Episode 180: Mending a Broken Heart

In this episode, Jonathan chats with Mark Little, Consultant Interventional Radiologist at the Royal Berkshire NHS Foundation Trust, Reading, UK, where he has set up a large embolotherapy research group in addition to his clinical work. The two discuss everything from their shared passion for aviation to developments in prostate artery embolisation.

Use these timestamps to navigate our episode!

(00:00)-Introduction

(02:32)-What led Little to pursue a career in radiology

(09:01)-Prostate artery embolisation

(15:02)-Genicular artery embolisation

(21:40)-Uterine artery embolisation

(24:43)-The TARGET trial: using augmented reality to guide prostate cancer biopsy

(28:05)-The role of AI in radiology

(31:50)-Innovations on the horizon for interventional radiology

(35:23)-Three wishes

In this week’s episode, Jonathan is joined by Stephanie Hanna, a Research Fellow for the Diabetes Research and Wellness Foundation, in the Division of Infection and Immunity, at Cardiff University’s School of Medicine, Wales, UK. In this fascinating episode, the pair discuss all things diabetes, including immunotherapy, the future of diagnosis, and how to predict your diabetes risk.

Use the following timestamps to navigate the content in this episode: 

(00:00)-Introduction

(01:22)-Getting into Type 1 diabetes (T1D)

(02:23)-Stages of T1D

(05:04)-Biomarkers of T1D

(07:01)-Phenotypic analysis of T and B-cells

(08:24)-Diabetes progression

(10:11)-Immunotherapy for T1D

(14:00)-Challenges in measuring immune response

(16:22)-Some thoughts on artificial intelligence

(18:11)-How to get involved in a study

(19:27)-Checking your own antibody status

(23:51)-Thyroid eye disease

(25:19)-Risks of overlooking T1D

(27:34)-Three wishes for the future of healthcare

Dr Teresa Amaral and Prof Mario Mandalà discuss: The typical patient for whom adjuvant therapy may be considered, and provide details on therapy choices. The long-term advantages of adjuvant treatments, and prospects for the use of biomarkers to help elucidate the best candidates for such therapies. The potential disadvantages of adjuvant therapy, and how more studies are needed to understand if these therapies can impact quality of life and fertility.

This content was fully funded by Novartis Pharma AG

This week’s episode focuses on innovations in diabetes technology, such as flash glucose monitoring and hybrid closed loop systems. Jonathan and Partha Kar, National Specialty Advisor in Diabetes for the National Health Service (NHS), UK, discuss promising innovations on the horizon, such as immunotherapy, as well as the importance of exercising caution on social media, and Partha’s Type 1 diabetes comic book.

Use the following timestamps to navigate the content in this episode: 

(00:00)-Introduction

(02:40)-Partha’s love of comic books

(04:30)-Why diabetes?

(06:09)-Promoting technology in Type 1 Diabetes 

(08:25)-Patient responsibility

(10:05)-Labelling patients with diabetes

(11:28)-Hybrid closed loop systems

(14:40)-Impact on the NHS and global healthcare

(16:04)-Pioneering the diabetes ‘super six’ model

(18:02)-Social media and combatting pseudoscience

(21:15)-Considering racism

(24:06)-Diabetes on ‘the big screen’

(27:31)-Game changing drugs for diabetes

(29:40)-Innovation: stem cells and immunotherapy

(31:24)-Partha’s three wishes for healthcare

(32:40)-Concluding remarks

Jonathan is joined by Geraldine Dawson, Director of the Duke Center for Autism and Brain Development, USA. In the second of a two-part episode, the pair discuss face processing in young children with autism, the use of datasets in autism research, and biomarkers for potential treatment.

Use the following timestamps to navigate the content in this episode: 

(00:00)-Introduction

(00:42)-Digital behaviour phenotyping for the early detection of autism

(07:11)-Research on early autism detection models based on electronic health records

(12:43)-The application of artificial intelligence and computer vision in early autism detection

(15:11)-Brain circuitry, and the techniques and implications of electrophysiological techniques

(20:16)-Three wishes for the future of healthcare

In this week’s episode, Jonathan is joined by Geraldine Dawson, Director of the Duke Center for Autism and Brain Development, and the Duke Autism Clinic, Durham, North Carolina, USA. In the first of a two-part episode, the pair discuss autism screening, the characteristics of autism in infancy, and the benefits of early intervention in social interactions.

Use the following timestamps to navigate the content in this episode: 
(00:00)-Introduction
(02:15)-What led Dawson to an academic career in psychology and autism
(05:09)-How do we characterise being ‘on the spectrum’?
(09:29)-Aetiology of autism: genetic and environmental factors
(13:20)-Dawson’s early, groundbreaking research into autism symptoms in infancy
(17:17)-Why is the incidence of autism increasing?
(19:45)-The Early Start Denver Model: early autism interventions
(23:24)-Time Magazine’s medical breakthrough of 2012

This week, James Hull, Consultant Respiratory Physician, Royal Brompton Hospital, London, UK, takes Jonathan on a deep dive into respiratory care, from combatting breathlessness to airway collapse in athletes. The pair also discuss the common misconceptions surrounding asthma diagnosis, recent technological advancements, and the potential challenges behind emerging treatments.

Use the following timestamps to navigate the content in this episode:

(00:00)-Introduction

(2:17)-What got Hull into medicine?

(03:34)-Relationship between exercise and breathlessness

(06:22)-Anxiety and breathlessness

(10:24)-Optimising respiratory health in elite athletes

(13:52)-RELACS; managing large airway collapse

(16:10)-New methods for diagnosing upper airway problems

(20:09)-New developments in treating asthma

(23:10)-Challenges in respiratory medicine

(25:04)-Respiratory medicine and sports committees

(26:38)-Three wishes for the future of healthcare 

The information contained in this podcast is intended for a European healthcare professional audience for continuing education purposes only. This podcast was supported by Jazz Pharmaceuticals, which  had input into the concept and topic, but not the content of the podcast. The views expressed in this podcast are those of the individual speakers and do not necessarily reflect the views of Jazz Pharmaceuticals.

Lennox–Gastaut syndrome (LGS) is a rare, severe, and progressive childhood-onset epilepsy characterised by recurrent seizures. LGS can be challenging to diagnose due to multiple aetiologies, varying clinical presentation at onset, and a lack of specific biological markers. These challenges can be compounded in adulthood due to the evolving presentation of LGS over time, and incomplete medical histories. In this insightful podcast, experts Steve Chung, University of Arizona, Phoenix, USA; and Rhys Thomas, Royal Victoria Infirmary, Newcastle, UK, explore the identification, diagnosis, and management of LGS in both children and adults based on their experiences in real-life clinical settings.