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    GUEST SERIES | Dr. Matt Walker: How to Structure Your Sleep, Use Naps & Time Caffeine

    enApril 17, 2024
    What is the difference between monophasic and polyphasic sleep?
    How does aging affect deep sleep quality?
    What are the benefits of napping for older adults?
    How does caffeine influence sleep patterns?
    What sleep habits can help maintain cognitive function?

    Podcast Summary

    • Exploring the Impact of Sleep Schedules on Health and PerformanceOptimizing sleep schedules, including monophasic vs polyphasic sleep, napping length and frequency, and body position, can significantly enhance mental health, physical health, and performance.

      That optimizing your sleep schedule, including considering monophasic versus polyphasic sleep, napping, and body position, can significantly impact your mental health, physical health, and performance. Monophasic sleep, which involves sleeping in one bout, is more common, while polyphasic sleep, which involves sleeping in multiple bouts, may offer benefits for some individuals. Napping length and frequency also depend on individual needs, and body position during sleep is crucial for restorative sleep. This episode, like the previous ones in the All About Sleep series, combines scientific insights with practical tools to help you improve your sleep. Additionally, the podcast is sponsored by BetterHelp, which offers online therapy, Element, an electrolyte drink, and Waking Up, a meditation app, all aimed at enhancing various aspects of your well-being.

    • Understanding Different Types of Sleep and Meditation PracticesMeditation practices like yoga nidra on Waking Up app can boost dopamine and enhance readiness. Three main types of sleep: monophasic, biphasic, and polyphasic. Infants are polyphasic sleepers, while adults typically have monophasic sleep patterns.

      There are various types of sleep and meditation practices that can benefit our mental and physical wellbeing in different ways. The Waking Up app offers a range of meditation practices, including yoga nidra, which can enhance dopamine levels in the brain and promote mental and physical readiness. Regarding sleep, there are three main types: monophasic (single phase), biphasic (two phases), and polyphasic (multiple phases). Infants are polyphasic sleepers due to their energy and feeding needs, as well as an underdeveloped circadian rhythm. As we age, our sleep patterns consolidate, with monophasic sleep becoming more common in adulthood. Understanding these sleep patterns can help us optimize our rest and improve overall health.

    • Sleep patterns and stages change significantly throughout human lifeFrom fetal REM sleep to monophasic adult sleep, sleep patterns and stages evolve, impacting our emotional, mental, and physical health

      Sleep patterns and stages change significantly throughout the human lifespan. Infants, for instance, sleep between 14 to 17 hours a day and spend almost 50% of their sleep in REM sleep. This contrasts greatly with adults, who typically sleep 7-9 hours a night and only spend about 20% of that time in REM sleep. Furthermore, the sleep of infants can't be fully defined by non-REM and REM stages as it's not yet fully formed. Moreover, the importance of sleep is evident across different species, from the four-hour sleep of elephants to the 17-18 hours of the little brown bat. Even birds, which sleep while perched, have adapted to their environment by having brief REM sleep periods and regaining muscle tone quickly. As children grow older, they transition to monophasic sleep, sleeping long bouts at night and being able to sustain wakefulness during the day. By the age of five or six, this monophasic pattern is locked in and continues throughout adulthood and into old age, with some caveats. So, in summary, sleep is a crucial aspect of human development, and its patterns and stages undergo significant changes throughout the lifespan. From the REM sleep-like state of a fetus to the monophasic sleep of an adult, sleep plays a vital role in our emotional, mental, and physical health.

    • REM sleep and brain development in infancyInfants have high volumes of REM sleep for brain development, while older children have more non-REM sleep, and humans may not be designed for monophasic sleep

      REM sleep plays a crucial role during infancy, particularly in the creation of synapses or neural connections in the brain. This high volume of REM sleep aids in the brain's development and growth. As infants grow older, the amount of REM sleep decreases, while non-REM sleep increases, with the ratio of non-REM to REM sleep stabilizing around a four to one ratio by the age of five or six. However, some evidence suggests that humans may not have been designed to sleep monophasically, as many ancient cultures practiced bi-phasic sleep, including napping in the afternoon and sleeping later into the night. These practices may align with our natural response to temperature changes, as temperature can be a strong predictor of wakefulness.

    • Understanding Variability in Perception of MidnightRecognizing chronotypes and their impact on our perception of midnight can help reduce vulnerability by accommodating individual needs and ensuring constant protection and care

      Our perception of time, specifically the concept of midnight, can vary greatly depending on individual chronotypes and lifestyle. Midnight may be the middle of the night for early risers like Jocko Willink, but for night owls, it might be just another hour before bedtime. Understanding this variability and reconciling it with societal demands can help reduce vulnerability as a collective by ensuring there are always people awake to protect and care for one another. This variability in sleep preferences, known as chronotypes, is a natural part of human biology, allowing for adaptability and survival in various light and dark conditions.

    • Genetics and environment shape our circadian rhythmsOur circadian rhythms are largely determined by genetics but can be influenced by external factors like light and caffeine. Different sleep patterns exist, such as biphasic, but understanding your rhythm can help improve overall health

      Our circadian rhythms, including our chronotype, are largely genetically determined but can be influenced by environmental factors. If both parents are extreme morning or evening types, it's likely that their child will also develop a similar rhythm. However, context and external factors can also cause shifts in our rhythms. For example, constant exposure to electric light at night or consuming too much caffeine can push someone towards a later chronotype. There are different types of sleep patterns, including monophasic (one long sleep period), biphasic (two sleep periods), and polyphasic (multiple sleep periods throughout the day). An example of biphasic sleep for adults is the "siesta" schedule, which includes a short nap during the day to match the natural dip in alertness. Another version of biphasic sleep, called "first sleep, second sleep," involves splitting your sleep into two phases across the night, with several hours of wakefulness in between. While this is an interesting concept, it's not biologically necessary for everyone. Overall, understanding our circadian rhythms and how they are influenced by genetics and the environment can help us make informed choices about our sleep habits and overall health.

    • Biphasic sleep pattern not definitively provenEvidence for biphasic sleep pattern is not conclusive, ability to fall asleep and lower core body temperature contributes to ease of sleeping horizontally, post-lunch dip can be improved with napping, but individual differences should be considered.

      The historical evidence of a biphasic sleep pattern, where people woke up in the middle of the night and then went back to sleep, is not definitive proof that this is how humans were naturally designed to sleep. While there are studies suggesting this pattern, the evidence is not conclusive due to the artificial nature of the studies, the small sample size, and the lack of a clear separation between sleep stages. Instead, it appears that our ability to fall asleep and maintain a lower core body temperature while lying down contributes to the ease of falling asleep in a horizontal position. Additionally, the post-lunch dip between 1 and 4 p.m. is a common experience for many people, and napping during this time can help improve alertness and productivity. However, the evidence for the benefits of napping is not definitive, and individual differences in sleep needs and preferences should be taken into account.

    • Naps improve cognitive and emotional functionNapping can enhance learning capacity by 20%, reset emotional compass, and boost attention, concentration, focus, energy, and decision-making

      Naps can significantly improve various aspects of cognitive and emotional function. A study showed that a 90-minute nap during the afternoon could enhance learning capacity by about 20%, while another study found that napping could reset the emotional compass by reducing fear response and increasing positive emotions. Sleep spindles during non-REM sleep are linked to learning benefits, while REM sleep is crucial for emotional recalibration. Additionally, naps can lead to improvements in attention, concentration, focus, energy, and decision-making. However, it's important to note that the benefits of napping depend on the situation and the quality of sleep obtained.

    • Optimal nap duration and benefitsNapping can release sleepiness and refresh you, but optimal duration depends on goals, with short naps promoting REM sleep and longer naps leading to grogginess. Keep naps under 90 minutes to avoid disrupting nighttime sleep.

      Napping can help release some of the built-up sleepiness, or adenosine, in your brain, making you feel more refreshed. However, for those struggling with insomnia, napping during the day may not be beneficial as it can decrease the amount of sleepiness built up for a good night's sleep. The optimal nap duration depends on what one is trying to optimize. REM sleep, which is beneficial for emotional processing and memory consolidation, can be achieved through short naps, while longer naps may lead to grogginess upon waking. To avoid disrupting nighttime sleep, it's essential to keep naps under 90 minutes and avoid napping too late in the day.

    • Power nap for 20 minutes for better alertness and focusA 20-minute power nap can enhance alertness, concentration, and motivation without causing grogginess or sleep inertia.

      A 20-minute power nap can significantly improve alertness, concentration, and motivation without causing the grogginess or sleep inertia associated with longer naps. This is because a 20-minute nap allows you to experience the benefits of healthy non-REM sleep without delving too deep into the cycle and encountering the negative effects of sleep inertia upon waking. However, longer naps can offer greater benefits if you're willing to endure the initial grogginess. The timing and duration of your nap are crucial factors to consider, with the best time being early afternoon and a duration of approximately 20 minutes.

    • The Power of a 20-Minute Nap for Cognitive Function and ProductivityA 20-minute nap can enhance cognitive function and productivity, but not everyone is a natural napper. Creating a quiet, dark environment can help, or try alternative practices like relaxation or deep rest.

      Napping, particularly a 20-minute nap between 3pm, can be beneficial for cognitive function and productivity. This is supported by research and personal experiences of high-performing individuals. However, it's important to note that not everyone is a natural napper, and forcing oneself to nap if it's not natural may not be effective or necessary. For those who want to try napping, creating a quiet and dark environment, similar to nighttime conditions, can increase the likelihood of falling asleep. It's also worth exploring alternative practices, such as progressive bodily relaxation or non-sleep deep rest, which can provide similar benefits to napping. Ultimately, the key is to find what works best for an individual's unique needs and preferences.

    • Creating an optimal nap environmentMasking noise and light, timing like post-lunch dip, and experiencing deep non-rem sleep can enhance nap productivity and energy.

      Creating an optimal environment for napping can increase the likelihood of a productive and restorative nap. This includes masking out noise and light, mimicking the post-lunch dip for timing, and potentially experiencing local deep non-rem slow-wave sleep. These liminal states, where the brain is still awake but experiencing local deep sleep, may be the key to the productivity and energy benefits of napping. NASA discovered this phenomenon in the 1980s and implemented a "NASA Nap" culture, which resulted in significant boosts in alertness, productivity, and task performance.

    • Exploring the benefits of power napping during long flightsPower napping early in long haul flights can help maintain alertness and improve overall performance, according to research.

      The optimal time for a power nap during long haul flights may not be at the end when one is struggling, but rather early on in the flight to sustain alertness throughout the journey. This counterintuitive finding came from research conducted by David Dinges and Mark Rosekind, who were looking for ways to mitigate risk during long haul flights, specifically during landing when the risk of catastrophic crashes is highest. They proposed the term "prophylactic napping," but faced resistance due to the stigma attached to the term. Instead, they settled on "power napping," a term that resonated with the mostly masculine pilot culture. The research has broader implications, suggesting that exploring biphasic sleep, or the practice of taking short naps in addition to regular sleep, could be beneficial for those who struggle with alertness during long hours or monotonous tasks. Non-traditional practices like yoga nidra, or non-sleep deep rest, can also offer similar benefits by promoting mental and physical restoration.

    • Timing of naps matters for sleep qualityMoving naps earlier in the day can improve sleep quality, while napping may not benefit individuals with insomnia

      The timing of naps can significantly impact the quality of your sleep later in the day. If you find yourself struggling to fall asleep or staying awake throughout the night after an afternoon nap, consider moving the nap earlier in the day. This could help you fall into a deeper sleep and reduce the likelihood of waking up in the middle of the night. However, if you have insomnia or other sleep disorders, it may be best to avoid napping altogether. The strongest evidence suggests that napping is not beneficial for individuals with insomnia. As always, it's important to experiment with different nap schedules and observe the effects on your sleep patterns.

    • The quality and quantity of deep sleep declines significantly as we age, affecting cognitive function and overall health.Deep sleep declines in older adults, leading to less efficient and effective brain function, and increasing the risk of negative health outcomes, including early mortality. Prioritize good sleep habits for optimal aging.

      As we age, the quality and quantity of our sleep declines significantly, with deep sleep being the most affected. This decline can begin in our mid-thirties and continues into old age. By the time we reach 65, we are down to just 5% of the deep sleep we had when we were young adults. This decline in deep sleep can lead to more fragmented and less efficient sleep, resulting in negative health outcomes, including a higher likelihood of early mortality. Napping in older adults may not be the root cause of these issues, but rather a symptom of poor nighttime sleep. The brain's development during adolescence involves a process called synaptic pruning, where the brain fine-tunes itself by removing unused synapses and redistributing resources to more active areas. However, as we age, the brain's ability to produce deep sleep declines, leading to a less efficient and less effective brain. Therefore, prioritizing good sleep habits, including maintaining a consistent sleep schedule, creating a sleep-conducive environment, and addressing any underlying sleep disorders, is crucial for maintaining cognitive function and overall health as we age.

    • Sleep quality matters for older adults' health and mortalityImprove sleep quality at night instead of eliminating daytime naps or excessive caffeine intake for older adults' health concerns

      The quality of sleep older adults get at night is crucial for their health and mortality. Daytime napping is not the root cause of health issues, but rather a symptom of poor sleep quality at night. Caffeine, on the other hand, works as an adenosine antagonist, blocking the adenosine receptors in the brain and preventing the feeling of sleepiness. The Napa Chino or caffeine nap can be beneficial due to the timing of caffeine intake, which takes effect around 12-17 minutes after consumption. However, over-reliance on caffeine can lead to a caffeine crash, requiring even more caffeine to recover. Ultimately, it's essential to focus on improving sleep quality at night rather than eliminating daytime napping or excessive caffeine intake as solutions for older adults' health concerns.

    • Temperature change and caffeine work together for alertnessDrinking a warm beverage and taking a caffeine nap can improve alertness, with temperature change providing an initial boost and caffeine providing additional energy later on.

      The initial feeling of improvement after consuming a warm beverage like coffee or tea, especially in the morning, is primarily due to the temperature rise rather than the caffeine content. This temperature change can help improve alertness and prepare the body for the day, while the caffeine provides an additional energy boost later on. Additionally, it was suggested that taking a nap after consuming a small amount of caffeine just before falling asleep could result in a "caffeine nap," allowing for the benefits of a nap without the grogginess of sleep inertia. Other methods, such as exercise or cold showers, can also help clear adenosine from the body and improve alertness.

    • The role of sleep in removing adenosineSleep helps clear adenosine, a substance causing fatigue. Deep sleep, anesthesia, or deep rest can mimic this effect. Delaying caffeine after waking could enhance sleep quality and reduce afternoon drowsiness.

      Sleep plays a crucial role in removing adenosine, a substance that builds up during wakefulness and makes us feel tired. The less metabolically active our brain is during deep sleep, the more effectively the natural mechanisms can clear adenosine. Therefore, anything that mimics a less metabolically active brain, such as anesthesia or deep rest, could potentially provide similar adenosine-reducing benefits. Additionally, the period immediately after waking may offer an opportunity to further reduce adenosine levels by delaying caffeine intake, which could lead to better sleep at night and fewer afternoon crashes. However, it's important to note that this is not a requirement for everyone, and individual needs may vary.

    • Timing of caffeine consumption impacts sleep-promoting chemicalConsidering the timing of caffeine intake may help assess sleep quality and improve energy levels and cognitive performance throughout the day

      The timing of caffeine consumption in relation to waking up can significantly impact how effectively adenosine, a sleep-promoting chemical, is cleared from the body. When we consume caffeine immediately after waking up, we may be preventing the clearance of adenosine, leading to a buildup and potential need for more caffeine later in the day. This can create a vicious cycle. Furthermore, delaying caffeine consumption may give us a better opportunity to assess the quality of our sleep and feel more rested and refreshed during the first few hours of the day. This doesn't mean everyone needs to change their habits, but it's worth considering as an experiment. By delaying caffeine, we may be able to better understand our sleep patterns and potentially improve our overall energy levels and cognitive performance throughout the day.

    • Caffeine's Impact on Sleep: Balancing Benefits and DrawbacksUnderstanding genetic variations and appropriate caffeine dosage and timing can help mitigate negative sleep effects, while excessive caffeine can lead to compromised deep sleep and potential reliance on alcohol as a sedative.

      While caffeine can negatively impact sleep, the benefits of consuming coffee, particularly its antioxidant content, outweigh the drawbacks for many people. However, the timing and dosage of caffeine intake are crucial factors to consider. Some individuals may be more sensitive to caffeine than others, and understanding genetic variations can help determine appropriate cessation hours before bedtime. Additionally, excessive caffeine consumption can lead to compromised deep sleep, which may not be noticeable but can result in reduced feelings of restoration and increased reliance on caffeine throughout the day. Furthermore, the use of caffeine during the day can lead some individuals to turn to alcohol as a nighttime sedative, creating a cycle of "uppers" and "downers." Overall, the health benefits of coffee, including its antioxidant content, make it a favorable choice for many people when consumed in moderation and at appropriate times.

    • Exploring the benefits of napping and caffeineOptimizing napping techniques and caffeine intake can lead to better sleep-wake cycles and overall alertness. Cold hand and face washing, and bright light exposure during naps showed the most significant improvements.

      Napping and caffeine consumption can enhance alertness and cognitive performance, but it's important to find the right dosage and timing for both. A study from a Japanese sleep research group explored different nap variations, including a caffeine nap, cold hand and face washing, and bright light exposure. The results showed that each method added benefits to the basic nap, with cold hand and face washing and bright light exposure showing the most significant improvements. These findings suggest that optimizing napping techniques and caffeine intake can lead to better sleep-wake cycles and overall alertness.

    • Enhancing wakefulness through a 'nap plus plus' routineCombine caffeine, cold water, and bright light for an optimized wakeful state. This involves having an espresso shot before bed, taking a short nap, and waking up to cold water and bright light exposure.

      Optimizing wakefulness goes beyond just napping. By combining elements such as caffeine, cold water, and bright light, one can create a "nap plus plus" routine for an enhanced wakeful state. This involves having an espresso shot before going to bed, setting an alarm for a short nap, waking up to cold water and bright light exposure. This protocol leverages the interaction of circadian rhythm, adenosine clearance, temperature modulation. The same principles can be applied after waking up in the morning. Additionally, while the discussion touched upon polyphasic sleep, an alternative approach is to focus on the morning routine, incorporating cold water and warm water for thermoregulation. Overall, these simple yet effective practices can significantly impact wakefulness and productivity.

    • Polyphasic Sleep: Myth or Reality?Study found no benefits, only poor sleep quality and potential risks with polyphasic sleep schedules

      The practice of polyphasic sleep, which involves splitting up your sleep into multiple short periods throughout the day instead of the traditional eight hours at night, has been proposed for improved mood, cognition, productivity, and health. However, a study conducted by scientists at Harvard found no supportive evidence for these claims and instead discovered that the quality of sleep on these schedules is poor, leading to decreased total sleep amount, impaired cognitive function, and mood disturbances. Additionally, there is a risk of increased road traffic accidents due to sleep deprivation. It's important to note that everyone's needs and circumstances are unique, and ultimately, the decision to pursue polyphasic sleep is a personal one. But the evidence suggests that it may not be the best choice for optimal health and well-being.

    • Sleep Deprivation and Car Accident RiskLess than six hours of sleep increases crash probability by 30%, five hours doubles-triples, and four hours nearly ten times

      The amount of sleep you get has a significant impact on your risk of getting into a car accident. A study showed that getting less than six hours of sleep a night increases the probability of a crash by 30%. The AAA reported that the risk increases to two to three times with five hours of sleep and nearly ten times with four hours of sleep. This means that the risk of a car accident isn't a linear increase with the amount of sleep, but rather an exponential one. Therefore, when making a decision about which taxi to take, for example, you would likely choose the one with a lower risk of an accident. This is a reminder to prioritize getting enough sleep to ensure safety and well-being. Sleep is a crucial topic with far-reaching implications for our health and daily life, and understanding the different phases, such as monophasic, biphasic, and polyphasic sleep, as well as the effects of naps, caffeine, and developmental shifts, can help us make informed decisions about our sleep habits.

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    In this episode, my guest is Dr. Teo Soleymani, M.D., a double-board-certified dermatologist and specialist in skin cancer and reconstructive surgery. We discuss science and clinically supported protocols to improve skin health and give your skin a more youthful appearance and structure, reducing premature aging and skin cancer risk. We discuss the impact of sun exposure on skin appearance and aging and the surprising relationship between sun exposure and skin cancer. We explain how mineral-based (inorganic) sunscreens differ from chemical (organic) sunscreens, whether sunscreen can minimize premature skin aging, reduce cancer risk, and if there are any health risks associated with sunscreen use. We discuss skincare routines to significantly improve skin appearance and how to select skincare products. We discuss how caffeine, nicotine, alcohol, and stress impact the skin and describe how nutrition and anti-inflammatory diets can improve skin health. We also discuss the causes and treatments for common skin conditions, including dandruff, acne, rosacea, eczema, psoriasis, and vitiligo. Our conversation also covers topics such as the use of retinoids, laser treatments, red-light phototherapy, supplements, and how to best monitor for skin cancer. This episode provides numerous actionable protocols, most of which are zero-to-low cost, for improving skin health and appearance, reducing cancer risk, and treating skin problems. Access the full show notes for this episode at hubermanlab.com. Pre-order Andrew's new book, Protocols, at protocolsbook.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman ROKA: https://roka.com/huberman Joovv: https://joovv.com/huberman Helix Sleep: https://helixsleep.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Dr. Teo Soleymani 00:01:35 Sponsors: ROKA, Joovv & Helix Sleep 00:05:45 Skin Turnover; Skin Appearance & Stress  00:13:35 Caffeine, Vasoconstriction & Skin Redness 00:16:31 Nicotine, Vaping & Skin Appearance 00:18:37 Alcohol, Skin Health 00:24:33 Hydration, Fluid Intake & Genetics 00:26:19 Tool: Selecting a Moisturizer 00:29:28 Sponsor: AG1 00:30:40 Puffiness Under Eyes & Cause 00:32:14 Tool: Skin Cleansing; Frequency, Showers 00:41:57 Dry & Flaky Scalp, Dandruff 00:46:09 Cost & Skincare Products 00:50:20 Tool: Sun Exposure & Skin Health, Mood 00:56:24 Sponsor: LMNT 00:57:35 Sunscreens vs. Sunblocks; Mineral-Based (Inorganic) vs. Chemical (Organic) Sunscreen 01:02:45 Physical Barriers, Sunscreens, Oral Supplements & Skin Cancer 01:07:27 Skin Cancer, Genetics; Sunscreen, Premature Aging 01:12:11 Premature Aging & Skincare 00:15:56 Choose Mineral or Chemical Sunscreen? 01:20:24 Polypodium Supplement, Sun Exposure, Skin Redness 01:26:02 Tool: Selecting Mineral-Based Sunscreens 01:28:30 Chemical Sunscreens & Blood-Brain Barrier 01:30:13 Nutrition, Gut Microbiome & Skin Health 01:34:28 Tool: Nutrition for Skin Health, Protein, Anti-Inflammatory; Collagen; Omega-3 01:42:58 Retinoids vs. Retinol, Skin Appearance 01:49:45 Laser Resurfacing; Exfoliation, Microdermabrasion 01:56:52 Red Light Therapy & Phototherapy, Face Masks, Light Panels 02:04:10 Psoriasis, Phototherapy 02:10:03 Vitiligo, Immune System & Skin Cancer Risk 02:15:41 Acne, High Glycemic Index Foods, Dairy 02:19:38 Rosacea, Types & Treatments 02:23:00 Eczema, Immune System 02:25:37 Popping Pimples & Acne Scars; Corticosteroids 02:30:15 Tattoos; Tool: Monitoring for Skin Cancer, Moles, Annual Exams 02:36:28 HPV, Cancer & Warts; Vaccine & Cancer Risk 02:43:31 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures
    Huberman Lab
    enAugust 19, 2024

    Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

    Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries
    I'm honored to share Episode 10, the final episode of Season 1 of Perform with Dr. Andy Galpin. Dr. Andy Galpin is a tenured full professor at California State University, Fullerton, where he co-directs the Center for Sport Performance and leads the Biochemistry and Molecular Exercise Physiology Laboratory. Andy is both a friend and a colleague, and I'm delighted to have assisted in the creation of this podcast. I'm certain you'll both enjoy and learn from it. Season 1 featured 10 episodes, where Dr. Galpin covered everything from building strength, the importance of strength for long-term health, the science of breathing, the benefits of sleep extension, genetic testing for personalized training, and nutrition for injury recovery. While we have Episode 10 of Perform with Dr. Andy Galpin here, please be sure to follow Perform with Dr. Andy Galpin on your preferred platform to listen to all the episodes from Season 1 and to get notified when Season 2 is released. Show notes for this episode can be found at performpodcast.com. Timestamps 00:00:00 Introduction from Dr. Andrew Huberman 00:01:08 Brain Health & Injury   00:05:06 Sponsors: LMNT & Continuum   00:08:16 Nutrition & Supplements for Brain Injury   00:12:44 Brain Injury Categories, Traumatic Brain Injury (TBI), Concussion   00:17:09 Brain Injury Pathophysiology   00:22:16 Burst Capillaries, Initial TBI Response   00:30:03 Delayed TBI Response, Neuroinflammation   00:34:19 Sponsors: Momentous & Maui Nui   00:36:52 Creatine Monohydrate; Second Impact Syndrome   00:41:52 Strength of Evidence Scale, Creatine   00:47:15 Creatine Doses, Frequency, Adverse Issues; Food Sources   00:53:22 Sponsors: AG1 & David Protein   00:56:05 Fish Oil, DHA, EPA   01:00:38 EPA & DHA Dosage, Timing, Adverse Issues; Food Sources; Omega-3 Index   01:04:46 Vitamin B2 (Riboflavin), Vitamin B   01:08:57 Riboflavin Dosages, Timing; Food Sources   01:11:25 Choline   01:18:37 Choline Supplements & Food Sources, Alpha GPC, Dosage   01:21:30 Branched-Chain Amino Acids (BCAAs), Sleep   01:25:04 BCAAs Dosage, Whole Food Sources   01:28:02 Magnesium   01:31:20 Magnesium Dosage, Timing, Supplements, Adverse Issue; Food Sources   01:33:09 Blueberry Anthocyanins   01:35:28 Anthocyanins Dosage; Food Sources   01:37:17 Caffeine & Brain Injury Recovery   01:38:50 Perform Episodes, Perform Newsletter, Acknowledgements   01:41:19 Zero-Cost Support, YouTube, Spotify & Apple Subscribe & Reviews, Sponsors, YouTube Feedback, Social Media   01:42:56 Conclusion by Andrew Huberman   Disclaimer
    Huberman Lab
    enAugust 14, 2024

    Dr. Layne Norton: Tools for Nutrition & Fitness

    Dr. Layne Norton: Tools for Nutrition & Fitness
    In this episode, my guest is Dr. Layne Norton, Ph.D., one of the world’s top experts in nutrition and training for physical fitness. We discuss how to evaluate scientific evidence and the validity of different practices aimed at achieving fat loss, muscle strength and hypertrophy, microbiome health, vitality, and longevity. We explore many hotly debated topics, including fasting, seed oils, saturated fats, sugar, red meat, artificial/low-calorie sweeteners, and GLP-1 agonists (e.g., Ozempic). Additionally, we delve into the timing of protein and carbohydrate intake relative to fasting and exercise, fat loss and sleep, and the benefits of dietary protein and fiber on overall health. We also discuss how to accelerate hypertrophy and fat loss, improve strength, whether we need to train to “failure,” how to enhance exercise recovery, and how to manage pain. We cover training before versus after age 50, whether metabolism changes with age, and the connection between muscle health and longevity. We also address why certain behaviors and supplements might work for some people but not others. Listeners to this episode will benefit greatly from Layne’s science-based expertise on a wide range of topics, including health, nutrition, and fitness. Access the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Mateina: https://drinkmateina.com/huberman Eight Sleep: https://www.eightsleep.com/huberman Maui Nui: https://mauinuivenison.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Dr. Layne Norton 00:01:49 Sponsors: Mateina, Eight Sleep, Maui Nui 00:06:39 Science-Based Evidence, Mechanism vs. Outcome 00:14:31 Meta-analysis, Methods, Evidence Quality 00:22:45 Evidence Hierarchy, Randomized Controlled Trials, Cohort Data 00:33:53 Sponsor: AG1 00:35:05 “Don’t Turn Your Brain Off”; Protein Synthesis 00:42:01 Protein Synthesis, Refractory Response; Resistance Training   00:46:05 Protein Intake, Intermittent Fasting & Training 00:54:52 Tool: Total Protein Intake, Distribution & Protein Synthesis 01:00:25 Muscle Quality, Protein Remodeling, Muscle Growth 01:05:34 Sponsor: LMNT 01:06:46 Early vs. Late Time-Restricted Eating; Fasting Blood Glucose & HbA1c 01:10:30 Carbohydrate Timing, Individual Response, Placebo; Tool: Tracking Diet 01:19:50 “The Norton Method”; Tool: Consistency 01:25:16 Resistance & Cardiovascular Training; Competition; Immune System & Rest 01:33:50 Mind & Body Effects, Stress; Belief Effects 01:41:30 Training to Failure, Reps in Reserve, Hypertrophy & Strength Training 01:50:24 Fatigue & Training to Failure, Speed, Strength Training 01:59:06 Tool: Training After 50, Consistency 02:09:12 Fat Cells, Diabetes, Exercise 02:16:50 Metabolism & Age-Related Changes?, Appetite 02:23:17 Ozempic, Mounjaro, GLP-1 Agonists, Lean Mass, “Food Noise” 02:33:42 GLP-1 Agonists, Judgement & Obesity 02:40:19 Sugar, Excess Calories, Body Weight 02:49:16 Satiety, Sugar & Calorie Budget 02:54:56 Tool: Individualization, Context & Diet Psychology 02:57:22 Seed Oils, Butter, Olive Oil 03:06:56 Red Meat, Carcinogenic?; Simple Diet; Fiber Benefits 03:13:43 Saturated Fat, Cholesterol; Seed Oils 03:18:41 Artificial & Low-Calorie Sweeteners, Insulin, Appetite 03:29:06 Artificial & Low-Calorie Sweeteners, Gut Microbiome; Cancer 03:37:58 Tools: Training Recovery, Glycogen Replenishment; Stress & Activity 03:45:56 Collagen Supplementation, Skin & Nails, Whey Protein 03:57:00 Evidence-Based Approach 04:01:41 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures
    Huberman Lab
    enAugust 12, 2024

    Dr. Martha Beck: Access Your Best Self With Mind-Body Practices, Belief Testing & Imagination

    Dr. Martha Beck: Access Your Best Self With Mind-Body Practices, Belief Testing & Imagination
    In this episode, my guest is Dr. Martha Beck, Ph.D., a Harvard-trained sociologist, bestselling author, and one of the world’s foremost experts on personal exploration and development.  Dr. Beck shares specific frameworks and practices to tap into your unique and deepest desires, core truths, and best life direction—all elements that comprise your authentic self. She also explains how to align your work and relationships of all kinds with your true self and how to embrace the discomfort and process of leaving unhealthy relationships. We discuss how to deal with negative thoughts and emotions, grapple with societal norms, and improve body awareness to gauge your inner truth. We also discuss codependency and self-abandonment - and how to exit and recover from these experiences.  By the end of the episode, you will have learned numerous practical tools to access your best self and live a richly fulfilling life.  Access the full show notes for this episode at hubermanlab.com. Dr. Beck's Wayfinder Life Coach Training: https://marthabeck.com/life-coach-training Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Helix Sleep: https://helixsleep.com/huberman LMNT: https://drinklmnt.com/huberman Waking Up: https://wakingup.com/huberman Timestamps 00:00:00 Dr. Martha Beck 00:01:34 Sponsors: BetterHelp, Helix Sleep & LMNT 00:05:34 Tool: Perfect Day Exercise 00:15:31 “Clear Eyed”, Male vs. Female 00:23:31 Family & Work; Directed Attention & Miracles 00:30:21 Sponsor: AG1 00:32:10 Unease, Restlessness & Guilt; Life Worth, Fear 00:37:22 Accessing the Subconscious; Compassionate Witness Self 00:46:16 Finding Self, Suffering, Anxiety; Tool: “KIST”, Self-Parenting 00:54:01 Self, Radiance, Death; Awakening 00:59:14 Suffering & Compassionate Attention 01:02:10 Challenging Internal Thoughts, Understanding Truth, Body & Mind; 01:08:44 Sponsor: Waking Up 01:10:20 Western Society & Pressure 01:18:30 Tool: Sensing Truth in Body; Meditation, “Stopping the World” 01:25:02 Energy, Magnetoreception, Pet’s Death 01:33:49 Lying to Ourselves, Addiction 01:38:18 Tool: “Integrity Cleanse”, Lies; The Light 01:47:32 Relationship with Loss; Love, Self-Abandonment & Codependency 01:55:10 Romantic Relationships; Jobs & Family 02:02:06 Hurting Others, Relationship Imbalance 02:06:55 Tool: True Empathy 02:11:26 “Happiness is an Inside Job”, Codependency 02:18:58 Live Your Joy, Western Society 02:24:41 Relationships, Love & Integrity, “Feeling Good By Looking Weird” 02:30:42 “I Like It!”, Punk Rock Music, Love 02:34:24 Honesty & Essential Self; Helping People & Healers 02:42:12 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures
    Huberman Lab
    enAugust 05, 2024

    AMA #18: Cold Therapy Advice, Skin Health Tips, Motivation, Learning Strategies & More

    AMA #18: Cold Therapy Advice, Skin Health Tips, Motivation, Learning Strategies & More
    Welcome to a special edition of the 18th Ask Me Anything (AMA) episode, part of Huberman Lab Premium. This episode is a recording of the live stream AMA, exclusive to our Premium members. We've decided to make the full-length version available to everyone, including non-members of Huberman Lab Premium. Huberman Lab Premium was launched for two main reasons. First, it was launched in order to raise support for the main Huberman Lab podcast — which will continue to come out every Monday at zero-cost. Second, it was launched as a means to raise funds for important scientific research. A significant portion of proceeds from the Huberman Lab Premium subscription will fund human research (not animal models) selected by Dr. Huberman, with a dollar-for-dollar match from the Tiny Foundation and other donors. If you're not yet a member but enjoyed this full-length livestream AMA, we invite you to join Huberman Lab Premium. By subscribing, you'll gain access to exclusive benefits including our regular monthly full-length AMA episodes, AMA transcripts, podcast episode transcripts, early access to live events and more. Additionally, a significant portion of your membership proceeds contributes to advancing human scientific research. You can learn more about the research we were able to support in our Annual Letter 2023. If you're a Huberman Lab Premium member, you can access the transcript for this AMA episode here. Timestamps 00:00 Introduction & Announcements 00:15 Supporting Mental & Physical Health Research 01:56 Exciting New Research Initiatives 03:39 Skin Health & Appearance 14:46 Cold Therapy Benefits & Guidelines 21:18 Self-Motivation Strategies 27:05 Understanding REM Sleep 28:45 Morning Routine: Exercise & Cold Exposure 29:17 The Importance of REM Sleep 29:49 Non-Sleep Deep Rest (NSDR) Protocols 31:27 REM Sleep Rebound & Compensation 32:55 Impactful School Strategies for Learning 34:19 Meditation & Micro Gaps in Learning 39:13 Physical Activity & Learning 41:01 Exploring Shilajit & Testosterone 47:51 Writing Process & Overcoming Obstacles 51:32 Addiction & Recovery Resources 53:47 Closing Remarks & Gratitude Disclaimer & Disclosures
    Huberman Lab
    enAugust 02, 2024

    Dr. Peter Attia: Supplements for Longevity & Their Efficacy

    Dr. Peter Attia: Supplements for Longevity & Their Efficacy
    In this episode, my guest is Dr. Peter Attia, M.D., a Stanford and Johns Hopkins School of Medicine-trained physician expert in improving human healthspan and lifespan. Dr. Attia is also the host of The Drive podcast and author of the best-selling book Outlive.  We discuss the NAD pathway in human cells and its possible links to aging and health. We evaluate how supplementation can augment molecules in the NAD pathway; we compare NAD, NMN, and NR, different routes of administration, their safety, and bioavailability. Then, we discuss the broader research and clinical literature on longevity to decide if supplementation with NAD, NR, NMN, rapamycin, or resveratrol can indeed extend lifespan.  Finally, we each describe our supplement regimens and compare the role of supplementation to behaviors such as sleep, nutrition, and exercise for longevity. We also discuss whether tests of biological age are true indicators of aging and whether normal radiation levels increase cancer risk.  Listeners of this episode will learn if supplements purported to improve lifespan show any efficacy and the behaviors and other factors that can prevent disease and extend lifespan. Access the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman Levels: https://levels.link/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps 00:00:00 Dr. Peter Attia, NAD Pathway 00:02:31 Sponsors: LMNT, Levels & Eight Sleep 00:06:38 Categories of Longevity Approaches 00:17:22 Peter’s Supplements; Rapamycin & Research Data 00:25:01 NAD Pathway: Energy & DNA Repair; Knock-Out & Knock-In, Klotho 00:30:35 Sponsor: AG1 00:32:25 Yeast, Sirtuins, Caloric Restriction & Lifespan 00:38:56 Sirtuins, Transgenic Mice, Gender & Lifespan 00:43:42 DNA Repair, Sirtuins, Cancer; Resveratrol 00:53:31 Perform with Dr. Andy Galpin Podcast 00:54:18 NAD & NADH, Reactive Oxygen Species (ROS), Mitochondrial Health 01:02:17 NAD vs NR vs NMN Supplementation; IV & Oral Routes 01:11:33 NR vs. NMN, Doses, Side Effects; Interventions Testing Program 01:17:43 Fatty Liver Disease & NR; NMN & Glucose; Clinical Significance 01:25:17 Safety & FDA, NMN & NR Supplementation; Skin Cancer Benefits 01:30:38 Longevity, NR & NMN Supplementation, Inflammation 01:41:00 Rapamycin & Immune Function 01:44:37 Biological Aging Tests, Chronologic & Biologic Age; Vigor  01:55:24 Radiation & Cancer Risk 01:58:12 Tool: Self-Care in 50s-70s & Aging; Energy Decline 02:07:12 Tool: Exercise Timing & Energy Levels 02:11:22 Peter’s Supplements 02:18:46 Andrew’s Supplements 02:24:34 Tool: Supplement Use vs. Critical Behaviors; Titanic Analogy  02:26:52 NAD Pathway Supplementation for Longevity? 02:28:52 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter Disclaimer
    Huberman Lab
    enJuly 29, 2024

    Dr. Stacy Sims: Female-Specific Exercise & Nutrition for Health, Performance & Longevity

    Dr. Stacy Sims: Female-Specific Exercise & Nutrition for Health, Performance & Longevity
    In this episode, my guest is Dr. Stacy Sims, Ph.D., an exercise physiologist, nutrition scientist, and expert in female-specific nutrition and training for health, performance, and longevity. We discuss which exercise and nutrition protocols are ideal for women based on their age and particular goals. We discuss whether women should train fasted, when and what to eat pre- and post-training, and how the menstrual cycle impacts training and nutrition needs. We also explain how to use a combination of resistance, high-intensity, and sprint interval training to effectively improve body composition, hormones, and cardiometabolic health, offset cognitive decline, and promote longevity.  We also discuss supplements and caffeine, the unique sleep needs of women based on age, whether women should use deliberate cold exposure, and how saunas can improve symptoms of hot flashes and benefit athletic performance. Dr. Sims challenges common misconceptions about women’s health and fitness and explains why certain types of cardio, caloric restriction, and low-protein diets can be harmful to women’s metabolic health. Listeners will learn a wealth of actionable information on how to improve their training and nutrition to enhance their health and how to age with greater ability, mobility, and vitality. Access the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Maui Nui Venison: https://mauinuivenison.com/huberman  Eight Sleep: https://eightsleep.com/huberman   Waking Up: https://wakingup.com/huberman  Timestamps 00:00:00 Dr. Stacy Sims 00:02:24 Sponsors: Maui Nui, Eight Sleep & Waking Up 00:07:03 Intermittent Fasting, Exercise & Women 00:12:50 Cortisol & Circadian Rhythm, Caffeine & Training 00:17:25 Reps in Reserve, Rate of Perceived Exertion (RPE); Age & Women 00:21:06 Pre-Training Meal & Brain, Kisspeptin 00:26:45 Post-Training Meal & Recovery Window 00:29:59 Sponsor: AG1 00:31:48 Hormones, Calories & Women 00:34:24 Women, Strength Improvements & Resistance Training 00:39:10 Tool: Women & Training Goals by Age Range 00:44:16 Women, Perimenopause, Training & Longevity 00:47:14 Women & Training for Longevity, Cardio, Zone 2 00:51:42 Tools: How to Start Resistance Training, Machines; Polarized Training 00:58:23 Perform with Dr. Andy Galpin Podcast 00:59:10 Menstrual Cycle & Training, Tool: Tracking & Individual Variability 01:04:31 Tool: 10-Minute Rule; High-Intensity Training & Menstrual Cycle 01:08:36 “Train Hard & Eat Well”; Appetite, Nutrition & Menstrual Cycle 01:12:22 Oral Contraception, Hormones, Athletic Performance; IUD 01:20:57 Evaluating Menstrual Blood, PCOS; Hormones & Female Athletes 01:26:31 Iron, Fatigue; Blood Testing & Menstrual Cycle 01:29:33 Caffeine & Perimenopause; Nicotine, Schisandra 01:34:24 Deliberate Cold Exposure & Women, Endometriosis; Tool: Sauna & Hot Flashes 01:42:19 Tools: “Sims’ Protocol”: Post-Training Sauna & Performance; “Track Stack” 01:49:37 Women, Hormones & Sleep, Perimenopause & Sleep Hygiene 01:52:54 Supplements: Creatine, Water Weight, Hair Loss; Vitamin D3 01:57:21 Protein Powder; Adaptogens & Timing 02:00:11 Pregnancy & Training; Cold & Hot Exposure 02:06:19 Tool: Women in 50s & Older, Training & Nutrition for Longevity 02:09:38 Tool: Women in 20s-40s & Training, Lactate 02:12:18 Tool: What is High-Intensity Training?, Cardiovascular Sets & Recovery 02:17:22 Training for Longevity, Cellular & Metabolic Changes 02:19:30 Nutrition, 80/20 Rule 02:23:30 Listening to Self 02:26:00 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter  Disclaimer & Disclosures
    Huberman Lab
    enJuly 22, 2024

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    Dad to Dad 147 Azim Khamisa - Lost His Son To Gun Violence & Through TKF.org Has Reached Millions About Forgiveness & Teaching Non-Violence

    Dad to Dad 147 Azim Khamisa - Lost His Son To Gun Violence & Through TKF.org Has Reached Millions About Forgiveness & Teaching Non-Violence
    Our guest on this Special Fathers Network Dad to Dad Podcast is Azim Khamisa. Azim was born in Kenya and is a successful international businessman. In 1995, Azim’s world was turned upside down when his 20-year-old son Tariq was murdered by a 14-year-old gang member. Azim now dedicates his life on the concept of forgiveness and helping others to avoid similar violent tragedies. In fact, Azim has befriended his son’s killer and his grandfather. It’s an incredible story about a truly special man and it’s all on this Special Fathers Network Dad to Dad podcast.

    CBS video: http://www.youtube.com/watch?v=mBDeFi-04VM

    NBC video: http://www.youtube.com/watch?v=tKJSOHigxhI

    Tariq Khamisa Foundation website: https://www.tkf.org

    TKF Program Video: https://www.youtube.com/watch?v=GaT90zQz8RM
    Azim's website: https://www.azimkhamisa.com

    Email: azim@azimkhamisa.com

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    About the Special Fathers Network -
    SFN is a dad to dad mentoring program for fathers raising children with special needs. Many of the 400+ SFN Mentor Fathers, who all are raising kids with special needs, have said: "I wish there was something like this when we first received our child's diagnosis. I felt so isolated. There was no one within my family, at work, at church or within my friend group who understood or could relate to what I was going through."

    SFN Mentor Fathers share their experiences with younger dads closer to the beginning of their journey raising a child with the same or similar special needs. The SFN Mentor Fathers do NOT offer legal advice or medical advice, that is what lawyers and doctors do. They simply share their experiences and how they have made the most of a challenging situation.

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