zebrafish

Laura Conour, the University's attending veterinarian, describes her team’s unflagging care for campus laboratory animals under pandemic conditions and shares early research toward vaccines and treatments for COVID-19. Transcript: https://princeton.edu/content/transcript-conour

As the Director of the Great Lakes Genomics Center in the School of Freshwater Sciences at the University of Wisconsin-Milwaukee, Professor Rebecca Klaper researches emerging contaminants such as nanomaterials and pharmaceuticals and how they affect freshwater organisms. In this episode we interview Dr. Klaper about the future of emerging contaminants and how her work relates to the development of sustainable nanomaterials.

(L: Rebecca Klaper is the Director of the Great Lakes Genomics Center in the School of Freshwater Sciences at the University of Wisconsin-Milwaukee. R: Zebrafish are often used in toxicology research (image from Oregon State University.)

Want more podcast episodes? You can find them all on our podcast page, or you can subscribe on iTunes or Stitcher.

Related links:

• Professor Rebecca Klaper
• EPA Scientist Weighs Emerging Contaminants
• About the National Exposure Research Laboratory (NERL)
• Environmental Defense Fund
• Our Stolen Future
• Using Gene Expression to Learn About Nanoparticle Toxicity
• Center for Sustainable Nanotechnology

Interviewee: Professor Rebecca Klaper

Interviewers: Natalie Hudson-Smith and Jaya Borgatta

Producer/Host: Miriam Krause

Music: Ketsa

Synaptic activity shifts dendritic lysosomes

Invading pathogens or other toxic agents can trigger the assembly of the inflammasome adaptor ASC into large, intracellular specks that activate caspase-1 to initiate a proinflammatory cell death called pyroptosis. Kuri et al. follow the dynamics of ASC speck formation in live zebrafish, revealing their lethal effects on epidermal keratinocytes and their subsequent engulfment and degradation by macrophages. This biosights episode presents the paper by Kuri et al. from the September 4th, 2017, issue of The Journal of Cell Biology and includes an interview with two of the paper's authors, Paola Kuri and Maria Leptin (EMBL). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.

The microbiome of hibernating bears, and zebrafish as a model for bacterial sepsis feature in this animal-centric episode of TWiM hosted by Vincent, Michael, and Michele.

Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt.

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Links for this episode

• Microbiome of hibernating brown bear and energy metabolism (Cell Rep)
• Ten animals that hibernate (Cons Inst)
• Zebrafish model of sepsis (mSphere)
• Image credit
• Letters read on TWiM 126

This episode is sponsored by ASM Agar Art Contest and ASM Microbe 2016

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.

Osmotic gradient is just the tonic for wounded epithelia

Rapid wound repair is generally thought to be initiated by intrinsic cues, such as changes in the structure or mechanics of damaged tissues. Gault et al. reveal that an extrinsic signal — the osmolarity of the external environment — can stimulate wound closure in zebrafish by inducing epithelial cell migration. This biosights episode presents the paper by Gault et al. from the December 22, 2014, issue of The Journal of Cell Biology and includes an interview with the paper's senior author, Philipp Niethammer (Memorial Sloan Kettering Cancer Center, New York). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.

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The Rockefeller University Press
biosights@rockefeller.edu

Centrosome positioning is thought to be important for both neuronal migration and axonogenesis. To investigate centrosome dynamics in vivo, Distel et al. develop a new method to simultaneously visualize multiple subcellular compartments in live zebrafish embryos. This biosights episode presents the paper by Distel et al. from the November 15, 2010 issue of The Journal of Cell Biology, and includes an interview with senior author Reinhard Köster (Helmholtz Zentrum, Munich, Germany). Produced by Caitlin Sedwick and Ben Short.

Subscribe to biosights via iTunes or RSS
View biosights archive

The Rockefeller University Press
biosights@rockefeller.edu