Immune

Immune reviews research showing that the migration of neutrophils between endothelial cells activates bactericidal function via mechanosensing.

Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer, and Brianne Barker

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Links for this episode

• MicrobeTV Discord Server
• Trans endothelial migration activates neutrophil killing (Immunity)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Juliet Morrison joins Immune to discuss her career and the research of her laboratory showing that pleural macrophages translocate to the lung during infection to promote improved influenza outcomes.

Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer, and Brianne Barker

Guest: Juliet Morrison

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Download Immune 76 (48 MB .mp3, 67 min)
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Links for this episode

• MicrobeTV Discord Server
• Publishing is broken (Solving for Science)
• Pleural macrophages move to the lung during influenza (PNAS)
• Time stamps by Jolene. Thanks!

Music by Steve Neal
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Ang Cui joins Immune to discuss her career and her work on establishing the Immune Dictionary, a compendium of single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines (>1,400 cytokine-cell type combinations) in mouse lymph nodes in vivo.

Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

Guest: Ang Cui

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Links for this episode

• MicrobeTV Discord Server
• Publishing is broken (Solving for Science)
• Immune Dictionary (Nature)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Carla Nowosad joins Immune to discuss her career and her work on germinal centers, the structure in secondary lymphoid tissues where B cells proliferate, differentiate, and diversify their immunoglobulin genes by somatic hypermutation.

Hosts: Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Carla R. Nowosad

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Links for this episode

• MicrobeTV Discord Server
• B cells and the intestinal microbiome (Sem Immunol)
• B cell selection in gut germinal centres (Nature)
• B cell antigen internalization (Methods Mol Biol)
• Immune synapse architecture (Nat Immunol)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Immune reveals the total mass (1.2kg), number (1.8 trillion), and distribution of immune cells in the human body, with macrophages contributing nearly 50% of the total cellular mass.

Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

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Become a patron of Immune!

Links for this episode

• MicrobeTV Discord Server
• Immune cells in the human body (PNAS)
• Letters read on Immune 73
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

From Cornell University in Ithaca New York, Vincent and Cindy meet with Ellen Rothenberg to review her career in science, starting with work on retroviruses to unraveling transcriptional networks underlying T-cell development and signaling.

Hosts: Vincent Racaniello and Cynthia Leifer

Guest: Ellen Rothenberg

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Download Immune 72 (53 MB .mp3, 73 min)
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Links for this episode

• MicrobeTV Discord Server
• Synthesis of infectious DNA of murine leukaemia virus (Nature)
• Runx factors launch T cell and innate lymphoid programs (Nat Immunol)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Immune explains how, in a mouse model of roundworm infection with Nippostrongylus brasiliensis, exposure to lung-migrating helminths protects mice against SARS-CoV-2 infection.

Hosts: Cynthia Leifer, Stephanie Langel, and Brianne Barker

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Links for this episode

• MicrobeTV Discord Server
• Helminth protects against murine SARS-CoV-2 infection (Sci Immunol)
• Pandemic spared Africa (ScienceInsider)
• Letters read on Immune 71
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Immune explains how mast cells, IgE antibody, and the brain collaborate to promote avoidance of certain foods to evade allergic responses.

Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

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Become a patron of Immune!

Links for this episode

• MicrobeTV Discord Server
• Mast cells and immune avoidance behavior (Nature)
• Immune sensing of food allergens promotes avoidance (Nature)
• Immunology that underlies picky eating (Nature)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Kevin joins Immune to discuss his work showing that antibodies against endogenous retroviruses promote immunotherapy of lung cancer.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guest: Kevin Ng

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Links for this episode

• MicrobeTV Discord Server
• Antibodies against ERVs and lung cancer (Nature)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Immune discusses immunological imprinting, also called original antigenic sin, in the context of infection with SARS-CoV-2 and influenza virus.

Hosts: Vincent Racaniello, Cynthia Leifer, and Steph Langel

Download Immune 66 (45 MB .mp3, 76 min)
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Become a patron of Immune!

Links for this episode

• MicrobeTV Discord Server
• Immunological imprinting (Immunity)
• COVID-19 vaccine imprinting (bioRxiv)
• Original antigenic sin (J Inf Dis)
• Are competition (LJII)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Immune explains the results of a study which show that in mice, functional T cells respond to vaccination for over 10 years and 51 successive immunizations, exhibiting supernumerary cell division and longevity.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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Become a patron of Immune!

Links for this episode

• MicrobeTV Discord Server
• T cells capable of supernumerary division (Nature)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Immune discusses the current understanding of immune memory to SARS-CoV-2 infection and COVID-19 vaccines, which supersedes that of any other acute infectious disease.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Become a patron of Immune!

Links for this episode

• MicrobeTV Discord Server
• COVID-19 immune memory (Imm Rev)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Jon joins Immune to discuss the research of his laboratory on understanding how the innate immune system recognizes and responds to pathogens, and his hypothesis that infection infidelities drive innate immunity.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guest: Jonathan C. Kagan

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Links for this episode

• MicrobeTV Discord Server
• Approaching the asymptote (Cold Spring Harb Symp Quant Biol)
• Infection infidelities drive innate immunity (Science)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Cindy, Steph, Brianne, and Vincent do a rapid review 11 immunology papers, including a wiring diagram for the immune system, group A streptococcus vaccines, systems immunology prediction of vaccines, class switch towards IgG4 after SARS-CoV-2 mRNA vaccination, very bad B cells, monoclonal antibody to two streptococcal M protein epitopes, transcriptional atlas of response to 13 vaccines, impact of SARS-CoV-2 exposure history on T cell and IgG response, neutrophilic inflammation predisposes to RSV infection, commensals avoiding recognition, and continuous germinal center invasion contributes to diversity of immune response.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Become a patron of Immune!

Links for this episode

• MicrobeTV Discord Server
• Tangled web of wires (Nature)
• Path to group A Streptococcus vaccines (Clin Inf Dis)
• Immune end-types predictive of vaccine responses (Nat Immunol)
• IgG4 switch after SARS-CoV-2 mRNA vaccination (Sci Immunol)
• Very bad B cells (Immunity)
• Two epitope Streptococcus monoclonal (EMBO Mol Med)
• Predictor of vaccine-induced antibody responses (Nat Immunol)
• Impact of SARS-CoV-2 exposure history on antibody an T cell response (Cell Rep Med)
• Neutrophilic inflammation and RSV infection (Science)
• Commensals avoiding recognition (Sci Immunol)
• Continuous germinal center invasion and immune response diversity (Cell)
• Time stamps by Jolene. Thanks!

Music by Steve Neal
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Cindy, Steph, Brianne, and Vincent review some of their favorite immunology papers of 2022.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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Links for this episode

• CAR T for SLE (Nat MEd)
• Maternal gut microbiome induced IgG (Sci Immunol)
• Long-primed germinal centers (Nature)
• Fc mediated protection against SARS-CoV-2 VOC (bioRxiv)
• Dark side of macrophages (Nat Med)
• Pregnancy and antibody protection against infection (Nature)
• Regulators of inflammatory response to mRNA vaccines (Nature Immunol)
• Antibody effector function and protection against RSV (Cell)
• Color coded antibodies (bioRxiv)
• Endogenous retroviruses and inflammation (Cell)
• CD8 T cells and vaccine protection against SARS-CoV-2 (Sci Immunol)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

De’Broski joins immune to reveal his remarkable career path and the research of his laboratory on neuroimmunology and the immune response to parasite infections.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guests D’Broski Herbert

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Links for this episode

• Immunology of helminth infections (Ann Rev Immunology)
• Neuroimmune regulatory networks (J Leuk Biol)
• Every cell is an immune cell (Immunity)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

From SLB22 on the Island of Hawai’i, Julia and Musa join Immune to reveal their remarkable career paths, and their research on understanding trained innate immunity.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guests: Julia Bohannon and Musa Mhlanga

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Links for this episode

• From the ashes (Richmond Register)
• Innate immune memory (J Immunol)
• Epigenetics and metabolism in trained immunity (Immunity)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Somali and Phil join Immune to discuss their approaches to immunology education.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guest: Sumali Pandey and Phil Mixter

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Become a patron of Immune!

Links for this episode

• ImmunoReach
• ASMCUE: ASM Conference for Undergraduate Educators (ASMCUE)
• Upcoming ASM Webinars: free Microedu Live! discussions:
  • Friday, October 14, 1:00 PM Eastern time/10:00 AM Pacific time, topic will be the assessment of learning. Register here.
  • Friday, November 4, 1:00 PM Eastern time/10:00 AM Pacific time, topic will be microbiology laboratory biosafety. Register here.
• Journals with relevant education resources:
  • AAI ImmunoHorizons ImmunoHorizons
  • Journal of Microbiology and Biology Education (ASM; open-source, see Tips & Tools for examples):Journal of Microbiology & Biology Education Table of Contents Volume 23, Issue 2 (asm.org)
  • CBE Life Sciences Education CBE–Life Sciences Education (LSE) (lifescied.org) 
• How to tell your professional story effectively – for instruction-focused scientists (including external review): Initiative: External Peer Review of Teaching – The Teaching Academy of the Consortium of West Region Colleges of Veterinary Medicine (westregioncvm.org)
•  ASM Carski Award for Educators: ASM Carski Award for Undergraduate Education
• Undergraduate degree program in Immunology at University of Alabama-Birmingham (only one in the USA): CAS – Undergraduate Immunology Program | UAB
• 3D printable antibody-antigen epitope models Antibody Epitope teaching kit by esuchman – Thingiverse
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

At Cornell University in Ithaca, NY, Mandy joins Immune to discuss her career and her research on understanding how Th17 cells develop and are influenced to be ‘good’ or ‘bad’ in their function.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guest: Mandy McGeachy

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Links for this episode

• Th17 cytokines in health and disease (Immunity)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Immune explains a study of three cohorts of patients with ulcerative colitis which finds major perturbations within the mucosal B cell compartment, highlighting a potential role for these cells in disease pathogenesis.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email
Become a patron of Immune!

Links for this episode

• Gut B cell dysbiosis in ulcerative colitis (Nat Med)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv