Immune 61: Training immune cells with Julia Bohannon and Musa Mhlanga

Immune reviews research showing that the migration of neutrophils between endothelial cells activates bactericidal function via mechanosensing.

Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer, and Brianne Barker

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Links for this episode

• MicrobeTV Discord Server
• Trans endothelial migration activates neutrophil killing (Immunity)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Juliet Morrison joins Immune to discuss her career and the research of her laboratory showing that pleural macrophages translocate to the lung during infection to promote improved influenza outcomes.

Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer, and Brianne Barker

Guest: Juliet Morrison

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Download Immune 76 (48 MB .mp3, 67 min)
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Links for this episode

• MicrobeTV Discord Server
• Publishing is broken (Solving for Science)
• Pleural macrophages move to the lung during influenza (PNAS)
• Time stamps by Jolene. Thanks!

Music by Steve Neal
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Ang Cui joins Immune to discuss her career and her work on establishing the Immune Dictionary, a compendium of single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines (>1,400 cytokine-cell type combinations) in mouse lymph nodes in vivo.

Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

Guest: Ang Cui

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Become a patron of Immune!

Links for this episode

• MicrobeTV Discord Server
• Publishing is broken (Solving for Science)
• Immune Dictionary (Nature)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Carla Nowosad joins Immune to discuss her career and her work on germinal centers, the structure in secondary lymphoid tissues where B cells proliferate, differentiate, and diversify their immunoglobulin genes by somatic hypermutation.

Hosts: Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Carla R. Nowosad

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Links for this episode

• MicrobeTV Discord Server
• B cells and the intestinal microbiome (Sem Immunol)
• B cell selection in gut germinal centres (Nature)
• B cell antigen internalization (Methods Mol Biol)
• Immune synapse architecture (Nat Immunol)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Immune reveals the total mass (1.2kg), number (1.8 trillion), and distribution of immune cells in the human body, with macrophages contributing nearly 50% of the total cellular mass.

Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Become a patron of Immune!

Links for this episode

• MicrobeTV Discord Server
• Immune cells in the human body (PNAS)
• Letters read on Immune 73
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

From Cornell University in Ithaca New York, Vincent and Cindy meet with Ellen Rothenberg to review her career in science, starting with work on retroviruses to unraveling transcriptional networks underlying T-cell development and signaling.

Hosts: Vincent Racaniello and Cynthia Leifer

Guest: Ellen Rothenberg

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Download Immune 72 (53 MB .mp3, 73 min)
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Links for this episode

• MicrobeTV Discord Server
• Synthesis of infectious DNA of murine leukaemia virus (Nature)
• Runx factors launch T cell and innate lymphoid programs (Nat Immunol)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Immune explains how, in a mouse model of roundworm infection with Nippostrongylus brasiliensis, exposure to lung-migrating helminths protects mice against SARS-CoV-2 infection.

Hosts: Cynthia Leifer, Stephanie Langel, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
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Links for this episode

• MicrobeTV Discord Server
• Helminth protects against murine SARS-CoV-2 infection (Sci Immunol)
• Pandemic spared Africa (ScienceInsider)
• Letters read on Immune 71
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Immune explains how mast cells, IgE antibody, and the brain collaborate to promote avoidance of certain foods to evade allergic responses.

Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
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Links for this episode

• MicrobeTV Discord Server
• Mast cells and immune avoidance behavior (Nature)
• Immune sensing of food allergens promotes avoidance (Nature)
• Immunology that underlies picky eating (Nature)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Kevin joins Immune to discuss his work showing that antibodies against endogenous retroviruses promote immunotherapy of lung cancer.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guest: Kevin Ng

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Become a patron of Immune!

Links for this episode

• MicrobeTV Discord Server
• Antibodies against ERVs and lung cancer (Nature)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Immune discusses immunological imprinting, also called original antigenic sin, in the context of infection with SARS-CoV-2 and influenza virus.

Hosts: Vincent Racaniello, Cynthia Leifer, and Steph Langel

Download Immune 66 (45 MB .mp3, 76 min)
Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Become a patron of Immune!

Links for this episode

• MicrobeTV Discord Server
• Immunological imprinting (Immunity)
• COVID-19 vaccine imprinting (bioRxiv)
• Original antigenic sin (J Inf Dis)
• Are competition (LJII)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv