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    #79 - Ric Elias: Earning the gift of life

    enNovember 11, 2019

    Podcast Summary

    • A podcast without ads, funded by subscribersThe Peter Attia Drive, a podcast focused on health and longevity, is ad-free and funded by subscribers, providing exclusive benefits like access to show notes, Ask Me Anything episodes, and discounts on recommended products.

      The Peter Attia Drive, a podcast focused on optimizing performance, health, and longevity, doesn't run ads because the host, Peter Attia, values trust and authenticity. Instead, he has implemented a subscriber model to fund the work necessary to produce the podcast and provide additional benefits to members. This includes exclusive access to show notes, Ask Me Anything episodes, and discounts on products that Attia already uses and loves. The podcast remains free to all listeners, but Attia hopes that many will find enough value in the content to support the production directly. During this episode, Attia shares a conversation with his dear friend and mentor, Rick Elias, discussing the impact of a pivotal moment in Elias' life and the wisdom he gained from it.

    • Cherishing Everyday MomentsReflecting on a near-death experience, CEO Rick Elias emphasizes the importance of cherishing everyday moments and not taking life for granted.

      Rick Elias, the CEO of Red Ventures, reflected on his life before a plane crash that changed everything. At the time, he was running a successful but stressful business with around 700 employees, balancing work and family life. He described himself as generally positive but stressed, often rationalizing his absence from his children's lives with the idea of "quality over quantity." On January 15, 2009, he took a common flight from LaGuardia to Charlotte, but that day, his routine was disrupted by a soft-serve ice cream detour at the airport. He enjoyed the ice cream so much that he went back for seconds before boarding, unaware that this seemingly insignificant moment would be his last before the plane crash. This conversation underscores the importance of cherishing everyday moments and not taking life for granted.

    • Unexpected emergency landing in the Hudson RiverDuring a crisis, focus on practical aspects and stay calm to effectively handle the situation

      The speaker shares an unexpected and harrowing experience of being on a plane that made an emergency landing in the Hudson River in 2009. Despite the initial uncertainty and fear, the speaker found clarity and focus during the crisis, focusing on the practical aspects of his life instead of the impending danger. The experience left a lasting impact on him, highlighting the importance of staying calm and present in the face of adversity. The speaker also emphasized the quickness of the events leading up to the landing, with only a few minutes between the engine explosion and the impact.

    • The importance of living in the momentA near-death experience reminded the speaker to prioritize relationships, responsibilities, and inner peace over material possessions and external validation.

      The near-death experience of being in a plane crash made the speaker realize the importance of living in the moment and letting go of regrets and ego. They understood that life can change in an instant, and they regretted not focusing on their responsibilities and relationships. Despite the sadness of nearly losing his life, the speaker found peace in accepting his past choices and was grateful for a second chance. The experience also clarified that material possessions and external validation do not matter in the face of death. The speaker did not seek compensation or attention after the incident, instead choosing to cherish the gift of life.

    • People react differently in times of crisisIn uncertain situations, people may defy expectations and make unconventional decisions, trusting instincts and expressing unexpected emotions.

      During times of crisis or imminent danger, people may react differently than what we might expect. The story of the plane coming in for an emergency landing, with the speaker's close encounter with the George Washington Bridge, illustrates this idea. The pilot, in making the decision to land in the water instead of attempting to reach the airport, went against protocol and saved the lives of all on board. This act of defying authority, even in the face of potential death, highlights the importance of trusting one's instincts and making difficult decisions when necessary. Moreover, the speaker's encounter with a helicopter crash survivor who expressed sadness rather than fear, adds to this theme. The survivor's account of his experience resonated with the speaker, who admitted that he would have expected to be afraid, but instead found himself contemplating the comfort of expressing love. These stories serve as reminders that in the face of uncertainty and danger, people may react with emotions and thoughts that are not easily predictable. It's essential to recognize and respect these differences, and to trust our instincts when making critical decisions.

    • Surviving a Plane Crash: Chaos and CompassionSurviving a plane crash involves immediate action, confusion, and compassion. The experience highlights life's fragility and the importance of being prepared.

      The experience of surviving a plane crash is a chaotic and surreal event. From the moment of impact, individuals go into survival mode, focusing on immediate actions such as evacuating the plane and finding safety. The experience can be confusing and disorienting, with questions about what has happened and what to do next dominating thoughts. The environment around the crash site can vary greatly, with some areas offering more resources and support than others. Despite the chaos, there are moments of compassion and selflessness, as well as moments of fear and panic. The emotional aftermath of such an experience is complex and long-lasting, with individuals processing the event at different speeds and in different ways. Ultimately, the experience serves as a reminder of the fragility of life and the importance of being prepared for the unexpected.

    • The impact of doing one's job well in a crisisDoing one's best in a crisis can bring comfort and hope to those affected, saving lives and reminding us of the importance of community and resilience.

      The importance of doing one's job to the best ability, even in the most dire circumstances, can make a significant impact on others. The story shared was about a man who survived the infamous Flight 1549 landing in the Hudson River. His sister, who was a pediatrician, was devastated when she heard the news of the crash and thought her husband had died. When he called to reassure her, she was overwhelmed and grateful. The first responders, including Captain Chesley "Sully" Sullenberger, acted swiftly and compassionately, saving everyone's lives. The man expressed his gratitude to Sully, who humbly replied that he was just doing his job. The experience made the man realize the importance of living each moment to the fullest and not taking anything for granted. Despite the media attention and chaos, the man found comfort in the love and support of his family, reminding him of the power of community and resilience.

    • The power of quick decision-making and experience in moments of crisisCaptain Sully Sullenberger's quick decision to land in the Hudson River saved lives, highlighting the importance of preparation and experience in crisis situations.

      In moments of crisis, quick decision-making and the ability to process information efficiently can be the difference between life and death. This was evident in the story of Captain Chesley "Sully" Sullenberger, who saved the lives of all his passengers by making the split-second decision to land his plane in the Hudson River after both engines failed. The speaker, who had the honor of introducing Sully at an awards show, was struck by the depth of connection they shared despite not exchanging words. Sully's preparation and experience as a pilot played a crucial role in his ability to act swiftly in the face of adversity. While it's impossible to know exactly how many commercial pilots could have acted in the same way, the speaker believes the number is likely low due to the unique combination of factors that came into play for Sully. Ultimately, the speaker was moved by the humility and dedication of a man who had spent his life preparing for the moment that saved so many lives.

    • Near-death experiences can lead to a renewed sense of obligation and commitment to lifeNear-death experiences can help individuals understand the importance of living a life of no regrets and focusing on what truly matters, as well as recognizing the complexity of truth and multiple perspectives to resolve conflicts and live a happier life.

      The experience of a near-death situation can lead to a profound sense of obligation and responsibility towards one's community and the world. This realization can lead to a commitment to living a life of no regrets and focusing on what truly matters. Additionally, recognizing that everyone has their own truth and understanding that most things in life are a shade of gray can help in resolving conflicts and living a happier existence. The speaker, who had a strong desire for justice in the past, learned the importance of surrendering to the idea that there are multiple perspectives and that the truth is not always black and white. This newfound perspective allowed him to let go of arguments and focus on building a happy life.

    • Embrace contradictions and cherish experiencesCollecting experiences and living in the moment, while maintaining a healthy lifestyle, allows us to fully live and prioritize what's important. Time is our most valuable currency.

      Collecting and enjoying life experiences, even if they seem contradictory, is essential for living fully and meaningfully. As shared in the discussion, collecting "bat wines" represents seizing opportunities and living in the moment, while maintaining a healthy lifestyle ensures the ability to continue playing the "infinite game" of life. A poignant example of this was realized during a recital for his daughter, where he felt like a ghost watching her grow up, emphasizing the importance of prioritizing family and cherishing life's moments. This realization led to a shift in priorities, recognizing time as the most valuable currency and making intentional choices to make the most of it.

    • Effectively managing time for personal and professional growthUnderstanding opportunity cost and prioritizing time can lead to personal and professional growth. Saying 'no' to distractions and focusing on what truly matters can lead to better outcomes.

      Protecting and valuing your time is crucial for personal and professional growth. The speaker shares his experience of learning to say no and prioritize his time effectively, drawing an analogy from a story about giving away wealth for health. He emphasizes the importance of understanding opportunity cost and being mindful of how every "yes" comes with the implicit cost of saying "no" to other opportunities. The speaker also shares how he has reduced his travel time to prioritize family and aims to continue minimizing distractions to focus on what truly matters. This mindset can be applied to various aspects of life, including being a father, husband, or CEO, where crises serve as defining moments that highlight the importance of preparation.

    • Preparing for crises and adapting to change as a leaderEffective leadership involves setting controls for electronics and social media use, allowing for tension in relationships, and embracing the gradual process of letting go as children grow.

      Effective leadership requires preparation for crises and the ability to adapt when change comes. This includes leading your organization through scenarios and finding the unique gifts of those you lead. As a parent, this means meeting your children where they are and encouraging their natural bent. When it comes to electronics and social media, parents should set controls and allow for tension in the relationship, recognizing that raising teenagers is a gradual process of letting go. Ultimately, being a leader, whether as a parent or in a professional setting, requires resilience and a willingness to learn from experience.

    • Focus on children's happiness and growth, not external validationParents should prioritize their children's well-being, adapt to the changing world, and let go of past methods to raise happy, successful individuals.

      Parents need to align their actions with their goals for their children, focusing on their happiness and growth rather than external validation. The current trend of over-scheduling and excessive pressure on children may do more harm than good, and it's essential to remember that the future world will be vastly different from the past. Parents should strive to create an environment where children feel comfortable and successful, allowing them to discover their potential at their own pace. The ultimate goal of parenting is to make life better for our children and future generations. It's essential to let go of the past and adapt to the changing world while keeping the core values of raising happy, well-adjusted, and contributing individuals.

    • Moving from Puerto Rico to Boston for college: Overcoming challenges and finding personal growthEmbracing challenges can lead to personal growth and success. Valuing independence, hard work, and treating others kindly are important lessons. Lead by example and instill these values in children. Recognize privilege and responsibility, using unique strengths to make a positive impact.

      Overcoming challenges and adapting to new environments can lead to personal growth and success. Rick Elias shared his experience of moving from Puerto Rico to Boston for college, feeling ill-equipped and facing numerous challenges. Despite these difficulties, he learned valuable lessons about independence, hard work, and treating others with kindness. He emphasized the importance of leading by example and instilling these values in his children, recognizing that they face their own unique challenges. Rick also reflected on the complexities of privilege and responsibility, acknowledging that while his children may have advantages, they also carry a heavy load. Ultimately, he encouraged the audience to embrace their unique strengths and use them to make a positive impact on the world.

    • Focus on what truly matters and leave a positive impactSuccessful individuals should focus on making a difference, apologize when necessary, and let go of insignificant disputes to leave a positive impact on the world.

      As successful individuals, it's our responsibility to model positive behaviors and give back to our community, rather than apologizing for our success or getting bogged down in insignificant disputes. The speaker emphasizes the importance of focusing on what truly matters, such as social impact and fighting against injustices, rather than wasting energy on trivial issues. He shares his personal growth in learning to apologize and let go of unnecessary arguments, and encourages using one's platform and resources to make a difference in the lives of others. The speaker's passion lies in addressing systemic failures and providing opportunities for those who are underserved, such as undocumented children who face barriers to education and employment. Ultimately, the goal is to leave a positive impact on the world and make progress in the "infinite game" of life.

    • Supporting underrepresented communitiesInitiatives like scholarships, coding programs, and adulting schools help underrepresented individuals, such as undocumented students and young adults, overcome barriers to education and employment, bridging the gap and allowing them to succeed in American society.

      There are numerous initiatives aimed at supporting underrepresented communities, particularly undocumented students and young adults, in their educational and professional journeys. These initiatives include scholarships, coding and tech training programs, and adulting schools. The importance of addressing this issue lies in the fact that many of these individuals face significant barriers to education and employment, leading to wasted talent and potential. Furthermore, the lack of opportunities can result in a sense of cultural disconnection and an inability to assimilate fully into American society. By investing in these initiatives and providing resources for underrepresented communities, we can help bridge the gap and give individuals the chance to succeed. Additionally, there is a need for empathy and understanding towards the complexities of immigration and the various perspectives surrounding it. Ultimately, it's crucial to recognize that immigration is a complex issue with both pros and cons, and that finding a solution will require a thoughtful and compassionate approach.

    • Unemployment and underemployment: Filling the skills gapThe unemployment rate is high, and there's a need for skilled workers. Effective leadership and team management are crucial for addressing underemployment and immigration policy implications.

      The unemployment rate is currently high, and there are jobs that go unfilled because no one wants to do them. This issue of underemployment and the need for skilled workers is a complex one, with implications for immigration policy and education. Another key takeaway is the importance of effective leadership and team management, as exemplified by the business review process at Red Ventures. Despite facing significant challenges in the early years, the founders' determination and refusal to accept complacency have been instrumental in the company's success.

    • Operating with flexible belief statements for growthSuccessful businesses adapt quickly by focusing on pace, being great people to work with, and leaving the world better, through no-frills, 20-minute meetings called Business Review.

      Successful businesses, like Red Ventures, evolve and adapt quickly to the changing world. Instead of relying on fixed values, they operate with flexible belief statements that allow for experimentation and growth. These beliefs include a focus on pace, being great people to work with, and leaving the world better than they found it. Business Review, a key component of Red Ventures, is an example of this approach in action. It's a no-frills, 20-minute meeting format where presenters clearly define their problems and get straight to the point, with no charts or PowerPoint decks allowed. By operating with this mindset, businesses can stay agile and responsive, and ultimately thrive in an ever-changing business landscape.

    • Effective business review meetings at AmazonAmazon's intense review meetings prioritize, improve presentation skills, make decisions, and foster company culture. Self-awareness, self-management, and intuition are essential skills for success in these high-pressure environments.

      Amazon's business review meetings are an effective way to prioritize, train presentation skills, make decisions, and build a strong company culture. These intense, time-boxed sessions involve quick question-and-answer exchanges, forcing presenters to be concise and clear. This method not only benefits the company but also provides valuable learning experiences for employees. Self-awareness and self-management are crucial skills for success in these high-pressure environments, as they enable individuals to effectively navigate interpersonal dynamics and manage their thoughts and emotions. Through repetition and pattern recognition, intuition develops, leading to improved negotiation skills and overall success.

    • Understanding motivations and intentions in negotiationMaster effective negotiation by recognizing what others value most and creating value for all involved. Be aware of negative energy and selfish behavior, and strive for mutual improvement and long-term success.

      Effective negotiation goes beyond the surface level of asking and answering questions. It requires understanding the underlying motivations and intentions of the other party. Masterful negotiators can create value by recognizing what the other party values most and finding a way to make it work for everyone involved. This skill, which involves seeing beyond the present situation to the larger context and potential future outcomes, is a valuable asset in both business and personal interactions. It's important to be aware of negative energy and selfish behavior in negotiations, as well as the subtler signs of these traits. Additionally, being driven by a desire to compete and improve oneself can lead to greater success and the ability to run the longer race. Ultimately, successful negotiation requires a deep understanding of human behavior and motivation, as well as the ability to influence and be influenced by others.

    • Energy levels for personal and philanthropic growthIndividuals should prioritize their philanthropic goals, seek new knowledge, and commit fully to making a positive impact in their communities, even in complex organizations.

      Energy, not just time, is crucial for personal and philanthropic growth. Fifteen years ago, energy levels were at zero percent, and they are now fifteen percent, with the potential to reach fifty percent. Individuals should consider what philanthropic goals they have yet to accomplish, as there may be knowledge or angles they have not discovered. The speaker is passionate about reversing trends in Puerto Rico and making businesses a force of good in their communities. Companies, including public ones, can contribute positively to society without sacrificing success. The speaker, who is overseeing a large, complex organization with diverse industries and international locations, faces challenges in leading a culture of immigrants after a long period of organic growth. Despite these challenges, the speaker remains committed to putting in their all and learning new skills. If given the chance to go back to January 15, 2009, the speaker would encourage themselves to catch their flight, as the events of that day gave them a sense of urgency, purpose, and a game to play with no regrets.

    • Learn from Dr. Peter Attia's resources on longevity, science, performance, and sleepStay updated with Dr. Peter Attia's insights and resources on longevity, science, performance, and sleep through his podcast, blog, and social media channels. Remember, this information is for general informational purposes only and does not constitute medical advice.

      Dr. Peter Attia provides valuable insights and resources related to longevity, science, performance, sleep, and more through his podcast, blog, and social media channels. However, it's important to note that the information shared is for general informational purposes only and does not constitute medical advice. Users should consult their healthcare professionals for any medical conditions they have. Dr. Attia also discloses his conflicts of interest and encourages users to visit his website for more information. To stay updated on his latest work and discoveries, consider signing up for his weekly email newsletter. You can find all of these resources and more on his website, peteratiamd.com.

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    We discuss:

    • How Peter keeps track of his takeaways from each podcast episode [5:15];
    • Luc van Loon episode: fat utilization, muscle protein synthesis, dietary protein, aging and inactivity, and more [8:45];
    • Behavioral changes that have come about from the conversation with Luc van Loon [23:45];
    • Courtney Conley episode: importance of toe strength and the impact of dedicated foot training [26:45];
    • Olav Aleksander Bu episode: the importance of VO2 max for lifespan, and the practicalities of measuring and improving VO2 max [36:45];
    • Behavioral changes that have come about from the conversation with Olav [56:00];
    • Alex Aravanis episode: liquid biopsies for cancer detection [1:01:30];
    • Colleen Cutcliffe episode: the importance of gut bacteria balance, and the potential therapeutic uses of probiotics, particularly Akkermansia [1:16:45];
    • Mark Rosekind: the significant issue of road fatalities and injuries, their causes, and practical safety measures to reduce risks [1:27:00]; and
    • More.

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    The Peter Attia Drive
    enJune 03, 2024

    #303 - A breakthrough in Alzheimer’s disease: the promising potential of klotho for brain health, cognitive decline, and as a therapeutic tool for Alzheimer's disease | Dena Dubal, M.D., Ph.D.

    #303 - A breakthrough in Alzheimer’s disease: the promising potential of klotho for brain health, cognitive decline, and as a therapeutic tool for Alzheimer's disease | Dena Dubal, M.D., Ph.D.

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    Dena Dubal is a physician-scientist and professor of neurology at UCSF whose work focuses on mechanisms of longevity and brain resilience. In this episode, Dena delves into the intricacies of the longevity factor klotho: its formation and distribution in the body, the factors such as stress and exercise that impact its levels, and its profound impact on cognitive function and overall brain health. Dena shares insights from exciting research in animal models showing the potential of klotho in treating neurodegenerative diseases as well as its broader implications for organ health and disease prevention. She concludes with an optimistic outlook for future research in humans and the potential of klotho for the prevention and treatment of Alzheimer’s disease.

    Disclosure: Peter is an investor in Jocasta Neuroscience, a company working to develop klotho as a therapy for people with Alzheimer’s disease.

    We discuss:

    • Dena’s fascination with aging and how she came to study klotho [3:30];
    • Biological properties of klotho: production, regulation, decline with age, and factors influencing its levels [11:45];
    • Potential benefits of klotho on brain health [22:00];
    • The relationship between soluble klotho protein, platelet factors, and cognitive enhancement [33:45];
    • The role of platelet factor 4 (PF4) and it’s interaction with GluN2B in mediating cognitive enhancement [46:45];
    • Benefits of klotho observed in a mouse model of Parkinson’s disease [55:45];
    • Benefits of klotho observed in a mouse model of Alzheimer’s disease [1:03:00];
    • Promising results of klotho in primate models, and the importance of finding an appropriate therapeutic dose before moving to human trials [1:08:00];
    • Speculating why a single klotho injection has such long-lasting effects [1:25:30];
    • Potential cognitive benefits of klotho in humans, the impact of the KL-VS genetic variant on klotho levels, and the need for human trials to confirm these effects [1:27:45];
    • The interaction between the KL-VS genetic variant and APOE4 and how it impacts risk of Alzheimer’s disease [1:34:45];
    • The significance of klotho levels: studies linking lower levels to increased mortality and the broader implications for organ health and disease prevention [1:47:15];
    • Measuring klotho levels and determining an individual’s KL-VS status [1:52:15];
    • The promising potential of klotho for Alzheimer’s disease treatment, and the importance of philanthropy for funding research [1:58:00]; and
    • More.

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    The Peter Attia Drive
    enMay 27, 2024

    #302 - Confronting a metabolic epidemic: understanding liver health and how to prevent, diagnose, and manage liver disease | Julia Wattacheril, M.D., M.P.H.

    #302 - Confronting a metabolic epidemic: understanding liver health and how to prevent, diagnose, and manage liver disease | Julia Wattacheril, M.D., M.P.H.

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    Julia Wattacheril is a physician scientist and director of the Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) program at Columbia University Irving Medical Center. In this episode, Julia delves deep into the complex world of liver health, beginning with a foundational overview of liver physiology. She provides an in-depth look at how alcohol impacts liver function, breaking down the metabolism of ethanol and its detrimental effects. Julia then shifts the focus to understanding liver function tests and optimal enzyme levels, providing a detailed explanation of AST and ALT and elucidating why fluctuations in these levels may or may not be concerning. She provides a primer on the four major stages of liver disease, discussing risk and emphasizing the importance of early diagnosis. Julia highlights the role of liver disease in increasing the risk of cancer and cardiovascular disease and covers in detail the various strategies for diagnosing, treating, and preventing the progression of liver disease.

    We discuss:

    • Julia’s training, the importance of liver health, and the challenges and innovations of hepatology [3:15];
    • The complex and crucial functionality of the liver, its four most essential functions, and more [8:45];
    • Liver injuries: historical and evolving understanding of causal factors, and the progression to liver diseases and cancer [13:15];
    • How the liver metabolizes nutrients and what happens in the presence of excess calories or alcohol [24:45];
    • Methods of diagnosing liver disease and how insights guide treatment and management strategies [33:30];
    • The poisonous nature of ethanol to the liver [40:30];
    • Varied responses to alcohol, damaging effects of alcohol beyond the liver, and the process of advising patients on their alcohol consumption [47:15];
    • Understanding liver enzymes AST and ALT—interpreting levels, lifestyle factors that affect them, and diagnostic approaches [58:30];
    • Interpreting liver function tests for fatty liver disease, and the challenges of diagnosing liver pathologies, particularly in children versus adults [1:13:15];
    • Comprehensive liver health assessments via imaging and various diagnostic tools to prevent overlooking potential liver pathologies [1:18:45];
    • Potential impact of recreational drugs, statins, and other medications on liver function test results [1:26:45];
    • Shifting nomenclature from NAFLD to MASLD to reflect accuracy in the underlying pathophysiology and understanding of liver diseases [1:30:30];
    • Pathophysiology of MASLD, the need for proactive screening, and the significance of liver fat percentage as an indicator of metabolic health [1:36:30];
    • The importance of screening for rare conditions alongside common metabolic diseases associated with fatty liver accumulation [1:42:45];
    • Practical strategies for managing MAFLD [1:45:30];
    • The impact of fructose consumption on liver health and the challenges of disentangling its effects from other factors like obesity and insulin resistance [1:52:45];
    • The potential of GLP-1 agonists for the treatment of MASLD [1:57:45];
    • How the four stages of liver disease have evolved [2:00:30];
    • Increased cancer and heart disease risk associated with early-stage MAFLD [2:05:15];
    • Emerging drugs and therapies for addressing fat accumulation and fibrosis related to MAFLD [2:12:15];
    • Peter’s major takeaways [2:18:45]; and
    • More.

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    The Peter Attia Drive
    enMay 20, 2024

    #301 - AMA #59: Inflammation: its impact on aging and disease risk, and how to identify, prevent, and reduce it

    #301 - AMA #59: Inflammation: its impact on aging and disease risk, and how to identify, prevent, and reduce it

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    In this “Ask Me Anything” (AMA) episode, Peter delves into the often misunderstood concept of inflammation. He first defines inflammation and differentiates between acute inflammation and chronic inflammation, the latter of which is linked to aging and a plethora of age-related diseases. Peter breaks down the intricate relationship between chronic inflammation, obesity, and metabolic health, and highlights the signs that might suggest someone may be suffering from chronic inflammation. From there, the conversation centers on actionable advice and practical steps one can take to manage and minimize chronic inflammation. He explores how diet plays a crucial role, including the potential benefits of elimination diets, and he examines the impact of lifestyle factors such as exercise, sleep, and stress management. Additionally, he discusses the relevance of food inflammatory tests and concludes by examining the potential benefits and drawbacks of drugs and supplements in managing inflammation.

    If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #59 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.

    We discuss:

    • Defining inflammation (and the cultural impact of Napoleon Dynamite) [1:45];
    • Acute vs chronic inflammation [8:00];
    • The connection between chronic inflammation, aging, and age-related diseases [11:00];
    • The impact of inflammation on metabolic health [18:30];
    • Understanding and diagnosing chronic inflammation: blood tests and other approaches, and challenges with measurement [20:00];
    • Factors that contribute to low-level chronic inflammation [28:00];
    • Minimizing inflammation through diet [29:45];
    • The important role of fiber for gut health and inflammation [33:45];
    • A closer look at the impact of trans fats and saturated fats on overall health [34:45];
    • Why Peter prefers dietary fiber from food sources over supplements [38:30];
    • Debunking “superfoods”: emphasizing proven methods over marketing claims for reducing inflammation [39:00];
    • Is there any value in over-the-counter food inflammatory tests? [42:30];
    • Food elimination diets: how they work, symptoms and markers to watch, challenges and limitations [45:15];
    • Identifying dietary triggers for gut-related symptoms through low-FODMAP diets like the “carnivore diet” [51:15];
    • Dairy: the complex role of dairy on inflammation and individual responses [55:00];
    • Wheat: the complexities and conflicting evidence around wheat's inflammatory effects [57:45];
    • How exercise influences inflammation [1:02:00];
    • How sleep quality and duration impacts inflammation [1:07:00];
    • The potential impact of chronic psychological stressors on inflammation [1:13:00];
    • The impact of oral health on inflammation and overall well-being [1:15:00];
    • The role of medications in managing chronic inflammation [1:18:15];
    • Supplements: evaluating the efficacy of various anti-inflammatory supplements [1:22:15];
    • Parting thoughts and takeaways [1:27:00]; and
    • More.

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    The Peter Attia Drive
    enMay 13, 2024

    #300 - Special episode: Peter on exercise, fasting, nutrition, stem cells, geroprotective drugs, and more — promising interventions or just noise?

    #300 - Special episode: Peter on exercise, fasting, nutrition, stem cells, geroprotective drugs, and more — promising interventions or just noise?

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    In this special edition celebrating 300 episodes of The Drive, Peter discusses a variety of popular topics and health interventions and classifies them based on their level of evidence and relevance using the following categories: proven, promising, fuzzy, noise, and nonsense. Peter first delves into the topic of geroprotective molecules, covering rapamycin, metformin, NAD and its precursors, and resveratrol. Next, he explores the significance of metrics like VO2 max and muscle mass, as well as emerging concepts like blood flow restriction and stem cells. The conversation extends to nutrition, addressing questions surrounding long-term fasting, sugar consumption, sugar substitutes, and the contentious role of red meat in cancer. Peter not only provides his current stance on each topic—most of which have been covered in great detail in the previous 300 episodes—but also reflects on how his opinion may have evolved over the years.

    We discuss:

    • Defining the categories of “proven, promising, fuzzy, noise, and nonsense” [3:15];
    • Rapamycin [9:30];
    • Metformin [17:00];
    • NAD and its precursors [24:30];
    • Resveratrol [32:45];
    • The importance of VO2 max, muscle mass, and muscular strength for lifespan [38:15];
    • Blood flow restriction (BFR) training [44:00];
    • Using stem cells to treat osteoarthritis or injury [51:30];
    • Fasting as a tool for longevity (and why Peter stopped his fasting protocol) [55:45];
    • The energy balance theory [1:06:30];
    • The idea that sugar is poison [1:12:00];
    • The idea that sugar substitutes are dangerous [1:22:15];
    • The debate on red meat and cancer [1:28:45]; and
    • More.

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    Special episode with Dax Shepard: F1 and the 30th anniversary of Ayrton Senna’s death

    Special episode with Dax Shepard: F1 and the 30th anniversary of Ayrton Senna’s death

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    This is a special episode of The Drive with Peter’s friend and fellow car enthusiast Dax Shepard. In this podcast, which commemorates the 30th anniversary of the death of Brazilian Formula One legend Ayrton Senna, Dax sits down with Peter to better understand what made Senna so special and why Peter remains an enormous fan. This conversation focuses on Senna’s life, the circumstances of his death, and his lasting impact and legacy on the sport of F1.

    We discuss:

    • Peter’s interest in motorsports began as a child [2:30];
    • The drama and dangers of F1 [6:00];
    • What made Senna special [13:00];
    • What Senna meant to Brazilians [24:00];
    • The cause of the fatal crash [28:15];
    • Why Peter is obsessed with Senna [40:30];
    • Being the best versus having the best record [43:30];
    • Senna’s unique driving style and incredible intuition about automotive engineering [46:30];
    • Back to the day of the dreadful race [53:00];
    • What Peter believes caused the crash [1:02:45];
    • Views on dying young, in the prime of life [1:13:00];
    • Senna lives on in his foundation and in safety changes adopted by F1 [1:21:00];
    • Statistics aren’t enough for fandom, and why people like who they do [1:24:15];
    • The biggest difference between F1 today and F1 in the 80s [1:28:30];
    • Senna’s driving superpower [1:30:30];
    • The fastest drivers currently in F1 [1:38:30];
    • Current F1 obsessions [1:45:00];
    • How hard it is to do what the top F1 drivers do [1:50:15];
    • Dax’s love of motorcycles and his AMG E63 station wagon [1:52:15];
    • Awesome Senna mementos from Etsy [2:01:15];
    • What makes specialists interesting, and Max’s devotion to F1 [2:10:15];
    • What Senna might have done if he had not died that day [2:14:00];
    • Michael Schumacher and Max Verstappen are also top F1 drivers [2:17:30];
    • Interlagos in Sao Paulo Brazil is always an incredible experience [2:18:45]; and
    • More.

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    #80 Change Agent: Gens Johnson

    #80 Change Agent: Gens Johnson
    Gens Johnson in "The Mindset Master." She is a Clarity Coach, Mastermind Facilitator, Executive Managing Director of eWomenNetwork, Dallas, and the host of three podcasts. This mom, wife, and fitness enthusiast loves people and helping them achieve success. With over 25 years of coaching, consulting, and training, she understands that individuals are productive and healthy when they are happy. In this episode, we talk about the impact Gen's parents had on her early success, the journey that led her from corporate to entrepreneurship, and how she came to know podcasting and network marketing. We discuss the importance of women supporting each other and creating an environment of love so that everyone can benefit. We talk about her podcasts, what she loves about each of them, and who they serve. Gens is passionate about helping others and adores her family, in addition to philanthropy and podcasting. She is genuinely a "change agent working to make a difference in the lives of those around her." Welcome to episode 80.

    If you would like to learn more about Gens, go to https://gensjohnson.com/ or check out her YouTube page at https://www.youtube.com/c/gensjohnson.

    For a transcript of this episode, go to www.startergirlz.com.

    Episode 280: Purple Patch Case Study Series - #4 - Vijay (Performance in Life)

    Episode 280: Purple Patch Case Study Series - #4 - Vijay (Performance in Life)

    This week on the Purple Patch Podcast, we continue our Purple Patch Performance Case Studies series. In this series, we delve into real-life examples and the experiences of real athletes to provide practical insights about performance.

    In this episode, IRONMAN Master Coach Matt Dixon looks beyond athletics and sports and outlines a path to sustained high performance in work and life. Through the case study of Purple Patch athlete Vijay, Matt highlights the results of adopting an athletic mindset and strategies for improving health and how one shows up in work and life.

    In our case studies, athletes have used the Purple Patch Pillars of performance to refocus their training, reframe their mindsets, and improve their race performances. However, what if you're like Vijay, having no interest in being a competitive athlete or struggling to balance work, health, and family?

    You don't need to become a health nut or fitness freak to perform better at work and improve your healthspan. Instead, Matt lays out small, simple steps to achieving emotional and physiological performance results to help you thrive rather than survive.

    With Vijay's story, we aim to inspire and motivate those struggling to adopt performance habits or integrate sports successfully into their daily lives.

    Relevant to the discussion is Matt’s recently published white paper on Sustained High Performance. In it, Matt combines his two decades of coaching observations with current empirical research and direct insights from high-performing C-Suite executives. He lays out a roadmap to amplify performance at the highest levels of business leadership. Click here to download your free copy and to access Matt's extensive experience in coaching individuals to the highest level of performance in world-class sports, executive performance, and corporate leadership.

     

    Episode Timestamps

    00:00 - 04:12 - Welcome and Episode Introduction

    04:19 - 07:46 - Matt's News-ings

    07:54 - 55:36 - The Meat and Potatoes - Episode 280: Purple Patch Case Study Series - #4 - Vijay (Performance in Life)

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    Spotlight: Covid-19 and The Economy: What You Need to Know

    Spotlight: Covid-19 and The Economy: What You Need to Know

    As new coronavirus outbreaks plague the U.S., observers worry that the economic revival will be disrupted, but what are the factors that must be considered? Steve Forbes on the increase in testing, the upswing in economic activity and stock market trends amidst the pandemic. 

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