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    Advances in the Management of Moderate-to-Severe Atopic Dermatitis

    enOctober 17, 2019
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    About this Episode

    Host: Peter A. Lio, MD
    Guest: Eric Simpson, MD, MCR
    Guest: Mark Boguniewicz, MD

    Please note: This activity is no longer available for continuing education credit.

    “I begged my doctor for something else – there had to be something else,” Pam.

    For over 50 years, Pam suffered with uncontrolled moderate-to-severe atopic dermatitis (AD). She experienced the evolution of treatment strategies over the course of the several decades, trying everything from topicals to off-label targeted systemic agents. She was willing to try anything to make the unbearable itch go away. In this roundtable discussion, we brought Pam and her dermatologist to discuss AD with a multidisciplinary physician panel. Together they weigh in on experimental and newly approved therapies, management strategies, impact on quality-of-life, and shared decision-making techniques, all supplemented by Pam’s unfiltered, down-to-earth reality check of what life with AD and all these drugs really feels like.

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    Defense: Argument for Anti-LAG3-based Frontline Combination ICI Treatment of Stage IV Melanoma

    Defense: Argument for Anti-LAG3-based Frontline Combination ICI Treatment of Stage IV Melanoma
    Host: Jeffrey S. Weber, MD, PhD
    Host: Jason J. Luke, MD, FACP
    Host: Ryan Sullivan, MD
    Host: Sapna Patel, MD

    Despite improved prognosis for melanoma patients due to advances in treatment options in recent years, survival rates for patients with metastatic disease remain low. With two mechanistically different immune checkpoint inhibitor combinations available, it is critical that clinicians be able to differentiate among currently approved regimens to inform frontline treatment selection in different patient populations. The crucial question revolves around which target, anti-CTLA-4 versus anti-LAG3, provides the greatest benefit in metastatic melanoma when combined with a PD-1 inhibitor.

    Report with a jury of your peers to debate the optimal frontline treatment approach for a patient with unresectable stage IV BRAF-wild type melanoma. View the persuasive evidence and listen to expert witnesses defend the pros and cons for this vulnerable patient population. Cast your polling vote as the case proceeds. We’ll see you in court to render a verdict in an important case with implications for your clinical practice!

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    Host: Jeffrey S. Weber, MD, PhD
    Host: Sapna Patel, MD
    Host: Jason J. Luke, MD, FACP

    Despite improved prognosis for melanoma patients due to advances in treatment options in recent years, survival rates for patients with metastatic disease remain low. With two mechanistically different immune checkpoint inhibitor combinations available, it is critical that clinicians be able to differentiate among currently approved regimens to inform frontline treatment selection in different patient populations. The crucial question revolves around which target, anti-CTLA-4 versus anti-LAG3, provides the greatest benefit in metastatic melanoma when combined with a PD-1 inhibitor.

    Report with a jury of your peers to debate the optimal frontline treatment approach for a patient with unresectable stage IV BRAF-wild type melanoma. View the persuasive evidence and listen to expert witnesses defend the pros and cons for this vulnerable patient population. Cast your polling vote as the case proceeds. We’ll see you in court to render a verdict in an important case with implications for your clinical practice!

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