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    320: Dennis Carroll | Planning an End to the Pandemic Era

    en-usMarch 03, 2020
    What are the benefits of turning a home into an Airbnb?
    Who are the hosts mentioned in the episode?
    What health risks are associated with wildlife populations?
    How is an epidemic different from a pandemic?
    What steps can individuals take to protect against viruses?

    • Sharing your home with Airbnb guests and connecting with travelersAirbnb hosting brings extra income and cultural connections, but awareness of health risks is important

      Turning your home into an Airbnb not only brings in extra income but also allows you to share a piece of your world with others. The hosts in this episode, Jen and Jason, have incorporated the Airbnb experience into their own home design, offering guests a comfortable and welcoming stay. This not only benefits the hosts financially but also allows them to connect with travelers from around the world. Additionally, the discussion with Dennis Carroll highlights the importance of being aware of the health risks associated with encroaching on wildlife populations and the potential for common diseases like the flu to become global pandemics. It's crucial for individuals to take steps to protect themselves and their communities, such as getting vaccinated and following public health guidelines. Overall, the episode emphasizes the value of opening up your home to others and being informed about potential health risks.

    • Understanding the origins and characteristics of emerging virusesDennis Carroll travels globally to anticipate new viral diseases by studying their origins and specific features, including the 'H' and 'N' domains in virus names, which refer to attachment and spread proteins, respectively. Fear lies in potential dangerous combinations of highly infectious and deadly viruses.

      Dennis Carroll travels around the world to anticipate and understand emerging viral diseases, such as COVID-19, by focusing on hot spots where new diseases are likely to emerge. He also explained that the naming of viruses like COVID-19 is done to reflect their point of origin and specific characteristics. For instance, the "H" and "N" in virus names refer to two different structural domains within the virus. The H domain refers to the hemagglutinin protein, which helps the virus attach to cells, while the N domain refers to the neuraminidase protein, which helps the virus spread from cell to cell. When these viruses infect humans, they can swap genetic material, leading to new and potentially dangerous combinations. The fear is that a highly infectious virus could commingle with a deadly one, resulting in a massive public health crisis. So, in essence, Carroll's work involves staying ahead of potential pandemics by studying the origins and characteristics of emerging viruses.

    • Monitoring and preventing the spread of deadly virusesPublic health officials aim to keep overall virus circulation low to minimize the risk of a deadly and contagious strain emerging, focusing on preventing the acquisition of deadly and transmissible features by known viruses and monitoring for potential spillover from wildlife to humans and livestock.

      The threat of a deadly and highly contagious flu virus is a major concern for public health officials. While some deadly viruses, like H5N1, have a low transmission rate to humans, the fear is that they could acquire the ability to spread easily between people. This would increase the risk of a pandemic. The seasonal flu, on the other hand, is highly contagious but less deadly. The goal is to keep the overall number of viruses in circulation low to minimize the chances of a deadly and contagious strain emerging. Most emerging viral threats are not entirely new but rather mutations of viruses we already know. Therefore, efforts focus on preventing the acquisition of deadly and transmissible features by these viruses. Many viruses circulate in wildlife without causing harm, but there is a risk of them spreading to humans or livestock, leading to potential pandemics. The key is to monitor and prevent the spillover of viruses from wildlife to humans and livestock.

    • Human population growth and expansion into wildlife habitats increase the risk of viral spilloverThe 21st century has seen an unprecedented frequency and intensity of viral spillover events, leading to epidemics and pandemics, due to human population growth and expansion into wildlife domains.

      As humans continue to expand our populations and encroach on wildlife habitats, there is an increasing risk of viruses jumping from animals to humans, leading to epidemics and pandemics. This process, known as viral spillover, has become more frequent and intense in recent decades due to human population growth and expansion into wildlife domains. While many of these viruses may not cause illness, some, like the coronavirus, can be highly lethal. The 21st century is unprecedented in terms of the frequency and intensity of these events, and it is impossible to have such population growth without seeing impacts at the epidemic and pandemic level. An epidemic refers to a disease outbreak that is geographically limited, while a pandemic is a global epidemic that spreads across multiple countries and continents. The ongoing coronavirus outbreak in China is a clear example of this trend, and as we move further into the century, we can expect to see more of these events. It is crucial that we continue to monitor and study these viruses to better understand their origins and potential impacts on human health.

    • Potential for flu and coronaviruses to cause epidemics or pandemicsFlu and coronaviruses are highly contagious and can cause epidemics or pandemics due to constant mutation, making it difficult for our bodies to build immunity and increasing the likelihood of new, potentially deadly strains emerging.

      Influenza and coronaviruses, which are part of the respiratory virus family, have the potential to cause epidemics and even pandemics due to their high transmissibility. An epidemic refers to sustained transmission in a limited geographic area, while a pandemic is when a virus spreads and has sustained transmission in at least two continents. The flu is particularly concerning because it is highly contagious, with each infected person potentially infecting up to 23 others. Additionally, influenza viruses constantly mutate, making it difficult for our bodies to build immunity and increasing the likelihood of new, potentially deadly strains emerging. Pandemic viruses, unlike seasonal flu viruses, are new to the human population and can cause widespread illness and death due to our lack of immunity. It's not a matter of if, but when the next flu epidemic or pandemic will occur.

    • Pandemics pose greater threat to middle-aged individuals due to immune system overreactionHistorically devastating pandemics can lead to millions of deaths due to immune system overreaction, and our current level of preparedness is inadequate.

      Pandemic viruses, unlike seasonal influenza, pose a greater threat to healthy, middle-aged individuals due to their immune systems overreacting and causing damage, a phenomenon known as a cytokine storm. This can lead to devastating societal impacts with potential deaths in the millions. Historically, pandemics, such as the 1918 flu, have resulted in significant mortality, and with increased global population and travel, the speed at which a pandemic can spread is alarmingly fast. Preparedness is crucial, as pandemics are inevitable, and our current level of preparedness is inadequate.

    • Impact of a deadly virus like the 1918 pandemic todayA 3% mortality rate from a modern deadly virus would result in 60 million deaths, overwhelming healthcare systems and causing significant economic and societal disruption.

      If a deadly virus like the one from 1918 were to emerge today, the consequences would be catastrophic. Even without modern medical interventions, bacterial infections were a significant contributor to the high mortality rate during the 1918 pandemic. With a population of 2 billion people, a 3% mortality rate would result in the deaths of 60 million people. The production and distribution of vaccines would not keep pace with the virus's spread, leading to a much higher death toll. Additionally, the economic and societal disruption caused by the pandemic would lead to preventable deaths from various causes. The pandemic would also put immense pressure on healthcare systems, making it difficult for people with chronic illnesses to access necessary medical care. The pandemic would not affect every community at the same time, but rather in waves, each lasting around 2 to 4 weeks. The records from the 1918 pandemic show that during the wave, deaths from other causes disappeared, and by the beginning of November, normal causes of death reappeared.

    • Protecting essential services and combating fear during a pandemicEnsure health workers are protected, maintain essential services, and combat fear and misinformation through accurate information to mitigate the impact of a pandemic.

      Preparing for a pandemic involves more than just mobilizing the health system to treat infections. It's also crucial to protect the health workers and ensure essential services like power, food, and safety are maintained. Misinformation and fear can spread rapidly during a crisis, making it essential to disseminate accurate information. Fear itself can be a significant consequence of a pandemic. The flu shot, for instance, may cause temporary discomfort but protects against serious illness. Vaccine refusal, such as not getting the measles vaccine, puts children at risk and is criminal behavior. In essence, being informed and taking necessary precautions are key to mitigating the impact of a pandemic.

    • Challenges in Developing a Universal VaccineMaintain good hygiene, practice social distancing, and wear masks to prevent virus spread while researchers work on universal vaccines. Vaccine hesitancy and misinformation hinder progress.

      The power of vaccination has significantly reduced the threat of various diseases, but the constant mutation of viruses like influenza makes developing a universal vaccine challenging. Vaccine hesitancy and the spread of misinformation can hinder public health advancements and potentially lead to outbreaks. The best prevention against infection includes good hygiene practices, social distancing, and wearing face masks when necessary. These measures can help protect individuals and prevent the spread of viruses to others. Despite the challenges, continued research and education are crucial in the fight against infectious diseases.

    • Protect yourself and others by wearing masks and practicing good hygieneWearing masks and practicing good hygiene not only protects individuals from getting infected with viruses but also reduces the risk of spreading them to others in the community. Being proactive in identifying and disrupting the spillover of viruses from animals to people is crucial in preventing future epidemics or pandemics.

      Wearing masks and practicing good hygiene not only protects individuals from getting infected with viruses like COVID-19 but also reduces the risk of further spreading the virus to others in the community. The use of masks is particularly important when interacting with infected individuals as it prevents them from spreading the virus. Moreover, being proactive in identifying and disrupting the spillover of viruses from animals to people is crucial in preventing future epidemics or pandemics. The Global Viro Project is an example of a proactive initiative that aims to catalog circulating viruses in wildlife, understand their geography and proximity to livestock and people, and rank their potential risks. By focusing on these areas, we can disrupt the spillover and lower the risk of new viruses spreading to humans.

    • Documenting and characterizing viral dark matter to prevent future outbreaksBy studying viruses in wildlife before they jump to humans, we can develop broad-spectrum vaccines and drugs, transforming the sciences around emerging viral diseases and preventing future outbreaks.

      We cannot continue to react to viral epidemics and pandemics after they have already spread widely. Instead, we must get ahead of the future by documenting and characterizing viral dark matter, the viruses circulating in wildlife before they move into people. This approach, as discussed in the Global Virome Project, can lead to the development of broad-spectrum vaccines and drugs effective against multiple members of a viral family. By utilizing big data and genetic profiles, we have the opportunity to transform the sciences around emerging viral diseases and prevent future outbreaks. It's essential to recognize that the world we live in now is not forever, and societies and architectures we take for granted will be footnotes in history. We must adapt and innovate to address the challenges of the future, including the threat of emerging viral diseases.

    • Learning from History: The Black Plague and Our VulnerabilityUnderstand the past to prepare for future epidemics and pandemics, minimize consequences through preparation and anticipation, and recognize the potential impact of special pathogens and poor healthcare systems.

      Diseases serve as a reminder of our vulnerability and the potential catastrophic consequences if large populations are affected. The Black Plague in the 14th century provides a stark example of how a pandemic can put a civilization on the brink of extinction. We remain just as vulnerable today, and it's crucial to learn from history to prepare and minimize the impact of future epidemics and pandemics. Fear is a natural response, but it should trigger action rather than paralysis. Preparation and anticipation are key to minimizing the consequences. The world is always running at overcapacity in terms of healthcare, and a catastrophic event could easily overwhelm the system. Special pathogens, which are highly contagious, hard to treat, and cause public panic, pose a significant threat. Wild animals, such as birds, can spread diseases rapidly across the globe. Poor areas and under-resourced hospitals are often the last to receive help, exacerbating the spread of diseases. While it's important not to overreact, it's equally important to be prepared and take action to minimize the impact of future epidemics and pandemics.

    • Building a strong network before you need it is crucialDuring the coronavirus pandemic, building strong relationships and networking is essential for dealing with shared risks. Check out Jordan Harbinger's free course on how to do so at jordanharbinger.com/course.

      The coronavirus is highly contagious and can affect billions of people, making it a shared risk for everyone. The solution to this global issue is shared action, not bombing, banning, or explaining. Building a strong network before you need it is crucial, and Jordan Harbinger offers a free course on how to do so at jordanharbinger.com/course. The importance of relationships and networking cannot be overstated, and Jordan can be found on social media as Jordan Harbinger. The episode was produced by Jen Harbinger, Jason DeFilippo, engineered by Jay Sanderson, show notes and worksheets by Robert Fogarty, and music by Evan Viola. Remember, we rise by lifting others, so share the show with those who may find it useful or interesting. For those concerned about infectious diseases, or for those who may be panicking too much or not enough, they would benefit from listening to this episode. So, please share the show with loved ones and even those you don't know. In the meantime, apply what you learn from the show to live what you listen. And, if you're looking for great deals for Mother's Day, head to Nordstrom Rack for amazing deals starting from just $30. So, go ahead and hit the turn signal if you know about this juicy gem of a detour.

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    • Sex trafficking knows no borders, and the United States stands out as a particularly active region for this crime. It victimizes individuals regardless of age — notably, more than a fourth of those trafficked are minors.
    • The scale of sex trafficking is difficult to determine accurately, with estimates varying widely. This uncertainty stems from the underground nature of the crime and challenges in data collection.
    • Sex trafficking victims often suffer severe physical and mental health consequences, including STIs, injuries, PTSD, anxiety, depression, and substance abuse issues. The average lifespan of women in prostitution is tragically short at around 34 years.
    • The issue of sex trafficking is frequently politicized and weaponized, sometimes exaggerated for political gain. However, it remains a serious problem that ruins thousands of lives through organized crime networks and individual traffickers.
    • Education and awareness are key tools in combating sex trafficking. By learning about the issue, discussing it openly, and spreading accurate information, we can help inform potential victims about the dangers and contribute to prevention efforts. Everyone can play a role in this by staying informed and sharing knowledge with others.
    • Connect with Jordan on Twitter, Instagram, and YouTube. If you have something you'd like us to tackle here on Skeptical Sunday, drop Jordan a line at jordan@jordanharbinger.com and let him know!
    • Connect with Andrew Gold on Twitter and Instagram, and check out On the Edge with Andrew Gold here or wherever you enjoy listening to fine podcasts!

    Like this show? Please leave us a review here — even one sentence helps! Consider leaving your Twitter handle so we can thank you personally!

    Full show notes and resources can be found here: jordanharbinger.com/1042

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