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    Extended Classic: “Are You Out of Your Mind?” with Oliver Sacks

    en-usSeptember 06, 2015

    Podcast Summary

    • Exploring the Mysteries of the BrainThe brain, a complex organ that sets us apart from animals, is a vast frontier for discovery in areas like language, abstract reasoning, art, philosophy, music, and science.

      The brain, which sets us apart from other animals, is a fascinating and complex organ that continues to mystify scientists. During this episode of StarTalk, Neil deGrasse Tyson and Chuck Nice discuss the brain and its capabilities, with a nod to the fact that even experts like Cara Santa Maria, brought on as a neuroscience educator, acknowledge that there is always more to learn. The brain's role in language, abstract reasoning, art, philosophy, music, and science sets us apart from other animals, but some animals, like dolphins, may surprise us with their intellectual abilities. The brain, like the universe, is a vast frontier with much to discover.

    • The complexity and uniqueness of the brainBrain damage can lead to unpredictable outcomes due to individual brain structures, with 100 billion nerve cells and a complex web of connections for storage and retrieval.

      The brain and its functions are complex and unique to each individual. Cara, a brain expert, emphasized that brain damage can lead to unexpected outcomes due to the complexity and variability of individual brain structures. The brain is estimated to have 100,000,000,000 nerve cells, and its storage and retrieval of information are more like a complex web of connections than a simple file cabinet. The exhibit at the American Museum of Natural History on the brain further highlights this complexity. Despite running the Hayden Planetarium, Chuck, a non-scientist, was sent to report on the exhibit, showcasing the irony of the "brainless" visiting a brain exhibit.

    • The Brain: A Dynamic Organ Influencing Our Everyday LivesThe brain is a complex organ that contributes to experiences, memories, and overall well-being. Experiences and environment shape brain development, and memory is ubiquitous in the brain. The hippocampus, a memory center, is just one of many regions involved. Memory can be triggered by stimuli, and sleep is essential for memory consolidation.

      The brain is a complex and essential organ that plays a significant role in our experiences, memories, and overall well-being. During a museum visit, Chuck, a school psychologist, shared his perspective on the brain and its impact on psychology. He emphasized that experiences and environment contribute to brain development and memory retention. Chuck also expressed his belief that the brain is like a muscle that needs to be used and exercised to maintain its functionality. The hippocampus, a deeper structure of the brain, was discussed as an essential part of memory. Initially, scientists believed it to be the sole seat of memory due to a famous patient, HM, who had his hippocampus removed during epilepsy surgery and could no longer form new memories. However, more recent research reveals that memory is ubiquitous in the brain, and the hippocampus is just one of the many regions involved in memory processing. Furthermore, memory can be triggered by various stimuli, such as smells, which can evoke powerful recollections of past experiences. Sleep is also crucial for memory consolidation, transferring short-term memories to long-term storage. In summary, the brain is a dynamic and multifaceted organ that influences our everyday lives, and it's essential to recognize its significance and take care of it through learning, using it, and ensuring proper rest.

    • Our senses connect memories and emotionsThe brain processes sensory experiences, like smell and taste, through the hippocampus, encoding memories before they're spread to the cortex for long-term storage. Unique animal abilities show brain's complexity and diversity.

      Our senses, particularly smell and taste, are deeply connected to memory and the encoding of memories in the brain. Comfort food, for example, not only provides nourishment but also triggers memories and emotions. The brain processes these sensory experiences through the hippocampus, which acts as a way station for encoding memories before they are spread out to other parts of the cortex for long-term storage. The brain's ability to encode and recall memories is fascinating, and it's worth noting that other animals, such as octopuses and dolphins, have unique ways of processing information and even sleeping. For instance, octopuses have mini brains in each limb that can make decisions autonomously, while dolphins sleep with one hemisphere at a time, allowing them to swim and breathe while the other half is resting. These examples illustrate the complexity and diversity of the brain and its functions.

    • How an electrical shock from a lightning strike changed a man's identityExternal electrical shocks can potentially alter brain function, influencing thoughts, emotions, and beliefs.

      Our brains, as electrical organs, play a significant role in shaping our identity and personality. This was discussed by Oliver Sacks in the context of a man who survived being struck by lightning and later experienced a profound emotional and musical transformation. The electrical current from the lightning may have caused neurological changes that influenced the man's newfound interest in music and religious beliefs. This case illustrates the potential for external electrical shocks to alter brain function and, consequently, our thoughts, emotions, and beliefs. It's important to note that this man, despite being a neurologist himself, chose to interpret his experience in a supernatural way. However, from a scientific perspective, it's plausible that neurological changes occurred as a result of the electrical shock. This is just one example of how our brains' electrical systems contribute to our sense of self.

    • Impact of Brain Damage on Memories and IdentityBrain damage can lead to altered memories, false memories, or even identity confusion. Emotional experiences and persuasive descriptions can also form false memories. Functional brain imaging can help distinguish truths from lies but not delusions.

      Our brains and memories are complex and intriguing. A famous case study involves a railroad worker who survived a tamping iron injury that went through his frontal lobe, leading to drastic personality changes. Brain damage can alter memories or even create false ones. People with dissociative fugue, a psychological condition, can experience memory loss and identity confusion. Functional imaging of the brain can help distinguish lies from truths, but not delusions. False memories can be formed through strong emotional experiences or implanted through persuasive descriptions. Oliver Sacks, a renowned neurologist, shared his experiences with false memories in his book "Uncle Tungsten." Our memories, though not always accurate, shape our identities and experiences.

    • Exploring New Realms of Thought with DrugsThe brain can create false memories and forget real ones, and drugs can alter brain functions, leading to unique experiences and perspectives, but their impact on intellectual abilities is not always positive.

      The brain is capable of both creating false memories and forgetting real ones. Furthermore, the use of psychoactive drugs can alter brain functions, leading to unique experiences and perspectives. Oliver Sacks, a neuroscientist and medical doctor, experimented with drugs in the 1960s to explore other forms of consciousness and found that they opened new domains of natural meaning for him. Drugs like cannabis and PCP have receptors in the brain, and while the effects can be creative, they may not always be positive or beneficial to intellectual acuity or problem-solving abilities. The use of drugs for intellectual enhancement is not a common motivation, but rather, people may seek to expand their consciousness and explore new realms of thought.

    • Exploring the relationship between altered states and personal growthSome profound experiences through drugs or other means can lead to new perspectives and personal growth, but cultural and individual contexts play a role in interpretation.

      Some people, like the speaker in this conversation, have had profound experiences through the use of drugs or other means, leading them to new perspectives and personal growth. This can be seen in the speaker's decision to write a book on migraines after his drug experience. However, it's important to note that such experiences are not unique to modern or western culture, as various cultures have used psychoactive substances for spiritual or religious purposes for centuries. Furthermore, the discussion touches upon the idea that these experiences may enhance one's ability to interact with others, as seen in the movie "The Pill," where the protagonist's enhanced mental abilities enable him to connect more deeply with people. However, it's also noted that having too much openness or lack of focus, such as in the case of ADD, can be detrimental. The conversation also touches upon the possibility that there might be a genetic predisposition for religious experiences, but it's not clear-cut and may depend on individual interpretation and context. Overall, the conversation sheds light on the complex relationship between altered states of consciousness, personal growth, and human connection.

    • The Complex Relationship Between Mind, Perception, and SubstancesPsychotropic drugs can alter perceptions and induce hallucinations, representing spiritual experiences or treating mental/physical conditions. Always be aware of potential risks and side effects.

      The use of psychotropic drugs, including those that induce hallucinations, can have profound effects on people's perceptions and experiences. Oliver Sacks, a neurologist and author, shared his personal experience of using drugs to induce a hallucination of the elusive "indigo" color, which he described as both luminous and numinous. This experience, he believed, was a metaphorical representation of something spiritual and transcendent. However, it's important to note that not all uses of psychotropic drugs are recreational or for the purpose of inducing hallucinations. Many are prescribed to treat various mental and physical conditions, such as ADHD, schizophrenia, depression, and anxiety. It's also important to be aware of the potential risks and side effects of these drugs, as illustrated by the example of someone who became disoriented and confused after taking Robitussin. Overall, the interview highlights the complex and often mysterious relationship between the mind, perception, and the substances we put into our bodies.

    • Understanding Hallucinations: Divine or Delusion?Hallucinations can be caused by various factors and are subjectively interpreted as divine or delusional experiences. Children and developing brains are particularly susceptible to long-term effects of certain medications.

      Our understanding of hallucinations and their connection to religion, dreams, and even the genesis of folklore and beliefs is complex and multifaceted. Hallucinations can be a result of various factors, including drugs, mental disorders, or even waking up in the middle of the night. Some people may interpret these experiences as divine or supernatural, while others may dismiss them as hallucinations. Children, too, can experience hallucinations, and the long-term effects of certain medications on their developing brains are still unknown. Oliver Sacks, an expert on the mind, emphasizes the importance of finding meaning and beliefs, which can shape our understanding of the world around us, even if they are not based on scientific evidence. Ultimately, the human brain and our experiences are complex phenomena that continue to intrigue and challenge us.

    • The belief in supernaturalism remains strong in American cultureScientific understanding can provide a sense of wonder and enlightenment, but it's important to respect diverse beliefs and keep religious and scientific perspectives separate.

      Despite the scientific advancements and the passing of time, the belief in supernaturalism remains strong in American culture, especially in the context of religion and cosmology. This is evident in the persistence of religious practices and the continued influence of religious beliefs, even among those who find fulfillment in the natural world. For some, like the speaker, a scientific understanding of the world can provide a sense of wonder and enlightenment that rivals or even replaces traditional religious beliefs. However, it's important to note that personal beliefs are a matter of individual choice, and it's crucial to keep religious and scientific perspectives separate in areas like education and politics to avoid causing harm. The speaker's personal experience of an "evolution and natural selection awakening" highlights the potential for scientific discovery to provide a profound sense of meaning and understanding, but it's essential to respect the diversity of beliefs and allow people to explore their own paths towards enlightenment.

    • The human need for understanding and explanationExploring the unknown through religion or science, driven by wonder and imagination, can lead to profound emotional responses and creativity. Embrace the mysteries of the universe as a source of beauty and inspiration.

      The human need for understanding and explanation, often manifested as a desire for comforting myths and figures, is a natural response to the complexities and uncertainties of the world. This need can lead us towards both religious and scientific paths, as we seek to make sense of the unknown. Oliver Sacks discussed the role of wonder and imagination in driving these explorations, whether through the lens of religion or science. He also highlighted the ability of art, even for those without religious beliefs, to evoke profound emotional responses and inspire creativity. Ultimately, Sacks saw the mysteries of the universe as a source of beauty and inspiration, and something to be embraced rather than feared.

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    23:34 - Causes of deficiency in neurotrophic factors - genetic and other

    26:40 - Drugs that stimulate production of BDNF - study of antidepressants
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    41:45 - Brain plasticity and depression
    43:50 - Other uses of antidepressants (e.g. stroke)
    45:38 - Common misconceptions about antidepressants

    48:30 - Take home messages


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