Clonal Expansion of Blood Stem Cells in Aging and Leukemia with Leonard Zon - Sanford Stem Cell Symposium 2023

Lisa Eyler, Ph.D., Colin Depp, Ph.D., Joe Garbanzos, M.B.A., and Irving Tragen, J.D., address various aspects of resilience, ageism, and healthy aging. They emphasize the need to challenge ageist stereotypes and create inclusive communities that support people of all ages. The importance of storytelling, community initiatives, and a commitment to creating possibilities for those aged 50+ is highlighted. Tragen, a centenarian, shares his unique perspective on aging with anecdotes and advice that everyone can apply to their daily lives. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 39130]

Explore ways to keep your brain and body in good shape as you get older.Alison Moore, M.D., M.P.H., F.A.C.P., Steve Cummings, M.D., Steve Hornberger, M.S.W., and Judy Pa, Ph.D. discuss the impacts of exercise, eating well, staying socially active, taking vitamins, and even trying new activities like learning a new language or playing music. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 39129]

Alison Moore, M.D., M.P.H., F.A.C.P., discusses the keys to healthy aging: staying active, mentally engaged, socially connected, having a positive outlook, and being resilient. Dr. Moore emphasizes the importance of these factors for a long and healthy life. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 39347]

Carla Kim, Ph.D., explains how aging impacts lung cell biology and its potential to reshape our understanding of diseases, including lung cancer. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39254]

Ronald DePinho, M.D., explains how telomerase, typically linked to telomere maintenance, serves as a transcriptional co-activator in the brain. Epigenetic repression of TERT, the gene for telomerase, occurs with aging, contributing to aging hallmarks like cellular senescence and inflammation. DePinho's team developed a compound that reactivates TERT, which, when administered to mice, reverses age-related changes. It restores cognitive function, reduces amyloid plaque, and alleviates inflammation. This suggests that maintaining TERT levels can counteract age-related cognitive decline and neurodegeneration, offering potential for treating neurodegenerative diseases like Alzheimer's. DePinho's work expands our understanding of telomerase's multifaceted role in aging and neurodegeneration, holding promise for interventions against these age-related processes. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39071]

Leonard Zon, M.D., discusses cutting-edge research on the intricate relationship between macrophages, stem cells, and the development of leukemia using the zebrafish model. He delves into the fascinating interactions between these cell types, highlighting the role of a "don't eat me" signal and the influence of the leukemic niche. Through cellular barcoding and single-cell RNA sequencing, he unveils a potential therapeutic target which may offer promising insights into treating leukemia by disrupting the stromal activities that support it. Zon showcases the power of zebrafish models in advancing our understanding of hematopoiesis and cancer, promising new avenues for research and treatment. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39064]

What drives longevity? Explore the keys to healthy aging in this panel discussion featuring leading experts in public health, nutrition, and medicine. You'll get a comprehensive analysis of how lifestyle choices, diet, and exercise profoundly impact our healthspan and longevity. The panelists discuss the significance of the Mediterranean diet, the role of physical activity in maintaining wellness, and the potential benefits of medications like Metformin for non-diabetic patients. This engaging session also highlights the crucial influence of our environment and social structures on individual health behaviors. Discover actionable insights and the latest scientific findings on aging gracefully and improving your quality of life. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 39127]

S. Jay Olshansky, Ph.D., shares how science is unlocking the secrets of aging. Learn how we can live healthier and longer lives by understanding the biology of aging. Find out about potential breakthroughs and the impact of genetics on diseases like cancer and Alzheimer's. Explore the "longevity dividend" and the quest to compress the "red zone" of aging. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 39126]

Anthony Lim, M.D., J.D. shares the keys to vibrant health. Dr. Lim shares methods to prevent kidney stones, tackle fatty liver disease through a whole-food, plant-based diet, and more. Learn how food choices can transform your well-being and get practical solutions. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 39020]

What drives human resilience? How can we harness resilience to improve the lives of older adults? Anthony J.A. Molina, Ph.D., shares how geroscience research is leading the way to longer, healthier, and more fulfilling lives. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 39125]