going to cause the heart sometimes to increase the heart rate which may seem counterintuitive. Again watching out for the elderly and grapefruit juice can be an issue with both of these.

     

    Okay, we talked about diuretics going from left to right uh you know figure out what goes where but with hypertension we're going to take some of them away. We're going to take the PCT ones away because those are for emergency conditions and then we're going to kind of focus on first the thiazides which are first line and then talk a little bit about Loop potassium sparing which are second line.

     

    Okay so first line you just cross everything else off really. The distal convoluted tubule with the thiazides especially Hydrochlorothiazide that's our really first line for hypertension and we'll probably combine this with triamterene as the form of Dyazide.

    "So, we have the hypo and hyperkalemia kind of balancing itself out, but that’s first line. Then we sure can take a look at maybe the potassium sparing diuretics: spironolactone, amiloride, triamterene, eplerenone. But really those and the loop diuretics (furosemide, torsemide, bumetanide) are definitely not first line for hypertension. Okay, alright. So Hydrochlorothiazide again, not only for hypertension but also edema. It blocks that sodium and water reabsorption in the distal convoluted tubule. We’re worried about hypokalemia with Hydrochlorothiazide and also that hyperuricemia if gout is an issue. Watching again for that sulfa allergy and then just making sure that the electrolytes, the labs are all on the up and up for the patient.

    Generally, we might pair certain diuretics with other potassium sparing diuretics to make sure that we don’t have that hypo or hyperkalemic effect. But note that when you do block aldosterone especially with spironolactone, you do have that issue with gynecomastia. Certainly if you’re going to have that maybe you’re going to have decreased libido. Those types of things come along with giving something like spironolactone when you’re going to block that aldosterone hormone. Okay, but again we’re talking about diuretics really that Hydrochlorothiazide is going to be our preferred medication.

    There are some oddballs and usually it’s just here’s a thing or two to remember about each one. The alpha agonist clonidine, we talked about how that really suppresses that norepinephrine outflow so you get that reduction in blood pressure but that can be terribly sedating and causes tremendous fatigue. Methyldopa is one of the ones that we can consider with pregnancy in certain situations.

    The peripheral vasodilators so hydralazine again maybe for an emergency or with pregnancy and then Nitroprusside is another dilator but a really strange toxicity to have that cyanide toxicity going along with it.

    And then the renin inhibitor aliskiren, that’s the one where we’re really worried about where we’re in the RAS system and it’s the area where the ACE inhibitors are and the Angiotensin II receptor blockers. This aliskiren works at the very beginning and just blocking renin altogether but we’ve just found that that’s really just not the way to go in practice.

    Again this is just informational purposes only if you’ve got a medical condition consult a medical professional. Thanks for listening to the Memorizing Pharmacology podcast. You can find episodes, cheat sheets and more at memorizingpharm.com. Again you can sign up for the email list at memorizingpharm.com to get your free suffixes cheat sheet or find our mobile friendly self-paced online pharmacology review course at residency.teachable.com/P/mobile. Thanks again for listening.

     

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    Ep 71 Statins and More (gemfibrozil, fenofibrate, niacin, ezetimibe, cholestyramine, PCSK9)

    Ep 71 Statins and More (gemfibrozil, fenofibrate, niacin, ezetimibe, cholestyramine, PCSK9)

    Statins and More (gemfibrozil, fenofibrate, niacin, ezetimibe, cholestyramine, PCSK9)

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    Hyperlipidemia treatments are really about statins and then what to do if that doesn't work. This episode has a few mnemonics that will help you remember them. 

     

    Auto Generated Transcript:

    Welcome to the Memorizing Pharmacology podcast. I’m Tony Guerra, pharmacist and author of The Memorizing Pharmacology book series, bringing you mnemonics, cases, and advice for succeeding in Pharmacology. Sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.com forward slash P forward slash mobile. Let’s get started with the show.

    Okay, today we’re going to talk about statins and more. Statin is an HMG COA reductase inhibitor that will be important as we kind of go through here, that’s how it works. I’ll focus a lot on the statins but I’ll also talk about some agile therapy as well or some other choices.

    So really what we’re talking about here is atherosclerosis and coronary artery disease and you’ve probably had physiology where you start with that normal artery and you get that fatty streak, you get a plaque and then a complicated plaque. So statins do a good job of lowering LDL and we can use l for lousy cholesterol or bad cholesterol and move cholesterol from the plaque to stabilize it. Now the evidence is a little bit weak in terms of you know making a plaque smaller but again it stops the madness I guess you would say.

    Okay, we’re always looking for lifestyle changes. I use the mnemonic changer Fates so increase fiber, increase food that’s good for you, decrease fat, decrease alcohol or stop Tobacco Stop alcohol exercise gotta increase exercise and then decrease your sodium. So again really the lifestyle changes are the first place that we go but um there are so many good medications for hyperlipidemia that we just go through them now.

    Okay so HMG-COA reductase Inhibitors let’s start with the suffix it’s vastatin be careful you’ll probably hear Statin a lot of times and that’ll usually get you by but for example if you look the bottom right Nystatin is not for lipids It’s actually an anti-fungal so just be careful with that.

    We’ll talk about this division in a second about how really you can use atorvastatin resuvastatin which are Lipitor and Crestor at higher Doses and then you can use them at lower Doses and that actually means something. And then just like you’re going to have to worry about lfts the liver function tests the other drugs are lfps so Lovastatin fluvastatin pravastatin and Simvastatin.

    Alright so let’s just talk about high intensity versus moderate intensity high intensity are the atorvastatin at greater than 20 milligrams and rosuvastatin is at 40 milligrams because once we start increasing those dosages we’re really worried about that myopathy that we’re going to get and liver issues and we’ll talk about adverse effects in a minute but just know that if the patient is more fragile we would use something moderate intensity if they’re less fragile high intensity.

    Uh so Lipitor I’m guessing that they were thinking like lipid Gladiator so this is the lipid lion uh that is being slain by the HMG co-a how do we figure out high intensity versus moderate intensity uh we’re really looking at the clinical atherosclerotic cardiovascular disease abbreviated As ascvd and we’re worried about peripheral artery disease myocardial infarction heart attack or a cerebrovascular accident.

    So if the patient is greater than 75 we’ll probably go moderate if they’re less than 75 we might go high intensity if their LDL is greater than 190 we’d go high intensity if they’re diabetic 45 to 70 and their ascvd score is less than 7.5 percent then moderate and then higher than 7.5 high intensity.

    And then 45 to 70 we would go greater than 7.5 percent moderate intensity so again it’s really just figuring out what their risk is of a coronary event and how these medications can help um you might see a bunch of Statin mnemonics there are a number of things that you kind of want to watch out for with statins uh first s skip the grapefruit juice there is an issue with so the grapefruit juice increases the Here is the corrected version of your text:

    “Statin level in your body and um some they say that some statins don’t have this effect and some do but you’ll be hard-pressed to not find somebody that’s going to say just go ahead and skip the grapefruit juice. The big one is toxic to muscles and joints and maybe Rhabdomyolysis is an unfamiliar term but if you work out too much too fast this will happen as well but it can be toxic to the muscles and joints and really it’s myopathy that we’re going to see first. A for alt AST monitoring so the lfts or liver function tests for liver injury uh and then T tints the eyes yellow uh again kind of going from that liver injury. I how does it work well it for lack of a better term it just inhibits cholesterol production and then n um one of the add-ons that we’ll talk about is niacin which is an add-on when the triglycerides are just not getting lowered enough so s skip grapefruit juice T toxic to muscles a a l t a s t t 10 size yellow I inhibits cholesterol production and niacin add-on for triglycerides uh atorvastatin or Lipitor it’s this is our big dog uh so hyperlipidemia and cardiovascular risk is the indication and mechanism it is an hmg-coa reductase inhibitor so the big things that we’re worried about are this that muscle myopathy that Rhabdomyolysis which is uh you know progression from the myopathy and then the yellowing eyes which comes from a progression from the liver issue so contraindications would be liver disease pregnancy and then the things that you really want to watch for as a healthcare professional you know so looking for that myopathy and I just put the Three L’s so you can think about lifting weights so it’s really more about the muscles than lifting weights lifestyle and the lfts uh Jim fry Brazil and which is lopid and fenofibrates tri-core these are not statins but they’re really important because they’re also good for hyperlipidemia and high triglycerides especially and so they can decrease cholesterol production and they can also cause myopathy Rhabdomyolysis and then the liver issues and especially with gemfibrazil we’re going to see that myopathy effect is more additive so when you have someone on a Statin engine for Brazil you’re going to see that that myopathy more often uh contraindications well liver disease and pregnancy and then again the The Three L’s the lifting the lifestyle and the lft is really just a way to remember the muscles are part of all this so the next piece we get to is kind of that combination therapy and we say okay well we haven’t decreased their LDL enough so it’s a Statin and so maybe it’s a Statin and niacin okay so niacin blocks the enzyme for making cholesterol and this would be good if we’re you know have those elevated triglycerides but also LDL to some extent uh the big thing with the niacin is that flushing and you can give the aspirin 30 minutes prior and then maybe exacerbation of gout because of its effect on uric acid so adding fluids uh blocking cholesterol absorption so acetamin or zedia against four cholesterol but it’s an absorption inhibitor so both acetamine and cholesterolamine those are going to block that cholesterol absorption and you’re going to see myopathy but with that blocking of cholesterol absorption you’re also going to see fat soluble vitamins D, E, A and K are going to be blocked as well. I always thought of it as a person named Deke, D-E-A-K, that’s how I remember the fat soluble vitamins but blocking those vitamins in addition to the cholesterol is a concern. Then cholestyramine which is question, this is not only for cholesterol but also if you have chronic diarrhea this can work as a bile acid sequesterant and again that the Deep vitamins are an issue here because it is blocking um those that cholesterol absorption blocks the enzyme that regulates the number of cholesterol receptors. So the reason I said it that way was because the real name is proprotein convert a subtilicin kexin type 9 which we abbreviate for good reason as PCSK9 Inhibitors so allerocumab which is probably and evolokumab which is repatha both of those are monoclonal antibodies that we would use for a specific type of cholesterol issue they’re like Uber expensive like super expensive combination therapy. So if we’re now trying to decrease triglycerides rather than LDL we would add the niacin for Brazil again just the way that they work they do a good job with those triglycerides and if we’re thinking of decreasing triglycerides and increasing HDL or just increasing HDL again niacin gem for Brazil are our choice there. So um kind of brings us back to this last slide which is a really expensive situation where somebody does need one of those PCSK 9 Inhibitors or they’ll go through the Rems to get them if omersin these are for familiar familial hypercholesterolemia so if somebody fails the high high dose statins then the alarokimab and evolution might be something you add on and then nipomeracin requires a Rems because of its liver damage but it works way differently it just binds to the messenger RNA of this really important protein LDL and VLDL and fails to translate so you get less of it but okay so again this is for informational purposes only it’s not medical advice if you have a medical question contact a medical professional. 

     

    Thanks for listening to the Memorizing Pharmacology podcast. You can find episodes cheat sheets and more at memorizingfarm.com. Again, you can sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.com forward slash P forward slash mobile. Thanks again for listening, sure.

     

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    Ep 70 OTC Cough and Cold

    Ep 70 OTC Cough and Cold

    OTC Cough and Cold 

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    Cough and Cold treatments really don't have a ton of medications, and this will episode will help you remember them.

    Auto Generated Transcript:

    Welcome to the Memorizing Pharmacology podcast. I’m Tony Guerra, pharmacist and author of the Memorizing Pharmacology book series, bringing you mnemonics, cases, and advice for succeeding in Pharmacology. Sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.com forward slash P forward slash metal games. Let’s get started with the show.

    Alright, welcome to OTC allergy cough and cold. We’ll go over antihistamines, decongestants, nasal inhalers, expectorants, cough suppressants, and analgesics but it’s an amazingly small number of medications with all of these different lists. So let’s start with antihistamines and we need to talk about the antihistamine snowman first to make sure we know what antihistamine we’re talking about.

    So we’re talking about H1 antihistamines versus H2 antihistamines. So an H1 antihistamine and this snowman has one nose our allergy antihistamine it’s like diphenhydramine which is Benadryl or Loratadine which is Claritin. So when we say antihistamine we’re thinking H1 but technically an H2 antihistamine and that’s why we have two buttons at the stomach our H2 blockers so they’re also antihistamines but we don’t call them that.

    And so famotidine which is Pepcid and now zantac’s brand name has taken famotidine which has always been Pepcid cymetidine and Tagamet nicetidine and acid for acid reduction. So just to be clear the antihistamines we’re talking about are the ones in the nose in this particular video.

    So let’s talk about the first versus second generation. The first generation is diphenhydramine or Benadryl and if you’ve ever gotten Tylenol PM that’s the PM part of it so Tylenol PM is actually two different drugs chlorpheniramine or Chlor trimeton is one that we don’t use a ton anymore uh it only lasted about four hours but it used to be in packages when you had some kind of really bad allergic issue they make you super sleepy so really not a good thing especially if you’ve got someone driving or somebody does driving for a living.

    So the second generation came along and what you’ll notice is that each one of these has a pair so the second generation non-drowsy antihistamines were loratadine and then when that went off patent all of a sudden destler adidine showed up which is Clarinex so Claritin declaren X when cetirizine’s packet patent went away levocetirizine comes along which is xyzel the owl if you’ve seen the commercials and then terphenidine was removed from the market because of cardiac issues but Fexofenadine which is the safe metabolite is Allegra.

    So those are our five second generation antihistamines that we use. So let’s take a look at Benadryl or diphenhydramine and it’s again we’re going to use the eye match mnemonic so indication mechanism adverse contraindications and what a healthcare professional should do to make it so that’s easier to take.

    So allergy and insomnia that’s the indication. The mechanism well it’s an H1 antihistamine so it’s first generation though so it’s also going to have anticholinergic effects that’s going to be important for adverse effects. So as we’ve kind of gone into really a lot of depth anticholinergic was our Bud cat so the drowsiness dry mouth confusion and there’s a paradoxical effect where in young children a lot of times it’ll actually make them hyper instead of tired so confusion is a little bit of an addition to the mnemonic I’ve used before.

    So uh angle closure glaucoma that’s one of the contraindications and then on the beers list so we want to avoid it in the elderly because of that drowsiness and confusion and we don’t want to have Falls and things like that. So A couple mnemonics some people call it better drill because you’re so tired and then no dryfin hydramine so no driving hydramine reminds you not to drive on this one.

    Claritin and alivert levocetirizine which is xyzel Fexofenadine which is Allegra these tend to be the popular ones now. The ones that have kind of Taken hold. So in terms of indication it’s all the same thing it’s all an allergy they’re all H1 blockers they’re all second generation not sedating and they really in terms of adverse effects and contraindications we really don’t have a ton there but you really do want to tell them to prophylax before allergy season not wait until allergy season and say okay we’ll take your antihistamines if you know allergy.

     Season is coming, go ahead and get on that regimen right away. So Loratadine has the adidine ending, be careful that’s a little bit close to t-i-d-i-n-e which is the H2 blocker so it’s famotidine and so forth. Uh levocetirizine or even cetirizine if you take that TIR make it a tear to remind you that it’s allergy eyes, it’s the saddest owl I could ever find. And then Allegra if you put the r here it makes a-l-l-e-r-g change the a to a y and you have allergy. So I got paid a million dollars to figure that out, I want to be that guy.

    Alright let’s go to the next one Alpha One Agonist and vasoconstriction like what’s going on? I thought we were just doing OTC stuff. Well an alpha one Agonist you’ll probably know pseudoephedrine which is Sudafed, oxymetazolin or oxymetazoline sometimes I hear is Afrin and then phenylephrine which is neo-sinephrine. The big difference is pseudoephedrine is something you take every day or you can take daily, it’s a tablet whereas oxymetazolin and phenylephrine are both inhaled or nasal inhalers and that’s going to make a really big difference when it comes to some side effects in terms of those.

    And I always use the pop mnemonic so just like your ears pop on the plane nasal congestion just think of a big pop once that nasal congestion goes away. So pseudoephedrine starts with a P, oxymetazoline with an O, phenylephrine with a p going on the pseudoephedrine um.

    So let’s start with what it’s for sinus congestion and it can be used as an adjunct in allergic rhinitis. It does have that alpha-1 vasoconstriction but the problem is it’s systemic versus that nasal which is a little bit more local so we’re going to get that anxiety and insomnia just kind of a restlessness that comes along with it.

    So the contraindications and I’ve got this little hand holding a heart so it’s angina coronary artery disease closed angle glaucoma hypertension all these things are really things you don’t want to have if you’re going to be taking pseudoephedrine. And the way that I think about all the adverse effects I just think of energy drinks if you have one too many energy drinks anxiety insomnia restlessness that’s pseudoephedrine.

    And then the next ones we’ll see in a second so watch out for any other stimulants that might interact with Sudafed. Okay oops next one here is oxymetazoline which is Afrin and phenylephrine neosinephrine we’re going to see it’s the exact same thing as sudafed or Pseudoephedrine with the i the M the a except we have something called rebound congestion.

    So around three to five days you might get rhinitis medicamentosa rhinitis medicamentosa is where and I’ve got this picture here of somebody who has congestion, the word breathe because now they can breathe they’ve taken their medication the phenylephrine and oxymetazolin and now they’ve got it again. So the rebound congestion that’s something that is really inherent to these and nasal inhalers contrasting the Sudafed or the pseudoephedrine tablets.

    Fluticasone mometasone we see that sewn ending so common with many of the steroids these are nasal versions of it so with those oral versions we’re always washing our mouth out to make sure that we don’t get candidiasis we don’t get dysphonia which is that hoarseness or difficulty speaking.

    So looking at the names, the brand names kind of give it away Flonase and Nasonex but they’re both for allergic rhinitis they’re both anti-inflammatory steroids. The adverse effect tends to be a dry nose and nosebleeds infections like TB and varicella are something that we really want to avoid reducing the immune response.

    And then you really want to use this daily as soon as that allergy season starts so it takes about three to four days to see that optimal effect and we do want to watch growth rate because it is a steroid after all. So they’ve got a guy here looking at his clock like I don’t understand when I took the oxymetazolin, the Afrin my nose was cleared in a couple minutes well it’s going to take a couple days with these guys.

    Alright dextromethorphan so this is the D and M so the dextro makes the D, the methorphan makes the m in Robitussin DM or Mucinex DM, they both have the same ingredients, the dextromethorphan part. Okay, we’ll get to the guaifenesin in a minute, that’s the cough suppressant for a non-productive cough. Okay, it works in the medullary cough Center and it can get that CNS toxicity, dizziness or something called robocopping that if you use it illicitly. Hepatitis is a contraindication and really what you want to try to do is stop that cough from happening in the first place, a cool humidifier can sometimes do that. You might call it instead of dextromethorphan, you might call it dry cough methorphan because that’s really what you want is if that’s a dry cough it’s not really producing anything uh dextromethorphan is your man.

    Okay guaifenesin so this is Robitussin or Mucinex with or without the DM so without the DM it is just guaifenesin with the DM it’s guaifenescent and dextromethorphan. So I want to make clear this is an expectorant we’ll talk about a mucolytic in a minute so this is an expectorant for mucose secretion that loosens and thins the phlegm makes it easier to expectorate. Adverse effects are just less common same with contraindications and really it’s just if you have that cough for a week maybe you should see a physician or a provider and I’ve just got a picture of kind of some slime here and exit for expectorant uh and I’ve heard it sometimes called Green flemisin instead of guaifenesin just kind of an easier way to remember what this thing does.

    Okay acetylcysteine now this is a mucolytic now this is not over the counter but what I wanted to do was contrast it because sometimes you’ll see that they say guaifenesin is a mucolytic, it’s an expectorant. So acetylcysteine though the actual utility in cystic fibrosis is somewhat unclear cystic fibrosis acetaminophen overdose those are two uses we would have for acetylcysteine or muco Mist. It is mucolytic and it loosens those bronchial secretions if you inhale it and then it replenishes the glutathione in the liver from the acetaminophen metabolites so if you’re doing those kinds of chemistry in your particular pharmacology class that’s really how it protects it against an acetaminophen overdose.

    Nausea and vomiting are adverse effect as well as you know you just want to be careful with asthma maybe a GI bleed or something like that and then there’s a poor taste when it’s inhaled. So the way to remember acetylcysteine is for Cystic Fibrosis is we have this cyst in cystic fibrosis and then when you look at acetyl you take the acetyl group and you think about n acetyl paraaminophenol what is an acetyl peraminophenol well that is acet amino fin okay so that’s the whole chemical name or APAP if you’ve had it abbreviated before okay uh so this is just a bigger picture of it if you want to see kind of how the cystic fibrosis compares to a healthy lung.

    Alright ibuprofen so Advil and Motrin and then the naproxen is the Aleve pain fever and inflammation this is important because we’re going to contrast it with acetaminophen in a minute mechanism. It’s a non-steroidal anti-inflammatory drug and NSAID so non-steroidal is just a way of saying it’s not prednisone but it’s an anti-inflammatory, it’s cycloxygenase inhibitor and we’re not going to get into the weeds with that right now. If you want to talk about Celebrex and celecoxib, you can kind of get into the weeds when you start putting in prescription drugs but GI distress, ulceration certainly adverse effects especially if you used a long term. If you have any kind of an allergy to aspirin or stomach ulcer, heart failure, liver disease this really tends to hold on to fluid and those are conditions where you really don’t want to hold on to fluid.

    And then always mentioning take it with food, it does tend to upset the stomach. So one contrast is well when do I take Ibuprofen when do I take them peroxin well ibuprofen you have to generally take like four times a day where an approxen maybe two times a day or three times a day so that tends to be it. And then I had a pretty decent graphic about peptic ulcers and then here is a larger version if you wanted to look at that uh just kind of explaining what’s going on we didn’t talk about helicobacter pylori which is really the causative factor in many ulcers but that’s getting into prescriptions and triple and quad therapy which we will not.

    Alright last one here is going to be acetaminophen or Tylenol. You’ll notice that in the indications it has pain and fever just like ibuprofen but the inflammation is missing so that’s the one question you get over and over again. It’s a non-narcotic analgesic and it’s just really liver damage, liver conditions that’s really one place we really want to be careful.

    And then watch for overdose with RX meds and what I mean by that is maybe somebody’s on something called Vicodin and there is acetaminophen in it and then they’re taking Tylenol over the counter or they’re maybe taking some combination cold product that has acetaminophen in it. Really you don’t want to go over 3 000 milligrams in a day, you know the upper end is 4 000 but you really want to be careful there.

    So n acetyl peroaminophenol that’s how we made acetaminophen or APAP and then here are the stages of liver damage and I just wanted to have it up here so that if that’s something you wanted to kind of go through you could. And then a larger version of the same graphic okay all right again this is for informational purposes only it is not medical advice if you have a medical condition consult a medical professional.

    Thanks for listening to the memorizing pharmacology podcast. You can find episodes cheat sheets and more at memorizingfarm.com. Again, you can sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.com forward slash P forward slash mobile. And thanks again for listening.

     

    Like to learn more?

    Find my book here: https://geni.us/iA22iZ

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to my YouTube Channel TonyPharmD here: https://www.youtube.com/c/tonypharmd

    Here is the Link to my Pharmacy Residency Coursesresidency.teachable.com

     

    Ep 69 Asthma Mnemonics Part 2 Theophylline, Cromolyn, Montelukast, Methylpred, Omalizumab

    Ep 69 Asthma Mnemonics Part 2 Theophylline, Cromolyn, Montelukast, Methylpred, Omalizumab

    Asthma Mnemonics Part 2 Theophylline, Cromolyn, Montelukast, Methylpred, Omalizumab

    Some oddball additional medications in asthma treatment, including theophylline, montelukast, cromolyn, methylprednisolone, omalizumab

    Find the book here: https://geni.us/iA22iZ 

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to TonyPharmD YouTube Channel here: https://www.youtube.com/c/tonypharmd

    Need more help; you can find many of my mnemonics books on Audible that you might be able to get your first for free if you've never had one before.  https://www.audible.com/pd/Memorizing-Pharmacology-Mnemonics-Audiobook/B07DLGC8MP?source_code=AUDFPWS0223189MWT-BK-ACX0-118296&ref=acx_bty_BK_ACX0_118296_rh_us

    Here is the Link to my Pharmacy Residency Coursesresidency.teachable.com

     

    Auto Generated Transcript:

    Welcome to the Memorizing Pharmacology podcast. I’m Tony Guerra, pharmacist and author of the Memorizing Pharmacology book series, bringing you mnemonics, cases, and advice for succeeding in Pharmacology. Sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.com. Let’s get started with the show.

    Okay, I wanted to go over a couple of ‘oddball’ asthma medications. It’s more that they’re just not used as much as that kind of beta 2 Agonist or anticholinergics or inhaled steroids and so we just want to at least touch on them to understand what they do. So again, we’re going to go back to what asthma is all about - that episodic bronchoconstriction and inflammation. With these medications, we’re really talking about Theophylline.

    We’re talking about primarily being a bronchodilator so taking care of that opening of the airway but Mata Lucas chromalin homilizumab predn methylpred um all of these are really meant to reduce inflammation. So let’s take a look at a couple of them and maybe some details about them.

    So Theophylline, there’s also aminophilin which is kind of a combination but the big thing to kind of take away is that we’re working about the bronchodilation so this is the opening up of that Airway it relaxes the smooth muscles and opens the airway. So if you look at the offaline and aminophilin you see o-p-i-n-o-p-i-n so one way to remind you that it’s the bronchodilator side more than the anti-inflammatory side.

    I have a little coffee cup here because it’s chemically a methazanthine so it is chemically similar to caffeine so if you want to think about what it’s like to have too many cups of coffee you have the idea of what it is to have toxicity from Theophylline and I’ll get to the um narrow therapeutic window in the next slide.

    It does have a lot of drug interactions and this is why it’s really fallen out of favor. I still have it, it’s just something that we just don’t use very often but you do want to check for potential interactions with those other drugs and the blood tests are going to be kind of part of this.

    So when we look at a narrow therapeutic window I thought of a castle in how they had those Arrow slits and the narrow therapeutic window is between 10 and 20 micrograms per milliliter and so if you think of the T within this Arrow slit and I intentionally picked the T to combine the T from Theophylline, the T from therapeutic, the T from 10, and the T from 20. So the four T’s and this narrow therapeutic window are maybe a good way to remember Theophyllin has this 10 to 20.

    Uh Montelukast, I change the colors a little bit because when you think of Singulair it’s kind of like that Claritin clear where you’ve got this picture of blue skies and green grass. This is for asthma and COPD that’s refractory to other medications. It’s just not - the other medicines are just not doing it.

    It’s a leukotriene inhibitor but you know what does that mean? Well leukotriene inhibitor is going to come from the mast cells and really it’s going to be part of that kind of cascade of the um asthmatic response. And so when we look at adverse effects I put Neuropsychiatric event because this is exactly what’s on the documents but really I think that you’re going to see something like suicidal ideation or something like that but Neuropsychiatric events is obviously a real concern especially since we’re talking about a medication that’s often used with children.

    Um lfts are probably a consideration with liver and then uh you really don’t use this alone um you really use this as something to add to an asthma um treatment regimen but you don’t use it alone and it’s not called Singulair because you don’t use it alone. It’s called singular because it’s once daily dosing and if you look at zapher look is what I think was the first one that came out - that one was four times a day so when you come out with one that you only take once a day, it’s gonna kind of knock the other one off the market and I think that’s exactly what happened. But look at the Lucas ending to remind you about the leukotrienes inhibitor as something that’s going to improve asthma.

    Okay, this is cromelin which is uh Intel um we use this for asthma and COPD and it’s what’s called a mast cells. This is crumbling and it’s again for asthma COPD. It’s a mast cell stabilizer. Think about the M for Mast and I’ve got a couple of pictures of ships here and the idea is that you’re kind of going through the storm here until we stabilize the Mast and we get this nice Placid kind of view of a sailboat.

    The idea is that to stabilize the mast cell is to stop releasing all of those things that are going to cause the asthmatic and allergic reactions. In terms of adverse effect, you get kind of a dry mouth, real irritation of the throat, and kind of a cough with it. So where you were rinsing your mouth out with inhaled steroids to avoid thrush, in this case, you’re maybe gargling or rinsing your mouth out a little bit to avoid the irritation and to avoid that cough.

    Uh contraindications really rare rare shortly shortness of breath or something like that um I often use IV steroids so this is not necessarily an oddball as much as it is that it’s just much more rare. So something like asthma would benefit from methyl pred if you did have an asthma attack. It is a steroid anti-inflammatory and it’s tough to say in terms of side effects because you’re talking about using it for a couple of days probably where you know maybe agitation changing mood maybe a little bit of weight gain but again we’re talking much shorter term steroid use.

    Infections always kind of an issue um you know we suppressing the immune system anytime we’re giving a steroid and then this is used in combination so Albuterol and petropium remembering that albuterol is that beta 2 Agonist it’s a bronchodilator and ipritropium is the anticholinergic that really relaxes those lungs.

    Okay uh omole is umab zolair uh this is kind of a Last Resort for many people who have allergic asthma or chronic hives where you don’t know why they have hives and then nasal polyps. It’s an ige blocker so it binds that ige antibody on mast cells and basophils and stops kind of the Cascade if you would flu-like symptoms might be one of the adverse effects but the real thing to worry about is that anaphylaxis can occur in the first dose and Beyond.

    And this kind of makes sense because of the way that the anaphylaxis Cascade goes but again just recognizing that anaphylaxis could happen and so making sure that the patient is aware that okay we’re gonna watch you while we give it to you but we’re also going to ask you to watch yourself as you kind of move on.

    And then last thing if this is a subcutaneous dosage so a little bit different than all the inhalers we’ve been talking about again this is for informational purposes only so it is not medical advice if you have medical condition consult a medical professional listening to the memorizing pharmacology podcast.

    You can find episodes cheat sheets and more at memorizingfarm.com again you can sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.com forward slash P forward slash mobile. And thanks again for listening.

     

    Like to learn more?

    Find my book here: https://geni.us/iA22iZ

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to YouTube Channel TonyPharmD here: https://www.youtube.com/c/tonypharmd

    Here is the Link to my Pharmacy Residency Coursesresidency.teachable.com

     

    Ep 65 Lab Values Mnemonic in 4 Minutes

    Ep 65 Lab Values Mnemonic in 4 Minutes

    Lab Values Mnemonic in 4 Minutes

    Just a quick review of some lab values as they relate to the Periodic Table of Elements. 

    Find the book here: https://geni.us/iA22iZ 

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to TonyPharmD YouTube Channel here: https://www.youtube.com/c/tonypharmd

    You can find more mnemonics here on Audible as well.  https://www.audible.com/pd/Memorizing-Pharmacology-Audiobook/B09JVBHRXK?source_code=AUDFPWS0223189MWT-BK-ACX0-281667&ref=acx_bty_BK_ACX0_281667_rh_us

    Here is the Link to my Pharmacy Residency Coursesresidency.teachable.com

     

    Auto Generated Transcript:

    Welcome to the Memorizing Pharmacology podcast. I’m Tony Guerra, pharmacist and author of the Memorizing Pharmacology book series, bringing you mnemonics, cases, and advice for succeeding in Pharmacology. Sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.

    Let’s get started with the show. I’m just going to go through a couple of the lab values and how to remember them in this quick mnemonic. So the first thing is that we’re going to go over this L that’s in the periodic table. I took out beryllium so hydrogen lithium sodium potassium magnesium and calcium and then these guys are plus one and this is plus two that becomes really important later but knowing that these guys are all in the same column hydrogen lithium sodium potassium that will do well.

    Alright so you probably never looked at it this way but hydrogen is the well it’s the negative log of the hydronium concentration that’s what you actually get with the pH but basically it’s how acidic or basic it is your body is a little bit higher than seven which is neutral so 7.35 to 7.45 for the pH but if you look down at sodium if you make that seven into a one kind of straighten it up it turns into a 135 to 145 just like you got 7.35 to 7.45.

    And then you can take that 35 from sodium and make the 3.5 from potassium to 0.5 or 2 5 ml equivalents per liter so just a quick way to kind of put the hydrogen the sodium and the potassium together but when we think about these lab values uh really it just comes down to some of the things I’ve heard in mnemonics I’ve come across so again hydrogen 7.5 to 7.45 looks a lot like the 135 to 145 mil equivalents per liter in sodium.

    I’ve also seen that you underline the OD and sodium to make odd numbers so the first three odd numbers are one three and five and you just add 10. potassium 3.5 to 5 I’ve heard three to five bananas in a bunch and they’re half off so the 3.525 lithium and serum creatinine you probably never put together before but 0.6 to 1.2 mil equivalents per liter would be lithium.

    And if you want you can take that it its atomic number is three multiply by two to get the six and 0.6 and multiply that 0.6 again to get 1.2 uh serum creatinine though is 0.6 to 1.2 milligrams per deciliter magnesium you could have taken the one three from sodium but 1.3 to 2.1 and then calcium and chloride you probably never put together but the nine point zero to ten point five very similar to the ninety-five to one hundred five.

    Though I’ve seen ninety-six to one hundred six for chloride as well but nine-one-one that’s the calcium mnemonic so nine to ten point five if you round up and then I’ve heard ninety-five to one hundred five is a hot tub temperature but be careful the maximum is actually one hundred four.

    Uh so Casino cratonin we talked about how that’s next to lithium or similar to lithium at zero point six to one point two, the bun though if you put it right under it retains that six gets rid of the decimal and you double the twelve to get twenty-four.

    So generally, I see six to twenty-four milligrams per deciliter but I’ve also seen the mnemonic where you’ve got bunions on your five toes and you got twenty digits total with your hands and your feet so five to twenty milligrams per deciliter for bun I’ve seen them both creatinine clearance so the sevens and eights.

    So creatinine clearance ninety-seven to one hundred thirty-seven milliliters per minute is the sevens forty is the difference and for women creatinine clearance eighty-eight to one hundred twenty-eight uh milliliters per minute these are the eights they end in eight uh forty is the difference again.

    So again, a quick review of some of the lab values that you really do need to know I just thought those mnemonics were really cool as always informations for informational purposes if you’ve got medical condition consult a medical professional thanks for listening to the memorizing pharmacology podcast.

    You can find episodes, cheat sheets, and more at memorizingfarm.com again, you can sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.com forward slash P forward slash mobile and thanks again for listening.

    Like to learn more?

    Find my book here: https://geni.us/iA22iZ

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to my YouTube Channel TonyPharmD here: https://www.youtube.com/c/tonypharmd

    Here is the Link to my Pharmacy Residency Coursesresidency.teachable.com

    Ep 64 Making Pharmacology Stick and Gaining Peace of Mind

    Ep 64 Making Pharmacology Stick and Gaining Peace of Mind

    Making Pharmacology Stick and Gaining Peace of Mind

    Find the book here: https://geni.us/iA22iZ 

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to TonyPharmD YouTube Channel here: https://www.youtube.com/c/tonypharmd

    If you want the peace of mind that comes from knowing you know the material, I have two book recommendations, Make it Stick: The Science of Successful Learning and this Memorizing Pharmacology Mnemonics that came 4 years after they wrote their book  https://www.audible.com/pd/Memorizing-Pharmacology-Mnemonics-Audiobook/B07DLGC8MP?source_code=AUDFPWS0223189MWT-BK-ACX0-118296&ref=acx_bty_BK_ACX0_118296_rh_us 

    Here is the Link to my Pharmacy Residency Coursesresidency.teachable.com

    It might be free if you've never had an audible book before. 

     

    Auto Generated Transcript:

    Welcome to the Memorizing Pharmacology podcast. I’m Tony Guerra, pharmacist and author of the Memorizing Pharmacology book series, bringing you mnemonics, cases, and advice for succeeding in Pharmacology. Sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.

    Let’s get started with the show. All right, I usually just talk about certain drug names, drug classes but I know that a number of you have emailed me about it being late in the second third week of your pharmacology and things are just a real struggle. So I want to give you a book that is actually not pharmacology but will help you quite a bit with pharmacology, patho and a number of other classes. It’s called Make It Stick: The Science of Successful Learning. It’s by Peter Brown, Henry Rodiger and Mark McDaniel.

    Basically, it teaches you what myths there are about learning and how some of the ways that you might be trying to study don’t work. So if you’re anyone who has gone through a ton of note cards and still done poorly on a test, this episode is for you. So if there’s one book I would recommend for somebody going to school, it’s my kids go to college. I would hope they would have this but I couldn’t expect them to maybe read an entire book like okay Dad, I’ll read the whole book right.

    So if you can’t read the whole book, I would at least start with chapter eight which is Make It Stick and although they summarize the entire book in the chapter and talk about stories that are in those chapters and it’s better to read the chapters before if you only have time for one chapter then that would be it. But if you only have time for one story to convince you that this is the book for you, I would go to chapter eight at the 23-minute mark where they talk about Michael Young, the medical school student.

    And how he went from getting barely enough of an MCAT score to get into medical school to being the top of his medical school class and I’m going to give you a couple of kind of pointers that I’ve used in Pharmacology class that I use but the big problem I have is the discomfort that comes along with some of the recommendations that they make especially the masked practiced one.

    Okay so first of all, the retrieval practice it feels like you’re doing your homework again but no you’re trying to remember but it feels like you’re failing at something versus Mass practice which makes you feel like you’re succeeding. So the example they give is about someone who’s going to just hit fastballs and get really good at hitting fastballs. You feel really good about it and then later on a different day you hit curveballs and you try to hit curveballs and feel really good about it. You get good at it but when you try to hit in a game, you don’t do very well because in a game they don’t tell you what’s coming.

    The fastball or the curveball and the same thing is true here might not make sense to do your patho home or your patho homework and then your farm homework and then back to your patho homework but that’s kind of how your semester goes and then within a class so if you’re doing pharmacology and you’re talking about respiratory drugs and then you go to diuretics and then back to respiratory drugs that may seem like it doesn’t make sense but it’ll be a lot easier on the exam when you get those drugs in different orders and so forth.

    So the first thing is retrieval practice and I’ll show you a little bit what I mean at the end but it’s unfortunate they use the word quizzes and don’t make clear what quizzing means and I’ll show you what I believe quizzing means but I don’t think quizzing means multiple choice questions where you can kind of pick up the answer from one of the answer choices. I think it means something a little bit harder so we’ll talk about that so first one’s retrieval practice next one is elaboration. So when I’m in discussion, I want the student to elaborate on their answer. Okay, they got it right but let’s hear your own words. And so if I’m talking about okay, well what’s a second-generation antihistamine? They say Loratadine, great they’ve answered the question okay but now I want them to expand. Alright, well why did they need Loratadine? Well because you don’t want an antihistamine making somebody drowsy. Okay well how did they make it from the drowsy antihistamine like diphenhydramine and Benadryl into something that isn’t drowsy? Well, they figured out how to make it not go through the blood-brain barrier.

    Okay so you don’t go through the blood-brain barrier and now that avoids drowsiness. So now that you have kind of a little story that goes with it, you now know diphenhydramine or Benadryl is first generation makes you drowsy and Loratadine which is Claritin is non-drowsy why because it doesn’t go through the blood-brain barrier to get to your brain to make you sleepy.

    That kind of elaboration helps. The other elaboration is talking about something in your own situation where oh yeah I used to take Claritin and I remember those Claritin clear commercials where you can hear oh Claritin clear clearing your sinuses or clearing your well it’s really an antihistamine so clearing your allergies is maybe better.

    Again, elaboration that’s why the instructor keeps talking even though you’ve answered the question because if you elaborate you have a story to go with it sticks in your brain then space practice. I think this is the one thing that’s the toughest to kind of put together which is studying three times as much they say that you should study three times but no it’s studying three times to study less.

    So what I mean by that is when you’re studying let’s say you are going to study total three hours over a whole week if you expend those three hours the night before it’s much less useful than if you spent it on Tuesday Thursday and Saturday before maybe a test on Monday right. So that’s really hard to do because you say well I’m so behind well you’re so behind because you’re spending all that time and what you find is that you don’t actually need to study three hours each time they find that you only need to study half an hour each time and that you get another hour and a half back to study for another class.

    So spaced practice just pick three days they can be together. You know so if you’re studying for a Monday test and classes on Friday just okay that’s gonna be Friday Saturday Sunday okay or if you have a class on Wednesday then Thursday Friday Saturday something like that but try to space it out at least a day so that you’ve got this time for your brain to kind of process what was going on.

    You come back to it, you’re like oh okay I remember and then all of a sudden some I would call Revelations come to you like oh I made this connection or that connection. You literally need to sleep on it to make it work better sharing this is one that often students hate which is when they get called on and it’s like well am I doing my homework again? You know why am I sharing this?

    Well if you go to the pyramid the learning pyramid, you see that there’s at the top it’s lecture, you get about five percent retention and at the bottom it’s 90 for someone who is teaching it. So when you are sharing and when you are presenting to the class maybe you’re just called on, you’ll remember that question and you don’t really think about it because it maybe happens once or twice or maybe even three times in a class but the more you’re sharing the more you’re going to remember.

    And it feels uncomfortable at the time but it doesn’t feel uncomfortable when you do really well in the exam okay all right so let’s go on to mnemonics. It’s one thing that everybody seems to know me for so Tony farm D the mnemonic guy uh I’m not supposed to memorize I’m supposed to understand right well mnemonics are for building structures for understanding.

    So if you’re trying to remember Loop Diuretics if you can put a mnemonic in that gets you from the glomerulus to the collecting duct on the right that can put the diuretics in order of mannitol than furosemide then Hydrochlorothiazide than spironolactone well, you understand that there is more diuresis at the beginning with Mannitol and a little bit less at furosemide a little bit less at Hydrochlorothiazide and then certainly less when spironolactone.

    So mnemonics aren’t just okay I memorized it, it’s that you’ve memorized it in an order that makes sense pathophysiologically or physiologically. So let’s take a look at that learning pyramid think it’s a little bit misunderstood but the big thing is is that when you are in discussion so maybe you have a recitation where you break out and you talk to your professor and that’s when you’re learning. Well, the more you’re part of the discussion the more you’re getting to that 50 retention that you’ll remember about half of it okay. However, if they give you an activity like sorting medications into certain drug classes and saying okay well go ahead and on your own go ahead and try to sort the diuretics from glomerulus to the collecting duct okay as you do that that’s the practice doing.

    And then when you get called on and you show others and tell others what you’ve learned that’s the teaching part. You get 90 so it’s almost 100 percent that you are going to remember what you were called on for. So it’s almost like if you really want to do well in the test, you want to get called on for every question. Obviously, it’s not true but the wanting to get called on with every question but the whole point is that you’re teaching others.

    So again, the more you participate in the discussion, the more you practice by doing the activities that were assigned and the more you help others and that’s why people get paired up or put in threes or fours so that you can show others what you learned. The more you do these guys, the better off you are. The more you sit and listen or just read it’s just not going to work anywhere near as well.

    So let’s see what that looks like here’s kind of my half of the pyramid that I care about the discussion, the practice doing and the teaching others. So I did write a book by Rising pharmacology mnemonics and and the point wasn’t for you to just absorb it like a lecture. It was okay I learned this cool mnemonic I want to share it with you that’s how you learn it.

    So I won’t belabor that but here’s an example of one of those mnemonics and I only took part of it because they’re pretty detailed because it’s meant for advanced pharmacology really those that are really going into clinical care and those types of things.

    So what are four second-generation antihistamines okay easy enough go find them cetirizine Des Loratadine levocetirizine loratadine okay well it’s an alphabetical list of them. It’s often what you have on the other side of a note card so the question is how can we change this in such a way that it’s more valuable to us?

    Well, we put a mnemonic together and we say well the order or the prescription called for non-drowsy so C cetirizine a avoid drowsiness l levocetirizine l Loratadine e entering the brain is prohibited is how that happens and then D desclaratidine is Clarinex.

    And so this is what’s in your brain all of these things but I don’t tend to put them on the cards because you don’t want to muddle the cards so much that your brain can’t remember what’s what but tear sounds awful lot like tears from allergy tears cetirizine should be second generation before levocetirizine which is third because two comes before three.

    The avoid drowsiness is what a second and third-generation antihistamine does Loratadine well that had the Claritin clear commercials so that would be easier to remember. The allergies, you can kind of picture that sunshiny very blue sky day and we would want the third generation Des Loratadine third generation after it Clarin next is the next Claritin right so it’s third generation.

    And how does it all work? How did diphenhydramine go to Loratadine? Well in entering the brain is prohibited. The mechanism of action of non-drowsy versus drowsy is that somebody figured out that well if I give histamine not go into the brain then it won’t make someone drowsy but really we want this kind of nice clean clear type of note card so we’re not sitting there muddled with all that other clutter but that’s definitely how I would do it.

    So again, really if you’re really stuck and you just need to hear a story I really recommend chapter eight uh the story about Michael Young. I think it’s one that’s both inspirational and telling as how someone who barely made it into Medical School ended up at the top of his medical school class and this applies to Pharmacists and nurses and other health professionals. But I know you’re maybe discouraged if you’re again your second year third week of classes and pharmacology is kicking your butt. Well, the way to kind of turn that around is to really understand what you should be doing and going back to those lessons you know retrieval practice where you ask yourself the question if you can’t remember it before the test how are you going to remember it on the test?

    So you really want to do that ahead of time and then that spaced practice so important to study on different days rather than try to keep it all for one day because that’s not really that short-term memory doesn’t work as well as the work that you’re going to do to get it into long-term memory.

    Thanks for listening to the memorizing pharmacology podcast. You can find episodes, cheat sheets, and more at memorizingfarm.com. Again, you can sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.com forward slash T forward slash mobile. Thanks again for listening.

     

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    Ep 63 Cholinergics Video Pharmacology SLUDGE CAT

    Ep 63 Cholinergics Video Pharmacology SLUDGE CAT

    Cholinergics Video Pharmacology SLUDGE CAT

    In this episode, I go over how you can use SLUDGE CAT, to remember the cholinergics and what that means for pharmacology indications and adverse effects in that drug group.

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    Memorizing Pharmacology Mnemonics HERE

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    Auto Generated Transcript:

    Welcome to the Memorizing Pharmacology podcast. I’m Tony Guerra, pharmacist and author of the Memorizing Pharmacology book series, bringing you mnemonics, cases, and advice for succeeding in Pharmacology. Sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.com. Let’s get started with the show.

    Okay, if you ran into this video before you ran into the anticholinergic Bud cat, I recommend that you go to episode 62 and go check that out. But the cholinergic sludge CAD is gonna get us through the opposite effects of antichrominergic anti-anti and we’re going to kind of make a U-turn here. So again, we are making a U-turn. We’re going from anticholinergic to cholinergic so many of the things that you’ll see are somewhat familiar but what we want to do is make sure that we have these clear in our head.

    The first thing is to get the vocabulary clear. If something is cholinergic, it is also a muscarinic Agonist. Again, this is our muscarin mushroom and this is where it all began. So people use that as synonyms or use them interchangeably. Oh that’s cholinergic oh that’s muscarinic they don’t say this as much but it also counts it is parasympathomimetic.

    Okay, so what were the opposites right? The opposite of cholinergic is anti-cholinergic. The opposite of muscarinic is anti-muscarinic or muscarinic antagonist. The opposite of parasympathomimetic is parasympatholytic.

    Okay, so let’s kind of look at how we can use these opposites. We learned but the wide-eyed tachycardic cat how that gives us the anticholinergics so let’s go to the opposite which is cholinergic Crisis that is we have way too much cholinergic activity too much acetylcholine and what we’ll do is we’ll kind of take a look at our new cat so our last cat was wide-eyed in the desert very dry our new cat Sledge cat is in the water with pinpoint pupils and is a bit bradycardic.

    Okay so the mnemonic itself sludge will get to but the Cat part is that it is a cholinergic starts with C Agonist begins with a ends with t okay all right so here are the Opposites so on the left hand side we have Bud cat from our anticholinergic presentation and blurry vision because of dry eyes urinary retention dry mouth or xerostomia constipation and hydrosis which is a lack of sweat and was tachycardic so again we had to say wide-eyed tachycardic Bud cat because there is a b and a t in the mnemonic and madriasis again is that wide-eyed m-y-d-r-i-a-s-i-s.

    Now you’ve probably seen the sludge mnemonic but what I want to do is show you where it comes from so the opposite of blurry vision because of dry eyes is lacrimation now yours starts with an L now you’re still blurry it’s just for a different reason before it was because your eyes were so dry now it’s because your eyes are so wet urinary retention the opposite is urinary incontinence dry mouth the opposite of salivation constipation obviously the opposite is diarrhea and hydrosis is sweating and then the opposite of tachycardia is bradycardia.

    Now to be fair you will have initial tachycardia in the presentation but it’ll eventually go to bradycardia and then meiosis the pinpoint pupils are the opposite of madriasis oh so let’s put those in the sludge order now and add the other pieces so we saw the salivation the lacrimation urinary incontinence and diarrhea and then we have the GI cramping and emesis so I have this crisis just ahead signpost with a big thunderstorm lots of rain coming to remind you that sludge is sludge because it’s so wet where does this come from well cholinergic crisis can come from pesticides and organophosphates.

    So I’ll put a little chalkboard thing here but the idea is that okay where where’s someone gonna get it okay it’s going to be the farm okay but we have two competing conditions we have a myosthenic crisis and we have a colon urgent crisis. The issue is that both of them are going to look very similar on presentation but one is because of low acetylcholine stimulation and then the other is because of excess acetylcholine stimulation. So I have a question down at the bottom which explains it better, but we use an antibody test now which can let us know which it is. But why did edrifonium, an acetylcholinesterase inhibitor, result in improvement in myasthenic crisis but worsening of cholinergic crisis?

    Well, if hydrophonium is an acetylcholinesterase inhibitor (capital A, capital C, little h, capital E), that means that it stops the breakdown of acetylcholine and there’ll be more of it around. So we’re basically adding acetylcholine. If we add acetylcholine to myasthenic crisis where we have low acetylcholine, it makes sense that they’re going to improve. It’s actually the class of drugs we’ll give, though this is not the one we’ll give because that one only lasted a very short amount of time.

    However, if you are in cholinergic crisis and you give them more acetylcholine in addition, well now you’re in trouble. Now you’re doing the wrong thing. So the reason we don’t give it anymore is because well we were adding it and making it a little bit worse and we don’t want to make it worse.

    So treatments on the myasthenic crisis side where we have too much acetylcholine right too little acetylcholine take it back so myostendic crisis too little acetylcholine we give an acetylcholine State race acetylcholine esterase inhibitor because what we want to do is have them have more acetylcholine so we stop the breakdown. It’s also an immune condition so we give immunosuppressants cyclosporin azathioprine steroids to suppress the immune attacking itself or the immune system attacking itself.

    On the coal energy crisis side, we treat, we remove the acetylcholinesterase inhibitor and we provide ventilation if they need it and then IV atropine. Why does IV atropine make sense? If you get that then you know you’ve gotten what I’m throwing down. Well Ivy atropine makes sense because you had a situation where you have too much acetylcholine. Atropine is anti-cholinergic so it goes against that acetylcholine.

    Okay, let me give you a visual make me make it a little more clear so here’s Myasthenia on the left is the normal neuromuscular Junction and then on the right we have Myasthenia with the antibodies against the receptor and those antibodies are not letting acetylcholine get through so the idea is we need more acetylcholine but we don’t do it directly we don’t say here you go here’s some more acetylcholine just the way that you know when we have certain conditions that in the blood-brain barrier we just can’t give dopamine well we have ways around it okay.

    So what we do is we treat myasthenia gravis which I call missing acetylcholine Gravely so just play on words to try to remember what the problem is by creating a situation where there will be more acetylcholine because we stop breaking it down okay one of the more telling signs is this ptosis ptosis which is where the upper eyelid droops over the eye okay all right so let’s move on to the symptoms.

    So myasthenia gravis symptoms: The D’s because everything seems to start with D so diplopia double vision drooping of one or both eyelids difficulty swallowing difficulty speaking chewing difficulty using your arms and hands and holding up your head because muscles are weak and so what do we do well if you need acetylcholine we’re going to use an acetylcholinesterase inhibitor and just kind of do this again and my autocorrect keeps correcting that Capital C to a lowercase C it’s capital a capital c lower h um acetylcholinesterase Inhibitors mechanism of action okay.

    We block the enzyme that breaks down acetylcholine called acetylcholine esterase ache, so you have more acetylcholine. If you have more acetylcholine, it enhances cholinergic action. Okay, how do we recognize acetylcholinesterase inhibitors? Well, they’re probably going to end with stigmine. Now some of them are for other conditions: isostigmine usually for toxicity and glaucoma, neostigmine from myasthenia gravis, pyridostigmine from myasthenia gravis. Doesn’t mean it’s the only thing they’re for like neostigmine, you can use as a reversal agent for pancuronium which is a neuromuscular blocker.

    So again, I haven’t gotten into nmbs in here but that’s the kind of toxicity we can talk about. Okay, alright well so we’ve talked a little bit about what cholinergic can do for Myasthenia and how it’s kind of the opposite of anticholinergic but let’s talk about the bladder control that we talked about with anticholinergic.

    So in anticholinergic, we had medications for an overactive bladder. Okay and that made sense. Okay so if the overactive bladder, we want to use the urinary retention that an anticholinergic causes but with bethenticol you’re a choline or devoid or two of the brand names we can use the U and the sludge mnemonic that cholinergics cause urinary incontinence.

    It’s a side effect but for people with atonic bladder or urinary retention it is a therapeutic effect. So again it’s a side effect for those that are taking you know cholinergics but if you have a tonic bladder or urinary retention it’s actually a therapeutic effect. It’s a relief that you can now void or you couldn’t okay.

    So the mechanism of action itself is to activate those cholinergic receptors and help someone as the brand name said do void so we just spell it d-o-v-o-i-d okay okay all right there are some considerations though with the then a call and and these cholinergic drugs remember a petropium as an anticholinergic that opened up the Airways well if you’re gonna give bethen a call and you’re going to give a cholinergic then asthma is a concern because it can constrict the Airways okay.

    If we think about that bradycardia which is the opposite of the tachycardia in Bud cat right when you decrease heart rate you can decrease blood pressure decrease blood pressure you can end up with orthostasis when you think of cholinergic the opposite of the anticholinergic constipation we would have diarrhea or defecation but if you have these kind of GI issues like a peptic ulcer or intestinal obstruction you could perf or perforate that ulcer which would be terrible or you can worsen the condition of intestinal obstruction.

    So imagine someone is impacted for example and you give them a laxative well if that impaction is uh you know some kind of obstruction something’s in the way it’s just going to make it worse. You’re just gonna make it so that you’re trying to get through this wall but it’s not working okay.

    So these would be the things that I really consider or to some extent contraindications asthma orthostasis um that’s more kind of a side effect um peptic ulcers and intestinal obstruction disclaimer this information is provided to you for your informational purposes only and is not intended to provide it should not be relied upon for medical or any other advice.

    I urge readers and listeners to consult with a medical professional with any medical condition foreign thanks for listening to the memorizing pharmacology podcast. You can find episodes cheat sheets and more at memorizingfarm.com again you can sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.com forward slash P forward slash Melbourne thanks again for listening!

     

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    Ep 62 Anticholinergics Video Pharmacology BUD the wide-eyed tachycardic CAT

    Ep 62 Anticholinergics Video Pharmacology BUD the wide-eyed tachycardic CAT

    Anticholinergics Video Pharmacology BUD the wide-eyed tachycardic CAT

    In this episode, I go over how you can use BUD, the wide-eyed tachycardia CAT (BUDCAT), to remember the anticholinergics and what that means for pharmacology indications and adverse effects in that drug group.

    Find the book here: https://geni.us/iA22iZ 

    here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    Find my book Memorizing Pharmacology Mnemonics HERE

    and subscribe to TonyPharmD YouTube Channel here: https://www.youtube.com/c/tonypharmd

    Here is the Link to my Pharmacy Residency Coursesresidency.teachable.com

     

    Auto Generated Transcript:

    Welcome to the Memorizing Pharmacology podcast. I’m Tony Guerra, pharmacist and author of The Memorizing Pharmacology book series, bringing you mnemonics, cases, and advice for succeeding in Pharmacology. Sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.

    Com forward slash P forward slash moving. Let’s get started with the show. Okay, today we’re going to do anticholinergics and our mnemonic will be Bud the wide-eyed tachycardic cat and I’ll explain all of this to you as the issue with anticholinergic and cholinergic is not necessarily getting it, it’s remembering all seven or more actually of the adverse effects that you have but if you can get those down then you are in good shape. So first let’s talk a little bit about Bud the wide-eyed tachycardic cat so b u d and c-a-t are all going to

    Stand for something so it’s going to stand for blurry vision urinary retention dry mouth constipation and hydrosis which is no sweating and tachycardia. The problem is we have a b and a t in our mnemonic so we have to use tachycardic to remind us that the T is for tachycardia and the B is FLIR from blurry vision because of dry eyes and then we want to say wide-eyed because madriasis is just not going to work in the mnemonic and finally we’re going to put this cat in the desert now he’s just on some tan

    Carpet so we’ll say that that’s the desert because anticholinergics are all about dry and when we get to cholinergics you’re going to see it’s all about wet okay to the mechanism of action anticholinergics inhibit acetylcholine capital a Capital C little h a neurotransmitter the issue we have is that it has two synonyms muscarinic antagonists which we sometimes call anti-muscarinics and parasympatholytics so we want to keep those three straight we want to keep those three together because we’re going to have the opposite

    Three when we get to cholinergics okay all right so what are the adverse effects what does bud cat stand for so again B for blurry vision that’s dry eyes U for urinary retention again dry we’re not urinating dry mouth you might sear it as xerostomia constipation if we pull water out of the bowel we’re going to plug things up and hydrosis is a lack of sweat and again this is our tachycardic cat so tachycardia and finally madriasis m-y-d-r-a-s-i-s for wide-eyed and it’s nice it has the word dry in the middle

    To remind you that all of this is very dry so why are we starting with adverse effects instead of indications well you’re going to hear all the time that oh that drug has anticholinergic properties watch out for that and what they’re saying is that maybe in the elderly something like diphenhydramine or Benadryl you don’t want to use because it causes sedation but it also has anticholinergic effects causing many of these problems so the reason we start with adverse effects is because we’re now going to go to indications

    So how do you take a quotation fingers bad thing and make it good well the blurry vision or dry eyes is one of the many things that happens when somebody has cholinergic crisis from an organophosphate so the pesticides and things like that atropine is the antidote we have urinary retention so if we retain urine that becomes an indication if we’re trying to treat over active bladder with oxybutynin tolteridine solofenacine if we have dry mouth or xerostomia okay we might want to reduce salivary secretions and we might use

    Glycopyrolate constipation is just a placeholder I don’t know why you would want to use this exactly for constipation there are other things you can use anhidrosis okay so atropine okay can help with hyperhidrosis or profuse sweating and the big one because it causes tachycardia it can help someone who is very bradycardic so madriasis wide-eyed might want to dilate the pupils although we don’t really use atropine we use something called homotropine we get that it’s a Madrid edict which is basically "Something that’s going to dilate and make those pupils wide just like our cat. So if you were using atropine IV, you know you would use it for that bradycardia, bronchial secretions or in that cholinergic crisis with the organophosphates. So atropine as the antidote okay, but let’s look a little bit more at that OAB and some mnemonics that we can use with some of those drugs themselves.

    So a normal bladder, the detruser muscle is contracting when the bladder is full. However, if an overactive bladder, we have the detruser muscle contracting before the bladder is full right. Well what could we do? We’ve got medications that have an indication for overactive bladder so oxybutynin is Ditropan or Oxytrol and oxybutynin kind of rhymes with keeping here and in tolteridine is detrol which takes the word letters from detruser and control solofenacin or Vesicare is fencing urine in if you’re kind of looking at the stem and then physica is Latin for bladder so literally it is vesica care they kind of just squish that word together and then Darth venison is an ablex where you’re again fencing the urine in with that stem but you’re enabling an exit from the house because many people with overactive bladder really feel uncomfortable going out they are worried that they’re going to have an accident and things like that so the nice thing is when we go back to our adverse effects for these four drugs we see that we have our cat back right you might have some blurry vision urinary retention dry mouth constipation and hydrosis tachycardia madriasis but these drugs are getting more specific for that urinary retention so the idea is that maybe some of these side effects would be quite minimized there are some other indications that we have with anticholinergics for example Scopolamine is called transderm scope and often it’s used in motion sickness so you put it on for um maybe a cruise or something like that where maybe it’s something that that really bothers you but what would we really expect with side effects we’ll get to that in a second and then ifritropium bromide or atrovent this is something that uh bronchodilates but really relaxes the smooth muscle of the lungs and when we go back to adverse effects sure enough who’s there well it’s bud so we might get blurry vision urinary retention dry mouth constipation and hydrosis and tachycardia so again the thing with anticholinergics is you know getting down that okay here are the medications we’ve got atropine we’ve got these glycopyrolate we’ve got these drugs for overactive bladder Scopolamine for that motion sickness and we’ve also got the you know generic atrovent or which is a neb um which is ipritropium and the idea is that okay we’ve got all of those but we already know what they’re going to do because we’ve got the adverse effects down for anticholinergic in the next section we’ll go over cholinergics disclaimer as always the information is provided for you for informational purposes only it’s not intended to provide should not be relied upon for medical or any other advice consult with a medical professional if you have a medical condition thanks for listening to the memorizing pharmacology podcast you can find episodes cheat sheets and more at memorizingfarm.com again you can sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile friendly self-paced online pharmacology review course at residency.teachable.com forward slash P forward slash mobile thanks again for listening.

     

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    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

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    Ep 61 Beta Agonists Mnemonic IMACH Isoproterenol Albuterol Salmeterol Terbutaline

    Ep 61 Beta Agonists Mnemonic IMACH Isoproterenol Albuterol Salmeterol Terbutaline

    Beta Agonists Mnemonic IMACH Isoproterenol Albuterol Salmeterol Terbutaline

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    Auto Generated Transcript:

    Welcome to the Memorizing Pharmacology podcast. I’m Tony Guerra, pharmacist and author of the Memorizing Pharmacology book series, bringing you mnemonics, cases, and advice for succeeding in Pharmacology. Sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.

    Com forward slash P forward slash moving. Let’s get started with the show. Hey, welcome to Memorizing Pharmacology podcast. I’m Tony Guerra. I wanted to give you with the beta agonists a more general way to look at drugs and remember what you’re supposed to know about them and I’m going to use a mnemonic eye match but it’s actually i-m-a-c-h and I’ll explain what I’m talking about here. So the way that I do this or kind of put drugs in my head to make it simple and create a story and I know many of you are like why am I taking English 1 and

    English 2 or comp one and comp2 to become a health professional and as an undergraduate English major although I’ve got my you know doctorate in healthcare and pharmacy my background in English reminds me that you know to remember something you really got to get the story together and the story comes from I am a considerate health professional so that’s my I match mnemonic uh I couldn’t get the T in there but what we’re trying to do is really say you know for indications mechanism of action which many people

    Overdue like you can say you know Methotrexate is going to affect certain enzyme but you can just say it’s an anti-metabolite. I don’t have to get too into it or something is cholinergic or anticholinergic that’s the mechanism of action and some of you call that drug class so however you want to do that but we start with indication mechanism of action adverse effects then some people call this contraindications really I think of it as considerations like if the patient is this then we don’t want to give this but in this

    Exception we might so it’s more of a consideration but many times we’ll call this a contraindication and we’re really being empathetic to what it is that their other conditions are and then health professionals so I am a considerate health professional and the H is really just as a health professional what do I need to do to help the patient and that depends on what you do. I mean are you a pharmacist physician nurse physician assistant you know what what are you what are you and what is your role in helping the

    Patient so indication mechanism of action adverse effects consideration slash contraindications and then how can we help the patient better take the medicine and I’ll show you how this works with the beta Agonist that we have in this group okay so let’s just start with I always like to just do one slide like what’s it for so indications when you have something like isoproterinol which is isopril inotrope is in the word and I’ll show you how to do that but this is something that’s you know for

    Shock or you know bradycardia those types of things Albuterol and we can underline the stem the tyrol stem let’s just know it’s a beta2 Agonist which is pro air brand name tells you what it’s for it’s a rescue inhaler so it provides air by you know bronchodilating salmeterol some people call it salmeterol. I like that the word meter is in there because it’s a metered dose inhaler but that’s also a terol and so we had this problem with the beta blockers where wait a minute you’ve got Albuterol and

    Salmeterol and they’re they do the same thing but they’re different why are they different well albuterol is short acting some meteorol is long-acting and I’ll talk a little bit about that mechanism of action in a minute but usually so meteorol has to be added to fluticasone there was a study that showed that salmeterol alone was no bueno so fluticasone has that sewn ending for a steroid and then we add these together to get error so that’s what Advair is but this is that what patients would call a controller inhaler

    Something they have to take every day sometimes twice a day those types of things and then terbutylene or breaking now that’s a subcutaneous there’s some other dosage forms but that’s even more short acting than albuterol but these are the indications that’s what it’s for but how do we remember all this okay well the mechanism of action can be really helpful if you know what to look for so isoproterinol or icprow this is that beta1 beta 2 agonists so it’s going to affect the heart and the lungs you’ve heard that mnemonic where you have two lungs so beta two one heart beta one albuterol that’s Pro air is just going to be beta 2 and we’ll talk a little bit how that isn’t always the case so beta 2 if it’s used properly but many uh patient cannot afford Advair or doesn’t take Advair on a regular basis their controller inhaler they need more and more Albuterol they keep complaining they’re well I’m so jittery and just you know got Tremors and all these things that’s from coming and using albuterol

    Wrong you’re not using it as a rescue inhaler you’re trying to use it as a controller inhaler that’s not what it’s meant for uh some meat roll with fluticasone is Advair so we have a beta 2 Agonist to open up the lungs for a long time and a steroid and so the steroid is to help with inflammation the two components of asthma are that bronchospasm and inflammation and then terbutaline that’s beta2 okay so this mechanism of action you’re going to see these terms so I just want to make them clear short acting selective

    Beta 2 Agonist is a mouthful so we just call it a Saba Saba that’s Albuterol and terbutylene and then a long-acting selective beta2 Agonist is a laba which is cell meteorol not the fluticasone it just happens to be in there all right so let’s start with isoproterinol and the kind of the mnemonic here so if you take the word isoproterinol and you get rid of the so the ER and the L you actually have all the letters for inotrope and that’s what it does so if you don’t remember what an inotrope is it increases the force of

    Contraction of the heart it’s also a chronotrope which increases heart rate but again inotrope is really when we’re talking about what it does that’s what it’s going to be so if we use our eye match mnemonic here and I get it you you probably get big lists of all these things like well it’s not that I don’t get what the adverse effect is is I don’t get which of the 10 adverse effects are in there or which of the 10 contraindications are in there and what I like to do is just say well let me

    Just start with the ones that I understand based on the mechanism of action so I can make a story okay so I put the different types of shock in here we’re not going to go into that I mean you know you can you know obstructive distributive cardiogenic hypovolemic and then you can get into the three types of distributive with septic and anaphylactic and neurogenic shock that’s going way down the rabbit hole what we want to do is just say all right well what is shock well shock is a decrease in blood pressure you know

    We’re going to have a decrease in cardiac output well what’s cardiac output made up of it you learn that cardiac output is heart rate type stroke volume well if we increase this heart rate we can increase the cardiac output we can increase the blood pressure which does the opposite of what shock is which is lowering it and then increasing heart rate obviously is the opposite of bradycardia so when we look at the indications of shock and bradycardia having an inotrope that’s going to increase heart rate increase blood

    Pressure cardiac output it’s a good thing. The mechanism of action can affect beta 1 and beta 2. So we’re going to affect that heart, affect the lungs. Adverse effects, so when you’re thinking about beta 1 especially really think about the CNS and how it just really kind of makes you jittery increasing that heart rate. So if we’re increasing heart rate, what would be a contraindication or consideration? Well, if somebody’s got hypertension, we’re trying to lower their you know heart rate blood pressure All that probably not the best medication for that and then in terms of how can we help the patient well when we get to you know you can kind of go in the weeds with shock but and losing that systemic vascular resistance but the big thing is that you know we we need to have that volume uh to make this all work so we want to definitely avoid dehydration okay okay with the albuterol um again this is for asthma COPD but this is the rescue inhaler so this is that short acting bronchodilating agent so it’s beta2 it opens up the two lungs

    And then again the CNS adverse effects you’re like well wasn’t that beta one well you can lose selectivity if you take this too much and that’s when we would kind of get that jitteriness the tremors and then you say well how can hypertension be it it’s beta 2 Agonist again if you lose selectivity then hypertension can be an issue then how can we help the patient well you know you want to open up the lungs before you take that next inhaler breath I know some people like to just squirt the inhaler a couple times right away get it

    Done with but really let’s wait a minute between Puffs to to help open up those bronchi especially if we’re going to use it before the controller inhaler so better to open up the lungs so more controller inhaler gets to the lungs and then kind of a you know bfo blinding flash of the obvious if you’re using a beta Agonist you probably don’t want to have beta antagonists on board especially something like Propranolol which specifically goes after those beta-2s uh so salmeterol and fluticasone or Advair same thing it’s an asthma COPD

    But the contrast is to that albuterol this is the controller inhaler the one that long acting beta 2 Agonist and the mechanism of action we’re opposing both sides of that asthma now with this controller inhaler the beta 2 Agonist open up the lungs deal with that bronchospasm and then the steroid for the as an anti-inflammatory okay got the little muscled lungs here as an image and then CNS when you lose selectivity again you get that kind of jitteriness that comes along with it but when we think about a steroid one of the things

    That it does and we use it for is an immunosuppressant but if your immunosuppressing locally like in the mouth you’re gonna get thrush so that’s why the washing the mouth out with water you know after each use makes so much sense and then pneumonia because again we’re immunosuppressing a little bit here hypertension so again that beta one you know if we lose that selectivity and diabetics you know that especially with when you add some kind of steroid you’re going to get that hyperglycemia because you know when

    Your body needs is when your body feels steroid it’s like okay well something’s gonna happen I’m going to need sugar for whatever events happening so it makes you hyperglycemic but obviously if you’re a diabetic that’s an issue and so again we’ve got that beta antagonist we want to watch out for and here we want to wash out the mouth with water and not swallow but expectorate and get that out of our mouth so we don’t get the thrush okay terbutylene don’t really see this as much but this again bronchosmith

    Bronchospasm and asthma exacerbation it’s a beta-2 Agonist it’s even shorter acting than albuterol it’s like super short acting and you know we can again get those CNS effects when you lose selectivity but there is a laundry list of adverse effects that can come along with terbutylene uh and then hypertension again we want to watch out for that and diabetic so it’s kind of the same as the other ones and of course we want to watch out for beta antagonists but I put a little image here of subcutaneous versus IM injection Although they did bring I am back during covid to avoid using a nebulizer um but really Sub-Q is where you go with tributaline as always uh disclaimer the information is provided for informational purposes only not intended to provide should not be relied for medical or other advice I urge readers to consult with a medical professional if you have a medical condition foreign thanks for listening to the memorizing pharmacology podcast you can find episodes cheat sheets and more at memorizingfarm.com again you can sign up

    For the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile friendly self-paced online pharmacology review course at residency.teachable.com forward slash P forward slash mobile thanks again for listening.

     

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    Ep 60 Alpha Agonists Mnemonic POP CAN - Phenylephrine Oxymetazoline Pseudoephedrine Clonidine

    Ep 60 Alpha Agonists Mnemonic POP CAN - Phenylephrine Oxymetazoline Pseudoephedrine Clonidine

    Alpha Agonists Mnemonic POP CAN - Phenylephrine Oxymetazoline Pseudoephedrine Clonidine

    In this episode, I go over how you can use the POP CAN mnemonic to remember the alpha agonists and what that means for pharmacology indications and adverse effects.

    Find the book here: https://geni.us/iA22iZ 

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to TonyPharmD YouTube Channel here: https://www.youtube.com/c/tonypharmd

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    Auto Generated Transcript:

    Welcome to the Memorizing Pharmacology podcast. I’m Tony Guerra, pharmacist and author of the Memorizing Pharmacology book series, bringing you mnemonics, cases, and advice for succeeding in Pharmacology. Sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.com.

    Let’s get started with the show. Hey, welcome to the Memorizing Pharmacology podcast. This one is on Alpha Agonist. The mnemonic is ‘pop can’ and the idea is just to remember a couple of medications that maybe are a little bit different so that we can kind of compare and contrast and do that kind of thing.

    So when we look at Alpha One agonists, we think of pseudoephedrine which is Sudafed, oxymetazolin which is Afrin, and phenylephrine which is Neosinephrine. There aren’t really stems; the only stem here is pseudoephedrine which has that driven sympathomimetic stem which just means it works like the sympathetic system but specifically it’s the alpha one that’s the big deal.

    We’ll look at that mechanism of action specifically on the alpha receptor. So pseudoephedrine or the pseudofed, it’s usually an oral tablet that you’re going to take. This stimulates Alpha receptors systemically so it’s going to go throughout the whole body. The nice thing about oxymetazolin which is Afrin and phenylephrine which is neo-sinephrine, they both stimulate Alpha receptors locally in the nose so you don’t get as much of that issue with cardiac contraindications and so forth.

    So again anybody that has heart issues they’re going to be very wary about using either these medications but all three result in vasoconstriction and decongestion and are adjuncts for allergic rhinitis treatment. So the big kind of take-home thing is if you’ve got vasoconstriction you’ve got a little bit increase in blood pressure and that’s something you don’t want with a cardiac patient.

    But when you talk about side effects though really with Pseudoephedrine it’s more excitability and nervousness just kind of a jitteriness rarely you’re going to see something like tachycardia oxymetazolin Afrin and phenylephrine eosinephrine the big thing here is that rebound congestion and it’s possible around three days you might see four or five days whatever but it’s called rhinitis medicamentosa so that’s the actual name for that rebound congestion.

    If something like that does happen you may need to take an oral steroid or you may need to have a steroid in such a way that we go one nostril at a time but that rebound congestion is very real thank you contraindications really it comes down to those cardiac issues so angina coronary artery disease and hypertension because it’s CAD coronary artery disease it also just happens to be closed angle glaucoma which is the more more concerning type of glaucoma and either of those would definitely be a contraindication to using these types of medications.

    The Alpha 2 you know the can of the pop can mnemonic so when you think pop you think okay well once my nose clears it kind of Pops open but the can part is just to remind you that c and N are in clonidine and clonidine has a couple of brand names that might help you remember what it’s for catapress so if you think of catabolizing blood pressure and then catapress TTS was the patch that also helped with blood pressure and then Cafe which is for ADHD or that’s how it’s marketed.

    But the mechanism of action is quite a bit different so it stimulates an alpha 2 receptors that decreases norepinephrine so norepinephrine would normally bind to Alpha One Alpha 2 beta 1 so you get a decrease in blood pressure and that seems a little bit counter-intuitive to say I’m stimulating something but I’m decreasing so that’s just the big thing is that it’s stimulating Alpha two it’s kind of shutting off the norepinephrine faucet and that’s why blood pressure decreases okay indications include hypertension ADHD ticks and Tourette Syndrome it can be an adjunct for cancer pain it can also be an adjunct for neonatal opioid withdrawal syndrome but again not the safest drug in the world not something we use a ton anymore but to be complete to have an alpha Agonist and not to go into those super medications that have many many alphas and betas this one is the alpha two prototype then adverse effects which you would expect when you lose epinephrine you would expect a decrease in blood pressure and that decrease in blood pressure tends to result in some dizziness and some light headedness but also quite a bit of fatigue imagine that you’re trying to turn on the system to increase your heart rate and blood pressure and all those things only to find out that the faucet for that particular neurotransmitter is not available so anyway just a reminder with all these this is just informational purposes this is not medical advice if you’ve got a medical problem contact a medical professional foreign thanks for listening to the memorizing pharmacology podcast you can find episodes cheat sheets and more at memorizingfarm.com again you can sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.com. Thanks again for listening.

    Like to learn more?

    Find my book here: https://geni.us/iA22iZ

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to my YouTube Channel TonyPharmD here: https://www.youtube.com/c/tonypharmd

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    Ep 59 Beta Blocker Generations Mnemonic PRO BAM CARLAB - Propranolol Metoprolol Carvedilol

    Ep 59 Beta Blocker Generations Mnemonic PRO BAM CARLAB - Propranolol Metoprolol Carvedilol

    Beta Blocker Generations Mnemonic PRO BAM CARLAB

    In this episode, I go over how you can use PRO BAM CARLAB to remember the beta blocker generations and what that means for pharmacology indications and adverse effects.

    Find the book here: https://geni.us/iA22iZ 

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to TonyPharmD YouTube Channel here: https://www.youtube.com/c/tonypharmd

    Get a hold of my book, Memorizing Pharmacology Mnemonics HERE

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    Auto Generated Transcript:

    Welcome to the Memorizing Pharmacology podcast. I’m Tony Guerra, pharmacist and author of the Memorizing Pharmacology book series, bringing you mnemonics, cases, and advice for succeeding in Pharmacology. Sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.com forward slash P forward slash moving. Let’s get started with the show.

    In this episode, I’m going to go over beta blocker generations mnemonic Pro bam car lab and I’ll explain what I mean there. So before we start with the stems, let’s just make sure that you’ve heard this that the all at the end of a beta blocker which indicates it’s a beta blocker. There are some exceptions to that but it’s two B’s backward so it’s Propranolol but if you connect the O and the L it should look like two backward B’s and the stems are a little bit different but also cause a problem.

    The first generation stem a law is the same as the second generation stem a law o-l-o-l and that causes a problem because Propranolol has beta 1 and beta 2 blocking activity and then second generation has beta one with bisoprolol Atenolol metoprolol so that’s why you kind of need the mnemonic to separate like okay which is first generation the pro and think of primary it’s your first grade and then bam b-a-m for your second generation.

    Then I put Car Lab just to give you two of the third generation ones these guys are very clever in their stems and they kind of fixed the all problem if you want to call it that so these third Generations will vasodilate and you see d-i-l-o-l in Corvette de la and you see a for Alpha Blocker in La Bay to law so that little change the dill and the a for Alpha blocking helps you know okay well these are third generation at least I get these guys but I still need to be able to tell the difference between first and second generation.

    Okay so when we kind of go to the next thing, the indications and giant schf hypertension really when we’re going to the generations we’re going to almost avoid problems as much as they are indications. So when you look at Propranolol when they first came out I mean this came out so long ago many of the patients were like my migraines are gone it’s like oh well let’s just try to use it for that and Propranolol is really good at helping prevent migraines in the first place.

    The issue is though because that beta 2 blocking activity we have these second generation bisoprolol Atenolol metoprolol which avoid the asthmatic issue of beta 2 blockade in general but then we want something that might print vent reflex tachycardia so if you can think of Carvedilol and labetalol as alpha blockers with beta blocking activity so that when you vasodilate which is a problem with the alpha blockers like prazasin you can prevent that reflex tachycardia because you are suppressing beta 1 receptors.

    So again, Propranolol is the beta 1 and beta 2 blocker, bisoprolol, Atenolol, metoprolol these are the beta one only, and then Carvedilol labetalol these are the beta one beta 2 and Alpha One blockers.

    Adverse effects tend to come from the mechanism of action so bradycardia can be a problem so if you get the heart rate below 60 and really a contraindication when you don’t really want somebody to go that low bronchospasm specifically with that Propranolol where you are battling that beta 2 receptor fatigue is really a big deal because think about it you go on a run and your heart rate increases but you’re taking a medicine that won’t let your heart rate increase so you’re going to get fatigued.

    A heart block if you use too much of it and then reflex tachycardia can come from stopping it abruptly so imagine that you’re kind of pushing down on a spring and then all of a sudden you let your hand go well that’s kind of what you’re doing if you take away a beta blocker very quickly.

    The considerations kind of come from the adverse effects so you want to be considerate of somebody who has asthma or COPD because if we’re using a beta blocker how do we choose the right one well if they’ve got asthma then we’re not going to choose that first generation somebody’s bradycardia certainly we don’t want to suppress their reduce their blood pressure too low.

    This one’s a big one, mask the signs and symptoms of hypoglycemia. So normally someone who’s hypoglycemic is going to get kind of very jittery palpitations but with a beta blocker they may not feel that at all and go into a hypoglycemic State and it might be masked or covered up.

    So again, hopefully that quick review of beta blockade and the generations kind of puts it together really quickly and if you need my help Tony the pharmacist gmail.com. This information is provided for informational purposes only this is not medical advice if you have a medical question contact a medical professional.

    Thanks for listening to the Memorizing Pharmacology podcast. You can find episodes, cheat sheets, and more at memorizingfarm.com. Again, you can sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.com forward slash P forward slash Melbourne. Thanks again for listening.

     

    Like to learn more?

    Find my book here: https://geni.us/iA22iZ

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to my YouTube Channel TonyPharmD here: https://www.youtube.com/c/tonypharmd

    Here is the Link to my Pharmacy Residency Coursesresidency.teachable.com

    Ep 56 Vaccine Schedule Mnemonic in 4 Minutes

    Ep 56 Vaccine Schedule Mnemonic in 4 Minutes

     Vaccine Schedule Mnemonic in 4 Minutes

    You can find the PDF version of the content here: https://residency.teachable.com/courses 

    Find the book here: https://geni.us/iA22iZ 

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to TonyPharmD YouTube Channel here: https://www.youtube.com/c/tonypharmd

    Here is the Link to my Pharmacy Residency Coursesresidency.teachable.com

    Here is a Vaccine Schedule Mnemonic that you can learn pretty quickly that I made using Excel but that you could easily do on a Google doc as well. 

    Auto Generated Transcript:

    Welcome to the Memorizing Pharmacology podcast. I’m Tony Guerra, pharmacist and author of the Memorizing Pharmacology book series, bringing you mnemonics, cases, and advice for succeeding in Pharmacology. Sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile friendly self-paced online pharmacology review course at residency.teachable.com forward slash P forward slash mobile. Let’s get started with the show.

    Hey, welcome to Memorizing Pharmacology podcast. I just wanted to go over a quick mnemonic set for you for the vaccination schedule. So we’re going to start with birth B for Hep B and the mnemonics are up at the top and the actual vaccines are down at the bottom. Then we want to be Dr. Hip at two months okay that’s Hep B, DTaP, rotavirus, hemophilus influenza inactivated polio virus vaccine and pneumococcal conjugate vaccine.

    And then at four months we’re just Dr. Hip no B for Hep B so DTaP, rotavirus, Hib, IPV, PCV. Then six months we want to be Dr. Hip again and that I N from again is for the influenza virus that we’re going to start that vaccine at six months.

    Then 12 months I have an HP monitor view literally this is these are HP monitors or Hewlett Packard monitors so it goes from Hep B to Hep A then we’re also going to still have our Hib our PCV and now we’re going to add MMR and varicella so an HP monitor view at 12 months.

    Then from 5 to 8 AM that’s kind of dawn so we keep our DTaP and then from four to six years we have dusk so around four to six PM starts to get the Sun starts to go down a little bit tougher to see and so it’s a bit dim so DIM for DTaP IPV and MMR and then view for varicella.

    At 11 to 12 years we have Tdap and the important thing is that you kind of think of ta-da because which is how you would say it but the key is to get from DTaP to Tdap and know that 11 to 12 is when we make that change. Papilloma there’s two L’s in the middle that looks like an 11 and then meningococcal 12 is when you become an adult or men when you look at the back of for example a Motrin liquid you see that it only goes up to 11.

    And so when you’re talking about dosing something like that that’s when you start using these adult doses and then it’s 16 year old men get kind of a boost and that’s the next booster for meningococcal.

    And then there’s some kind of goofy ones at 19 years with Tdap that’s really if you’re an adult you’ve never had tetanus before 19 and over you definitely want to do that and then in pregnancy to prevent whooping cough it reduces it by like 78 percent for someone that’s under two months you’re going to do 27 to 36 months now how do you remember that well the reason I put them together is that it makes up one two three here so 19 years for that adult 27 to 36 months for someone who’s pregnant.

    And then the 20 to seven to thirty six how do you remember that well it’s two three going up and seven six going down. So hopefully that’s helpful to see the vaccine schedule mnemonic in four minutes or less.

    Like to learn more?

    Find my book here: https://geni.us/iA22iZ

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to my YouTube Channel TonyPharmD here: https://www.youtube.com/c/tonypharmd

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    Ep 54 Video OER - GI Pharmacology Case Studies

    Ep 54 Video OER - GI Pharmacology Case Studies

    Video OER - GI Pharmacology Case Studies

    In this episode, we go into the pharmacology of the Gastrointestinal (GI) system and some relevant case studies. You can find all the GI episodes here at https://www.memorizingpharm.com/oer  

    Find the book here: https://geni.us/iA22iZ 

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to TonyPharmD YouTube Channel here: https://www.youtube.com/c/tonypharmd

    Here is the Link to my Pharmacy Residency Coursesresidency.teachable.com

     

    Auto Generated Transcript:

    Welcome to the Memorizing Pharmacology podcast. I’m Tony Guerra, pharmacist and author of The Memorizing Pharmacology book series, bringing you mnemonics, cases, and advice for succeeding in Pharmacology. Sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.com forward slash P forward slash mobile. Let’s get started with the show. Hey, welcome to the Memorizing Pharmacology podcast. We’re going to be talking about GI case studies today in Pharmacology. I’m Tony Gary, your host, and let’s just get started.

    So, we’re gonna actually go all the way to 7.3 which is our critical thinking activity. A patient who underwent surgery recently has a medication order for daily pantoprazole. The nurse reviews the patient’s medical history and finds no history of GERD or peptic ulcer disease. The patient does not report any symptoms of heartburn, stomach pain, or sour stomach. The nurse reviews The Physician orders for an indication for this medication before calling the provider to clarify what is the likely indication for this drug therapy for this patient.

    So let’s start there okay so this is an excerpt from Memorizing Pharmacology Relaxed Approach second edition and we see pantoprazole is here with the brand name Protonix. Many students will only memorize the generic names because that’s all that’s going to be required on for example the NCLEX but it actually makes there’s two reasons to memorize brand names one it’s easier to know what it’s for and two if you’ve ever tried to remember somebody’s name and you try to remember their first and last name it’s always easier.

    So when I’m taking role for the class and you know we class start classes again here in January I’m going to always put the first and last name and I’m going to take the time to learn their first and last name and although I’ll probably only address them by their first name it just is so much easier for me to remember their name with the first and last.

    So here we are in pantoprazole Protonix we see that prezol is the ending and that’s for a proton pump inhibitor something that makes it so that we have less acid in the stomach and the brand name is protonic so it mixes protons that’s where the name came from where it gets rid of protons and pantoprazole like esomeprazole or beprazole comes in an IV form but the most important thing is that now we know what it does but we’re not necessarily sure why it’s there for this particular patient.

    So we know it stops proton pumps and that it reduces acid so let’s go back to that case and the patient has no symptoms they don’t have heartburn they don’t have stomach pain they don’t have sour stomach why in the world are there are they on you know this medication well the key is actually here they underwent surgery and because they underwent surgery there’s a stress response where they might get a stress ulcer and by suppressing that HCL or hydrochloric acid that’s why we’re using it we’re trying to avoid stress ulcers.

    Alright let’s go on to the next one anti-diarrheal medication a number critical thinking activity 7.4 a a patient has been prescribed loperamide for diarrhea associated with gastroenteritis patients begins to complain of heart palpitation what is the nurse’s best response and then we’ll talk about two what child Aid 6 has diarrhea the mother asked the nurse what OTC medications she can provide her child to help resolve the diarrhea what’s the nurse’s best response.

    So let’s go back to the book again and we’ll go to the anti-diarrheals here and we see loperamide and the brand name is imodium so loperamide doesn’t have an ending or a stem that’s going to be useful it’s in a mide but that’s just a chemistry term that’s not really going to help us but what you can do is you look at loperamide and you see low Lo and then per which is the first part of peristalsis Is a way to think of an anti-diarrheal that will slow down peristalsis and will help prevent diarrhea. Also, Imodium is like the word immobile and it is really immobilizing the bow for a little while to prevent that diarrhea as well. So two mnemonics there to help you remember it. So we go back to the question here and what is the deal with the heart palpitations? We know that the patient is taking something for diarrhea. It’s meant for cons it’s meant to actually create a more constipating effect but now we know what to do now we know what to look for and there is a black box warning on low paramide that an abnormal heart rhythm can happen so the nurse will do an assessment. I want to make sure we have understand heart rhythm and heart rate and then obviously contacting the provider is key to provide those results.

    Now this age six child it kind of depends if the child is in you know having severe multiple diarrhea over the course of the day that’s a very different thing where the patient might become very dehydrated and that’s a real concern but if this is just a one-time thing maybe we’re thinking about something like adding yogurt which is you know a good source of probiotics or something like that it just kind of really depends and the big thing I want you to take away is that diarrhea is not a disease it is simply a symptom and so if it is a symptom something else is probably going on if just the one-time thing no problem little yogurt that’s fine but if it’s happening more than once we really want to kind of think about contacting a provider.

    Let’s go to 7.4 B okay so this is our third of the four cases we’ll do today. A patient went under underwent hip surgery two days ago I was not had a bowel movement since before admission. The patient is receiving Oxycontin ER 10 milligrams every 12 hours an oxycodone five milligrams every four hours for pain. Patient describes abnormal discomfort and the nurse finds decreased bowel sounds in all quadrants. Nurse notifies The Physician follows the bowel protocol and administers docusate sodium to the patient.

    One, what are the potential causes of constipation that should be addressed for the patient? Two, what is the mechanism of action for docusate? Three, the patient asks how quickly the medication will work what is the nurse’s best response? Four, what other preventative measures for constipation should the nurse teach the patient? And then if docusate is not effective within 24 hours what other medications can the nurse anticipate to be ordered?

    Alright so we’ve got quite a bit to unpack here but let’s let’s kind of go back um so this is a bit of an error to put the not caps here to show that Oxycontin ER is a brand name and that’s this is a long acting opiate and then oxycodone is a short-acting one for breakthrough pain so you’ve got a long-acting opiate and a short-acting one and that amount of opioids is certainly going to cause issues with constipation so we’ve kind of got what’s going on um with that so the opiates for sure and there might be some side effects of anesthesia, the fact that they’re not really moving around they’re sedentary and that you know you’re not really going to take a ton of I can drink a ton of water eat a lot of food um just after surgery so all of those things really kind of come together to necessitate this docusate so the potential causes of constipation that should be addressed you know the opiates are we using the lowest amount possible uh you know are we adding the docusate are they taking it on time and so forth how does the docusate work well it. 

    It really helps to go back to the mnemonics here and what docusate sodium you would want to think of docusate rhyming with penetrate because what it really does is help water penetrate the bowel and soften the stool. That’s how it works and then you can also think of the brand name Colace that improves the Colon’s pace. So again, I know that you don’t have to have the brand name for many of your exams but makes it so much easier to know what this is for and also remember how to use it but going back to that question.

    Docusate softens the stool and then that way we’re going to get more bowel movements. This is a real disappointment for patients or how quickly does it work it can take half a day but it can also take up to three days and the patient will likely have been given this pretty quickly but they’re going to be a bit uncomfortable for a while and they might be asking for something more rapid and it’s tough to say well you know right now we’re just going to kind of stick with this make sure we’re drinking enough water making sure we’re moving around and doing those things but this is the gentlest kind of best way to work with these constipation issues.

    So the other preventative measures for constipation would include you know kind of increasing that fluid increasing the fiber moving around and again using the fewest opiates that you need to still provide pain relief for the patient. And then how do we know when to kind of go with docusate you know so if it doesn’t work in a day well it can take up to three days but you can add something a little bit stronger maybe like bicycodile suppository or something like that which would only take only an hour or two or you could use an enema and those go 15 minutes but really you know a little bit of patience here is really good because you know some things really happened you really just kind of need to get moving around need to make sure you get the water in and then things can kind of get going again.

    Last one 7.5 antiemetics so critical thinking activity 7.5 a nurse is caring for a patient who underwent surgery earlier today and is experiencing nausea and vomiting. The original post-op orders included Prochlorperazine but the patient continues to experience vomiting despite receiving this medication. Nurse calls the provider receives a new order for ondansetron orally dissolving tablets eight milligrams three times daily as needed. One, how will the nurse assess for symptoms of dehydration? Two, when administering the medication, the patients say this tastes terrible why can’t I have a normal pill to swallow what’s the nurse’s best response? And then what other measures should the nurse teach the patient reduce the feelings of nausea and avoid dehydration?

    Okay well let’s take a minute to unpack this I’ll take a minute and go back to memorizing pharmacology. The well this is the Kindle book but most people like the audiobook they’ve got the British narrators we’ll start with prochloroperazine okay so Prochlorperazine is Compazine and it’s a phenotizing that we used as an antiemetic um again it really is more about um you know making sure that the patient understands what the medications are for and what we’re trying to do but ondansetron is that next step up.

    And the on Dance Tron does have that ending, the Citron ending, and you may see ODT which doesn’t taste bad because it’s an orally disintegrating tablet and that’s a choice that might make things a little bit easier for someone that’s so sensitive to taste. It does affect neuro, the neurotransmitter serotonin which is located in the GI tract and it’s kind of neat that in the word in dancetron if you’re on dancetron if you’re one of those people that likes word scrambles it’s got every letter but the letter I from serotonin which might have been how they named it.

    So going back to the question so now we know these are two antiemetics kind of doing a stepwise process here uh. The first thing we would do in making sure that the patient is not dehydrated, you know we want to check what they’re you know to make sure they’re not hypotensive make sure their heart rate is not tachycardic uh make sure that they do have you know a good urine output um and then check the skin for tenting uh and then you know checking the mucous membranes for dryness any or all of those can kind of let us know okay where are we looking in terms of dehydration.

    In terms of uh, you know, the taste terrible if they have a tablet that dissolves um, The ODT that makes it a lot easier for the patient and it really does dissolve super quickly and then what? Other measures to reduce feelings of nausea and avoid dehydration sometimes include giving the medication before a meal, which may not cause as much of an issue with the nausea. Depending on the diet, if you’re a little bit more on the bland side rather than the take-out spicy side, you’re in much better shape. Again, more fluids will take care of the dehydration but that also might make them feel a little bit more nauseous. So the speed at which you rehydrate them, making sure that they’re maybe taking sips rather than just downing something to get rehydrated.

    Okay so let’s go back just to the book itself and we’ll kind of go here on Amazon just so you can kind of see. This second edition of Memorizing Pharmacology was meant to be more of a friendly textbook as it were. Most people don’t get the paperback, most people get the Kindle because they like to be able to search. It’s kind of nice when you’re doing your homework, you’re trying to find something and that one’s I think 10 bucks but the audiobook if you’ve never had it before and you just kind of want to get better at pharmacology over the weekend or on the wave to and from school.

    The way they work it is if you go to Audible or if you go to Amazon.com and I own it so it’s not going to be up there but they’ll let you have it for free and then make sure you know if you don’t want to be part of that Audible thing you cancel within the first 30 days. But I found that a lot of my students when they make pharmacology part of their day morning and night because this is in a specific order starts with gastrointestinal musculoskeletal and so forth that if they kind of keep hearing it and that they don’t have this kind of jerky I’m going to do some Farm on Tuesday some Farm on Friday or all farm on Sunday night that’s what causes all of that anxiety.

    By doing a little bit each day and just kind of embracing it I think it works well so a lot of people will say you know I’m not good at farm and what we really want to say is well I’m not really good at Farm yet. It’s something I got from a chemistry professor here which I’ll have an interview for you a little bit later but you’re just not good at pharmacology yet and it takes some time to do that and it’s really hard to do it if you’re doing it once a week or twice a week and that you’re not really kind of embracing it and listening to it each day and getting the rhythm of it.

    Because what happens is that once you kind of get GI, you’re still going to get a couple of other ones for example the musculoskeletal. You’ll have talked a little bit about opioids opiates because you’re going to have to talk about how to deal with the constipation and then when you get to the opiates like oh yeah yeah I remember when I was doing that GI chapter I remember the medications for the opiates and then now you kind of get into musculoskeletal and you think about okay well diazepam is one of those ones that affects muscles but isn’t that used for isn’t that used for seizures and stuff in neuro.

    And as you’re going through each chapter, it just makes it a little bit easier for you. So again, I did spend a lot of money on a British narrator because I get it pharmacology is not the most exciting for many people and by having that British narrator, it just kind of elevates it a little bit makes it more pleasant to get through.

    So alright well that’s it for this week. The GI pharmacology cases hopefully those are helpful for you and I will bring back a new pathophysiologic class next week. Thanks for listening to the Memorizing Pharmacology podcast. You can find episodes cheat sheets and more at memorizingfarm.com again. You can sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile-friendly self-paced online pharmacology review course at residency.teachable.com forward slash P forward slash mobile thanks again for listening.

     

    Like to learn more?

    Find my book here: https://geni.us/iA22iZ

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to my YouTube Channel TonyPharmD here: https://www.youtube.com/c/tonypharmd

    Here is the Link to my Pharmacy Residency Coursesresidency.teachable.com

    Ep 51 Video OER - Pharmacology Antiarrhythmics Mnemonic

    Ep 51 Video OER - Pharmacology Antiarrhythmics Mnemonic

    Pharmacology Antiarrhythmics Mnemonic

    In this video, we go over a mnemonic to help you remember the five Vaugh-Williams classifications of antiarrhythmic medications. 

    Find the book here: https://geni.us/iA22iZ 

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to TonyPharmD YouTube Channel here: https://www.youtube.com/c/tonypharmd

    In this chapter, we begin our dive into Cardiac System pharmacology. You can find all the respiratory episodes here at https://www.memorizingpharm.com/oer6  

    Here is the Link to my Pharmacy Residency Coursesresidency.teachable.com

     

    Auto Generated Transcript:

    Welcome to the Memorizing Pharmacology Podcast. I’m Tony Guerra, pharmacist and author of the Memorizing Pharmacology book series, bringing you mnemonics, cases, and advice for succeeding in Pharmacology. Sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile friendly self-paced online pharmacology review course at residency.teachable.com forward slash P forward slash mobile. Let’s get started with the show.

    Hey, welcome to the Memorizing Pharmacology Podcast. I’m excited to talk to you a little bit about the cardiac section. So what we’re going to do is we’re going to do an interactive activity with the antiarrhythmics and I think it gets a little bit confusing when we talk about them but we have class one which is the n a or sodium blockers and then we have well fast sodium channel blockers we have within that one a one B one C so procainamide uh lidocaine and phenytoin in one b and then flecanide in one C then we have the two which is the beta blockers but we can have you know the first gens which are like Propranolol second gen metoprolol and third gen Carvedilol uh we kind of moved down to class three which is amiodarone and then class four would be the Verapamil and deltaizum so the amiodarone is going to be a potassium blocking and then the calcium channel blockers are going to be the Verapamil and deltaism so one two three and four and then five we’ll talk a little bit about adenosine uh in a second here.

    Now what we’re going to do is we’re going to go over the antiarrhythmic agents or sometimes called the anti-disrhythmic agents and what we’re going to do is we’re going to just do a little matching here but what I want to give you is a bit of a mnemonic that can help you remember which class goes with which medication and the mnemonic is Nab K C A so NAB for sodium and a and the B for beta blocker and it may help if you do NAB and ABB that may help you even more and then k for potassium blocker or potassium channel blocker really and then C A for calcium channel blocker and then the last one is adenosine for five so this comes from the Vaughn Williams classification.

    And you’ll be told about the Roman numerals from a numeral one which looks like an i which is class one uh class two is two eyes class three is three eyes class four is an i with a V and class five is a v by itself so what we’re going to be going over and I’m not going to answer these in the order that they’re in I’m going to go class 1 Class 2 class 3 class 4 and then adenosine class five because what I want for you to do is to remember it using this mnemonic so class one what we’re looking for is the word sodium or n a in one of the answers.

    So here are the answer choices. And I know they’re a little bit long but I just want to read them so that you can hear how kind of jumbled it is when you just try to read them without having any mnemonic or anything uh first one is medications prolonged repolarization by blocking the potassium channels in cardiac cells that are responsible for repolarization number two says anti-disrhythmic medications slow conduction and prolonged depolarization by decreasing sodium influx into cardiac cells medications increase the refractory period of the AV node by slowing the influx Flux Of calcium ions thus decreasing the ventricular response and decreasing the heart rate medications are beta blockers that are used to decrease conduction velocity automaticity and the refractory period of the cardiac conduction cycle.

    And then a unique medication given to patients who are experiencing paroxysmal supraventricular tachycardia okay so our keywords were potassium sodium calcium beta blocker and then medication so now let’s use our mnemonic our NAB K C A so the N A from NAB would be class one okay. And we saw that it was this answer anti-disrhythmic medication slow conduction and prolonged depolarization by decreasing sodium influx into cardiac cell so one is na in NAB class one Class 2 are beta blockers two B’s okay so n a b b medications are beta blockers that are used to decrease conduction velocity automaticity.

    And refractory period of cardiac conduction cycle class three was K so again it’s NAB KCA so little bit tricky here because potassium when you look at periodic table it K calium it synonym potassium potassium comes from pot ash uh which where this comes from let’s put that class 3 there medications prolonged repolarization by blocking potassium channels in cardiac cells responsible repolarization class four medications okay we’re going match this increase refractory period AV node by slowing influx calcium ions RCA thus decreasing ventricular response decreasing heart rate but also use as class 5 which adenosine okay check okay see they’re all right.

    So again going from one we have our sodium which was our n a from periodic table again that’s little bit tricky one also because it’s natrium but we don’t say that somebody is hyposodium emic we say that they are hyponatremic okay and then class two was our BB our beta blockers okay our class 3 was our k for calium which is potassium on periodic table class four was calcium RCA and then a for adenosine is our class 5 which really mechanism action kind question mark but so class one class two class three class four class five uh hopefully little bit easier way of remembering those uh from this cardiac module interactive activity.

    Thanks for listening to the Memorizing Pharmacology Podcast. You can find episodes cheat sheets and more at memorizingfarm.com again. You can sign up for the email list at memorizingfarm.com to get your free suffixes cheat sheet or find our mobile friendly self-paced online pharmacology review course at residency.teachable.com forward slash P forward slash mobile. Thanks again for listening.

     

    Like to learn more?

    Find my book here: https://geni.us/iA22iZ

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to my YouTube Channel TonyPharmD here: https://www.youtube.com/c/tonypharmd

    Here is the Link to my Pharmacy Residency Coursesresidency.teachable.com

    Ep 44 Video OER Legal Ethical Pharmacology Cases and Critical Thinking Chapter 2

    Ep 44 Video OER Legal Ethical Pharmacology Cases and Critical Thinking Chapter 2

    OER Legal Ethical Pharmacology Cases and Critical Thinking Chapter 2

    Find the book here: https://geni.us/iA22iZ 

    or here: https://www.audible.com/pd/B01FSR7HLE/?source_code=AUDFPWS0223189MWT-BK-ACX0-059486&ref=acx_bty_BK_ACX0_059486_rh_us

    and subscribe to TonyPharmD YouTube Channel here: https://www.youtube.com/c/tonypharmd

    In this chapter, we take a deep dive into some of the legal and ethical issues surrounding pharmacology. You can find all the episodes here at https://www.memorizingpharm.com/oer

    Here is the Link to my Pharmacy Residency Coursesresidency.teachable.com

     

    Auto Generated Transcript:

    Hey, welcome to the Memorizing Pharmacology podcast. We’re going to be starting the critical thinking activities in Chapter 2 of Nursing Pharmacology and what I wanted to do is show you where all of these videos and audio are going to be. So here is the Nursing Pharmacology book and what I’ve done is I’ve put it at memorizingfarm.com. And if you go to the front page, I know that this is a little bit small because this is what it would look like on a mobile and it’s just click here for the OER Nursing Textbook videos and audio which will take you to this page and here we have all of the links that you need to Memorizing Pharmacology, Memorizing Pharmacology Mnemonics and the Nursing Pharmacology Textbook and here are the kinetics and Dynamics. This is where you would find all of those videos so this Kinetics and Dynamics Chapter 1 button here will take you to the videos so we had video One video two and video three or part one part two and part three.

    Alright, and the nice thing is that it’s not really hard to figure out where this is because it’s memorizingfarm.com OER one and then Chapter two will be OER2. And so eventually I’ll record the entire chapter readings again this will take some time so that will all be here for you so but right now we’re kind of going one chapter at a time and now we’re gonna hit Chapter two okay.

    Alright, our first critical thinking activity is here at 2.2 a. I’ll read it to you and then I will give you a detailed response so critical thinking activity 2.2 a a nurse is preparing to administer medications to a patient while reviewing the chart the nurse notices two medications with similar mechanisms of action have been prescribed by two different providers what is the nurse’s best response well first I’m going to give you my answer and then I’ll show you another resource on the memorizing Farm web page that can really help you here.

    So when you look at two similar medications with mechanisms of action for example maybe both of them reduce heart rate well we could make the patient bradycardic or both increase heart rate and they can tachycardic. And so the first thing is to clarify both with both providers that you know letting them know that we have this duplicate because they may not know that the other person is doing it and this is not uncommon for someone to go to their primary care physician I’d get a prescription and then go to maybe their cardiologist and get another prescription and only to find out that the cardiologist and primary care physician are not really communicating and that we have some kind of duplicate or something like that.

    So I want to do is take you to Two web pages on the website. The first one is memorizingfarm.com forward slash drug hyphen prefixes hyphen and hyphen suffixes. This suffix and prefix list allows you to find a number of the medications and their suffixes. And these are the suffixes from Memorizing Pharmacology, The First Edition Just 200 medications. And for example, we can look in here and we can see that prizol isn’t anti-ulcer agent but when we go to immune okay there’s a connazole okay that is a systemic anti-fungal okay and in neuro we see piprazole which is a psychotropic.

    "Searchable documents make it a lot easier for you to find it much more comprehensive. But in terms of usability, I might use the one before it. But when we’re talking about the same mechanism of action, if we see the same endings, then we’re going to have the same mechanism of action likely. Okay, but you have to kind of go a little bit into the weeds because if you have, for example, esomeprazole and omeprazole, well you actually have two proton pump inhibitors and both of the physicians were thinking, ‘Hey, you know I want to reduce this patient’s gastric acid.’ One gave them one medication and the other one gave him the other and they both didn’t mean to give the same type of medication. But if a patient is on let’s say Omeprazole and fluconazole and aripiprazole for a GI issue, an immune issue, well it’s an antifungal and then we’re also talking about an antipsychotic then well we may have physicians that all three want to write those medications and those are not duplicates but that again is what the memorizing pharmacology books are all about making sure that you can not only understand memorize the medications but also increase your patient’s safety. Okay so that was 2.2a maybe I went a little bit too deep into that one but the bottom line is same mechanism of action you want to clarify with both prescribers here is critical thinking activity 2.

    2 B okay a nurse is preparing to administer metoprolol, a cardiac medication to a patient and implement the nursing process assess the vital signs prior to administration and discovers the heart rate is 48 so patient is bradycardic diagnosis that the heart rate is too low to safely administer the medication for the parameters provided establishes the outcome to keep the patient’s heart rate within the normal range of 60 to 100 so again below 60s bradycardic above 100s tachycardic plans to call the physician as well as report this incident in the shift handoff report implements interventions by withholding metoprolol at this time documenting the incident that the medication is withheld and notifying the provider continuous to evaluate the patient’s status throughout the shift after not receiving the metoprolol. The nurse is providing patient teaching to a patient about the medication before discharge. The nurse provides a handout with instructions as well as a list of current medications what other information should be provided to the patient? Well here what we’re going to do is uh we’re gonna make sure to let them know hey when are you need to take the medication what kind of side effects you’re going to watch out for uh and adverse effects and then maybe there’s diet over-the-counter restrictions herbal supplement restrictions as well but let’s just give one so with beta blockers one of the things that is maybe a little bit of a surprise to something called exercise intolerance where all of a sudden patient goes home goes tries to exercise like whoa what is going on I just did not feel "Like myself, that’s something they should know before they go home with the medication that okay that’s gonna happen with a beta blocker that will reduce you know heart rate very sometimes significantly and that’s kind of one of the things that should be in there. The other thing is to make sure that you’re looking at the patient so if the patient is diabetic okay beta blockers mask this signs and symptoms of hypoglycemia because normally a hypoglycemic patient would get a rapid heart rate and kind of get tremors and those types of things and if that’s not the case then the patient might not realize that they’re hypoglycemic so that’s another one of the counseling points to put in there. So that kind of tiredness that a patient might feel is going to be somewhat normal with a beta blocker especially at first and then if a patient’s diabetic want to make sure that they know that the signs and symptoms of hypoglycemia might be covered up. All right critical thinking activity 2.

    3 A Levofloxacin is an antibiotic that received FDA approval however the drug was on the market it was discovered that some patients who took levofloxacin developed serious irreversal adverse effects such as tendon rupture. The FDA issued a black box warning with recommendations to reserve levofloxacin for use in patients who have no alternative treatment options for certain indications uncomplicated UTI acute exacerbation of chronic bronchitis acute bacterial sinusitis. A nurse is preparing to administer medications to a patient notices that levofloxacin has been prescribed for the indication of pneumonia there’s no other documentation in the provider’s notes related to the use of the medication what’s the nurse’s best response? So we’ll give you a second since this is not one of the normal indications we’re going to want to first clarify that the prescriber whether a nurse practitioner or physician whatever really meant to give levofloxacin for this patient that’s the first thing we’re going to do um and then we want to make sure that we document that then if it is a go ahead then we want to make sure we tell the patient okay take the levofloxacin with water make sure you take it at the same time each day you can take it with or without food but the patient should be told that they need to avoid dairy products like you know milk yogurt things like that at least two hours before or after because it will chelate or bind with um those types of things and make it much less effective it’ll also bind with things like antacids calcium carbonate and magnesium hydroxide aluminum hydroxide and and I didn’t want to go into the weeds with that but the idea is that multivalent cations multivalent again this is why chemistry is so important so multivalent means it’s plus two or plus three multi meaning many and so if you look in group two of the periodic table group theory of the period three of the periodic table in group two you see calcium and magnesium and in group three you see aluminum and so if you see those those are going to bind with the levofloxacin or fluoroquinolones more generally and they’re going to make them ineffective so that’s if you get the go ahead from the prescribed okay let’s go on to critical thinking activity 2.

    3 B A nurse is providing discharge education to a patient who has recently had surgery and has been prescribed hydrocodone with acetaminophen tablets to take every four hours as needed at home. The nurse explains that when medication is no longer needed when the post-op pain subsides should be dropped off at a local pharmacy for disposal in a collectible receptacle."

    In a collection receptacle, the patient states, ‘I don’t like to throw anything away. I usually keep unused medications in case another family member needs it.’ What is the nurse’s best response?

    'Alright, well the first thing is we really don’t want to share medications. It is illegal, especially with controlled substances like hydrocodone with acetaminophen, which is Vicodin or Lortab. Not only does the other patient, we don’t know what other issues they might have. For example, let’s say that a patient has trouble breathing or just something like that. You can have respiratory depression if you take too many of these. So what we want to do is talk about the dangers of potential drug interactions, dietary interactions, other side effects of the medication for themselves where the prescriber and the nurse have already looked at their record. But to give a medication to someone and you haven’t even evaluated the other medications, that would be irresponsible and in this case also illegal.

    Let’s do number two or part two here. A nurse begins a job on a medical surgical unit. One of the charge nurses on this unit is highly regarded by her colleagues and appears to provide excellent care to her patients. The new nurse cares for a patient that the charge nurse cared for on the previous shift. The new nurse asks the patient about the effectiveness of the pain medication documented as provided by the charge nurse during the previous shift. The patient states, ‘I didn’t receive any pain medication during the last shift.’ The nurse mentions this incident and the preceptor states, ‘I’ve noticed the same types of incidents have occurred with previous patients but didn’t want to say anything.’ What’s the new nurse’s best response?

    ‘Well this is an issue where we may have an impaired nurse and this could obviously endanger the patient and themselves to be honest. So it’s their obligation to report suspected drug use to the nurse manager and supervisor and then in maybe in some cases to the board of nursing. But if that happens and certainly if it happens on a consistent basis then it’s not to take it on your own. It’s to talk to the right people about this and kind of go from there.’

    Alright, critical thinking activity 2.3 C: A nurse is preparing to administer morphine, an opioid, to a patient who recently had surgery.

    1. Explain the five rights that the nurse will check prior to administering this medication to the patient.

    2. Outline three methods the nurse can confirm patient identification.

    3. What should the nurse assess prior to administering this medication to this patient?

    4. Which should be monitored after administering the medication?

    5. Which should the nurse teach the patient and/or family member about the medication?

    6. What information should be included in the shift handoff report about this medication?

    Alright, let me re-read each question each time I do this just because there are a lot of pieces to this.

    So number one: Explain the five rights that the nurse will check prior to administering this medication to the patient.

    The five rights are: right patient, right medication, right dose, right route, right time. And then of course we’re going to want to make sure that we check the expiration date and check allergies although it’s not on here. A sixth right is correct or right documentation as well.

    The second question said: Outline three methods that a nurse can confirm patient identification.

    Let’s kind of break this up: You could scan a barcode on both medication and patient’s armband if they have it; you can ask their name and date of birth; you could just check their armband or identification band itself.

    But sometimes you’re going to be in settings like long-term care where there might not be an armband and also if you’re talking about dementia patients they may not know their name or date of birth so what we want to do is maybe if their medication record has an image of them that would be one way to do it but probably the best way is to get somebody who is working there as well Here is the corrected version of your text:

    "And say, ‘You know, I think this is such and such,’ or just say, ‘Look, I know who I think this person is. I just want you to identify them to match it so that you don’t already say, hey, this is this person.’ The person says, ‘Yeah, that’s that person.’ What we do in the pharmacy is we’ll generally ask for somebody’s address and that’s just an innocuous way of saying, ‘Okay, we have the same person.’ So Tom Smith, we’re just hoping that Tom Smith and Tom Smith don’t both live in the same place or in the same address. And even if they do live in the same building like we’re in some place like New York where you could have many people living in the same building, making sure to pay attention to the apartment number or something like that.

    Alright, what should the nurse assess prior to administering this medication to the patient? So we weren’t really that specific. We just said it was some kind of opioid so we know that there’s going to be some issue with pain. So what’s the patient’s pain level? Are they conscious and alert? What’s their respiratory rate? Again, we know that an overdose of opioids can reduce the respiratory rate cause respiratory depression. And then are they oxygenating? So what do we do then if there is a respiratory rate that’s decreased or an oxidation level that’s decreased or sedation is too high? We want to make sure that we contact the prescriber, talk about withholding the medication things like that. And then of course if there’s some kind of overdose.

    I definitely want to start talking about interventions. Number four: What should be monitored after administering this medication? Well again, we’re monitoring respiratory rate, that oxygenation level, the sedation status. And then you know, is it effective in treating the pain? You know, is it doing its job?

    Okay number five: Which should the nurse teach the patient and/or family member about the medication? So this would be the common side effects and we’re not talking about toxicity. We’re talking about patient’s probably going to be constipated and this would be a good time to check the medication record to make sure that maybe there’s some docusate sodium on board or something like that. Some degree of laxative that’s going to help them or a stool softener. And then let them know that drowsiness is going to be something that does happen but also to maybe let them know okay well what are the signs of toxicity where we would be going kind of a little bit further than the common side effects.

    And then the sixth one was: What information should be included in the shift handoff report about this medication? So again we’re talking about the pain. Where is that pain coming from? What’s the pain level? What medications were given and what times during the shift? And then how did the patient respond? Is the patient comfortable? Is the patient doing well?

    Alright let’s go on to 2.3 D: Okay a nurse is disciplined by the Wisconsin Board of Nursing for an incident reported by her employer that she arrived to her shift intoxicated. Then our shares with a nursing colleague: ‘I love taking care of patients. I work so hard to obtain my nursing license. I don’t want to lose it. I know my drinking has gotten out of control but I don’t know where to turn.’ What is the best advice by a nursing colleague for this patient with a drinking problem?

    Well most boards are going to have some level of assistance so in Wisconsin you’d have a professional assistance procedure where a patient committed to recovery is able to get treatment and support. And what we want to do is prioritize patient safety but also acknowledge that a nurse has rights as well to get help especially if she’s committed to recovery.

    Alright, question 2.4: A nurse is providing education to a mother regarding a liquid antibiotic prescribed for her child to take at home. The prescription states amoxicillin 250 milligrams one teaspoonful (5 mL) every eight hours for seven days. After talking with the mother, the nurse realizes the family does not have measuring spoons in their home. What is the nurse’s best response?

     

    So this is a really common thing that happens especially when maybe you have a spoon that gets lost or someone just forgot their medication itself. If you go to any pharmacy, they’ll give you a syringe. You don’t have to ask, ‘Do I need to pay for a syringe?’ I mean, you could buy one, but just go up to the counter and say, ‘Hey, can I just get a measuring spoon or a syringe?’ Now to be fair, the syringe is actually a bit more accurate. I don’t want to say it’s necessarily more accurate, but the data show that patients do better with the syringe than they do with the measuring spoon in terms of giving the appropriate dose. So going to a pharmacy to get this, don’t try to use the spoons at home. The tablespoons, the teaspoons, that is not the way that you want to do it to make sure that the patient, especially a child, gets the right medication.

    Alright, we’re in our last section. We’re going to do two more critical thinking activities.

    Activity 2.5 A: The nurse is performing medication reconciliation for an elderly patient admitted from home. The patient does not have a medication list and cannot report the names, dosages, and frequency of the medication taken at home. What other sources can the nurse use to obtain medication information?

    In this case, what we’re going to do is we’re going to try to compile everything for them. Often in the pharmacy world, we’ll have brown bag events where the patient just kind of brings all their medications including over-the-counter stuff. We don’t want to exclude that. We don’t want them to just bring prescribed medications and what we want to do is make sure that we compile them into a list that we can print out for the patient so that when they go to their next provider they can provide this list to them. Again, the medications will change and things like that but making sure that all the medications are correct and appropriate. That we don’t have medications they were using before they don’t need anymore and then making sure that they go home with the list.

    Critical Thinking Activity 2.5 B: A nurse is preparing to administer insulin to a patient. The nurse is aware that insulin is a medication on the ISMP list of high alert medications. Which strategy should the nurse implement to ensure safe administration of this medication to a patient?

    So of course, we’re going to use the five rights. We’re going to want to make sure that the blood glucose level is where we want it to be. What type of insulin are they taking? Concentration? When was it opened? So we want to make sure that it’s good and then also what kind of storage was happening with the medication? The nurse should draw the dose; they can confirm the correct dose with another nurse prior to giving it; and then knowing the onset peak and duration of action to monitor for potential side effects like hypoglycemia which is quite common with insulin unfortunately.

    But let me show you a page of memorizing pharmacology so that you can kind of see where memorizing some of these insulins would be really useful.

    Okay when you’re looking at this and you’re working on memorizing these you want to memorize them in order some kind of order in this case with insulin you want to memorize the rapid acting those that start working in 15 minutes last about four hours those are going to work so quickly you’ve got to make sure that the patient has a meal so we’re talking about insulin lice Pro or Humalog something like that short acting Works in about 30 minutes and this lasts about six to eight hours and this is regular insulin Humulin R.

    The intermediate NPH Humulin N about an hour or two last 14-24 hours and then that long duration insulin glargine Lantus and Tujeo those start working about an hour and last about 24 hours but when you memorize them you want to remember Humalog then Humulin R and Humulin N then Lantus or Tujeo.

    We want to do that in order put them in your brain in order because then when you’re saying okay I’m giving insulin if you’re giving Humalog you know okay well I’ve got to talk to the patient about what they’re eating with R you know that there’s maybe some kind of "Know titration up or down where you know maybe we’re kind of looking at their blood glucose first and then giving our NPH should be given to you know kind of control insulin levels over a much longer period of time and then certainly insulin glargine you know are we giving it you know at night time or daytime uh which time are we kind of choosing uh to do that so my advice is when you get to that insulin and you know that insulin can be you know life-saving but it can also be very dangerous memorize them in order Humalog, Humulin R, Humulin N and then Lantus or Tujeo.

    And just to be clear this is the book that I’m talking about it’s right here: Memorizing Pharmacology Relaxed Approach Second Edition. And this was the Kindle version. The audiobook obviously is gonna you know narrate those types of things but I just want to make clear this is where this is coming from.

    Alright well let’s kind of go back to the beginning here so again this was a nursing pharmacology lesson this was chapter two legal and ethical and the next thing you do is go into antimicrobials which is chapter three and I’ll talk a little bit about the way that I teach and the way that I put them in order.

    I always put my classes and then I ask the patient, the patients I ask the students to always put their groups in order so they would put um gastrointestinal musculoskeletal respiratory immune neurocardio endocrine. I asked them to always put the medications on the patient’s med list in that order so that they can look for duplicates and things like that and then when they’re studying for and collect snat applex whatever it is they’re studying for to also continue to study in that order so that in your brain you kind of have these partitions and you know okay the first partition is GI the second partitions musculoskeletal the third partition is respiratory because I think it gets confusing when you use multiple books or multiple resources and you’re in a different order but so if you need my help or want to get in touch with me Tony the pharmacist gmail.com. I hope you’ve enjoyed this episode and hope it’s been helpful.

     

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    Ep 41 Video OER Pharmacology Cases and Critical Thinking Chapter 1 Kinetics and Dynamics Part 1

    Ep 41 Video OER Pharmacology Cases and Critical Thinking Chapter 1 Kinetics and Dynamics Part 1

    Video OER Pharmacology Cases and Critical Thinking Chapter 1 Kinetics and Dynamics Part 1

    This is Chapter 1, Part 1 of the Critical Thinking exercises in Chapter 1 of the OER Nursing Pharmacology book where I go over a little more detail on the answers to help you better understand pharmacology with the engagement of small case studies. 

    Find the book here: https://geni.us/iA22iZ 

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    Auto Generated Transcript:

    Hey, welcome to the Memorizing Pharmacology podcast. I’m Tony Guerra, a pharmacology professor and author of the Memorizing Pharmacology and Memorizing Pharmacology Mnemonics series of books. What we’re going to do today is go over the critical thinking activities in chapter one of this Nursing Pharmacology OER book. That is, it’s an open educational resource so you can get it for free if you like. We’re just going to go over the critical thinking activities in the first chapter. So, we’re not going to be skipping around as much as we’re just going to kind of zero in on those activities that really focus on critical thinking. If you want more information, you can always go back to the book itself to check it out.

    So, the way it works is we’re just going to go here and we see okay critical thinking activity 1.5. Metabolism can be influenced by many factors within the body. If a patient has liver damage, the patient may not be able to break down or metabolize medications as efficiently. Dosages are calculated according to the liver’s ability to metabolize and the kidneys’ ability to excrete. When caring for a patient with cirrhosis, how does this condition impact the doses prescribed for the patient?

    So when we have somebody that has cirrhosis, the first thing we’re really kind of saying is that the liver is damaged right? So if these transformations or biotransformations as we call them are in the liver and normally are taken care of by liver enzymes and those liver enzymes are damaged and so forth then they’re not going to work as well.

    So what happens? Well, what we really want to talk about here where if you have less and if you have more ability to metabolize these medications. So let’s think about it this way: The liver can normally metabolize some amount of medication right? If it’s damaged, it’s gonna be like when you’re at work and there’s one less person there and you can’t get things done as quickly.

    So for example, it’s very often that you know you’re in a restaurant and they’ll tell you hey you know we just don’t have enough waiters tonight sorry times are a little bit slow okay all right so your food isn’t going to get there as quickly. When we’re talking about metabolism and medications that means that we’re going to have more or less medication hanging around.

    Well if the liver’s job is to break down the medication then that means we’re actually going to have more medication sticking around okay and that means that we need to do what with the dosage? Okay, the dosage needs to go down because the amount of medicine still in the body because the liver can’t break it down is going up okay so we’re basically lowering dosages to decrease that toxicity okay.

    So again as we go through these critical thinking activities you can kind of stop the recording say okay well let me try to answer it and then kind of go from there okay so we’re in now excretion so if we’re thinking about pharmacokinetics we have absorption distribution metabolism and excretion.

    The liver is the organ that is most associated with the breakdown of medications or transformation of medications and Metabolism but when it comes to an excretion we’re talking about now how good is the kidney function okay so when providing care for a patient who has chronic kidney disease how does this disease impact medication excretion?

    Well if many of these medications and metabolites, the kidney filters them when we are not able to get rid of them okay we might find that we are now getting reserved back into the bloodstream. The kidneys aren’t working they’re just kind of hanging around hanging around and we have a very similar effect to the liver but just to be clear: The liver hasn’t been able to break it down and we keep more medication around with chronic kidney disease.

    The medication excretion okay is going to be slowed down because we just can’t get rid of it. The kidney is damaged okay all right let’s go on to the next one pharmacodynamics so we have pharmacokinetics and pharmacodynamics pharmacokinetics is really the absorption distribution metabolism and excretion pharmacodynamics now we’re going to talk a little bit about how a medication and its effects are going to create a need for an assessment or different type of assessment.

    "Administration, well, let’s start by defining that word, inotropic. Okay, inotropes are generally going to increase or decrease the strength of contraction of the heart. Whether it’s a positive inotrope where it increases the strength of contraction or a negative inotrope where it reduces the strength of contraction. So, digoxin is a positive ionotrope. Other ones include dopamine, dobutamine, adrenaline or adrenaline. Those are positive ionotropes increasing the strength of contraction. Negative inotropes include like amiodarone.

    Amlodipine, carvedilol, metoprolol, propranolol, ramipril, valsartan those types of things. So when we’re talking about these medications we’re looking and saying okay we have a beta blocker this is a negative ionotrope this is going to reduce the force of contraction okay but what’s it going to do as far as its chronotropic effect so again we want to define well what is a chronotropic effect so a positive chronotrope is one that’s going to increase heart rate get you closer to tachycardic and then a negative chronotrope is one that’s going to reduce heart rate it’s going to get you closer to bradycardic and again to define that bradycardia is right 60 beats per minute tachycardia is 100 beats per minute.

    So to give you some examples if we talk about the positive chronotropes we would think like atropine, dopamine, dobutamine, epinephrine. If we think about the negative chronotropes we’re talking about digoxin, diltiazem, varapamil, metoprolol but really we could say beta blockers in general so it’s important that we see that atenolol has negative inotropic and chronotropic effect so what should the nurse assess before administration now that we know what these are for well it’s reasonable that if you’ve got something that’s going to reduce heart rate and maybe reduce heart blood pressure then the first thing that we want to do is we want to assess the patient’s pulse and blood pressure and make sure they’re normal.

    What we don’t want to do is have somebody that maybe is already bradycardic and bring them even down lower okay now I run marathons or I run long distance so my normal heart rate is probably in the 50s so they would just check okay well that’s normal that’s fine it’s not that something is happening okay but that’s what we would do.

    Alright let’s go on to 1.9 we have two parts to this one first at 05:00 number one at 05:00 your patient who had a total knee replacement yesterday rates his pain while walking at seven out of ten physical therapy is scheduled at nine patient oh 09:00 okay so 9 A.M. to us the patient has acetaminophen Tylenol 625 milligrams ordered every four hours as needed for discomfort what should you consider in relation to the administration and timing of the patient’s pain medication.

    So there are really three things that we’re going to do here first we have 05:00 okay that’s what time it is now okay the patient needs medication will give them medication now right we know they’re going to need it in about four hours so what we can do is after about an hour check with the patient see how they’re doing see if their pain is improved then just before the physical therapy session we want to make sure that they get their medication because we don’t want them to have one dose at five then four hours later start their physical therapy session and be in pain while that’s happening so we want to make sure it’s a little ahead of time.

    The last thing we want to do is we want to make sure that we don’t exceed the maximum Tylenol for the day and there’s a couple of numbers here generally we say that we really don’t want to be above 4 000 but if you actually talk to the makers of Tylenol they would prefer that number be even closer to 3 000 a much safer amount if the patient and this isn’t in the paragraph but if there were some alcohol disorder or patient as a drinker we would want to reduce that Tylenol even more because we want to be careful with the liver.

    So 05:00 patient had a total knee replacement yesterday pain walking seven out of ten physical therapy scheduled at nine. We give the first dose at five then we check with them about an hour later make sure that it’s working then just before the physical therapy we give them another dose okay then four hours after that they’ll get another one and what we’re making sure is throughout the day that the patient isn’t going over the amount they should have now.

    "We can do a quick calculation here if 625 is ordered every four hours let’s see what that total would be and I know what it is I can do it in my head but I’m just saying let’s let’s get the Google Calculator. Okay, so the first thing we want to do is we want to be careful we don’t multiply the 625 times 4 because it’s every four hours we would multiply the 625 times 6 and we see that that number 3750 milligrams is right there between three thousand and four thousand and what we want to make sure is that okay maybe it’s around the clock but maybe it’s not because this isn’t for inflammation Tylenol doesn’t acetaminophen doesn’t help with inflammation if the patient can sleep through the night then okay maybe one of those doses we won’t use will get a lot closer to that 3000 number or maybe it’ll go out a little bit further closer to the five hour mark something like that and we get down to three thousand but we’re really hovering on the edge so this is where we really want to be careful if someone says okay well the pain isn’t being taken care of let’s add some Vicodin or something like that and Vicodin in it or vicoprofen would have an additional or Vicodin not vicoprofen Vicodin would have an additional amount of acetaminophen so we definitely want to be careful of that okay.

    Alright, well let’s look at the second one here. Number two, your patient is prescribed NPH insulin to be given breakfast and supper. As a student nurse, you know that insulin is used to decrease blood levels in patients with diabetes mellitus. During a report, you hear that this patient has been ill with GI upset during the night and the nursing assistant just inform you he refused this breakfast tray. While reviewing this medication order, you consider the purpose of the medication and information related to the medication onset peak and duration again we’re talking about the NPH insulin right now when reviewing the drug reference you find that NPH insulin has an onset of about one to three hours after medication administration. What should you consider in relation to the administration and timing of the patient’s insulin?

    So let’s take a minute to think about it. Alright, so you’re back and let’s think about this. So the insulin is supposed to decrease blood sugar levels but the patient’s stomach’s been hurting quite a bit and he’s just not hungry. Well wait a minute, insulin can be used to reduce blood glucose levels but our expectation is that glucose levels are going to be increased each time the patient eats. If the patient is not eating well then we need to really make sure that we’re not going to cause hypoglycemia. So again hyperglycemia is glucose that is too high in the bloodstream hypoglycemia is when it’s too low so insulin is one of those high alert medications and so if this continues to happen, the patient keeps refusing the food but keeps getting the insulin, we could be in a lot of trouble so we want to make sure that we work with the patient make sure that we’re checking if they’re eating and make sure that the insulin dose is appropriate for how much they’re eating and we would do that by doing some blood glucose tests throughout the day to make sure that those blood glucose and blood sugar levels are where we want them to be.

    Alright, here is critical thinking activity 1.10 a Mr Parker has been receiving Gentamicin 80 milligrams this is under medication safety has been receiving Gentamicin 80 milligrams IV three times daily to treat his infective endocarditis he has his Gentamicin level checked one hour after the end of his previous Gentamicin infusion was completed. The result is 30 micrograms per ml based on the results in the above patient scenario what action will the nurse take based on the result of the Gentamicin level of 30 micrograms per ml okay so I’ll give you a minute.

    Alright, the normal lab value okay that’s kind of the first thing that we have to do okay it’s like five to ten mcgs or micrograms per ml right or if you’re using micro moles it’s like 10 to 20. It’s a little higher okay per liter what we can do is see if this patient has good kidney function there might be some kind of renal impairment that is not helping with excretion and we need to make sure that we adjust the dose on the next time so again we’ve got a result. We compare the result to the normal Gentamicin levels, we see that the level is high and now we’re going to check maybe kidney function what’s going on because Gentamicin itself is ototoxic damaging to the ears but also nephrotoxic and can actually damage the kidney itself.

    Alright, I’m actually going to stop it there before we go to 1.12 module learning activities. I think that you know that 15 minutes or somewhere between 15 and 20 minutes is a good amount of time so again you can go to the nursing pharmacology book and we went through 1.5 metabolism, 1.6 excretion, 1.7 pharmacodynamics, 1.9 okay we’re examining the effect, 1.10 medication safety okay so again if you want to check out a course on pharmacology that has all those mnemonics and things like you’re welcome to check out the self-paced pharmacology course with mobile quizzes and videos at residency.teachable.com forward slash P forward slash mobile and you can always get half off h-a-l-f-o-f-f again it’s h-a-l-f-o-f-f to get half off.

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    Ep 40 Video Peptic Ulcer Disease Triple Therapy Mnemonic

    Ep 40 Video Peptic Ulcer Disease Triple Therapy Mnemonic

    Peptic Ulcer Disease Triple Therapy Mnemonic

    Here's the Mnemonic for Peptic Ulcer Disease Triple therapy that can include PPIs and H2 blockers in addition to the ones listed in the actual mnemonic. The important thing is that we reduce acid and kill the H. Pylori bacteria to help institute ulcer healing.

    Find the book here: https://geni.us/iA22iZ 

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    Auto Generated Transcript:

    Hey, welcome to the Memorizing Pharmacology podcast. I’m excited to bring you another mnemonic that’s going to help you through pharmacology class. So, what I wanted to do is talk a little bit about Peptic Ulcer Disease where we’re going to have these triple and quad therapies. In this section, we’re going to talk about the triple therapy where you take a couple of antibiotics and you add something to reduce the acid and there are a number of choices that you can make. So, I just wanted to be clear that it doesn’t have to be this proton pump inhibitor. There are many proton pump inhibitors that you can use and some prescribers even use H2 blockers such as Famotidine and so forth. So, as we go through this lesson, think of it more as what kind of antibiotics am I going to use and what kind of acid reducers would I use more generally and then have a better understanding of how we protect the stomach and allow it to heal and get rid of the ulcer.

    Question number six: Name three antibiotics in a triple Peptic Ulcer Disease regimen and how we dose the PPI? Number six: Triple Peptic Ulcer Disease (PUD) therapy. We’ll use the mnemonic ‘aced PUD’. ‘A’ Amoxicillin brand name Moxatag, ‘C’ Clarithromycin brand name Biaxin, ‘E’ Esomeprazole brand name Nexium, ‘D’ Double dosing of the PPI.

    Quick summary: Triple therapy means we are using three drugs usually one acid reducer and two antibiotics. Quad therapy adds another antimicrobial for four drugs in total. After a recent update to H pylori preferred drug regiments, a round of first-line triple therapy now includes Metronidazole but it would be confusing to throw it in this mnemonic.

    Peptic Ulcer Disease describes ulcers that develop in the stomach or duodenum and extend deep into the mucosa. Ulcers can lead to GI bleeds. Three main Peptic Ulcer Disease causes are stress, NSAID use, and H pylori - a helicopter-like organism that burrows into the stomach lining.

    The Mainstay treatment for H pylori ulcers includes antibiotics to wipe out infection and ppis to reduce acid. Treatment typically lasts 10 to 14 days. Traditionally, H pylori infection treatments have included triple therapy - a PPI, Amoxicillin, and Clarithromycin.

    For triple therapy, I used ‘Ace’ as the mnemonic as the three-drug combination aced killing Helicobacter pylori - the causative organism. You can include any of the ppis in the treatment regimen but Esomeprazole’s ‘E’ made creating mnemonics easier.

    ‘A’ Amoxicillin - a penicillin antibiotic. The ‘cillin’ stem lets us know Amoxicillin is a penicillin antibiotic with Amoxicillin side effects we worry about penicillin allergic patients.

    ‘C’ Clarithromycin - a macrolide antibiotic. Clarithromycin has a throw T-H-R-O substance with mycin M-Y-C-I-N as a suffix or you could look at the throw T-H-R-O which rhymes with the crow CRO in macrolide. Be careful with mycin it only lets you know the bacteria comes from the Streptomyces class but it does not tell you the antibiotic class.

    For Clarithromycin, we think of the metallic taste and QT prolongation.

    ‘E’ Esomeprazole - a proton pump inhibitor.

    And ‘D’ Double dosing of the PPI means we use bid twice daily dosing rather than traditional QD once daily dosing.

    Why do we use two or three antibiotics?"

    If you use more than one antimicrobial, you can reduce resistance and decrease dosages to lower the risk of side effects. Why do we use quad therapy? If a patient is penicillin allergic, we might use the bed M regimen which we’ll look at next.

    Alright, let’s continue with a couple of quiz questions from the teachable course. What are two antibiotics used in triple therapy to treat Peptic Ulcer Disease? Is it Vancomycin and Cefepime, Amoxicillin and Clarithromycin, Cefdinir and Ciprofloxacin or Tobramycin and Levofloxacin? Yep, if you answered Amoxicillin and Clarithromycin, you can check your answer and that is correct.

    Alright, continuing to the next question. How do you dose a proton pump inhibitor in triple therapy to treat Peptic Ulcer Disease? Do you have the dose triple the dose double the dose or quadruple the dose? So again, how do you dose a proton pump inhibitor in triple therapy to treat Peptic Ulcer Disease? Is it half triple double or quadruple? Awesome, if you answered double the dose, you can check that. You see that it is correct.

    And what you want to do is you want to make sure you get that significant acid suppression to help that ulcer heal. Again, if you want to continue on in a course that helps you out in Pharmacology, there’s really three ways that I’ve kind of set it up. You can just get the audiobook Memorizing Pharmacology: Relaxed Approach Second Edition. Again, Audible’s very good about giving you a free book if you’ve never been with Audible before.

    You can take a self-paced pharmacology course with mobile quizzes and videos. You can always get half off with the discount code H-A-L-F-O-F-F all caps at residency.teachable.com forward slash P forward slash mobile or you can take a pharmacology class with me at Des Moines Area Community College completely online completely asynchronous it’s PHR185 Pharmacology and you can find that by just hitting really the easiest ways to just put in DMACC pharmacology in the Google box and you’ll get to it.

    But if you’ve got questions I’m always happy to send emails back. A lot of people have me help them with their homework too if you’re having some struggles with pharmacology and there’s a question or two that you really don’t understand why it was right or wrong or something like that Tony the pharmacist gmail.com I’m happy to help you out again I just want you to succeed need in Pharmacology okay thanks again for listening to the memorizing pharmacology podcast excited to have you again make sure to get on our email list at residence not at residency.teachable.

    Com but at memorizingfarm.com okay just go down to the bottom and then you can get our best pharmacology cheat sheet I just your first name and an email address just so we can keep in touch and that pharmacology cheat sheet again has the suffixes and prefixes for over 350 medications making it a lot faster to learn pharmacology thanks for listening.

     

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    and subscribe to my YouTube Channel TonyPharmD here: https://www.youtube.com/c/tonypharmd

    Here is the Link to my Pharmacy Residency Coursesresidency.teachable.com