biosights: February 17, 2014
Shroom takes embryos to new dimensions
During development, the planar polarized distribution of Rho kinase and Myosin II helps Drosophila germ-band cells intercalate so that the embryo extends along its anterior-posterior axis. Simões et al. reveal how Rho GTPase and the actin-binding protein Shroom combine to regulate the localization of Rho kinase and actomyosin contractility during axis elongation. This biosights episode presents the paper by Simões et al. from the February 17, 2014, issue of The Journal of Cell Biology and includes an interview with first author Sérgio de Matos Simões (formerly at Memorial Sloan Kettering Cancer Center, New York and currently at the University of Toronto). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.
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