psma

In this podcast, Dr. Alicia Morgans discusses recent data presented at the 2022 ASCO GU Cancers Symposium, including trials evaluating the use of first-line PARP inhibitors in combination with abiraterone for mCRPC, continuation of enzalutamide after progression, and imaging modalities as predictive and prognostic biomarkers. This activity is available for CE/CME credit. Claim your credit at pce.is/ascogu.

Contributors: 

Dr Morgans has disclosed that she has received funds for research support from Atellas, AstraZeneca, Bayer, Myovant, and Pfizer, and consulting fees from AAA, Astellas, AstraZeneca, Bayer, Blue Earth, Clovis, Dendreon, Janssen, Lantheus, Merck, Myovant, Novartis, Pfizer, Sanofi, and Telix.

Ms Martone has no relevant conflicts of interest to report. 

In this episode, Chris Parker, MD, and Bertrand Tombal, MD, PhD, discuss the clinical implications of the latest data on radiopharmaceuticals in the treatment of patients with metastatic castration-resistant prostate cancer (CRPC). Topics include:

• Data from the PEACE-3 trial on the effect of bone-protective agents on fracture risk with enzalutamide plus radium-223
• Efficacy and toxicity of PSMA lutetium plus standard of care in the VISION trial
• Ongoing trials evaluating radionuclides in combination with other agents in metastatic CRPC

Presenters:

Chris Parker, MD
Professor of Prostate Oncology
Institute of Cancer Research
Clinical Oncologist
Department of Uro-oncology
Royal Marsden Hospital
Sutton, Surrey, United Kingdom

Bertrand Tombal, MD, PhD
Professor of Urology
Institut de Recherche Clinique (IRC)
Cliniques universitaires Saint-Luc
Chairman
Department of Surgery
Cliniques universitaires Saint-Luc
Brussels, Belgium

Link to full program, including downloadable slides: 
https://bit.ly/36IEnNE

Radiopharmaceutical scans (PETS) are a vital tool in our fight against cancer. 

These special PET scans allow us to make earlier cancer diagnoses while a cancer is still contained in the original organ.   With an earlier diagnosis, treatments can still stop the cancer before it is able to move to other parts of the body, or become metastatic.  

These special scans also are our best tools to evaluate whether our treatments are working, or if we have developed resistance to the treatments.  FDA approved treatments are limited, so we have  to take full advantage of them while they work.  Since most treatments will eventually stop working, we need to also have an immediate and accurate way to measure whether we are still benefiting from our treatments, or have developed resistance to them.

Sadly, the future of these scans is in jeopardy.  The current insurance reimbursement schedule only supports the use of these scans for three years, after which reimbursement rates might not cover the costs, making these very important scans unavailable despite having been approved by the FDA.  Currently these scans could be looking  at a 3 year life, after which adequate reimbursement might disappear (as will the availability of the scan to patients). 

Cancer ABCs is working to change the law so that reimbursement of these scans will keep them affordable and available as we need them.  Join us and help us preserve the availability of these scans.  To learn more about this issue,  and to lend your support, reach out to us at info@CancerABCs.org

Cancer ABCs would like to thank its podcast sponsors for their support of this podcast program.  Our sponsors include:

• Myovant/Pfizer
• Foundation Medicine
• Bayer 
• Dendreon