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    E37: NYC rejects far-left mayoral candidates, new developments in lab leak theory, Apple's App Store breakup potential & more

    enJune 25, 2021

    Podcast Summary

    • Understanding Fears and PerspectivesFear and weaknesses shape us, and understanding them can lead to better decision-making. Elevating conversations and providing multiple perspectives can help navigate through challenging situations.

      Everyone has their unique fears and weaknesses, and understanding them can help navigate through challenging situations. Jason shares his fear of dentists, while David Sacks emphasizes the importance of elevating conversations and providing multiple perspectives instead of relying on sound bites to influence opinions. The group also discusses the potential of a Q&A format and debates the merits of sticking to their current format or trying something new. Ultimately, they agree that everyone needs guidance and that understanding different perspectives can lead to better decision-making. Additionally, Chamath suggests a new segment called "Chamath does a dramatic reading" where he reads out excerpts from their group chat.

    • Fostering thoughtful conversations and supporting collaboratorsThe team values different perspectives, facilitates informed discussions, and plans to compensate collaborators for their work

      While it's understandable for some issues to be complex and nuanced, it's important for commentators to take definitive stances and engage in meaningful debates. Henry Belcaster, a frequent collaborator, runs his videos by the team as a courtesy, but they ultimately have creative control. The team values understanding different perspectives and acknowledges that many debates involve multiple valid viewpoints. They aim to facilitate informed discussions rather than dictating a single opinion. The team also recognizes the potential business opportunities for collaborators like Henry and Dylan, and plans to compensate them for their work. In essence, the team's approach is to foster thoughtful conversations and support the growth of their collaborators.

    • Fostering productive conversations through shared values and understandingHaving nuanced conversations and acknowledging the validity of different viewpoints can lead to progress and a deeper understanding of complex issues

      Recognizing shared values and understanding different perspectives can lead to more productive conversations and progress in society. It's important to remember that having different opinions doesn't make someone evil, but rather, it makes them unique. People should aim to broaden their perspectives and consider various points of view before forming opinions. David Sacks and Robert Friedberg, despite their disagreements, emphasized the importance of having nuanced conversations and acknowledging the validity of different viewpoints. They also agreed that the goal of their discussions should not be to engage in sound bites, but rather to explore various perspectives and arrive at a deeper understanding of complex issues.

    • Opening up taboo debates for nuanced discussionsThe All In Pod encourages open debates on complex and nuanced issues, allowing for a deeper understanding of different perspectives and finding common ground.

      The conversation around important issues, such as merit versus diversity in business and crime prevention, is often shut down due to moral indictments and lack of open debate. The example given was the Frank Slootman controversy, where a CEO's statement supporting diversity without jeopardizing merit led to an uproar and apology, preventing a serious discussion on the topic. The All In Pod aims to reopen these debates and expand the Overton window by allowing people to discuss taboo topics. Another example given was the mayoral race in New York City, where Eric Adams, a former police officer, is running on a platform that includes support for stop and question policing techniques. Despite the controversy surrounding stop and frisk, Adams argues that when deployed correctly, it can be an effective tool for reducing crime. The conversation around these issues is complex and nuanced, and it's important to have open and respectful debates to understand different perspectives and find common ground.

    • Mayoral Race in NYC: Crime Tops Voters' ConcernsEric Adams, a former cop, won NYC mayoral race by prioritizing public safety, indicating communities' desire for practical solutions to crime concerns, and crime remaining a significant issue for Americans.

      The mayoral race in New York City between Eric Adams and his opponents highlighted the importance of crime as a major issue for voters. Despite being criticized by the progressive left and Democratic elites, Adams, a former cop who supports strong policing, won the election with a clear message of prioritizing public safety. This victory underscores the disconnect between the radical left and the communities they aim to represent, particularly in predominantly black and Latino neighborhoods. These communities are seeking practical solutions to their concerns, rather than abstract ideologies. The Adams win also indicates that crime will remain a significant concern for Americans in the coming years.

    • Eric Adams' Social Media Following Didn't Determine NYC Mayoral WinFocusing on real-life issues, like crime and safety, can lead to political success, even with fewer social media followers.

      The Eric Adams win in the New York mayoral race serves as a reminder that social media does not dictate real-life outcomes. Despite having fewer Twitter followers than his competitors, Adams' focus on addressing crime and safety resonated with voters, ultimately securing his victory. This win challenges the notion that progressive, woke voices on social media hold significant sway over public opinion and policy. Additionally, politicians and business leaders should not base their decisions solely on the opinions expressed on social media, as these voices may not accurately represent the larger population.

    • New York City mayoral race shows voters prefer moderation over extreme online stancesDespite pressure to conform to progressive ideologies online, voters chose a moderate and reasonable candidate in the NYC mayoral race, emphasizing the importance of reason over extreme views.

      The pressure to conform to progressive ideologies, fueled by social media, can lead people to adopt certain stances publicly, but when it comes to voting, moderation and reason still prevail. This was evident in the New York City mayoral race, where candidates' online actions and words were scrutinized, and those who were perceived as not progressive enough faced backlash. However, when it came to the ballot box, voters chose a moderate and reasonable candidate, in this case, Eric Adams, over one who may have been more progressive but too focused on online opinions. Additionally, a researcher named Jesse Bloom's discovery of missing COVID genes submitted to a database has sparked interest and raised questions about the accuracy of the data being used to study the virus. This discovery highlights the importance of rigorous scientific research and the potential consequences of incomplete or inaccurate data.

    • Researcher finds missing COVID-19 genomic data, sparks debate on originA researcher discovered deleted COVID-19 genomic samples, raising questions about their removal and the virus's origin. The findings highlight the importance of transparency and cooperation in scientific research, as well as the value of open-access platforms.

      A researcher discovered missing genomic samples related to the origin of COVID-19 from an openly available database and managed to retrieve the data using Google Cloud API. The intrigue lies in why these samples were deleted, with US officials confirming they made the request at the behest of Chinese officials. The data, while inconclusive, suggests there may have been two lineages of the virus in the early days of the outbreak, with the Wuhan meat market potentially being the origin or just one of the branches. The researcher's findings have sparked debate about the origin of the virus and the importance of transparency in scientific research. This incident underscores the need for clear communication and cooperation between nations to prevent such incidents and ensure the progress of scientific research. Additionally, the researcher's quick publication on a preprint server highlights the importance of open-access platforms for sharing research findings promptly.

    • Normalization of Shutdowns and Cover-Up HypothesisThe normalization of shutdowns as a response to emerging risks and potential cover-ups fuel speculation, hindering society's ability to respond effectively to future health crises. Focus should be on improving vaccine production and transparency.

      The normalization of shutdowns as a response to emerging viruses or risks is a concerning trend that could hinder society's ability to function properly in the face of future health crises. The discussion also touched upon the hypothesis that there may have been a cover-up regarding the origins of COVID-19, with some suggesting that the US may have been involved. The lack of transparency and the obstructing of investigations fueled speculation, but it's important to note that this is just a hypothesis. The focus should be on finding ways to bring vaccines to market faster and more effectively to combat the inevitable emergence of new variants. Additionally, the role of institutions like the WHO and potential conflicts of interest were raised as potential contributing factors to the lack of transparency.

    • Understanding the origins of COVID-19 and China's responseThe debate over COVID-19's origins raises concerns about China's transparency and knowledge, emphasizing the importance of understanding for future preparedness and the significance of gain-of-function research.

      The origins of COVID-19 and how China obtained the information to develop their response to the virus before the rest of the world is still a mystery. The debate revolves around whether it was an intentional or accidental lab leak. While it's unlikely that it was intentional due to the potential risks to China, an accidental leak raises concerns about China's transparency and knowledge of the virus before the rest of the world. Friedberg emphasized that understanding the origins is crucial for informing future plans, especially as new variants continue to emerge. Moreover, the discussion highlighted the importance of gain-of-function research in understanding viruses and their potential impact on humans. This research involves making intentional changes to a virus to study its effects on biology and prepare for future outbreaks. The controversy surrounding COVID-19 lies in the fact that China may have conducted such research on the virus, but the details of their findings remain unknown. The speakers also acknowledged that the implications of COVID-19 were significant, and it's crucial to understand the changes China made in their lab to better prepare for future pandemics. However, accessing this information remains a challenge. In summary, the discussion underscores the importance of transparency and collaboration in scientific research, especially during global health crises.

    • Possible decoupling between US and ChinaThe Wuhan lab leak discovery could lead to decoupling, resulting in economic, political, and cultural separation between the US and China, with potential consequences including a cold war-like situation or accelerating democracy in China due to demographic challenges.

      The discovery of the origin of the Wuhan lab leak, if proven true, could lead to significant geopolitical consequences, including decoupling between the US and China. Decoupling refers to the process of reducing economic, political, and cultural interdependence between two countries. The motivating principles behind decoupling are the need for greater self-sufficiency in essential industries like pharmaceuticals and the realization of China's demographic challenges. However, there are opposing forces that may prevent decoupling, such as the desire for economic integration and the financial interests of multinational corporations. The potential decoupling could result in a cold war-like situation or accelerate democracy in China due to its demographic challenges. The speakers also emphasized the importance of reassessing the relationship with China and being more realistic about the nature of the Chinese regime.

    • Collaborative efforts for understanding and countering COVID-19Focus on cooperation and open dialogue in research communities to better understand and combat COVID-19 and future pandemics, and explore advancements in technology like vaccine printers for faster vaccine production and distribution.

      Instead of focusing on assigning blame for the origins of COVID-19, we should prioritize collaborative efforts to ensure that all variants of the virus are well-characterized and publicly available for global research. This open and cooperative dialogue within the academic and research communities is crucial for understanding the virus and developing effective countermeasures. Additionally, advancements in technology, such as vaccine printers, could lead to a more efficient and effective response to future pandemics by combining research and vaccine production in one facility. This cross-disciplinary approach could lead to faster development and distribution of vaccines, ultimately securing our future against potential health crises.

    • Collaboration and Innovation in Science and TechInterdisciplinary collaboration among scientists and engineers is essential for scientific advancements and solving complex problems. Engineering processes are crucial for production systems, but proper checks and balances are necessary. Geopolitical challenges and antitrust regulations are shaping the tech industry.

      Interdisciplinary collaboration among scientists and engineers is crucial for scientific advancements and solving complex problems like the production of cheap and fast vaccines. The engineering process, which involves building a distributed production system, is an essential aspect of this collaboration. However, it's important to ensure proper checks and balances in these labs to prevent potential issues. Another topic of discussion was the geopolitical challenge posed by China, which has become a significant global player and requires careful navigation. In the tech industry, antitrust bills targeting big tech companies like Apple are gaining momentum, which could lead to changes in their business models and market dynamics. Apple, with its significant market power and control over app stores, faces scrutiny and potential regulation. Overall, these discussions highlight the importance of collaboration, innovation, and regulation in various fields.

    • Proposed legislation aims to loosen Apple's app controlThe proposal seeks to allow sideloading on Apple devices, challenging Apple's 30% take rate and technical guardrails, while considering privacy concerns and potential risks.

      The proposal by Representative Cicelyne, a democrat from Rhode Island, aims to loosen Apple's control over apps on Apple devices by allowing sideloading. Apple argues that alternatives like Android and the open web are not viable competitors due to the overwhelming development and revenue in the iOS app ecosystem. Breaking up Apple's ability to dictate a 30% take rate and loosen technical guardrails is seen as a significant step forward. However, Apple's strong focus on privacy and potential risks associated with sideloading should be considered. The speed and quality of the antitrust bills passed in recent times is impressive, but some argue it sets a dangerous precedent. Ultimately, the debate revolves around consumer happiness and the role of monopolies in the tech industry. Apple and Alphabet's success is rooted in their ability to create high-quality consumer products, not just blocking out competitors.

    • Apple's App Store Controls: Promoting Own Products and Consumer DemandsApple's tight control over its App Store and hardware creates a significant barrier to competition, making it hard for new entrants to gain traction.

      Apple's control over its App Store and the restrictions it imposed on third-party apps were driven by its desire to promote its own products and meet the demands of consumers. Apple set standards for the App Store, allowing apps that adhered to them, such as YouTube and Google Chrome, while blocking others like open-source players and browsers. Apple's monopolistic control over the App Store and its hardware is a significant barrier to competition, making it difficult for new entrants to gain traction due to the network effects of existing apps. Microsoft's Windows monopoly serves as a cautionary tale, and while some argue that government intervention can help, others believe that disruptive technology and innovation are the best ways to challenge monopolies and promote competition.

    • Regulating tech giants: A delicate balanceAddressing concerns like app store fees and monopolistic practices can promote competition and innovation without hindering the dynamic consumer market.

      The complex issue of regulating tech giants like Apple and Amazon requires careful consideration. Breaking up these companies might not be the best solution, as it could lead to regulatory burdens that hinder innovation and competition in the long run. Instead, addressing concerns such as app store fees and monopolistic practices could be more effective. The consumer market is dynamic, and new players can emerge, as seen with Shopify and AWS. These companies have the resources to foster innovation and support emerging businesses. Ultimately, the focus should be on allowing consumers to make their own choices and promoting a competitive market without undue regulatory burden.

    • Apple's shift from revolutionary to gatekeeperApple's rigid business practices and high take rates have turned potential allies into enemies, risking loss of innovative geniuses and rise of competitors

      Apple's rigid business practices and high take rates have led to a backlash from various companies and creators, turning potential allies into enemies. This mistake could have been avoided by implementing a lower take rate and gradually reducing it over time. The article by Antonio Garcia Martinez, titled "Bad Apple," highlights Apple's shift from being a revolutionary company to a gatekeeper collecting rents. The loss of innovative geniuses like Steve Jobs and the current management's focus on avoiding losses rather than driving gains could lead to the rise of competitors like Shopify, Square, and Stripe over the next decade.

    • Amazon's impact on competitors and potential regulatory interventionAmazon's dominance may face challenges from competitors, but potential regulatory intervention could slow their growth, leading to more reasonable and innovative ideas and a net positive impact on consumers and businesses.

      Despite Amazon being challenged by companies like Shopify, Stripe, and Square, all four entities have the potential to win. The precise entry points and constraints these companies face due to Amazon's existence may lead to regulatory intervention and potential slowdowns in their growth. However, this could also result in more reasonable and innovative ideas being accepted, ultimately benefiting consumers and businesses. The human capital equation may change, but it's unlikely that the government will completely solve the issue. Instead, they may only slow down the overreach of these companies for the next few decades. The current trend of cancel culture and hysteria is predicted to end, allowing for a more open and accepting environment for new ideas. Ultimately, this could lead to a net positive impact on the world.

    • Lifestyle Changes for Improved Appearance and EnergySpeaker implements IF, reduces carbs, goes plant-based, and cuts back on alcohol for improved appearance, energy, and weight loss goal of 170 pounds.

      The speaker in this conversation is implementing various lifestyle changes, including intermittent fasting, reducing carb intake, and attempting to be more plant-based, to improve his physical appearance and energy levels. He has also cut back on drinking alcohol. The conversation suggests that these changes have led to noticeable improvements for the speaker, and he is aiming for a weight goal of 170 pounds. The speaker also mentions the potential for monetizing their Imessage chat group, but the details are unclear. Overall, the conversation highlights the speaker's dedication to making positive lifestyle changes and the impact those changes have had on him.

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    Referenced in the show:

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    https://x.com/emilyakopp/status/1795482121739354552

    https://x.com/R_H_Ebright/status/1795454118594568312

    https://www.youtube.com/watch?v=jGxSlW0NrB4

    https://www.cidrap.umn.edu/dual-use-research/feds-lift-gain-function-research-pause-offer-guidance

    https://www.washingtonpost.com/opinions/a-flu-virus-risk-worth-taking/2011/12/30/gIQAM9sNRP_story.html

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484390

    https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30418-9/fulltext

    https://oversight.house.gov/release/new-covid-select-memo-details-allegations-of-wrongdoing-and-illegal-activity-by-dr-faucis-senior-scientific-advisor

    https://fiscaldata.treasury.gov/americas-finance-guide/national-deficit

    https://x.com/KatherineEban

    https://x.com/emilyakopp

    https://www.semafor.com/article/05/28/2024/a-dying-empire-led-by-bad-people-poll-finds-young-voters-despairing-over-us-politics

    https://www.youtube.com/watch?v=nvQTXAgtA6s

    https://s23.q4cdn.com/574569502/files/doc_financials/2025/q1/CRM-Q1-FY25-Earnings-Press-Release-w-financials.pdf

    https://www.investors.com/news/economy/federal-reserve-core-pce-inflation-gdp-q1-jobless-claims-sp-500

    https://www.nytimes.com/live/2024/05/30/nyregion/trump-trial-verdict

    https://www.google.com/finance/quote/DELL:NYSE

    https://www.bloomberg.com/news/articles/2024-05-30/us-gdp-grew-at-softer-pace-as-spending-inflation-marked-down

    Scarlett Johansson vs OpenAI, Nvidia's trillion-dollar problem, the "vibecession," plastic in our balls

    Scarlett Johansson vs OpenAI, Nvidia's trillion-dollar problem, the "vibecession," plastic in our balls

    (0:00) Bestie intros: Recapping "General AI Hospital"

    (2:46) Scarlett Johansson vs. OpenAI

    (14:37) OpenAI's novel off-boarding agreements, ex-employee equity problem, and safety team resignations

    (25:35) Nvidia crushes earnings again, but it faces a trillion-dollar problem

    (40:05) Understanding why economic sentiment is so negative among US citizens despite positive data

    (1:02:36) New study shows plastics in testicles

    Follow the besties:

    https://twitter.com/chamath

    https://twitter.com/Jason

    https://twitter.com/DavidSacks

    https://twitter.com/friedberg

    Follow on X:

    https://twitter.com/theallinpod

    Follow on Instagram:

    https://www.instagram.com/theallinpod

    Follow on TikTok:

    https://www.tiktok.com/@all_in_tok

    Follow on LinkedIn:

    https://www.linkedin.com/company/allinpod

    Intro Music Credit:

    https://rb.gy/tppkzl

    https://twitter.com/yung_spielburg

    Intro Video Credit:

    https://twitter.com/TheZachEffect

    Referenced in the show:

    https://x.com/BobbyAllyn/status/1792679435701014908

    https://x.com/sama/status/1790075827666796666

    https://openai.com/index/how-the-voices-for-chatgpt-were-chosen

    https://www.washingtonpost.com/technology/2024/05/22/openai-scarlett-johansson-chatgpt-ai-voice

    https://x.com/SydSteyerhart/status/1792981291266138531

    https://www.vox.com/future-perfect/351132/openai-vested-equity-nda-sam-altman-documents-employees

    https://x.com/sama/status/1791936857594581428

    https://x.com/ilyasut/status/1790517455628198322

    https://x.com/janleike/status/1790603862132596961

    https://x.com/janleike/status/1791498184671605209

    https://openai.com/index/openai-announces-leadership-transition

    https://nvidianews.nvidia.com/news/nvidia-announces-financial-results-for-first-quarter-fiscal-2025

    https://www.google.com/finance/quote/INTC:NASDAQ

    https://www.morningstar.com/stocks/nvidia-2023-vs-cisco-1999-will-history-repeat

    https://www.fool.com/investing/2024/03/06/is-nvidia-doomed-to-be-the-next-cisco-what-investo

    https://www.elitetrader.com/et/threads/nvidia-and-the-cautionary-tale-of-cisco-systems.379022

    https://chamath.substack.com/p/2023-annual-letter

    https://www.forbes.com/sites/theapothecary/2024/03/23/summers-inflation-reached-18-in-2022-using-the-governments-previous-formula

    https://www.theguardian.com/us-news/article/2024/may/22/poll-economy-recession-biden

    https://fred.stlouisfed.org/series/CCLACBW027SBOG

    https://x.com/KariLake/status/1792986501820850333

    https://www.stlouisfed.org/on-the-economy/2024/apr/how-big-mac-index-relates-overall-consumer-inflation

    https://www.google.com/finance/quote/MCD:NYSE

    https://www.wsj.com/economy/gdp-and-the-dow-are-up-but-what-about-american-well-being-87f90e6d

    https://www.consumerreports.org/health/food-contaminants/the-plastic-chemicals-hiding-in-your-food-a7358224781

    https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2605.2007.00837.x

    https://pubmed.ncbi.nlm.nih.gov/12708228

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559247

    https://pubmed.ncbi.nlm.nih.gov/21524797

    https://academic.oup.com/toxsci/advance-article/doi/10.1093/toxsci/kfae060/7673133

    https://www.youtube.com/watch?v=o6yuYkfNh-k

    https://www.youtube.com/watch?v=EYQjShJxCtM

    https://www.youtube.com/watch?v=r_4jrMwvZ2A

    GPT-4o launches, Glue demo, Ohalo breakthrough, Druck's Argentina bet, did Google kill Perplexity?

    GPT-4o launches, Glue demo, Ohalo breakthrough, Druck's Argentina bet, did Google kill Perplexity?

    (0:00) Bestie Intros: Recapping Phil Hellmuth's birthday weekend

    (7:38) OpenAI launches GPT-4o: better, faster, cheaper

    (29:40) Sacks demos Glue: How AI unlocked his Slack killer

    (40:12) Friedberg walks through his major breakthrough at Ohalo

    (1:01:35) Stanley Druckenmiller bets on Argentina and Javier Milei: strategy, roadmap for the US

    (1:13:54) Jason's bet on Athena, how AI will change company building

    (1:22:21) Google launches AI summaries in search

    Follow the besties:

    https://twitter.com/chamath

    https://twitter.com/Jason

    https://twitter.com/DavidSacks

    https://twitter.com/friedberg

    Follow on X:

    https://twitter.com/theallinpod

    Follow on Instagram:

    https://www.instagram.com/theallinpod

    Follow on TikTok:

    https://www.tiktok.com/@all_in_tok

    Follow on LinkedIn:

    https://www.linkedin.com/company/allinpod

    Intro Music Credit:

    https://rb.gy/tppkzl

    https://twitter.com/yung_spielburg

    Intro Video Credit:

    https://twitter.com/TheZachEffect

    Referenced in the show:

    https://www.pokernews.com/news/2024/05/phil-hellmuth-60th-birthday-bash-las-vegas-45984.htm

    https://x.com/OpenAI/status/1790130703721521305

    https://x.com/OpenAI/status/1790089513387143469

    https://crfm.stanford.edu/helm/mmlu/v1.3.0/#

    https://www.businessinsider.com/inflection-implosion-chatgpt-stall-ai-consumer-chatbot-problem-2024-3

    https://www.opencompute.org

    https://glue.ai

    https://ragie.ai

    https://ohalo.com

    https://www.cnbc.com/2024/05/07/cnbc-exclusive-cnbc-transcript-billionaire-investor-stanley-druckenmiller-speaks-with-cnbcs-squawk-box-today.html

    https://www.forbes.com/sites/theapothecary/2024/03/23/summers-inflation-reached-18-in-2022-using-the-governments-previous-formula

    https://twitter.com/DavidSacks/status/1378034932006592512

    https://www.athenawow.com/jcal

    https://calacanis.substack.com/p/startup-productivity-in-the-age-of

    https://blog.google/products/search/generative-ai-google-search-may-2024

    https://www.youtube.com/watch?v=XEzRZ35urlk

    https://finance.yahoo.com/quote/GOOG

    https://startuptalky.com/apple-failed-products

    In conversation with Sam Altman

    In conversation with Sam Altman

    (0:00) Welcoming Sam Altman to the show!

    (2:28) What's next for OpenAI: GPT-5, open-source, reasoning, what an AI-powered iPhone competitor could look like, and more

    (21:56) How advanced agents will change the way we interface with apps

    (33:01) Fair use, creator rights, why OpenAI has stayed away from the music industry

    (42:02) AI regulation, UBI in a post-AI world

    (52:23) Sam breaks down how he was fired and re-hired, why he has no equity, dealmaking on behalf of OpenAI, and how he organizes the company

    (1:05:33) Post-interview recap

    (1:10:38) All-In Summit announcements, college protests

    (1:19:06) Signs of innovation dying at Apple: iPad ad, Buffett sells 100M+ shares, what's next?

    (1:29:41) Google unveils AlphaFold 3.0

    Follow Sam:

    https://twitter.com/sama

    Follow the besties:

    https://twitter.com/chamath

    https://twitter.com/Jason

    https://twitter.com/DavidSacks

    https://twitter.com/friedberg

    Follow on X:

    https://twitter.com/theallinpod

    Follow on Instagram:

    https://www.instagram.com/theallinpod

    Follow on TikTok:

    https://www.tiktok.com/@all_in_tok

    Follow on LinkedIn:

    https://www.linkedin.com/company/allinpod

    Intro Music Credit:

    https://rb.gy/tppkzl

    https://twitter.com/yung_spielburg

    Intro Video Credit:

    https://twitter.com/TheZachEffect

    Referenced in the show:

    https://twitter.com/EconomyApp/status/1622029832099082241

    https://sacra.com/c/openai

    https://twitter.com/tim_cook/status/1787864325258162239

    https://openai.com/index/introducing-the-model-spec

    https://twitter.com/SabriSun_Miller/status/1788298123434938738

    https://www.archives.gov/founding-docs/bill-of-rights-transcript

    https://twitter.com/ClayTravis/status/1788312545754825091

    https://www.inc.com/bill-murphy-jr/warren-buffett-just-sold-more-than-100-million-shares-of-apple-reason-why-is-eye-opening.html

    https://www.youtube.com/watch?v=snbTCWL6rxo

    https://www.digitimes.com/news/a20240506PD216/apple-ev-startup-genai.html

    https://www.theonion.com/fuck-everything-were-doing-five-blades-1819584036

    https://blog.google/technology/ai/google-deepmind-isomorphic-alphafold-3-ai-model

    In conversation with Sheryl Sandberg, plus open-source AI gene editing explained

    In conversation with Sheryl Sandberg, plus open-source AI gene editing explained

    (0:00) Welcoming Sheryl Sandberg and remembering Dave Goldberg

    (11:10) What led Sheryl to get involved with "Screams Before Silence"; reaction to sexual violence on and after 10/7

    (28:18) Paths forward, documentary decisions, involvement of women in protests

    (53:03) Post-interview debrief

    (59:45) Science Corner: Open-source AI gene editing with OpenCRISPR-1

    Follow Sheryl:

    https://twitter.com/sherylsandberg

    Watch Screams Before Silence:

    https://www.youtube.com/watch?v=zAr9oGSXgak&rco=1

    Follow the besties:

    https://twitter.com/chamath

    https://twitter.com/Jason

    https://twitter.com/DavidSacks

    https://twitter.com/friedberg

    Follow on X:

    https://twitter.com/theallinpod

    Follow on Instagram:

    https://www.instagram.com/theallinpod

    Follow on TikTok:

    https://www.tiktok.com/@all_in_tok

    Follow on LinkedIn:

    https://www.linkedin.com/company/allinpod

    Intro Music Credit:

    https://rb.gy/tppkzl

    https://twitter.com/yung_spielburg

    Intro Video Credit:

    https://twitter.com/TheZachEffect

    Referenced in the show:

    https://twitter.com/fakechamath

    https://www.youtube.com/watch?v=zAr9oGSXgak&rco=1

    https://www.cnn.com/2023/11/20/opinions/sheryl-sandberg-something-we-can-all-agree-on/index.html

    https://news.un.org/en/story/2024/03/1147477

    https://thegrayzone.com/2024/03/07/media-concocts-un-hamas-rape-report/amp/

    https://www.nytimes.com/2024/01/29/world/middleeast/israel-hamas-sexual-violence-un.html

    https://github.com/Profluent-AI/OpenCRISPR

    Meta's scorched earth approach to AI, Tesla's future, TikTok bill, FTC bans noncompetes, wealth tax

    Meta's scorched earth approach to AI, Tesla's future, TikTok bill, FTC bans noncompetes, wealth tax

    (0:00) Bestie Intros: Reservation Tips!

    (5:20) Meta goes scorched earth in AI, why the stock was down despite beating on earnings

    (22:20) Tesla's roadmap, ranking the company's highest-upside bets outside of cars for the next 10 years

    (47:25) FTC bans noncompetes: impact on startups and company formation

    (1:00:33) Besties reminisce on their encounters with Steve Jobs

    (1:10:25) TikTok "divest-or-ban" bill is signed into law: Will China comply? What's it worth without the algorithm? Will a deal get done?

    (1:27:22) Biden's proposed capital gains hikes and a 25% wealth tax for those with $100M+ in assets

    Follow the besties:

    https://twitter.com/chamath

    https://twitter.com/Jason

    https://twitter.com/DavidSacks

    https://twitter.com/friedberg

    Follow on X:

    https://twitter.com/theallinpod

    Follow on Instagram:

    https://www.instagram.com/theallinpod

    Follow on TikTok:

    https://www.tiktok.com/@all_in_tok

    Follow on LinkedIn:

    https://www.linkedin.com/company/allinpod

    Intro Music Credit:

    https://rb.gy/tppkzl

    https://twitter.com/yung_spielburg

    Intro Video Credit:

    https://twitter.com/TheZachEffect

    Referenced in the show:

    https://ai.meta.com/blog/meta-llama-3

    https://huggingface.co/meta-llama/Meta-Llama-3-8B

    https://about.fb.com/news/2024/04/introducing-our-open-mixed-reality-ecosystem

    https://about.fb.com/news/2024/04/meta-ai-assistant-built-with-llama-3

    https://www.cnn.com/2024/04/25/investing/meta-stock-plunges-ai-spending/index.html

    https://www.youtube.com/watch?v=kiMTRQXBol0

    https://twitter.com/AravSrinivas/status/1781099224169320500

    https://wow.groq.com/12-hours-later-groq-is-running-llama-3-instruct-8-70b-by-meta-ai-on-its-lpu-inference-enginge

    https://twitter.com/lauramaywendel/status/1782040453266710551

    https://twitter.com/naveengrao/status/1781491370114633816

    https://twitter.com/winglian/status/1783456379199484367

    https://www.meta.ai

    https://twitter.com/chamath/status/1780302197772952049

    https://electrek.co/2024/03/16/tesla-full-self-driving-beta-v12-finally-rolls-out

    https://www.reuters.com/business/autos-transportation/tesla-cuts-price-full-self-driving-software-by-third-8000-2024-04-21

    https://fortune.com/2024/04/15/elon-musk-tesla-cut-10-percent-global-workforce-14000-employees-slowing-ev-demand

    https://www.reuters.com/business/autos-transportation/tesla-take-shareholder-vote-shifting-incorporation-texas-musk-says-2024-02-01

    https://www.ft.com/content/46aac746-4a54-437f-a0b7-9b81b154c21d

    https://www.google.com/finance/quote/TSLA:NASDAQ

    https://www.cnbc.com/2024/04/24/tesla-stock-up-after-elon-musk-says-new-affordable-ev-models-coming.html

    https://www.tesla.com/blog/master-plan-part-deux

    https://twitter.com/chamath/status/1776663647735218491

    https://digitalassets.tesla.com/tesla-contents/image/upload/IR/TSLA-Q1-2024-Update.pdf

    https://www.cnbc.com/2024/04/25/gdp-q1-2024-increased-at-a-1point6percent-rate.html

    https://palmetto.com

    https://www.youtube.com/watch?v=pja_n8ThDsU

    https://www.fastcompany.com/90972171/cruise-suspends-driverless-vehicle-operations-in-san-francisco-after-dmv-revokes-permit

    https://twitter.com/DavidSacks/status/1777496946263134414

    https://www.nytimes.com/2023/11/03/technology/cruise-general-motors-self-driving-cars.html

    https://thehill.com/business/4615452-ftc-votes-to-ban-non-compete-agreements

    https://www.ftc.gov/news-events/news/press-releases/2024/04/ftc-announces-rule-banning-noncompetes

    https://www.techemails.com/p/steve-jobs-emails-adobes-ceo

    https://venturebeat.com/business/how-steve-jobs-felt-betrayed-by-eric-schmidt-over-googles-android

    https://www.youtube.com/watch?v=CWOt9Cjq2mw

    https://www.theverge.com/2024/4/24/24139036/biden-signs-tiktok-ban-bill-divest-foreign-aid-package

    https://abcnews.go.com/Politics/senate-returns-95b-foreign-aid-package-ukraine-israel/story?id=109506150

    https://www.cnbc.com/2023/12/06/tiktok-parent-bytedance-offers-share-buyback-at-268-billion-valuation.html

    https://www.theinformation.com/articles/bytedance-exploring-scenarios-for-selling-tiktok-without-algorithm?rc=pxkrxo

    https://www.aclu.org/press-releases/senate-reauthorizes-and-expands-section-702-surveillance

    https://twitter.com/DavidSacks/status/1783220583075111401

    https://www.wsj.com/tech/tiktok-ban-chinese-owners-bytedance-1a857a06

    https://x.com/MsMelChen/status/1783524423963697262

    https://x.com/Jason/status/1783556155924705388

    https://x.com/Jason/status/1783604248569360516

    https://www.atr.org/biden-calls-for-44-6-capital-gains-tax-rate-highest-capital-gains-tax-since-its-creation-in-1922

    https://home.treasury.gov/system/files/131/General-Explanations-FY2025.pdf

    https://www.bloomberg.com/news/articles/2024-04-24/tax-on-rich-to-save-social-security-popular-with-swing-state-voters-poll

    https://balajis.com/p/all-it-takes-is-all-you-got

    https://twitter.com/maceskridge/status/1783290784311058788

    Related Episodes

    Cold Confusion: Alexandros Marinos unpacks the TOGETHER Trial with Bret

    Cold Confusion: Alexandros Marinos unpacks the TOGETHER Trial with Bret

    Bret speaks with Alexandros Marinos, who has analyzed the TOGETHER trial, which aims to identify effective repurposed therapies to prevent the disease progression of COVID-19.

    Alexandros is the Founder/CEO of http://balena.io & aspiring practical philosopher. Find him on:

    https://twitter.com/alexandrosm

    https://doyourownresearch.substack.com/

    Mentioned in this episode:

    https://www.togethertrial.com/

    https://doyourownresearch.substack.com/p/the-problem-with-the-together-trial

    *****

    Find Bret Weinstein on Twitter: @BretWeinstein, and on Patreon.

    https://www.patreon.com/bretweinstein

    Please subscribe to this channel for more long form content like this, and subscribe to the clips channel @DarkHorse Podcast Clips for short clips of all our podcasts:

    https://www.youtube.com/channel/UCAWCKUrmvK5F_ynBY_CMlIA

    All removed videos can be found on Spotify Video and Odysee: https://open.spotify.com/show/57R7dOcs60jUfOnuNG0J1R

    https://odysee.com/@BretWeinstein:f

    Check out the DHP store! Epic tabby, digital book burning, saddle up the dire wolves, and more: http://www.store.darkhorsepodcast.org

    Theme Music: Thank you to Martin Molin of Wintergatan for providing us the rights to use their excellent music.

    *****
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    Farrow SkinFood is lard-based skincare that nourishes the skin without preservatives or added chemicals.

    Go to http://farrow.life/darkhorse for 20% off your first purchase; additional 15% off with a recurring subscription.

    *****

    Timestamps:

    (00:00) Introduction

    (03:11) Better Skeptics project – analyzing COVID podcasts

    (08:12) TOGETHER trial and its timeline

    (15:35) Ads

    (19:08) Dosage & initial TOGETHER trial design 

    (25:29) Confusing paper and placebo group dropout?

    (31:23) IVM dose too low and new protocol

    (35:04) Trial recruitment over time and key 10-week period

    (43:42) Systemic errors

    (51:33) Placebo arm from earlier period?

    (57:11) Trial data not being released

    (01:02:27) Exclusion criteria flipped

    (01:06:38) Hypothesis on algorithm rebalancing arms

    (01:13:35) Allocation to Fluvoxamine arm

    (01:17:12) TOGETHER trial authors believe IVM has an effect

    (01:20:15) Credible intervals and Bayesian statistics

    (01:25:55) Will we ever get the full story? 

    (01:30:28) Dosing and weight limit

    (01:34:52) Background use of IVM in Brazil

    (01:47:19) “Independent” committee monitoring trial

    (01:54:29) Cavallo study and inconsistency in response

    (01:57:41) Press releases and cold confusion

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    Support the show

    #143 - John Ioannidis, M.D., D.Sc.: Why most biomedical research is flawed, and how to improve it

    #143 - John Ioannidis, M.D., D.Sc.: Why most biomedical research is flawed, and how to improve it
    John Ioannidis is a physician, scientist, writer, and a Stanford University professor who studies scientific research itself, a process known as meta-research. In this episode, John discusses his staggering finding that the majority of published research is actually incorrect. Using nutritional epidemiology as the poster child for irreproducible findings, John describes at length the factors that play into these false positive results and offers numerous insights into how science can course correct. 
     
    We discuss:
    • John’s background, and the synergy of mathematics, science, and medicine (2:40);
    • Why most published research findings are false (10:00);
    • The bending of data to reach ‘statistical significance,’ and the how bias impacts results (19:30);
    • The problem of power: How over- and under-powered studies lead to false positives (26:00);
    • Contrasting nutritional epidemiology with genetics research (31:00);
    • How to improve nutritional epidemiology and get more answers on efficacy (38:45);
    • How pre-existing beliefs impact science (52:30);
    • The antidote to questionable research practices infected with bias and bad incentive structures (1:03:45);
    • The different roles of public, private, and philanthropic sectors in funding high-risk research that asks the important questions (1:12:00);
    • Case studies demonstrating the challenge of epidemiology and how even the best studies can have major flaws (1:21:30);
    • Results of John’s study looking at the seroprevalence of SARS-CoV-2, and the resulting vitriol revealing the challenge of doing science in a hyper-politicized environment (1:31:00);
    • John’s excitement about the future (1:47:45); and
    • More.

    Learn more: https://peterattiamd.com/

    Show notes page for this episode: https://peterattiamd.com/JohnIoannidis 

    Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/

    Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/

    Connect with Peter on Facebook | Twitter | Instagram.

    How to save the world, in three easy steps.

    How to save the world, in three easy steps.

    Dr. Robert Malone is the inventor of mRNA Vaccine technology. 
    Mr. Steve Kirsch is a serial entrepreneur who has been researching adverse reactions to COVID vaccines. 
    Dr. Bret Weinstein is an evolutionary biologist. 
    Bret talks to Robert and Steve about the pandemic, treatment and the COVID vaccines. 

    Steve's paper on COVID vaccine reactions: https://trialsitenews.com/should-you-get-vaccinated/ 

    Steve's Twitter: @stkirsch 
    COVID-19 Early Treatment Fund: https://www.treatearly.org/team/steve-kirsch 
    Dr. Malone's website: https://www.rwmalonemd.com/mrna-vaccine-inventor 
    Robert's LinkedIn profile: https://www.linkedin.com/in/rwmalonemd 
    Robert's Twitter: @RWMaloneMD 

    --- 

    Find Bret Weinstein on Twitter: @BretWeinstein, and on Patreon. 

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    Theme Music: Thank you to Martin Molin of Wintergatan for providing us the rights to use their excellent music. 

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