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    university of texas health science center

    Explore " university of texas health science center" with insightful episodes like "C-Suite Quick Takes: OIS Goes Behind the Scenes with Four Emerging Biotech Companies" and "Data-driven optimization to improve mobile health care in disadvantaged communities" from podcasts like ""OIS Podcast | Ophthalmology's leading Podcast" and "Science Nation"" and more!

    Episodes (2)

    C-Suite Quick Takes: OIS Goes Behind the Scenes with Four Emerging Biotech Companies

    C-Suite Quick Takes: OIS Goes Behind the Scenes with Four Emerging Biotech Companies

    OIS Podcast host Carey Powers caught up with four ophthalmology execs and one principal investigator to talk about some of the most exciting developments in retina R&D.

    Her guests include:

    • Houman David Hemmati, MD, PhD, Cofounder and Chief Medical Officer of Optigo Biotherapeutics   
    • Michael Tsipursky, MD, CEO and Cofounder of Revive Biotech
    • Michael Singer, MD, Clinical Professor of Ophthalmology at University of Texas Health Science Center, Director of Clinical Research at Medical Center Ophthalmology Associates, and Principal Investigator for Unity Biotechnology’s BEHOLD trial
    • Samarendra Mohanty, PhD, President and Cofounder; and Sulagna Bhattacharya, CEO and Cofounder of Nanoscope Therapeutics

    Optigo is developing binders intended to extend the duration of top-performing intravitreal drugs without compromising efficacy. The company has already had promising results in clinical trials with aflibercept. What’s next?

    Revive Biotech focuses on central retinal artery occlusion. Its products work by injecting oxygen-loaded nanobubbles into the eye intravitreally. Preclinical studies have advanced through proof of concept. Nanobubbles?

    Dr. Singer is a principal investigator in Unity Biotechnology’s clinical trial for UBX-1325, a therapeutic in development to treat diabetic macular edema and wet AMD. If approved, the product could work as an adjunct to anti-VEGF therapies.

    Nanoscope Therapeutics is developing gene therapies that focus on ambient light-sensitive molecules to treat inherited and acquired retinal diseases. Its lead product, MCO-010, is moving through Phase II trials. Why ambient light?

    Tune in to hear today’s experts discuss:

    • How Optigo plans to extend the duration of aflibercept
    • The impact of extending duration activity on patients, physicians, and payers
    • What Optigo plans to accomplish over the next 12 months
    • What’s behind Revive Biotech’s proprietary technology and what makes it unique.
    • The milestones it has completed so far with relation to clinical trials, intellectual property, and funding
    • The new class of therapeutics being developed by Unity Biotechnology
    • The data released so far on the UBX-1325 BEHOLD trial
    • If approved, the impact of UBX-1325—an agent that may potentially extend the life of anti-VEGF therapies—on clinical practice
    • The potential impact of Nanoscope Therapeutics’s MCO-010 on patient communities
    • The feedback reported from clinical trial participants
    • The critical milestones Nanoscope Therapeutics intends to achieve over the next year

    [Listen Now]

    Data-driven optimization to improve mobile health care in disadvantaged communities

    Data-driven optimization to improve mobile health care in disadvantaged communities
    The overall goal of this National Science Foundation (NSF)-supported project is to optimize and implement a data-based program to improve the efficiency and effectiveness of mobile health clinics. Led by health economist Rigoberto Delgado, of the University of Texas Health Science Center at Houston, a team of researchers wants to help Texas Children's Hospital and other providers target their limited resources where they can do the most good. The team is mining public domain data in new ways, using geospatial mapping science and predictive analytics to forecast areas of highest risk for outbreaks. The researchers want to figure out not only where to send the mobile health clinics, but ultimately, how to prevent illness outbreaks in the first place and reduce the number of emergency room visits. Delgado's colleague on the project, optimization expert Jiming Peng, of the University of Houston, is assisting with the modeling, algorithm design and analysis. "We're designing a way to predict the future demand for mobile clinic services in various communities, based on new modeling that uses many data sets from different sources," explains Peng. "And, a challenging issue is that all the optimization models developed in the project have binary variables with uncertain parameters and constraints due to the numerical errors in the process of data analysis, and the dynamic nature of the target population." But, the researchers have already identified communities with high demand for some specific mobile clinic services in Houston and made recommendations to their hospital partners. Ultimately, they hope to reduce healthcare costs and disparities by identifying policies and strategies to encourage comprehensive and collaborative programs of mobile health units in Texas and across the United States. The research in this episode was supported by NSF award #1637347, Increasing Healthcare Access to At-risk Populations: Research-based Policies for Mobile Health Clinics.
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