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    AMA #12: Thoughts on Longevity Supplements (Resveratrol, NR, NMN, Etc.) & How to Improve Memory

    enOctober 31, 2023

    Podcast Summary

    • The effectiveness of Resveratrol in increasing lifespan debunked, Grape seed extract shows positive effects on vascular function. Increasing NAD levels in cells suggested for potential lifespan extension.Resveratrol does not extend lifespan, but grape seed extract can improve vascular function. Increasing NAD levels in cells may potentially extend lifespan, but further research is needed.

      The belief that supplementing with Resveratrol can increase lifespan has been debunked. While Resveratrol may have certain health benefits, there is little to no direct evidence that it can extend lifespan. However, grape seed extract, which contains Resveratrol, has been found to have positive effects on vascular function and blood flow. Although grape seed extract is not among the top recommended supplements, it can be taken as part of a supplementation stack for general health purposes. As for NAD-related pathways, increasing NAD levels in cells has been suggested as a way to potentially extend lifespan. Methods like NR and NMN supplementation or NAD infusion have been explored, but the effectiveness of increasing NAD in extending lifespan is still under debate.

    • Enhancing Energy Levels with NR and NMN Supplements: Exploring the Potential Benefits and ConsiderationsNR and NMN supplements, along with NAD infusions, can potentially boost energy levels and overall well-being, but their effects on lifespan are not yet proven. Individual experiences may vary.

      Taking NR and NMN supplements can provide sustained mental and physical energy throughout the day. Andrew Huberman, who personally takes both supplements, experiences increased energy levels without any significant side effects. However, it's important to note that the purpose of taking NR and NMN is not to increase lifespan but to boost the levels of NAD in the body. While there are animal studies suggesting a potential increase in lifespan, there is currently no conclusive evidence in humans. Additionally, NAD infusions can also improve energy levels and well-being, although they may cause discomfort and require anti-nausea medication. It's essential to approach these supplements and infusions with an open mind, understanding that individual experiences may vary.

    • Exploring longevity tools and techniques: potential effects and important considerationsPrioritize lifestyle factors like light exposure, movement, nutrition, stress modulation, and social relationships before considering NAD infusions, NR, NMN, metformin, or other interventions. Consult a physician, as these methods can be uncomfortable, expensive, and may have side effects.

      Exploring tools and techniques like NAD infusions, NR, NMN, and metformin for the purpose of increasing lifespan is still highly debated and not yet supported by conclusive evidence. However, these interventions may have subjective effects on vitality and energy levels. It is important to consult with a physician before trying any of these methods, as they can be uncomfortable, expensive, and potentially have side effects. Supplements should be seen as supplements, not as the foundation of mental and physical health. Prioritizing factors like light exposure, movement, nutrition, stress modulation, and social relationships is essential. More research and debate are needed in this area to fully understand the potential benefits and risks.

    • Lack of Data on Metformin and Rapamycin as Longevity SupplementsPrioritizing lifestyle factors like sleep, exercise, nutrition, stress management, and social connections have a greater impact on health and lifespan before considering supplements or drugs. Consult a physician before making any changes to your regimen.

      There is currently insufficient data to support taking metformin or rapamycin for the purpose of increasing lifespan. While there is ongoing scientific exploration on the potential longevity benefits of these drugs, it is important to note that the data is not yet strong enough to justify their use solely for this purpose. Other interventions, such as getting sufficient quality sleep, exercise, nutrition, stress modulation, and maintaining social connections, have a much greater impact on overall health and lifespan. Before considering any supplements or drugs, it is crucial to prioritize these foundational aspects of a healthy lifestyle. Additionally, it is always advisable to consult a board-certified physician before making any changes to your regimen.

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    Recently I had the pleasure of hosting a live event in Sydney, Australia. This event was part of a lecture series called The Brain Body Contract. My favorite part of the evening was the question and answer period, where I had the opportunity to answer questions from the attendees of each event. Included here is the Q&A from our event at the ICC Sydney Theatre. Sign up to get notified about future events: https://www.hubermanlab.com/events Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps 00:00 Introduction 00:15 Live Event Recap: The Brain Body Contract 00:32 Sponsors: AG1 & Eight Sleep 03:30 Q&A Session Begins: Napping and Sleep Quality 06:34 The Power of the Placebo Effect 11:31 Entering Rest and Digest State: Techniques and Tools 15:35 Muscle Growth, Learning & the Brain 20:13 Hallucinogens: Personal Experiences & Clinical Insights 27:28 The Misunderstood Effects of MDMA 27:42 Exploring the Potential of MDMA in Clinical Settings 29:25 The Complex World of Psychedelics & Mental Health 30:07 Ketamine: From Misconception to Medical Use 31:53 The Fascinating Science of DMT 33:11 Supporting Science: Funding & Future Directions 34:48 The Gut-Brain Axis: A Key to Overall Health 40:41 Sleep Patterns and Chronotypes: Personalizing Rest 42:50 Addressing ADHD & Focus in the Modern World 49:27 Closing Remarks & Gratitude Disclaimer
    Huberman Lab
    enMay 17, 2024

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