suppress

I talk with David about the disaster of shutting out dialog. No matter who we want to blame; the one who refuses to talk about it is responsible for divisiveness.

Dialog is always a two-way street.

One of the lesser-known aspects of the eClinicalWorks EHR, Rules Engine Alerts contain enormous power to improve care by holding providers accountable for attending to care issues as they arise. Jose Rocha of Performance Medical Management explains how a practice can use alerts to help ensure that providers and staff deal with care issues on the spot, capturing all necessary claims data.

On the Secret Witch Show today, Nicole dives into how and why women’s doubt of magic is a common sign they may be a Magical One. She explores the typical journey of a Phosphoric Witch, in alignment with her new philosophy of the Remedies of the Wild, dosing healing for all the magical ones who are scared of being their magical medicine.

In this magical episode, Nicole shares the common place her women begin their journeys, the deep, open-hearted, sensitivity and the layers of trauma from living in the linear mundane world that have magical ones armour up, instead of believe in magic, and talks to the magic vs science debate and how the fact that science hasn’t yet explained magic doesn’t mean it isn’t real.

What You’ll Learn from this Episode:

• Only true Magical Ones suppress and feel a deep resistance to magic, because it wouldn’t even occur to them, if it wasn’t in their field. Likewise, we can only notice that something is missing because it was there in the first place, so if you’re feeling you miss magic, it’s likely it was there always there.

• Magical, Phosphoric women are so deeply sensitive and open that when they come across the criticism of magic from the mundane world, they often immediately shut it down, armour up and close off to their souls - which results in them denying magic

• This is one of the great paradoxes of being a Magical One - that in the early phases, we have to learn to both love magic and also be ok with not always loving it due to our trauma responses and fear

• The conditioning to deny magic and choose and favour logic - which underlies their armour - is actually a trauma response to the Phosphoric woman’s fear of her sensitivity and openness. There are lots of things that can layer over a Magical One’s core and stop her believing in her magic. The deep work is to love ourselves in that.

• Science is wonderful - AND - like everything, has a point where it isn’t all the everything. Science by its very nature is here to try and explain the unexplainable, so magic is everything that science has not yet explained.

• There is always doubt in magic for magical ones, and ultimately, you have a choice: you can continue to live as you are in logic and control (and in the mundane world) - or, you can follow your deep, burning fire and passion, and grant yourself permission to be magical. This isn’t easy work, but it’s well worth it to be who your soul came here to be.

Resources and things that we spoke about:

• Join our Invoke your Wild Apothecary crucible to learn to invoke the Remedies of the Wild

• Join us in the Secret Witch Circle sisterhood on Facebook

Thank you for listening, we’d love to know what comes alive for you in this week’s episode, so please let us know!

If you loved it, there’s a fresh episode every other week - subscribe so you don’t miss it!

Thank you,

Nicole xox

Whether it's Multiple Sclerosis, Type 1 Diabetes, Lupus, or Crohn's Disease, autoimmunity is a rapidly growing problem that traditional pharmaceuticals have failed to completely cure. While these diseases have very different symptoms, they all have the same root cause -- the body’s immune system is attacking its own healthy organs. Lurking within ourselves are a group of T cells called regulatory T cells that have the power to suppress immune function. These cells have huge potential to be engineered and utilized as a platform to cure any autoimmune disease. Unfortunately, they easily lose their suppressive abilities and can even exacerbate autoimmunity if handled incorrectly. Looking to stabilize regulatory T cells, Jessica and her colleagues perform a CRISPR screen to map which genes are responsible for maintaining their suppressive function. Using this data, Jessica takes the first step to bring this incredibly powerful cell type to the clinic to help millions of patients suffering from a myriad of diseases.

About the Author

• Jessica performed this work in the lab of Professor Alex Marson at the University of California, San Francisco. The Marson lab is renowned for their work in building and applying synthetic biology tools to understand and improve the therapeutic value of immune cells.
• Jessica is driven to understand and cure autoimmune diseases because her mother, her sister, and her have all been diagnosed with autoimmune diseases.

Key Takeaways

• Regulatory T cells can suppress immune reactions, making them an attractive therapeutic to be used to cure any autoimmune disease.
• These regulatory T cells do not easily maintain their suppressive function, necessitating some engineering to make sure they maintain their therapeutic value.
• With CRISPR, Jessica turned every gene off one-by-one in regulatory T cells to find which genes were involved in maintaining its suppressive function.
• Jessica found a gene, USP22, that when expressed, inhibited regulatory T cell function making it a useful target for both autoimmunity and cancer.

Translation

• While Jessica focused on one of the hits from the screen, there were many more that have massive potential as drug targets or as engineering steps for T cell therapies against autoimmunity.
• Maintaining a stable regulatory T cell is the vital first step to creating a world where all autoimmune diseases are cured using cells.

First Author: Jessica Cortez

Paper: 

CRISPR screen in regulatory T cells reveals modulators of Foxp3

Life is a constant battle of processing good vs bad, reality vs denial, all through the filters of both optimism and pessimism. Perhaps the most challenging aspect of said evolution relates to mortality -- not only to that of our own, but also for those of whom we love dearly. How is that best not only confronted and balanced, but also/ultimately, accepted? 

In this episode you're going to get to listen in on a conversation with my dear friend Steve Masley, M.D. Dr. Masley is a physician, nutritionist, author, speaker, award-winning patient educator, and a fellow with the American Heart Association, and you're going to learn about fats you should be eating, fats you should NOT be eating and the keys to living a longer, healthier life. Dr. Masley and I discuss our favorite smart fats, how to cook with delicious oils and fats without damaging them and so much more so you can increase your energy, suppress your appetite and get healthy!