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    Taking A New Look At Some Old Bones

    en-usJune 07, 2021

    Podcast Summary

    • Exploring Animal Evolution through Fossilized Bones and OsteocytesPaleontologist Yara Haridi studies fossilized bones to learn about animal behavior and evolution through examining osteocytes and their 'snow angel' imprints, but current technology limits a complete understanding of their functions.

      Bones, which are the libraries of the past, hold valuable information about animal evolution and behavior. Paleontologist Yara Haridi studies these ancient clues by examining the structure of bones and the cells within them, specifically osteocytes. These cells, which help maintain bones and communicate with each other, leave behind a "snow angel" imprint in the bone when they die. By studying these imprints, Yara can learn about the behavior and conditions of extinct animals. However, a limitation in current technology prevents her from gaining a complete understanding of these cells' functions. Thus, the study of fossilized bones and their cellular structures continues to be an essential field in unraveling the mysteries of our planet's history.

    • Ancient bones provide concrete evidence of past events and biological evolutionNew technique reveals intricate details of ancient osteocytes, providing valuable insights into bone biology and our past

      Ancient bones provide concrete evidence of historical events and biological evolution, unlike theoretical models. Paleontologist Yara Haridi, whose PhD focuses on bone evolution, emphasizes that fossil bones tell us what actually happened in the past, rather than just potential possibilities. However, studying fossil osteocytes, the cells responsible for bone maintenance, posed a challenge for Yara as the traditional methods she used failed to provide satisfactory results. She was unable to observe the empty spaces where these cells once lived in sufficient detail. But she didn't give up. With a bit of luck and the help of her collaborators, Yara discovered a new technique that allowed her to generate the best images of ancient osteocytes yet. These images not only revealed fascinating details about the ancient fish's bones but also provided valuable insights into our own bone biology. This innovative approach demonstrates the importance of persistence and collaboration in scientific research, as well as the potential for groundbreaking discoveries that can challenge our current understanding of the natural world.

    • A researcher discovers an unexpected technique for observing cells in detailStaying curious and open to new ideas, even from unexpected sources, can lead to groundbreaking discoveries. Interdisciplinary collaboration can also open up new avenues for research.

      Sometimes the most groundbreaking discoveries can come from the most unexpected places. In this case, a researcher named Maddie stumbled upon a method for observing cells in the most intricate detail, but she had no idea that it already existed and was being used in other fields. Maddie was working on a completely unrelated project when she came across a poster in the hallway of the Helmholtz Institute in Berlin. The images on the poster looked like fossilized cells, and Maddie was shocked to discover that her colleagues had been using a technique called focused ion beam scanning electron microscopy (FIB-SEM) to create these stunning images. At first, Maddie was skeptical and even thought her colleagues might be cheating on her or working with someone else. But when she asked about the method, they were nonchalant and explained that it was a common technique used in their field. Maddie was amazed that she had never heard of it before, despite her extensive background in cell biology. The discovery of FIB-SEM allowed Maddie to observe cells in three dimensions and even observe how they communicate with one another. It was a game-changer in her field and opened up new avenues for research. This story illustrates the importance of staying curious and being open to new ideas, even if they come from unexpected sources. It also highlights the value of interdisciplinary collaboration and the potential for breakthroughs when researchers from different fields come together.

    • Exploring the Evolutionary Purpose of Osteocytes using Advanced Imaging TechnologyScientists are using 3D modeling technology to study the role of osteocytes in bone tissue, which could have given early animals a significant advantage by allowing them to recycle minerals and redistribute them for muscle and brain function.

      Scientists are using advanced imaging technology to create 3D models of osteocytes, cells found in the bone tissue of many animals. This technology, which involves taking slices of a "cake-like" sample and capturing images of each new layer, is not new but applying it to fossils is. Researchers, like Yara, are using this technology to explore the evolutionary purpose of osteocytes. The theory is that these cells evolved to help with mineral metabolism, allowing animals to recycle minerals from their bones and redistribute them to other parts of the body for use in muscles and the brain. This could have given animals with osteocytes a significant advantage over those without, making it an intriguing area of study for the origins of this cell type. Essentially, osteocytes act as a "battery pack" within the skeleton, storing and releasing minerals as needed. The potential discovery that the earliest osteocytes may have had this capability could provide valuable insights into the evolutionary history of these cells.

    • Discovering bone metabolism in a 420 million-year-old fishResearchers found evidence of bone metabolism in a 420 million-year-old fish, revealing its presence in early fish and contributing to the evolution of complex bone structures in vertebrates.

      Researchers have discovered evidence of bone metabolism in a 420 million-year-old ancient fish, providing insights into the evolution of this essential process in vertebrates. Using advanced imaging technology, they found osteocytes, bone cells, and observed signs of bone resorption, which was previously assumed but lacked concrete evidence. This discovery suggests that this process was present in early fish with bones and likely contributed to the dominance of bone structures with osteocytes for millions of years. Yara Harini, the lead researcher, expressed her excitement about the findings, acknowledging the element of luck in the discovery but also emphasizing the importance of diligent research and exploration. This study sheds light on the deep history of bone metabolism and its significance in the development of complex bone structures in vertebrates.

    • Rasha's Departure from NPR's Shortwave TeamRasha leaves NPR, but her love for science and advocacy for creepy crawlers continues. BlackRock's CEO discusses retirement and global capital market challenges on The Bid podcast.

      Rasha, a beloved member of the NPR shortwave team, is leaving her full-time position as a short waiver. Despite her departure, her passion for science and advocacy for creepy crawlers will continue. The team expresses their gratitude for her contributions and believes she will achieve great things in the future. In other news, Larry Fink, the chairman and CEO of BlackRock, discusses challenges facing investors on the latest episode of The Bid podcast. These challenges include retirement and the role of global capital markets in finding solutions. Listeners are encouraged to tune in and subscribe for insights from BlackRock's thought leaders. Overall, Rasha's departure marks an end to an era, but her impact will continue, and BlackRock's podcast offers valuable insights for investors.

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